AutismKB 2.0

Annotation Detail for NRP2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:NRP2 ( MGC126574,NP2,NPN2,PRO2714,VEGF165R2 )
Gene Full Name: neuropilin 2
Band: 2q33.3
Quick LinksEntrez ID:8828; OMIM: 602070; Uniprot ID:NRP2_HUMAN; ENSEMBL ID: ENSG00000118257; HGNC ID: 8005
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Axon guidance
Signaling by VEGF
Pathway IDPathway Name
200151VEGFR1 specific signals
200161Signaling events mediated by VEGFR1 and VEGFR2
No data
Pathway IDPathway Name
500103NrCAM interactions
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1934Cancer
2124Autistic disorder
Desease Name
PSYCH
Autism
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of NRP2 mRNAincreases expression 19933214
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NRP2 mRNAaffects expression 16483693
D001104 Arbutin Arbutin results in increased expression of NRP2 mRNAincreases expression 17103032
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in decreased expression of NRP2 mRNAdecreases expression 18687144
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of NRP2 mRNAaffects expression 17484886
D002713 Chlorine [Ozone co-treated with Chlorine] results in increased expression of NRP2 mRNAaffects cotreatment|increases expression 18636392
D002117 Calcitriol Calcitriol results in decreased expression of NRP2 mRNAdecreases expression 16002434
D002117 Calcitriol Calcitriol results in increased expression of NRP2 mRNAincreases expression 16002434
D007608 Kainic Acid NRP2 protein affects the susceptibility to Kainic Acidaffects response to substance 18657176
C064769 N-acetylsphingosine sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of NRP2 mRNA]decreases expression|decreases reaction 15741222
C029938 nickel sulfate nickel sulfate results in increased expression of NRP2 mRNAincreases expression 16780908
D010126 Ozone [Ozone co-treated with Chlorine] results in increased expression of NRP2 mRNAaffects cotreatment|increases expression 18636392
D010433 Pentylenetetrazole NRP2 protein affects the susceptibility to Pentylenetetrazoleaffects response to substance 18657176
C006253 pirinixic acid pirinixic acid results in increased expression of NRP2 mRNAincreases expression 18301758
C006253 pirinixic acid pirinixic acid results in increased expression of NRP2 mRNAincreases expression 12832660
C025299 polyphenols polyphenols results in decreased expression of NRP2 mRNAdecreases expression 16293270
C035988 procymidone procymidone results in decreased expression of NRP2 mRNAdecreases expression 15686871
C410733 scriptaid scriptaid affects the expression of NRP2 mRNAaffects expression 18813790
C060506 sphingosine 1-phosphate sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of NRP2 mRNA]decreases expression|decreases reaction 15741222
C060506 sphingosine 1-phosphate sphingosine 1-phosphate inhibits the reaction [Thalidomide results in decreased expression of NRP2 mRNA]decreases expression|decreases reaction 15741222
D013792 Thalidomide sphingosine 1-phosphate inhibits the reaction [Thalidomide results in decreased expression of NRP2 mRNA]decreases expression|decreases reaction 15741222
C025643 vinclozolin vinclozolin affects the expression of NRP2 mRNAaffects expression 19015723
C025643 vinclozolin vinclozolin results in decreased expression of NRP2 mRNAdecreases expression 15686871
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Thalidomide 4.508333272
MESH:D000138 Acidosis Ammonium Chloride 3.5018287403
MESH:D055371 Acute Lung Injury Chlorine 15.0020601635
MESH:D055371 Acute Lung Injury nickel sulfate 15.0012718980 16100012 19131640 11954676
MESH:D055371 Acute Lung Injury pirinixic acid 15.0018653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.4216434500
MESH:D000544 Alzheimer Disease Ozone 2.4215513908
MESH:D000690 Amyotrophic Lateral Sclerosis Thalidomide 4.3116510725
MESH:D001008 Anxiety Disorders vinclozolin 3.5819015723
MESH:D001169 Arthritis, Experimental Thalidomide 4.189598899
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5415570426
