AutismKB 2.0

Annotation Detail for SUCLA2


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Basic Information Top
Gene Symbol:SUCLA2 ( A-BETA,SCS-betaA )
Gene Full Name: succinate-CoA ligase, ADP-forming, beta subunit
Band: 13q14.2
Quick LinksEntrez ID:8803; OMIM: 603921; Uniprot ID:SUCB1_HUMAN; ENSEMBL ID: ENSG00000136143; HGNC ID: 11448
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-5690TCA cycle variation III (eukaryotic)
Pathway IDPathway Name
hsa00020Citrate cycle (TCA cycle)
hsa00640Propanoate metabolism
hsa01100Metabolic pathways
Pathway IDPathway Name
Pyruvate metabolism and Citric Acid (TCA) cycle
No data
No data
Pathway IDPathway Name
500713Citric acid cycle (TCA cycle)
Related Diseases/Disorders Top
No data
No data
No data
No data
Desease Name
Mitochondrial DNA depletion syndrome, encephalomyopathic form, with methylmalonic aciduria
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of SUCLA2 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of SUCLA2 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of SUCLA2 mRNAaffects expression 17562736
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of SUCLA2 mRNAaffects cotreatment|affects expression 17602206
C055162 clopidogrel clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of SUCLA2 mRNA]decreases reaction|increases expression 19172522
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of SUCLA2 mRNAaffects cotreatment|affects expression 17602206
D008070 Lipopolysaccharides clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of SUCLA2 mRNA]decreases reaction|increases expression 19172522
D015741 Metribolone Metribolone results in increased expression of SUCLA2 proteinincreases expression 17152098
D010126 Ozone Ozone results in decreased expression of SUCLA2 mRNAdecreases expression 16183385
D017239 Paclitaxel SUCLA2 protein affects the susceptibility to Paclitaxelaffects response to substance 16217747
D014747 Vinblastine SUCLA2 protein affects the susceptibility to Vinblastineaffects response to substance 16217747
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D054058 Acute Coronary Syndrome clopidogrel 6.2019106084
MESH:D055371 Acute Lung Injury Lipopolysaccharides 4.1818653653 11850527
MESH:D000236 Adenoma Diethylnitrosamine 2.936695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.0918056438 17162532 16434500 17620307 19052882 19061943
MESH:D000544 Alzheimer Disease Ozone 2.4615513908
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5815570426
MESH:D001249 Asthma Ozone 2.6717854713 16373670
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001859 Bone Neoplasms Paclitaxel 4.7215867366
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.4017474063
MESH:D001943 Breast Neoplasms Paclitaxel 2.4011325840 16273361 16115903 18234424 18323546 16244791 18223236 15136595
MESH:D016535 Bronchial Hyperreactivity Ozone 3.7919059883 18417511 16777450 15516495 14754758 18315731 17626835
MESH:D002100 Cachexia Ozone 4.9316183385
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 9.0916705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 9.0916705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.093084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 9.0917761372 19383236 20935162 16830150 20007298 18978308 11831363 20512989 19539802 20432363 16935385 18788625 17138121 18494052 20214788 19394651 3084413 18971187 20524982 3581430 16288022 19335982 19701751 16698587 19052882 16681979 21159647 19418558 18210153 19519916 18506893 18691550 17173139 16540662 16569478 19107877 19919837 16328049 17055752 20084675 20727157 20101231 19822196 18665156 18785209 17162532 16779866 16502159 19208518 18056438 18393292 16878318 17428255 16807293 10672840 20514400 17978847 10737359 19171122
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 9.0916313753
MESH:D002292 Carcinoma, Renal Cell Vinblastine 3.841485588
MESH:D002318 Cardiovascular Diseases clopidogrel 4.7020180610
MESH:D002386 Cataract Acetaminophen 2.6610977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.016135515
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 7.0117174075 2727394 7505956 21159647
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.8119052882
MESH:D015179 Colorectal Neoplasms Paclitaxel 3.0718802399
MESH:D015179 Colorectal Neoplasms Vinblastine 3.0718802399
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.4918551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.4918551238
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2220387270
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.2818551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.2821346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.2812392966 18071297 17522070 17906064 12153990 11287661 11834606 19416960 16177239 16081117 19164858 14725611 16109766 11739529 19420014 11743745 16227642 16781746 19923254 11529661 10663392 10915739 15619225 19739265 14550746 12705907 19085960 11461765 12958197 16485898 12594235 2444490 17562736 15968718 19370779 14986274 10774834 16393943 11421492 18713872 12540782
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 9.2819107877
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D019446 Endotoxemia Lipopolysaccharides 4.5915328337 15821434 17637181
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.3316302075
MESH:D004938 Esophageal Neoplasms Paclitaxel 2.9216481741
MESH:D005234 Fatty Liver Diethylnitrosamine 3.3221071580 20387270
MESH:D005334 Fever Lipopolysaccharides 4.1411852909 9205823
MESH:D005756 Gastritis Acetaminophen 3.8916983495
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.5216366002
MESH:D006689 Hodgkin Disease Vinblastine 4.1518180244 18501091
