AutismKB 2.0

Annotation Detail for NRP1


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Basic Information Top
Gene Symbol:NRP1 ( BDCA4,CD304,DKFZp686A03134,DKFZp781F1414,NP1,NRP,VEGF165R )
Gene Full Name: neuropilin 1
Band: 10p11.22
Quick LinksEntrez ID:8829; OMIM: 602069; Uniprot ID:NRP1_HUMAN; ENSEMBL ID: ENSG00000099250; HGNC ID: 8004
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04360Axon guidance
Pathway IDPathway Name
Axon guidance
Signaling by VEGF
Pathway IDPathway Name
200151VEGFR1 specific signals
200161Signaling events mediated by VEGFR1 and VEGFR2
Pathway IDPathway Name
P00007Axon guidance mediated by semaphorins
Pathway IDPathway Name
500097L1CAM interactions
500075SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
500077CRMPs in Sema3A signaling
500100Signal transduction by L1
500101CHL1 interactions
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C063609 1,2-dimethyl-4-nitrobenzene 1,2-dimethyl-4-nitrobenzene results in increased expression of NRP1 mRNAincreases expression 19784758
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of NRP1 mRNAdecreases expression 19933214
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in increased expression of NRP1 mRNAincreases expression 20406850
D000082 Acetaminophen Acetaminophen affects the expression of NRP1 mRNAaffects expression 19784758
D000082 Acetaminophen Acetaminophen results in decreased expression of NRP1 mRNAdecreases expression 19784758
D000082 Acetaminophen Acetaminophen results in increased expression of NRP1 mRNAincreases expression 19784758
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of NRP1 proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NRP1 mRNAaffects expression 16483693
D000968 Antimycin A Antimycin A results in decreased expression of NRP1 mRNAdecreases expression 19304788
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of NRP1 mRNAdecreases expression 20064835
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of NRP1 mRNAincreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of NRP1 mRNAdecreases expression 20382639
19150397
C053541 bicalutamide bicalutamide results in decreased expression of NRP1 mRNAdecreases expression 15638997
C006780 bisphenol A bisphenol A affects the expression of NRP1 mRNAaffects expression 20170705
C459604 candoxin candoxin results in increased expression of NRP1 mRNAincreases expression 16309724
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of NRP1 mRNAaffects expression 17484886
D003520 Cyclophosphamide Cyclophosphamide results in decreased expression of NRP1 mRNAdecreases expression 15331540
D016572 Cyclosporine Cyclosporine affects the expression of NRP1 mRNAaffects expression 20106945
C014347 decitabine [decitabine co-treated with Depsipeptides] results in decreased expression of NRP1 mRNAaffects cotreatment|decreases expression 17064661
D047630 Depsipeptides [decitabine co-treated with Depsipeptides] results in decreased expression of NRP1 mRNAaffects cotreatment|decreases expression 17064661
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of NRP1 mRNAincreases expression 14664709
D002117 Calcitriol Calcitriol results in decreased expression of NRP1 mRNAdecreases expression 16002434
D004317 Doxorubicin NRP1 protein affects the susceptibility to Doxorubicinaffects response to substance 16217747
D004958 Estradiol Estradiol results in increased expression of NRP1 mRNAincreases expression 14664709
D000431 Ethanol Ethanol results in decreased expression of NRP1 mRNAdecreases expression 15353170
D005419 Flavonoids Flavonoids results in increased expression of NRP1 mRNAincreases expression 18035473
D005472 Fluorouracil NRP1 protein results in decreased susceptibility to Fluorouracildecreases response to substance 15956974
C056507 gemcitabine NRP1 protein results in decreased susceptibility to gemcitabinedecreases response to substance 15956974
C010176 halofuginone halofuginone results in increased expression of NRP1 mRNAincreases expression 17180598
D008345 Manganese Manganese results in increased expression of NRP1 mRNAincreases expression 17175027
C025340 manganese chloride manganese chloride results in increased expression of NRP1 mRNAincreases expression 17175027
D008769 Methylnitronitrosoguanidine Methylnitronitrosoguanidine results in increased expression of NRP1 mRNAincreases expression 15120970
C064769 N-acetylsphingosine N-acetylsphingosine results in decreased expression of NRP1 mRNAdecreases expression 15741222
C064769 N-acetylsphingosine sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of NRP1 mRNA]decreases expression|decreases reaction 15741222
C022838 nickel chloride nickel chloride results in decreased expression of NRP1 mRNAdecreases expression 12839937
D009578 Nitrobenzenes Nitrobenzenes analog results in increased expression of NRP1 mRNAincreases expression 19784758
C030110 oxaliplatin oxaliplatin results in increased expression of NRP1 proteinincreases expression 18790786
D017239 Paclitaxel Paclitaxel results in increased expression of NRP1 mRNAincreases expression 19682730
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of NRP1 mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of NRP1 mRNAdecreases expression 19482888
C006253 pirinixic acid pirinixic acid results in increased expression of NRP1 mRNAincreases expression 18301758
D012402 Rotenone Rotenone results in decreased expression of NRP1 mRNAdecreases expression 19304788
C060506 sphingosine 1-phosphate sphingosine 1-phosphate inhibits the reaction [Thalidomide results in decreased expression of NRP1 mRNA]decreases expression|decreases reaction 15741222
