AutismKB 2.0

Annotation Detail for GMPS


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Basic Information Top
Gene Symbol:GMPS ( - )
Gene Full Name: guanine monphosphate synthetase
Band: 3q25.31
Quick LinksEntrez ID:8833; OMIM: 600358; Uniprot ID:GUAA_HUMAN; ENSEMBL ID: ENSG00000163655; HGNC ID: 4378
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-841purine nucleotides de novo biosynthesis II
Pathway IDPathway Name
hsa00230Purine metabolism
hsa00983Drug metabolism - other enzymes
hsa01100Metabolic pathways
Pathway IDPathway Name
Metabolism of nucleotides
No data
Pathway IDPathway Name
P02738De novo purine biosynthesis
Pathway IDPathway Name
500226Purine ribonucleoside monophosphate biosynthesis
Related Diseases/Disorders Top
No data
No data
No data
No data
Desease Name
Leukemia, acute myelogenous
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of GMPS mRNAaffects expression 21346803
D001151 Arsenic Arsenic results in decreased expression of GMPS mRNAdecreases expression 19654921
C006632 arsenic trioxide arsenic trioxide results in decreased expression of GMPS proteindecreases expression 19364129
C484027 oligofectamine oligofectamine results in increased expression of GMPS mRNAincreases expression 14668052
C443641 poly(propyleneimine) poly(propyleneimine) analog results in decreased expression of GMPS mRNAdecreases expression 16308212
D018038 Sodium Selenite Sodium Selenite results in increased expression of GMPS mRNAincreases expression 18175754
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of GMPS mRNAincreases expression 19465110
C025643 vinclozolin vinclozolin affects the expression of GMPS mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1814514962 15322242 11752688
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3319825857 11798837
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7116835633
MESH:D018246 Adrenocortical Adenoma Arsenic 5.5917306315
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D001008 Anxiety Disorders vinclozolin 3.8319015723
MESH:D020261 Arsenic Poisoning Arsenic 2.9218414634 12569548 16251483 16835338
MESH:D050197 Atherosclerosis Arsenic 3.3819371607 12928151
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.7816206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.7812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9115746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6820435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5911589617
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.7117687452 15504454
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.8416705839
MESH:D006528 Carcinoma, Hepatocellular Arsenic 4.8416507464 17306315
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.8416217749 15553829 14691202 11135700 15073043
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.2519014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3512490120
MESH:D002294 Carcinoma, Squamous Cell Arsenic 2.7417687452 18922899 15504454
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.3018640142
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4918670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Arsenic 3.6115738583 19152805 17938729
MESH:D002340 Carotid Artery Diseases Arsenic 4.5216973168 18022660
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.936135515
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D019457 Chromosome Breakage Sodium Selenite 5.0615894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1912621046 15340226 16354765 15668235 8697196
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2717141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 4.4712609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.5310525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5320055451 15322242 10048152
MESH:D003456 Cryptorchidism vinclozolin 4.6214966744
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.3218551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.3615213294
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9916285004
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.5621346803 18551238
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 6.5615131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.5620420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2816714409 15322242 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2510568697 9294722
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3612903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005234 Fatty Liver arsenic trioxide 3.5315073043
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.2520067830
MESH:D005534 Foot Diseases Arsenic 5.946392382
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5416904648
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.2716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.6816417039
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4411294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2015340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4216354765 16959395 15340226 18606429 8697196
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.6817050553
MESH:D006973 Hypertension Arsenic 5.4916076760 11953799 9931084
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.4918850075 18670907
MESH:D006987 Hypesthesia Arsenic 5.9416093927
MESH:D007248 Infertility, Male vinclozolin 3.1916467254
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9612878042 12200463
MESH:D007333 Insulin Resistance Sodium Selenite 3.4214714311
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D007642 Keratosis Arsenic 5.3316930632 12749816
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.1816705839
MESH:D007938 Leukemia arsenic trioxide 2.9315070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0417077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.6416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6014633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.0019077051
MESH:D015470 Leukemia, Myeloid, Acute marker/mechanism
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1716968895 20471514 16467208 19850784 17050201
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 8.2817339181
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 8.2819075265 16330433 15622746 19225113 9834237 15748426 16891316 16331271 19642359 17869043 17712046 11161223 16823087 15336539 12712474 12018890 19035177 12679006 11468182 16966277 17649720 15213294 17107899 16112521 17217047
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.6316882451
MESH:D007984 Leydig Cell Tumor vinclozolin 5.0716417039
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008107 Liver Diseases Arsenic 2.5911134558
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 11.377678174
MESH:D008113 Liver Neoplasms Arsenic 11.3716368122
MESH:D008113 Liver Neoplasms arsenic trioxide 11.3714682389
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.3716984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.636135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 10.6320377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.6312151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5315213294
MESH:D008175 Lung Neoplasms Arsenic 3.5717976673 17306315 19168569
MESH:D008175 Lung Neoplasms arsenic trioxide 3.5711798837 19825857
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5719555203 11884234
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.3214737004
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2711468182 19549372 19417148 15949261 14977855
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.0518349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2616105982 16882451
MESH:D017202 Myocardial Ischemia Arsenic 9.6515371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.6512213967
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.2018551238 7678174
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2416624393
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4914600291
MESH:D009436 Neural Tube Defects Arsenic 7.9416620997
MESH:D009436 Neural Tube Defects arsenic trioxide 7.9410525206
MESH:D020078 Neurogenic Inflammation Arsenic 4.6417056641
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.6616049721
MESH:D010051 Ovarian Neoplasms Arsenic 5.2317306315
MESH:D010051 Ovarian Neoplasms arsenic trioxide 5.2312452020 19769630 16624393
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.5915580305
MESH:D010235 Paraganglioma arsenic trioxide 4.4219927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.4616093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.336392382 15371236 16905509
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.6411399792 11222880 11118676 11896295
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 10.6418042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.2718220299
MESH:D011471 Prostatic Neoplasms Arsenic 2.6116140617
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.6119131511
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.6118760546
MESH:D011472 Prostatitis vinclozolin 5.2718629315
MESH:D011507 Proteinuria Arsenic 4.2621343184
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2416646077
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6918551238
MESH:D012871 Skin Diseases Arsenic 2.8019834688 16702368 16353154 17050553 15952646 17548696 18709164 16759981 17938729 17453740 6392382
MESH:D012878 Skin Neoplasms Arsenic 6.0417976673 15504454 17029826 17050553 19538983 16251483
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 6.0416192470
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.2719014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.3015213294
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.8616049721
MESH:D001749 Urinary Bladder Neoplasms Arsenic 8.8617976673 19429237 19322015 17306315 11144890 15987713 18640142
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.8612845720 20435036 12973940 11780464
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.6610091137
MESH:D014652 Vascular Diseases Arsenic 5.0717056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
Pathway ID Pathway Name
KEGG:00983 Drug metabolism - other enzymes
KEGG:01100 Metabolic pathways
REACT:1698 Metabolism of nucleotides
KEGG:00230 Purine metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28763
  • No data
    No data
    Releated drug ID Related drug Name
    PA10090l-glutamine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00130 - L-Glutamine Dietary supplement;Micronutrient;Non-Essential Amino Acids
    DB00142 - L-Glutamic Acid Dietary supplement;Micronutrient;Non-Essential Amino Acids
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018