MESH:D006930 Hyperalgesia Acetaminophen 2.8116870215
MESH:D007249 Inflammation Diethylnitrosamine 5.5018785209
MESH:D007249 Inflammation Lipopolysaccharides 5.5017963957 9205823 17237260 12878042 17255318
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.7817255318
MESH:D007674 Kidney Diseases Acetaminophen 2.2712587719 15629191
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.7616705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.7616705839
MESH:D007970 Leukopenia Lipopolysaccharides 4.8915821434
MESH:D008080 Liposarcoma Paclitaxel 4.9717353645
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8920032147 18407596 18522880 18665156 19638242
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 2.2612878042
MESH:D008107 Liver Diseases Acetaminophen 4.0119784758 12969438 19014921 16611625 19460945 11587558 12587719 16610002
MESH:D008107 Liver Diseases Diethylnitrosamine 4.0117034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3717185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.797678174
MESH:D008113 Liver Neoplasms Clofibric Acid 7.7917602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 7.7920118626 21278145 20434301 18754104 10737359 19812893 19551842 19638242 20405173 12112319 21071580 19690152 21167192 19294768 20492335 20137499 19996281 19427195 19255062 18644402 20583210 18977376 2862719 19499222 19090486 19833225 20501860 19073162 15885732 18648771 19850985 12771043 19642983 20101389 18978307 21047994 2422723 19426721 20452335 19254457 19256749 15175105 9163691 16942905
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.202876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 6.2019519916 18544905 18308698 18093689 19539802 18253720 17854601 18775883 17942915 18164116 16267830 19126423 19009564 3124819 19004024 18079962 18282651 21159647 16842330 2563599 17174075 9362446
MESH:D008171 Lung Diseases Ozone 3.478266340 19066396
MESH:D055370 Lung Injury Lipopolysaccharides 9.8321114838
MESH:D055370 Lung Injury Ozone 9.8320417186
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.6120970405 21163286 6695378 20512841
MESH:D008175 Lung Neoplasms Ozone 2.618597069 7614698
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 4.2114749477
MESH:D008545 Melanoma Paclitaxel 3.9716342250 12040289 12025231
MESH:D008545 Melanoma Vinblastine 3.9715577323 12374674 18505091 17761969 16432458 16248763 16809738 18176117 18332650 15577320
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D008679 Metaplasia Ozone 5.3210496685
OMIM:609560 MITOCHONDRIAL DNA DEPLETION SYNDROME 2 (MYOPATHIC TYPE) marker/mechanism
OMIM:251880 MITOCHONDRIAL DNA DEPLETION SYNDROME 3 (HEPATOCEREBRAL TYPE) marker/mechanism
OMIM:612073 MITOCHONDRIAL DNA DEPLETION SYNDROME 5 (ENCEPHALOMYOPATHIC WITH METHYLMALONIC ACIDURIA) marker/mechanism
MESH:D009101 Multiple Myeloma Paclitaxel 3.7814749477
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.0018551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.0018551238 7678174
MESH:D009362 Neoplasm Metastasis clopidogrel 10.0811875746
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 10.083581430 9029167
MESH:D009362 Neoplasm Metastasis Paclitaxel 10.0815867366
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.5818514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.5820387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.3320387270
MESH:D009503 Neutropenia Vinblastine 4.7217378895
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.3312819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.3316049721
MESH:D010014 Osteolysis Paclitaxel 5.1715867366
MESH:D010051 Ovarian Neoplasms Paclitaxel 3.0311161223
MESH:D010146 Pain Acetaminophen 2.5016870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4616540662
MESH:D010538 Peritonitis Ozone 4.3116369182
MESH:D011014 Pneumonia Lipopolysaccharides 11.7612224865 11605937
MESH:D011014 Pneumonia Ozone 11.7618929643 18007984 18381685
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.682563599
MESH:D011471 Prostatic Neoplasms Paclitaxel 3.8316729912 17136230 16356831 17172428
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.8210835634
MESH:D012170 Retinal Vein Occlusion clopidogrel 6.3019371211
MESH:D012640 Seizures 2,4-dinitrotoluene 6.1818551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.1818551238
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.6918456281
MESH:D013274 Stomach Neoplasms Paclitaxel 2.6918396642 18506536
MESH:D024801 Tauopathies Paclitaxel 5.0116930453
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.3015821434
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.097505956
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.1816049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.1816049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.6510091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.6510091137
MESH:D014581 Urticaria Acetaminophen 3.1210982225
MESH:D014625 Vaginal Neoplasms Vinblastine 5.2215577323
Pathway ID Pathway Name
KEGG:00020 Citrate cycle (TCA cycle)
KEGG:01100 Metabolic pathways
KEGG:00640 Propanoate metabolism
REACT:1046 Pyruvate metabolism and Citric Acid (TCA) cycle
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA36245
    • No data
    Releated disease ID Related disease Name
    PA444997Muscular Diseases
    PA157379134Myalgia unspecified
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00139 - Ubicoenzyme Anti-Ulcer Agents;Dietary supplement;Micronutrient;Radiation-Protective Agents
    No data
    No data
    No data

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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