C060506 sphingosine 1-phosphate sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of NRP1 mRNA]decreases expression|decreases reaction 15741222
C060506 sphingosine 1-phosphate sphingosine 1-phosphate inhibits the reaction [Thalidomide results in decreased expression of NRP1 mRNA]decreases expression|decreases reaction 15741222
D014284 Triiodothyronine Triiodothyronine results in increased expression of NRP1 mRNAincreases expression 15953391
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of NRP1 mRNAincreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of NRP1 mRNAdecreases expression 20159946
19933214
D013792 Thalidomide sphingosine 1-phosphate inhibits the reaction [Thalidomide results in decreased expression of NRP1 mRNA]decreases expression|decreases reaction 15741222
D013792 Thalidomide Thalidomide results in decreased expression of NRP1 mRNAdecreases expression 15741222
D013792 Thalidomide sphingosine 1-phosphate inhibits the reaction [Thalidomide results in decreased expression of NRP1 mRNA]decreases expression|decreases reaction 15741222
D013853 Thioacetamide Thioacetamide results in increased expression of NRP1 mRNAincreases expression 19784758
D014107 Tosyllysine Chloromethyl Ketone Tosyllysine Chloromethyl Ketone inhibits the reaction [FGF2 protein results in increased expression of NRP1 mRNA]decreases reaction|increases expression 16289960
C012589 trichostatin A trichostatin A results in increased expression of NRP1 mRNAincreases expression 16330548
C012589 trichostatin A trichostatin A results in increased expression of NRP1 proteinincreases expression 16330548
C113580 U 0126 U 0126 inhibits the reaction [FGF2 protein results in increased expression of NRP1 mRNA]decreases reaction|increases expression 16289960
C025643 vinclozolin vinclozolin affects the expression of NRP1 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 16.4217676605 18926900
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 16.426195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 16.4211752688 14514962 15322242
MESH:D000014 Abnormalities, Drug-Induced Thalidomide 16.428333272
MESH:D000138 Acidosis Ammonium Chloride 8.8518287403
MESH:D000138 Acidosis Ethanol 8.8511192467
MESH:D000168 Acrocephalosyndactylia U 0126 5.0017694057
MESH:D055371 Acute Lung Injury pirinixic acid 2.6718653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 8.9620127859 20464547
MESH:D000230 Adenocarcinoma Doxorubicin 8.9617418594
MESH:D000230 Adenocarcinoma Estradiol 8.9611473722
MESH:D000230 Adenocarcinoma Fluorouracil 8.9617638652
MESH:D000236 Adenoma Benzo(a)pyrene 2.366695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 14.4717620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 14.4716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 14.4716835633
MESH:D000419 Albuminuria Doxorubicin 4.0821441931
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 4.8215451039 15451040
MESH:D000686 Amyloidosis Diethylstilbestrol 4.0215469931
MESH:D000690 Amyotrophic Lateral Sclerosis Thalidomide 4.0416510725
MESH:D000740 Anemia Fluorouracil 7.2815504547 17963324 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.2811748828
MESH:D000756 Anemia, Sideroblastic Manganese 9.5816910769
MESH:D000756 Anemia, Sideroblastic manganese chloride 9.5816910769
MESH:D000799 Angioedema Acetaminophen 3.3510982225
MESH:D000853 Anophthalmos Ethanol 4.3415513904
MESH:D001008 Anxiety Disorders Ethanol 7.7311141031
MESH:D001008 Anxiety Disorders vinclozolin 7.7319015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.6019183758
MESH:D001161 Arteriosclerosis Cyclophosphamide 4.1315014928
MESH:D001169 Arthritis, Experimental Thalidomide 3.919598899
MESH:D001321 Autistic Disorder Acetaminophen 1.4818445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 12.8319483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 12.8312125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 12.8319483382
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.2915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.4415746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.2014601052
MESH:D001859 Bone Neoplasms Paclitaxel 4.1215867366
MESH:D001862 Bone Resorption bisphenol A 3.4311985600
MESH:D001932 Brain Neoplasms Doxorubicin 3.3917150277
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 8.8317474063 20146248
MESH:D001943 Breast Neoplasms bisphenol A 8.8317123778
MESH:D001943 Breast Neoplasms Calcitriol 8.8311237771
MESH:D001943 Breast Neoplasms Cyclophosphamide 8.8315093573 11325840 17020986 18234424 16978400 17388661 12006526 15136595 18323546
MESH:D001943 Breast Neoplasms decitabine 8.8318320071 19208741
MESH:D001943 Breast Neoplasms Diethylstilbestrol 8.8315324884 17129689
MESH:D001943 Breast Neoplasms Doxorubicin 8.8318382427 16264153 15994142 16115903 16595493 11325840 17369602 16096432 15634643 19526202 16826403 18628466 17983394 15939500 15993339 18695136 15567936 15668708 15692762 15136595 16322301 16935488 18234424 17426702
MESH:D001943 Breast Neoplasms Estradiol 8.8319861407 17261762 17289903 14630087 18497071 16675129 17018787 12948864
MESH:D001943 Breast Neoplasms Fluorouracil 8.8316595493 16110121 16557594 15136595 18608205 18357371 19217205
MESH:D001943 Breast Neoplasms gemcitabine 8.8317039268 18382427
MESH:D001943 Breast Neoplasms Paclitaxel 8.8318323546 18223236 16273361 16115903 16244791 18234424 15136595 11325840
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 8.8320435547
MESH:D002056 Burns Ethanol 4.1816374292
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.9816111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.3116097048 15721981 10355542 18705752 3786805 15700767 16011737 15673190 16050911 16124888 16227642 16192424
MESH:D002276 Carcinoid Tumor Doxorubicin 10.7016051944
MESH:D002276 Carcinoid Tumor Fluorouracil 10.7016051944
MESH:D002277 Carcinoma Fluorouracil 6.9017121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 6.9016835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 33.2416705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 33.243084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 33.2421507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 33.2418788625
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 33.2419701751
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 33.2416924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 33.2416234567 18059187 16023760 17876044
MESH:D006528 Carcinoma, Hepatocellular Estradiol 33.2416924424
MESH:D006528 Carcinoma, Hepatocellular Ethanol 33.2415289165 18788625 15763234
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 33.2417045692 17088986 17971768 18930000 16799960 16332177
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 33.2416313753
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 33.2420007298 1701930 20935162 17173139 6705139
MESH:D006528 Carcinoma, Hepatocellular Thalidomide 33.2416313753
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 33.2417997003
MESH:D002278 Carcinoma in Situ bisphenol A 4.5017123778
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 4.4016152834
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 9.4616201981
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 9.4616201981 1485588
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 9.4618695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 12.5520419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 12.5511237771
MESH:D002294 Carcinoma, Squamous Cell decitabine 12.5519215824
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 12.556189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 12.5516280240 16757204 18986760 17066447
MESH:D006332 Cardiomegaly Ethanol 5.9019332462
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 5.9016120746 18670907 18850075
MESH:D009202 Cardiomyopathies Doxorubicin 3.2017007740 18627295 16242529 17131338 17974986 16364871 16731534 17519947 15811867 15476868 16952015 17308081 16109756 16612575 17928571 17351982 16278810 16651473 15792986 17329180 16455267 17924179 15505089 17382496 16269455
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.7617334414 16243910
MESH:D002386 Cataract Acetaminophen 2.2810977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 17.476135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 17.4720889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 17.4712371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 17.4718566989
MESH:D002471 Cell Transformation, Neoplastic Methylnitronitrosoguanidine 17.472727394
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.784080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 13.9116835633
MESH:D018281 Cholangiocarcinoma Thalidomide 13.9118291259
MESH:D018281 Cholangiocarcinoma Thioacetamide 13.9118291259
MESH:D002779 Cholestasis Cyclosporine 6.5419486331
MESH:D002779 Cholestasis pirinixic acid 6.5419176532
MESH:D002971 Cleft Lip Ethanol 3.3215513904
MESH:D002972 Cleft Palate Ethanol 5.2015513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.2015340226 16354765 8697196 15668235 12621046
MESH:D003092 Colitis Thalidomide 4.3816680017
MESH:D003110 Colonic Neoplasms decitabine 5.3317616700
MESH:D003110 Colonic Neoplasms Fluorouracil 5.3317725105 17172411 16510598 17169374 15001691 17018589 16340194 18772588 17016597 17287894
MESH:D003110 Colonic Neoplasms oxaliplatin 5.3316024531 16004971 16510598
MESH:D015179 Colorectal Neoplasms decitabine 5.8518981723
MESH:D015179 Colorectal Neoplasms Doxorubicin 5.8518259882 18802399
MESH:D015179 Colorectal Neoplasms Fluorouracil 5.8518448328 16331619 18949393 17454858 18288408 16391804 14970324 16303861 17255274 20501625 17094418 18383874 15148649 16282729 17594712 18509181 15289873 16524972 17016601 18802399 17401013 17695437
MESH:D015179 Colorectal Neoplasms oxaliplatin 5.8518509181 17255274 17401013 18448328 17695437 17594712
MESH:D015179 Colorectal Neoplasms Paclitaxel 5.8518802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.6514669216 17141729
MESH:D016510 Corneal Neovascularization Thalidomide 5.109301478
MESH:D003389 Cranial Nerve Diseases Thalidomide 5.819200351
MESH:D019465 Craniofacial Abnormalities Ethanol 3.6010194807 15513904 11873399 15451039 19302082 11198716 15451040
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.6020055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Thalidomide 3.609200351
MESH:D003424 Crohn Disease Thalidomide 3.9116078585
MESH:D003456 Cryptorchidism Diethylstilbestrol 9.8312952375 16002989
MESH:D003456 Cryptorchidism vinclozolin 9.8314966744
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.5418551238
MESH:D003556 Cystitis Cyclophosphamide 4.4910700343 15643279 12388444 12161096 18483878 15276878 18372110 18093676 16651033 16413132 17979934 12913760 18710439 18433785 16989017 18295254 16614059 17010015 11948286 10498854
MESH:D007644 Darier Disease Fluorouracil 4.3016733453
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.1818249437
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 3.6710990075 15331540 11751995
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.0518772604
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.5417107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.0019279558
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 16.0518551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 16.0516781746 16177239 11739529 17906064 12594235 19739265 12392966 11287661 10663392 17522070 11743745 16081117 18713872 12705907 19420014 16109766 19370779 12958197 10774834 2444490 12153990 11421492 14550746 14986274 16393943 18071297 11461765 15619225 12540782 11834606 19164858 10915739 11529661 15968718 17562736 19085960 19416960 19923254 14725611 16227642 16485898
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 16.0516227642 3786805 6884620 4309450 2869522 15998439 21278145 11566570 10092053 17522070 19085960 15968718 10915739 19336974 7440962 7179309 9327722 6623471 16177239 15027814 3732212 7120509
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 16.0517416283
MESH:D056486 Drug-Induced Liver Injury Ethanol 16.0511566570
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 16.0520420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 16.0512963478
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.6019426721
MESH:D004362 Drug Toxicity Doxorubicin 6.9018602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 6.9011462148
MESH:D004421 Dystonia Phenobarbital 3.551851702
MESH:D004487 Edema pirinixic acid 5.1212083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.1212711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.4115322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 3.4815138306
MESH:D004701 Endocrine Gland Neoplasms decitabine 12.3719294695
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 12.3719294695
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.2116402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 10.6215700306 16804899
MESH:D016889 Endometrial Neoplasms Doxorubicin 10.6217359293
MESH:D016889 Endometrial Neoplasms Estradiol 10.6218566989 11473722 19148513
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.609294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.6618037988
MESH:D004802 Eosinophilia Cyclophosphamide 3.7511006010
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.633659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.383922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.6320417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.136401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 3.787750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.533659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 12.2220426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 12.2216530937
MESH:D004938 Esophageal Neoplasms Ethanol 12.2216704527
MESH:D004938 Esophageal Neoplasms Fluorouracil 12.2216785472 17638652 16481741 16337965 15173087
MESH:D004938 Esophageal Neoplasms Paclitaxel 12.2216481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.6511564622
MESH:D005218 Fat Necrosis Thioacetamide 5.2216456712
MESH:D005234 Fatty Liver Carbon Tetrachloride 15.2261145 16239168 12795759 15959796 12631006 16045604 19224547 17595544
MESH:D005234 Fatty Liver Cyclosporine 15.2219224547
MESH:D005234 Fatty Liver Ethanol 15.2219236843 18620774 16409862
MESH:D005234 Fatty Liver pirinixic acid 15.2219236843 20131406
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.1717920746
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.3515751030 16611131 16002989 16513791 16534752
MESH:D005310 Fetal Alcohol Syndrome Ethanol 4.8115513904 10194807 15451040 16946407
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.9811858732
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.1019069698
MESH:D005355 Fibrosis Carbon Tetrachloride 11.9718705752
MESH:D005355 Fibrosis Cyclosporine 11.9712639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 11.9720067830
MESH:D005756 Gastritis Acetaminophen 9.4816983495
MESH:D005756 Gastritis Ethanol 9.4815046732
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.4516973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.8016417039
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.4616452187
MESH:D005871 Giant Lymph Node Hyperplasia Thalidomide 5.8112701121
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.738708960
MESH:D005909 Glioblastoma Doxorubicin 10.2317150277
MESH:D005909 Glioblastoma Manganese 10.2317043766
MESH:D005909 Glioblastoma trichostatin A 10.2318801729
MESH:D005910 Glioma Fluorouracil 5.7516145905
MESH:D005910 Glioma Thalidomide 5.7516327979
MESH:D018316 Gliosarcoma Cyclophosphamide 5.0311389073
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.1010696789
MESH:D006086 Graft vs Host Disease Cyclophosphamide 4.5615172196 16376943 11014644
MESH:D006258 Head and Neck Neoplasms decitabine 11.0619215824
MESH:D006258 Head and Neck Neoplasms Doxorubicin 11.0615692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 11.0618337622 15102660 15162350
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 5.5420471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.5410048152 11294989
MESH:D006331 Heart Diseases Doxorubicin 3.1412587719 14766674 16244371 17875725 16144979 16495754 16330681 16879835 17888722 16707910 18006777 18674790 16244372
MESH:D006333 Heart Failure Doxorubicin 6.0117481944
MESH:D006333 Heart Failure pirinixic acid 6.0120558911
MESH:D006394 Hemangiosarcoma Doxorubicin 3.4715692506
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.9315720958
MESH:D006467 Hemophilia A Cyclophosphamide 4.8111918545
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.9011000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.1418665440 15929193 17276928
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.0414986274
MESH:D006505 Hepatitis Carbon Tetrachloride 7.9519900420 19110552
MESH:D006505 Hepatitis Thioacetamide 7.9516456712
MESH:D006529 Hepatomegaly Phenobarbital 11.6416109766
MESH:D006529 Hepatomegaly pirinixic acid 11.6416221962 18467677 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 11.6412621046 16120746 15340226
MESH:D006558 Herpes Genitalis Estradiol 4.5315709030
MESH:D006689 Hodgkin Disease Cyclophosphamide 6.3716135485 17606976
MESH:D006689 Hodgkin Disease Doxorubicin 6.3715147373 18501091 17606976
MESH:D019584 Hot Flashes Estradiol 3.2617088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.558697196 16959395 15340226 16354765 18606429
MESH:D006930 Hyperalgesia Acetaminophen 10.9916870215
MESH:D006930 Hyperalgesia Ethanol 10.9918783367
MESH:D006930 Hyperalgesia oxaliplatin 10.9917418472
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.0416899240
MESH:D006943 Hyperglycemia pirinixic acid 2.7620558911
MESH:D006965 Hyperplasia Diethylstilbestrol 9.7314722030 12960047
MESH:D006965 Hyperplasia halofuginone 9.7311874485
MESH:D006973 Hypertension Cyclosporine 4.2610903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.2618850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.6115338365
MESH:D007021 Hypospadias Diethylstilbestrol 4.1016002989
MESH:D007154 Immune System Diseases Cyclophosphamide 4.8316076520
MESH:D007246 Infertility Diethylstilbestrol 3.8915036965
MESH:D007248 Infertility, Male Cyclophosphamide 9.4516517039 7193160
MESH:D007248 Infertility, Male decitabine 9.4517581917
MESH:D007248 Infertility, Male vinclozolin 9.4516467254
MESH:D007249 Inflammation Flavonoids 6.9017296493
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 6.9012200463 12878042
MESH:D007249 Inflammation Thalidomide 6.9016134734
MESH:D007333 Insulin Resistance bisphenol A 10.4116393666
MESH:D007333 Insulin Resistance Estradiol 10.4116627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 10.4116306350
MESH:D007569 Jaw Abnormalities Ethanol 8.6715513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.6716580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.9415604871
MESH:D007674 Kidney Diseases Acetaminophen 12.0012587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 12.008314463 18776723 10903974
MESH:D007674 Kidney Diseases Doxorubicin 12.0016775033 15699352 15369732
MESH:D007674 Kidney Diseases Estradiol 12.0015618244
MESH:D007676 Kidney Failure, Chronic Doxorubicin 3.7216707910
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 19.1416705839
MESH:D007680 Kidney Neoplasms Cyclosporine 19.1412371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 19.1416762066 14681315 15003126
MESH:D007680 Kidney Neoplasms Estradiol 19.1415610895
MESH:D007680 Kidney Neoplasms Fluorouracil 19.1416985049
MESH:D007859 Learning Disorders Diethylstilbestrol 8.2117184923
MESH:D007859 Learning Disorders Ethanol 8.2115451040
MESH:D007898 Leishmaniasis, Visceral Thalidomide 3.9716514283
MESH:D007938 Leukemia Cyclophosphamide 5.8310602166
MESH:D007938 Leukemia decitabine 5.8319235587 18980019
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.6616085563
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.2717296974 18172266 18587576 17802794 17658394 17008537
MESH:D007948 Leukemia, Monocytic, Acute U 0126 4.8216972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 3.7210373061
MESH:D007951 Leukemia, Myeloid decitabine 3.5719117987 17236224 18454857
MESH:D015470 Leukemia, Myeloid, Acute decitabine 5.7517679729 18704418 18460780 18206229 19010910 19387464
MESH:D015470 Leukemia, Myeloid, Acute Thalidomide 5.7518720364
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 5.7518206229
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 4.9618055864
MESH:D007970 Leukopenia Cyclophosphamide 4.4811830472 10052129
MESH:D007984 Leydig Cell Tumor vinclozolin 4.2416417039
MESH:D017880 Limb Deformities, Congenital Ethanol 7.5617676605
MESH:D017880 Limb Deformities, Congenital Thalidomide 7.5610473037
MESH:D008080 Liposarcoma Paclitaxel 4.3717353645
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 17.7616943688 11903743 11408273 17334410 16239168 16221502 17174718 17157831 21278145
MESH:D008103 Liver Cirrhosis Ethanol 17.7615289165
MESH:D008103 Liver Cirrhosis halofuginone 17.7617180598
MESH:D008103 Liver Cirrhosis Phenobarbital 17.7621047994
MESH:D008103 Liver Cirrhosis Thalidomide 17.7617174718 16943688
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.6118295389
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 14.1317869086 15650968 14620537 18429990 18412020 10355542 18277467 15893842 18395914 17721639 17698563 15931870 17481882 18420326 17823541 17565644 17640975 17944888 17805973 17922224 16136751 18317297 18472332 16116963 18210741 12632512 15673190 15057751 12898905 16192424 15818738 18705752 12445418 16097048 17557913 17631135 15925388 18187930 17761835 14716833 14716496 17900296 18006644 12649538 18156304 16027843 17714472 18481824 14748882 18166357 18376398 18395095 18418968 12741479 16248980 15959796 15876570 18339082 18472094 15123356 15730626 15052691 16015684 12586293 12389079 16011737 12632514 17766677 18251166 11481614 15370692 16033810 13678700 17976157 12958196 20821823 12666154 18263696 18054572 15996030 17525996 18205269 12445421 14724832 12667390 18279442 14512876 12609069 15338365 16638106 12546737 15362042 17708605
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 14.1316595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 14.1314659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 14.1318166357
MESH:D008106 Liver Cirrhosis, Experimental halofuginone 14.1316489207 18458672 11172339 12175628 14739098
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 14.1315474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 14.1312878042
MESH:D008106 Liver Cirrhosis, Experimental Thalidomide 14.1315465738
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 14.1312531686 11172339 16511523 16343077 17050028 15716488 12175628 16126171 15095483 16248980 18263696 18031379 12679928 18458672 17127702 12891558 18295389 15288472 15362042 18380797 16489207 17292413 12557150 16097051 14739098 15316131 15465738 17355460 15334695 18606216 11481614 15078482 17629604 15158331 18416461 12085344 18615449 11682029 16098781 18032466 15075984 10677585 18395095 15474484 15288473
MESH:D008107 Liver Diseases marker/mechanism 19784758
MESH:D008107 Liver Diseases Acetaminophen 8.1416610002 16611625 12587719 12969438 19014921 19784758 11587558 19460945
MESH:D008107 Liver Diseases Carbon Tetrachloride 8.1416964402 16246199 17285989 15720792 15830285
MESH:D008107 Liver Diseases Phenobarbital 8.1419363144
MESH:D008107 Liver Diseases Thioacetamide 8.1418374380 16337175 15158337
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.1817207112 17347304
MESH:D017093 Liver Failure Carbon Tetrachloride 3.6915123358
MESH:D017114 Liver Failure, Acute Acetaminophen 13.8016871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 13.8014706259 16899240
MESH:D017114 Liver Failure, Acute Thioacetamide 13.8015313186 17276928 12479984 15633222
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 26.007678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 26.0018177683 15890375 2125692 9163691
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 26.0020195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 26.0019294768
MESH:D008113 Liver Neoplasms Diethylstilbestrol 26.0016712894 15890375
MESH:D008113 Liver Neoplasms Fluorouracil 26.0015113037 18383874 16603448 17045692
MESH:D008113 Liver Neoplasms Phenobarbital 26.0015975961 8742319 19482888 19812893 21047994 19073162
MESH:D008113 Liver Neoplasms pirinixic acid 26.0020007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 26.0016984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 19.272876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 19.278603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 19.2715583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 19.2716842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 19.271399818 6150874 17172636 2563599 18308698
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 19.2712151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 5.7914755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 5.7920135361 18569708 6695378 17053015 20869020 20464547 20064080 18816296 18520028
MESH:D008175 Lung Neoplasms Doxorubicin 5.7917418594 6189445
MESH:D008175 Lung Neoplasms Fluorouracil 5.7915246190
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 5.7911884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.3015086387
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.6615166399
MESH:D008223 Lymphoma Cyclophosphamide 15.0212854902
MESH:D008223 Lymphoma decitabine 15.0219470736
MESH:D008223 Lymphoma Diethylstilbestrol 15.0215700306
MESH:D008223 Lymphoma Doxorubicin 15.0216098063
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 4.1516675587
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 12.3711911406
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 12.3717654614
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 12.3714749477
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.0915621674
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.0216002989
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 5.0615458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.0617203775 16891317 11408345 11807958
MESH:D020149 Manganese Poisoning Estradiol 11.3519453300
MESH:D020149 Manganese Poisoning Manganese 11.3516551646 19453300 16568477
MESH:D008545 Melanoma decitabine 8.6717785578 16505122
MESH:D008545 Melanoma Doxorubicin 8.6716827129
MESH:D008545 Melanoma Paclitaxel 8.6716342250 12025231 12040289
MESH:D008545 Melanoma Thalidomide 8.6712829675 16098027 17089043
MESH:D008545 Melanoma trichostatin A 8.6716505122
MESH:D008546 Melanoma, Experimental Acetaminophen 9.2519513568
MESH:D008546 Melanoma, Experimental Cyclophosphamide 9.2516388313
MESH:D008569 Memory Disorders Ethanol 3.7315451040 18411066
MESH:D008654 Mesothelioma Doxorubicin 2.8517638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.2916801185
MESH:D053842 Microsatellite Instability Methylnitronitrosoguanidine 5.4017671175
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.0615792986
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 7.2816381670
MESH:D009062 Mouth Neoplasms Fluorouracil 7.2816757204 18986760
MESH:D009069 Movement Disorders Manganese 4.5616551646
MESH:D052016 Mucositis Doxorubicin 4.3017415656
MESH:D009101 Multiple Myeloma decitabine 14.4818172295
MESH:D009101 Multiple Myeloma Paclitaxel 14.4814749477
MESH:D009101 Multiple Myeloma Thalidomide 14.4819112201 15744524 19112817 19372569 15939924 15920492 17168659 15741222 15867202 16445831
MESH:D009101 Multiple Myeloma trichostatin A 14.4818172295
MESH:D009135 Muscular Diseases pirinixic acid 3.0316239165
MESH:D009190 Myelodysplastic Syndromes decitabine 6.9219157545 18608210 16882708 19010910
MESH:D009190 Myelodysplastic Syndromes Thalidomide 6.9218720364
MESH:D009203 Myocardial Infarction Doxorubicin 4.9715857846 19429709
MESH:D009203 Myocardial Infarction pirinixic acid 4.9719151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.6312213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.0016810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.0016411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 3.9917484760
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.3818551238 7678174
MESH:D009362 Neoplasm Metastasis Doxorubicin 5.4118259882
MESH:D009362 Neoplasm Metastasis Paclitaxel 5.4115867366
MESH:D009369 Neoplasms Benzo(a)pyrene 16.4211141357
MESH:D009369 Neoplasms Cyclophosphamide 16.4218854779
MESH:D009369 Neoplasms decitabine 16.4217925555 19116145 19470736
MESH:D009369 Neoplasms Diethylstilbestrol 16.4215313581
MESH:D009369 Neoplasms Fluorouracil 16.4216928823 18239605 18600527
MESH:D009369 Neoplasms pirinixic acid 16.4217405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.2517289903
MESH:D009401 Nephrosis Doxorubicin 4.2916899518 16636307
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.9417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 7.9319348381 18481113
MESH:D009404 Nephrotic Syndrome Doxorubicin 7.9316889571 15640375
MESH:D009410 Nerve Degeneration Manganese 7.6016551646
MESH:D009410 Nerve Degeneration Rotenone 7.6015790535 17356569 18619942
MESH:D009421 Nervous System Malformations bisphenol A 25.8616427766 11399458
MESH:D009421 Nervous System Malformations Diethylstilbestrol 25.8611399458
MESH:D009421 Nervous System Malformations Estradiol 25.8611399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 25.8614600291
MESH:D009421 Nervous System Malformations Thalidomide 25.8616859833
MESH:D009447 Neuroblastoma Cyclophosphamide 6.3215176712 16115947 8761367
MESH:D009447 Neuroblastoma Doxorubicin 6.3215555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.4818514411
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 4.4012837982 8761367
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.1016436463
MESH:D009503 Neutropenia Cyclophosphamide 3.888291058
MESH:D009765 Obesity pirinixic acid 1.6820558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.0116049721
MESH:D009845 Oligospermia Cyclophosphamide 4.2316517039
MESH:D010014 Osteolysis Paclitaxel 4.4915867366
MESH:D010018 Osteomalacia Phenobarbital 3.8817016548
MESH:D012516 Osteosarcoma Doxorubicin 3.7215930896
MESH:D010049 Ovarian Diseases bisphenol A 4.5011985600
MESH:D010051 Ovarian Neoplasms decitabine 16.5719331143 19259094
MESH:D010051 Ovarian Neoplasms Estradiol 16.5719401270
MESH:D010051 Ovarian Neoplasms Paclitaxel 16.5711161223
MESH:D010051 Ovarian Neoplasms Thalidomide 16.5716288038
MESH:D010051 Ovarian Neoplasms trichostatin A 16.5719331143
MESH:D010051 Ovarian Neoplasms U 0126 16.5716211241
MESH:D010146 Pain Acetaminophen 5.5616870215
MESH:D010146 Pain Cyclophosphamide 5.5618093676 12161096
MESH:D010190 Pancreatic Neoplasms marker/mechanism 15956974
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 21.8211332152
MESH:D010190 Pancreatic Neoplasms decitabine 21.8219294695
MESH:D010190 Pancreatic Neoplasms Ethanol 21.8212384795
MESH:D010190 Pancreatic Neoplasms Fluorouracil 21.8219003803 16929163 16500647 15113037
MESH:D010190 Pancreatic Neoplasms gemcitabine 21.8211504793 17440100 18383843 16929163 18992248
MESH:D010190 Pancreatic Neoplasms Phenobarbital 21.8216965848
MESH:D010190 Pancreatic Neoplasms trichostatin A 21.8219294695
MESH:D010291 Paresis Thalidomide 5.819200351
MESH:D010300 Parkinson Disease Manganese 5.1111181820
MESH:D010300 Parkinson Disease Rotenone 5.1111535288 18619942 15451049 16412576 11445065 19232380 16140633 18191903 19114014
MESH:D020734 Parkinsonian Disorders Manganese 8.1016140633
MESH:D020734 Parkinsonian Disorders Rotenone 8.1015574749 15795934 18197244 15927086
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.7512520081
MESH:D003557 Phyllodes Tumor Doxorubicin 4.6617983394
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.6714722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.1915687265 16977796
MESH:D010997 Pleural Neoplasms Doxorubicin 4.6617638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.1018163543
MESH:D011230 Precancerous Conditions Cyclosporine 7.6112371664
MESH:D011230 Precancerous Conditions Phenobarbital 7.612563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 7.1121297632
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Thalidomide 7.1117031469
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 19.2610548101
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 19.2617184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 19.2611399792 11896295 11118676 11222880
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 19.2618042343 18220299 19015723
MESH:D055728 Primary Myelofibrosis decitabine 10.8417616702
MESH:D055728 Primary Myelofibrosis trichostatin A 10.8417616702
MESH:D011469 Prostatic Diseases vinclozolin 4.4518220299
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.2915572423
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 9.1020887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.1020887781
MESH:D011471 Prostatic Neoplasms marker/mechanism 17013881
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 4.6417292933
MESH:D011471 Prostatic Neoplasms bicalutamide 4.6419011039 19240160 15638997 17914592 18487222
MESH:D011471 Prostatic Neoplasms bisphenol A 4.6416740699
MESH:D011471 Prostatic Neoplasms Calcitriol 4.6416289102 16644109 18247401 15754350 12479363
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 4.6417136230
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 4.6415846301 17136230 15046698
MESH:D011471 Prostatic Neoplasms Doxorubicin 4.6416868541 15897917 16888761 18437689 15749863 16729912
MESH:D011471 Prostatic Neoplasms Estradiol 4.6416740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 4.6419082440 18626508
MESH:D011471 Prostatic Neoplasms Paclitaxel 4.6417172428 16729912 16356831 17136230
MESH:D011471 Prostatic Neoplasms Thalidomide 4.6416729912
MESH:D011471 Prostatic Neoplasms trichostatin A 4.6419789329 18798265
MESH:D011472 Prostatitis vinclozolin 4.4518629315
MESH:D011536 Prurigo Thalidomide 5.8112755975
MESH:D019310 Pseudolymphoma Phenobarbital 4.0012752131
MESH:D011565 Psoriasis Cyclosporine 2.0416882103
MESH:D011629 Puberty, Precocious bisphenol A 4.3010548101
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 3.0816636934
MESH:D012004 Rectal Neoplasms Fluorouracil 3.6018286688 18722050 16160472 15538739
MESH:D051437 Renal Insufficiency Doxorubicin 3.7517922066
MESH:D015427 Reperfusion Injury pirinixic acid 2.1319058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.3718990726
MESH:D012208 Rhabdomyosarcoma decitabine 3.9519155313
MESH:D012509 Sarcoma Doxorubicin 3.5718313854 17710206 15675481 15625365 17203757 16767912
MESH:D012512 Sarcoma, Ewing's Doxorubicin 3.7816326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.3017846226
MESH:D019873 Schnitzler Syndrome Thalidomide 5.4516096327
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 4.3716636934
MESH:D012640 Seizures 2,6-dinitrotoluene 7.9418551238
MESH:D012640 Seizures Ethanol 7.949754883
MESH:D012640 Seizures Phenobarbital 7.943137016 4039156 11442880 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.336407741
MESH:D012871 Skin Diseases halofuginone 3.3711874485
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 7.9810029692 19755658
MESH:D012878 Skin Neoplasms Doxorubicin 7.9815692506
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 7.9816192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.0917203757 16767912 15625365
MESH:D013088 Spermatocele Diethylstilbestrol 4.2216709447 16002989
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 5.0316517039
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 5.742093021 20155912
MESH:D013274 Stomach Neoplasms decitabine 5.7419037991
MESH:D013274 Stomach Neoplasms Ethanol 5.7418456281
MESH:D013274 Stomach Neoplasms Fluorouracil 5.7417522103 19084572 18396642 19015929 18567086 16424979 16951190 15786421 17498489 17172411
MESH:D013274 Stomach Neoplasms Paclitaxel 5.7418506536 18396642
MESH:D013276 Stomach Ulcer Ethanol 6.3816755016 9562338 17918041 17189318 11906479 9211565
MESH:D013276 Stomach Ulcer Thalidomide 6.3815138204
MESH:D019966 Substance-Related Disorders bisphenol A 3.5016684133 16045194
MESH:D013375 Substance Withdrawal Syndrome Ethanol 3.839754883
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 4.5712837982
MESH:D024801 Tauopathies Paclitaxel 4.3316930453
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.4112697716
MESH:D013964 Thyroid Neoplasms decitabine 9.9117967635
MESH:D013964 Thyroid Neoplasms Doxorubicin 9.9117909728 16010429
MESH:D013964 Thyroid Neoplasms Phenobarbital 9.911399818
MESH:D013978 Tibial Fractures Estradiol 4.1919048282
MESH:D014062 Tongue Neoplasms Fluorouracil 3.5716280240
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 17.1016049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 17.1017053015
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 17.1014692829
MESH:D001749 Urinary Bladder Neoplasms decitabine 17.1019087683 17616700
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 17.1016712894 17306315 16452187
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 17.1017653716
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 3.8310091137
MESH:D014581 Urticaria Acetaminophen 2.5310982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 8.1816175088
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 8.1816803524
MESH:D014591 Uterine Diseases bisphenol A 12.1614652134
MESH:D014591 Uterine Diseases Diethylstilbestrol 12.1614652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 3.6115809267 16690809
MESH:D014604 Uveal Neoplasms decitabine 4.4217785578
MESH:D014605 Uveitis Cyclosporine 3.491336536
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 3.9616513791 16002989
MESH:D014652 Vascular Diseases Thalidomide 4.9915741222
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.1012125929
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 3.7517678736 16364871 17638931 17334414
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.7515886252
MESH:D014947 Wounds and Injuries sphingosine 1-phosphate 5.0615541073
MESH:D014985 Xerophthalmia Cyclosporine 3.9417120751
Pathway ID Pathway Name
KEGG:04360 Axon guidance
REACT:18266 Axon guidance
REACT:12529 Signaling by VEGF
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA31783
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    PA445062Neoplasms
    Releated drug ID Related drug Name
    PA448478l-arginine
    PA450635nitric oxide
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00039 - Palifermin Antimucositis Agents
    DB04895 - Pegaptanib
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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