MESH:D001249 Asthma Ozone 2.6217854713 16373670
MESH:D001321 Autistic Disorder marker/mechanism 17427189
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.0819483382
MESH:D001943 Breast Neoplasms Calcitriol 2.6211237771
MESH:D016535 Bronchial Hyperreactivity Ozone 3.6218417511 19059883 15516495 14754758 18315731 17626835 16777450
MESH:D002100 Cachexia Ozone 4.6816183385
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.7216192424 16011737 16050911 18705752 3786805 16124888 15673190 10355542 15721981 16097048 16227642 15700767
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.4218788625
MESH:D006528 Carcinoma, Hepatocellular Thalidomide 3.4216313753
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 2.6011237771
MESH:D018281 Cholangiocarcinoma Thalidomide 4.8118291259
MESH:D002779 Cholestasis pirinixic acid 2.7719176532
MESH:D003092 Colitis Thalidomide 4.7916680017
MESH:D003110 Colonic Neoplasms polyphenols 2.6616293270
MESH:D016510 Corneal Neovascularization Thalidomide 5.519301478
MESH:D003389 Cranial Nerve Diseases Thalidomide 6.259200351
MESH:D019465 Craniofacial Abnormalities Thalidomide 2.969200351
MESH:D003424 Crohn Disease Thalidomide 4.1316078585
MESH:D003456 Cryptorchidism vinclozolin 4.2814966744
MESH:D003643 Death Pentylenetetrazole 6.686431079
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 3.6116823706 16780908 11298694
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3918249437
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 4.1015027814 4309450 6884620 19085960 3786805 7440962 6623471 16177239 15998439 9327722 7179309 15968718 21278145 16227642 10915739 2869522 3732212 17522070 10092053 11566570 7120509 19336974
MESH:D056486 Drug-Induced Liver Injury polyphenols 4.1019370779
MESH:D004417 Dyspnea Chlorine 4.5720016425
MESH:D004487 Edema pirinixic acid 2.4212083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 3.8715138306
MESH:D004832 Epilepsy, Absence Pentylenetetrazole 5.586426943
MESH:D005234 Fatty Liver Carbon Tetrachloride 7.4715959796 12795759 12631006 16239168 17595544 61145 16045604 19224547
MESH:D005234 Fatty Liver pirinixic acid 7.4720131406 19236843
MESH:D005355 Fibrosis Carbon Tetrachloride 3.3918705752
MESH:D005739 Gas Poisoning Chlorine 4.9520016425
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.8716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.2416417039
MESH:D005871 Giant Lymph Node Hyperplasia Thalidomide 6.2512701121
MESH:D005910 Glioma Thalidomide 3.7916327979
MESH:D006333 Heart Failure pirinixic acid 2.5020558911
MESH:D006505 Hepatitis Carbon Tetrachloride 3.5319110552 19900420
MESH:D006529 Hepatomegaly pirinixic acid 2.9318467677 16221962 19772884 19176532
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.4716899240
MESH:D006943 Hyperglycemia pirinixic acid 3.1220558911
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.0215338365
MESH:D007248 Infertility, Male vinclozolin 3.0016467254
MESH:D007249 Inflammation polyphenols 5.6616366677
MESH:D007249 Inflammation Thalidomide 5.6616134734
MESH:D007333 Insulin Resistance pirinixic acid 2.5916306350
MESH:D007898 Leishmaniasis, Visceral Thalidomide 4.2916514283
MESH:D015470 Leukemia, Myeloid, Acute Thalidomide 3.2118720364
MESH:D007984 Leydig Cell Tumor vinclozolin 4.6716417039
MESH:D017880 Limb Deformities, Congenital Thalidomide 4.4110473037
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.9217334410 17157831 11408273 17174718 21278145 11903743 16239168 16221502 16943688
MESH:D008103 Liver Cirrhosis Thalidomide 6.9217174718 16943688
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.5716136751 15052691 12898905 17721639 17698563 17708605 17922224 18210741 17481882 14724832 17714472 18418968 18054572 15123356 17869086 17565644 18277467 18339082 12609069 11481614 17557913 15338365 14716833 17766677 18472094 15650968 16033810 18481824 18420326 12958196 16015684 10355542 12445418 18279442 16011737 18166357 14748882 15730626 18395914 18705752 18376398 20821823 15931870 17900296 18251166 15876570 12649538 18156304 18263696 16097048 15959796 13678700 15370692 17631135 12546737 15673190 14512876 18187930 18412020 12445421 17823541 12667390 12666154 15057751 14716496 12632514 15818738 17640975 18472332 12632512 15925388 15362042 17976157 15893842 18006644 17805973 16638106 18429990 18395095 18205269 14620537 17525996 12389079 12741479 16248980 16116963 17944888 16027843 18317297 16192424 15996030 12586293 17761835
