AutismKB 2.0

Annotation Detail for IL18R1


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Basic Information Top
Gene Symbol:IL18R1 ( CD218a,CDw218a,IL-1Rrp,IL18RA,IL1RRP )
Gene Full Name: interleukin 18 receptor 1
Band: 2q12.1
Quick LinksEntrez ID:8809; OMIM: 604494; Uniprot ID:IL18R_HUMAN; ENSEMBL ID: ENSG00000115604; HGNC ID: 5988
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04060Cytokine-cytokine receptor interaction
No data
Pathway IDPathway Name
200034IL12-mediated signaling events
200131IL23-mediated signaling events
200197IL12 signaling mediated by STAT4
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1779Cervical cancer
1809HIV infection
1834Sarcoidosis
2074Asthma
Desease Name
Celiac Disease
IMMUNE
Desease Name
Asthma
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of IL18R1 proteinaffects expression 20106945
D001151 Arsenic [Arsenic co-treated with Fluorides] results in decreased expression of IL18R1 mRNAaffects cotreatment|decreases expression 19962721
D001151 Arsenic Arsenic results in decreased expression of IL18R1 mRNAdecreases expression 19962721
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of IL18R1 mRNAdecreases expression 20106945
D000001 Calcimycin [Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL18R1 proteinaffects cotreatment|increases expression 14994387
D016572 Cyclosporine Cyclosporine results in increased expression of IL18R1 mRNAincreases expression 20106945
D016264 Dextran Sulfate IL18R1 protein affects the susceptibility to Dextran Sulfateaffects response to substance 12940437
D004137 Dinitrochlorobenzene Dinitrochlorobenzene results in increased expression of IL18R1 mRNAincreases expression 11708898
D005459 Fluorides [Arsenic co-treated with Fluorides] results in decreased expression of IL18R1 mRNAaffects cotreatment|decreases expression 19962721
D005459 Fluorides Fluorides results in decreased expression of IL18R1 mRNAdecreases expression 19962721
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of IL18R1 mRNAaffects binding|increases activity|increases expression 19710929
D013755 Tetradecanoylphorbol Acetate [Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL18R1 proteinaffects cotreatment|increases expression 14994387
C024746 tobacco tar tobacco tar results in decreased expression of IL18R1 mRNAdecreases expression 19559774
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.2718653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0120127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.736695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.6716434500
MESH:D018246 Adrenocortical Adenoma Arsenic 5.4317306315
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2519183758
MESH:D020261 Arsenic Poisoning Arsenic 2.9016835338 12569548 16251483 18414634
MESH:D050197 Atherosclerosis Arsenic 3.3312928151 19371607
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2919483382
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0220146248 17474063
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.6615504454 17687452
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 3.2812907637 21507988 12619106
MESH:D006528 Carcinoma, Hepatocellular Arsenic 3.2817306315 16507464
MESH:D002294 Carcinoma, Squamous Cell Arsenic 7.8618922899 17687452 15504454
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.8620419170
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 7.8618922899
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.2118640142
MESH:D002318 Cardiovascular Diseases Arsenic 3.5415738583 17938729 19152805
MESH:D002340 Carotid Artery Diseases Arsenic 4.4316973168 18022660
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.3212371664
MESH:D002471 Cell Transformation, Neoplastic tobacco tar 7.3219559774
MESH:D002779 Cholestasis Cyclosporine 8.1019486331
MESH:D002779 Cholestasis pirinixic acid 8.1019176532
MESH:D003092 Colitis Dextran Sulfate 5.7816375993 15652231 12065299 18023891
MESH:D003093 Colitis, Ulcerative Dinitrochlorobenzene 3.8917373747 19159591
MESH:D017449 Dermatitis, Allergic Contact Dinitrochlorobenzene 4.3715491423
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4818249437
MESH:D004487 Edema pirinixic acid 7.4612083418
MESH:D004487 Edema Tetradecanoylphorbol Acetate 7.468113982 16716910 7812673 11698051 8273558 15177302 9599246
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0416530937
MESH:D005234 Fatty Liver Cyclosporine 8.0319224547
MESH:D005234 Fatty Liver pirinixic acid 8.0319236843 20131406
MESH:D005355 Fibrosis Cyclosporine 3.3212639820 12168785
MESH:D005534 Foot Diseases Arsenic 5.786392382
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.418708960
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7220471113
MESH:D006333 Heart Failure pirinixic acid 2.6220558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6215720958
MESH:D006529 Hepatomegaly pirinixic acid 3.1716221962 19772884 19176532 18467677
MESH:D006943 Hyperglycemia pirinixic acid 3.3120558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.5917050553
MESH:D006973 Hypertension Arsenic 5.4616076760 11953799 9931084
MESH:D006973 Hypertension Cyclosporine 5.4610903974
MESH:D006987 Hypesthesia Arsenic 5.7816093927
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 3.1511698051 8273558 7562506 7812673 15177302
MESH:D015212 Inflammatory Bowel Diseases Dextran Sulfate 4.6915339030 20423518
MESH:D007333 Insulin Resistance pirinixic acid 2.7216306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6615604871
MESH:D007642 Keratosis Arsenic 5.1812749816 16930632
MESH:D007674 Kidney Diseases Cyclosporine 2.4118776723 10903974 8314463
MESH:D007680 Kidney Neoplasms Cyclosporine 2.8512371664
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.6417339181
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3415474484
MESH:D008107 Liver Diseases Arsenic 2.5711134558
MESH:D008113 Liver Neoplasms Aflatoxin B1 11.129163691 15890375 2125692 18177683
MESH:D008113 Liver Neoplasms Arsenic 11.1216368122
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.1221137059 20195826
MESH:D008113 Liver Neoplasms pirinixic acid 11.1220007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 2.828603461
MESH:D008175 Lung Neoplasms Aflatoxin B1 5.0314755239
MESH:D008175 Lung Neoplasms Arsenic 5.0317306315 19168569 17976673
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 5.0318520028 20869020 17053015 20064080 18569708 6695378 20464547 18816296 20135361
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 5.0311807781
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 3.448985016
MESH:D008545 Melanoma Dinitrochlorobenzene 3.2112202904 17334785
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0116801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3016381670
MESH:D009135 Muscular Diseases pirinixic acid 3.6816239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1919151258
MESH:D017202 Myocardial Ischemia Arsenic 4.0915371236
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0516411023
MESH:D009369 Neoplasms Benzo(a)pyrene 5.0311141357
MESH:D009369 Neoplasms pirinixic acid 5.0317405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4119348381 18481113
MESH:D009436 Neural Tube Defects Arsenic 3.5416620997
MESH:D020078 Neurogenic Inflammation Arsenic 4.5217056641
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D010051 Ovarian Neoplasms Arsenic 2.7817306315
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 3.1715976015
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 4.4712065085 18404319 8330346 18922899
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.3416093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.1816905509 6392382 15371236
MESH:D011230 Precancerous Conditions Cyclosporine 3.3512371664
MESH:D011471 Prostatic Neoplasms Arsenic 3.2716140617
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.2717292933
MESH:D011507 Proteinuria Arsenic 4.1521343184
MESH:D011565 Psoriasis Cyclosporine 2.2716882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4519058328
MESH:D012871 Skin Diseases Arsenic 2.7817453740 19834688 16759981 15952646 17548696 17938729 16702368 6392382 17050553 18709164 16353154
MESH:D012878 Skin Neoplasms Arsenic 9.9617976673 19538983 17029826 17050553 15504454 16251483
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.9619755658 10029692
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 9.9618404319 11807781 8330346 12065085 8985016
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D001749 Urinary Bladder Neoplasms Arsenic 5.3319322015 19429237 11144890 15987713 17976673 18640142 17306315
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.3317053015
MESH:D014605 Uveitis Cyclosporine 4.201336536
MESH:D014652 Vascular Diseases Arsenic 4.9317056641
MESH:D014985 Xerophthalmia Cyclosporine 4.6617120751
Pathway ID Pathway Name
KEGG:04060 Cytokine-cytokine receptor interaction
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29804
    • No data
    Releated disease ID Related disease Name
    PA443652Celiac Disease
    PA443815Crohn Disease
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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