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5715474484
MESH:D008106 Liver Cirrhosis, Experimental Thalidomide 3.5715465738
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.2715720792 17285989 16964402 16246199 15830285
MESH:D008107 Liver Diseases polyphenols 4.2716698588
MESH:D017093 Liver Failure Carbon Tetrachloride 4.1015123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.6314706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.3519294768
MESH:D008113 Liver Neoplasms pirinixic acid 4.3516377806 20007298 15890375
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.5712014681 15583823
MESH:D008171 Lung Diseases Ozone 3.3319066396 8266340
MESH:D055370 Lung Injury Asbestos, Crocidolite 9.0317365036
MESH:D055370 Lung Injury Ozone 9.0320417186
MESH:D008175 Lung Neoplasms Ozone 2.098597069 7614698
MESH:D008545 Melanoma Thalidomide 3.0816098027 12829675 17089043
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.1616966607 16166281 18303189
MESH:D008679 Metaplasia Ozone 5.0510496685
MESH:D009101 Multiple Myeloma Thalidomide 4.1419112201 15920492 15741222 15867202 15744524 17168659 15939924 19112817 16445831 19372569
MESH:D009135 Muscular Diseases pirinixic acid 3.4416239165
MESH:D009190 Myelodysplastic Syndromes Thalidomide 4.1918720364
MESH:D009203 Myocardial Infarction pirinixic acid 2.1119151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.8916411023
MESH:D009369 Neoplasms pirinixic acid 1.9217405874
MESH:D009421 Nervous System Malformations Thalidomide 4.8616859833
MESH:D009765 Obesity pirinixic acid 1.8020558911
MESH:D010051 Ovarian Neoplasms Thalidomide 3.4716288038
MESH:D010291 Paresis Thalidomide 6.259200351
MESH:D010538 Peritonitis Ozone 4.0716369182
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.8310923243
MESH:D011014 Pneumonia Ozone 4.3318381685 18929643 18007984
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Thalidomide 4.1917031469
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 3.8419015723 18220299 18042343
MESH:D011469 Prostatic Diseases vinclozolin 4.8718220299
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.7215572423
MESH:D011471 Prostatic Neoplasms Calcitriol 3.8115754350 18247401 16644109 16289102 12479363
MESH:D011471 Prostatic Neoplasms Thalidomide 3.8116729912
MESH:D011472 Prostatitis vinclozolin 4.8718629315
MESH:D011536 Prurigo Thalidomide 6.2512755975
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.0017365031 17322281 17975199 15814490
MESH:D015427 Reperfusion Injury pirinixic acid 2.3519058328
MESH:D012120 Respiration Disorders Chlorine 5.1618579056
MESH:D019873 Schnitzler Syndrome Thalidomide 5.8816096327
MESH:D012640 Seizures marker/mechanism 18657176
MESH:D012640 Seizures Kainic Acid 7.2217827730 14637104 10686065 1641125 18657176 16336964 15686955 19414003 19186208
MESH:D012640 Seizures Pentylenetetrazole 7.2218164287 18657176 16054440 8954991 15475178 3037702 6431079 3352866 19660546 2616065
MESH:D012893 Sleep Disorders Kainic Acid 5.6319414003
MESH:D013276 Stomach Ulcer Thalidomide 4.1115138204
MESH:D013705 Temporomandibular Joint Disorders polyphenols 5.2017997062
MESH:D014652 Vascular Diseases Thalidomide 5.4215741222
MESH:D014947 Wounds and Injuries sphingosine 1-phosphate 5.4015541073
Pathway ID Pathway Name
REACT:18266 Axon guidance
REACT:12529 Signaling by VEGF
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA31784
    • No data
    Releated disease ID Related disease Name
    PA443937Drug Toxicity
    Releated drug ID Related drug Name
    PA449212daunorubicin
    PA448478l-arginine
    PA450635nitric oxide
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved