AutismKB 2.0

Annotation Detail for SOCS2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:SOCS2 ( CIS2,Cish2,SOCS-2,SSI-2,SSI2,STATI2 )
Gene Full Name: suppressor of cytokine signaling 2
Band: 12q
Quick LinksEntrez ID:8835; OMIM: 605117; Uniprot ID:SOCS2_HUMAN; ENSEMBL ID: ENSG00000120833; HGNC ID: 19382
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04910Insulin signaling pathway
hsa04630Jak-STAT signaling pathway
hsa04930Type II diabetes mellitus
No data
Pathway IDPathway Name
200082IL2-mediated signaling events
Pathway IDPathway Name
P00035Interferon-gamma signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1904Diabetes mellitus
1944Breast cancer
2051Leukemia
Desease Name
height
METABOLIC
DEVELOPMENTAL
diabetes, type 2
Desease Name
Height
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C014211 2,3,7,8-tetrachlorodibenzofuran 2,3,7,8-tetrachlorodibenzofuran affects the expression of SOCS2 mRNAaffects expression 18343893
C023035 3,4,5,3',4'-pentachlorobiphenyl 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of SOCS2 mRNAincreases expression 15371557
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of SOCS2 mRNAdecreases expression 16788091
C026137 3-hydroxyacetanilide 3-hydroxyacetanilide results in decreased expression of SOCS2 mRNAdecreases expression 18544908
C002202 4-oxoretinoic acid 4-oxoretinoic acid results in increased expression of SOCS2 mRNAincreases expression 15982314
D000082 Acetaminophen Acetaminophen results in decreased expression of SOCS2 mRNAdecreases expression 18544908
D000082 Acetaminophen Acetaminophen results in increased expression of SOCS2 mRNAincreases expression 11264010
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of SOCS2 proteinaffects expression 20106945
C103303 alitretinoin alitretinoin results in increased expression of SOCS2 mRNAincreases expression 15982314
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SOCS2 mRNAaffects expression 16483693
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of SOCS2 mRNAincreases expression 18687144
D019324 beta-Naphthoflavone beta-Naphthoflavone results in increased expression of SOCS2 mRNAincreases expression 15371557
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of SOCS2 mRNAincreases expression 20106945
C006780 bisphenol A bisphenol A results in decreased expression of SOCS2 mRNAdecreases expression 16029874
D003010 Clorgyline Clorgyline results in increased expression of SOCS2 mRNAincreases expression 19691856
D003513 Cycloheximide Cycloheximide promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of SOCS2 mRNA]increases expression|increases reaction 15371557
D016572 Cyclosporine Cyclosporine results in increased expression of SOCS2 mRNAincreases expression 20106945
C007262 deoxynivalenol deoxynivalenol results in increased expression of SOCS2 mRNAincreases expression 19625342
D002945 Cisplatin SOCS2 protein affects the susceptibility to Cisplatinaffects response to substance 16217747
D004054 Diethylstilbestrol Diethylstilbestrol results in decreased expression of SOCS2 mRNAdecreases expression 15171707
D002117 Calcitriol Calcitriol results in decreased expression of SOCS2 mRNAdecreases expression 16002434
D004958 Estradiol Estradiol results in increased expression of SOCS2 mRNAincreases expression 17272397
D006581 Hexachlorobenzene Hexachlorobenzene affects the expression of SOCS2 mRNAaffects expression 15159207
C075954 indolo(3,2-b)carbazole indolo(3,2-b)carbazole results in increased expression of SOCS2 mRNAincreases expression 15371557
D001556 Lindane Lindane results in decreased expression of SOCS2 mRNAdecreases expression 17785943
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of SOCS2 mRNAincreases expression 12057914
C030957 methylmercury II methylmercury II results in increased expression of SOCS2 mRNAincreases expression 17905399
D015741 Metribolone Metribolone results in increased expression of SOCS2 mRNAincreases expression 16751804
C006253 pirinixic acid pirinixic acid results in decreased expression of SOCS2 mRNAdecreases expression 17426115
18445702
20059764
11798191
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in decreased expression of SOCS2 mRNA]decreases expression|increases reaction 20059764
C059514 resveratrol resveratrol results in decreased expression of SOCS2 mRNAdecreases expression 19371625
D015474 Isotretinoin Isotretinoin results in increased expression of SOCS2 mRNAincreases expression 15982314
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of SOCS2 mRNAincreases expression 20106945
D013749 Tetrachlorodibenzodioxin AHR protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of SOCS2 mRNA]increases expression|increases reaction 15371557
D013749 Tetrachlorodibenzodioxin AHR protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of SOCS2 protein]increases expression|increases reaction 15371557
D013749 Tetrachlorodibenzodioxin Cycloheximide promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of SOCS2 mRNA]increases expression|increases reaction 15371557
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the expression of SOCS2 mRNAaffects expression 18343893
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of SOCS2 mRNAdecreases expression 18372398
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of SOCS2 mRNAincreases expression 15371557
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of SOCS2 proteinincreases expression 15371557
D013755 Tetradecanoylphorbol Acetate [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of SOCS2 mRNAaffects cotreatment|affects expression 16979875
D014212 Tretinoin Tretinoin metabolite results in increased expression of SOCS2 mRNAincreases expression 15982314
D014212 Tretinoin Tretinoin results in increased expression of SOCS2 mRNAincreases expression 15982314
D014212 Tretinoin Tretinoin results in decreased expression of SOCS2 mRNAdecreases expression 16788091
D014415 Tunicamycin Tunicamycin results in decreased expression of SOCS2 mRNAdecreases expression 17127020
C025643 vinclozolin vinclozolin affects the expression of SOCS2 mRNAaffects expression 19015723
D015032 Zinc [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of SOCS2 mRNAaffects cotreatment|affects expression 16979875
D019287 Zinc Sulfate Zinc Sulfate results in increased expression of SOCS2 mRNAincreases expression 16330358
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Isotretinoin 7.4418769834
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.4414514962 15322242 11752688
MESH:D000015 Abnormalities, Multiple Isotretinoin 4.6418769834
MESH:D000138 Acidosis Ammonium Chloride 9.3518287403
MESH:D000138 Acidosis Zinc Sulfate 9.357265320
MESH:D017486 Acneiform Eruptions Isotretinoin 5.9016232082
MESH:D000152 Acne Vulgaris Isotretinoin 5.0916185265 18769834
MESH:D000169 Acrodermatitis Zinc 5.0216889938 17202136 17190629
MESH:D058186 Acute Kidney Injury Cisplatin 7.7612690470 17670903 15814532
MESH:D058186 Acute Kidney Injury resveratrol 7.7616538975
MESH:D055371 Acute Lung Injury Lipopolysaccharides 7.8811850527 18653653
MESH:D055371 Acute Lung Injury pirinixic acid 7.8818653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.4920127859 20464547
MESH:D000230 Adenocarcinoma Cisplatin 6.4917638652 11798837
MESH:D000230 Adenocarcinoma Estradiol 6.4911473722
MESH:D000236 Adenoma Benzo(a)pyrene 9.966695378
MESH:D000236 Adenoma beta-Naphthoflavone 9.9619389873
MESH:D000236 Adenoma resveratrol 9.9615688382
MESH:D018248 Adenoma, Liver Cell 3,4,5,3',4'-pentachlorobiphenyl 15.2516628245
MESH:D018248 Adenoma, Liver Cell pirinixic acid 15.2516434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 15.2516835633
MESH:D000382 Agricultural Workers' Diseases Lindane 4.0012661182
MESH:D000505 Alopecia Tretinoin 3.3215955085
MESH:D000544 Alzheimer Disease resveratrol 4.1716183991 16162502
MESH:D000544 Alzheimer Disease Zinc 4.1716325427 16580781 17119284 16410023
MESH:D000686 Amyloidosis Diethylstilbestrol 4.1215469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6211748828
MESH:D000755 Anemia, Sickle Cell Zinc 4.5416916123
MESH:D000799 Angioedema Acetaminophen 3.4610982225
MESH:D000860 Anoxia Zinc Sulfate 4.647265320
MESH:D001008 Anxiety Disorders vinclozolin 3.3419015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.7019183758
MESH:D001169 Arthritis, Experimental resveratrol 6.7217115116
MESH:D001169 Arthritis, Experimental Tretinoin 6.7216412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.1716292516
MESH:D001249 Asthma Tretinoin 4.6416456186
MESH:D001249 Asthma Zinc 4.6417085522
MESH:D050197 Atherosclerosis resveratrol 3.0517967414 16873680
MESH:D001321 Autistic Disorder Acetaminophen 1.4618445737
MESH:D001471 Barrett Esophagus Tretinoin 4.0416935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 13.3019483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 13.3012125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 13.3016206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5215746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.5014601052
MESH:D001862 Bone Resorption bisphenol A 3.5211985600
MESH:D001930 Brain Injuries Zinc 4.3217109824
MESH:D002545 Brain Ischemia resveratrol 3.9017600658
MESH:D001943 Breast Neoplasms alitretinoin 9.1016344269
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 9.1020146248 17474063
MESH:D001943 Breast Neoplasms bisphenol A 9.1017123778
MESH:D001943 Breast Neoplasms Calcitriol 9.1011237771
MESH:D001943 Breast Neoplasms Cisplatin 9.1019526202 18382427
MESH:D001943 Breast Neoplasms Diethylstilbestrol 9.1017129689 15324884
MESH:D001943 Breast Neoplasms Estradiol 9.1017261762 16675129 18497071 19861407 12948864 17289903 14630087 17018787
MESH:D001943 Breast Neoplasms Hexachlorobenzene 9.1015061365 12709520
MESH:D001943 Breast Neoplasms Lindane 9.1014688026
MESH:D001943 Breast Neoplasms resveratrol 9.1017651959 16393696 17534123
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 9.1020435547
MESH:D001943 Breast Neoplasms Tretinoin 9.1016443354 16873071 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.2116813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.0816111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5016835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.7716168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 12.983084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 12.9821507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 12.9817982673
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 12.9815948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Estradiol 12.9816924424
MESH:D006528 Carcinoma, Hepatocellular resveratrol 12.9816227395 19321006
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 12.981917145
MESH:D002278 Carcinoma in Situ bisphenol A 4.6117123778
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.2116675471
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 2.9016685392 12023789
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 23.9120419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 23.9111237771
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 23.9117066447 18337622 6189445
MESH:D002294 Carcinoma, Squamous Cell Isotretinoin 23.9111237771
MESH:D002294 Carcinoma, Squamous Cell resveratrol 23.9116227395
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 23.9118922899
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 23.9116051514 16096774
MESH:D002294 Carcinoma, Squamous Cell Zinc 23.9116543248
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.1516120746 18850075 18670907
MESH:D002318 Cardiovascular Diseases resveratrol 6.7715458977
MESH:D002318 Cardiovascular Diseases Zinc 6.7716936243
MESH:D002386 Cataract Acetaminophen 6.4710977129
MESH:D002386 Cataract Tretinoin 6.4717460283
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 5.7012371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 5.7018566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.2116129372
MESH:D018281 Cholangiocarcinoma 3,4,5,3',4'-pentachlorobiphenyl 8.7516628245
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.7516835633
MESH:D002779 Cholestasis Cyclosporine 6.8219486331
MESH:D002779 Cholestasis pirinixic acid 6.8219176532
MESH:D002822 Choriocarcinoma Tretinoin 4.7716461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.2015340226 8697196 15668235 16354765 12621046
MESH:D002972 Cleft Palate Tretinoin 5.209407595
MESH:D003092 Colitis resveratrol 8.3916474422
MESH:D003092 Colitis Tretinoin 8.3917035595
MESH:D003110 Colonic Neoplasms resveratrol 2.3916338953
MESH:D015179 Colorectal Neoplasms Cisplatin 2.7015273666
MESH:D015179 Colorectal Neoplasms resveratrol 2.7016550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7417141729 14669216
MESH:D003327 Coronary Disease resveratrol 3.5116507316
MESH:D019465 Craniofacial Abnormalities 3,4,5,3',4'-pentachlorobiphenyl 6.8417686920
MESH:D019465 Craniofacial Abnormalities Isotretinoin 6.849879862 18769834
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 6.8420055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 6.849211117 14991402 9142499 8800419 9224671 9664655 10589399 9125849 16925845 17551590
MESH:D019465 Craniofacial Abnormalities Zinc 6.8419302082
MESH:D003456 Cryptorchidism Diethylstilbestrol 10.1712952375 16002989
MESH:D003456 Cryptorchidism vinclozolin 10.1714966744
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2418249437
MESH:D003920 Diabetes Mellitus Zinc 3.8916479319
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.4616873680
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.5717107852
MESH:D003928 Diabetic Nephropathies Estradiol 7.9619279558
MESH:D003928 Diabetic Nephropathies resveratrol 7.9616286809
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.1617562736 18713872 12705907 19739265 19085960 19164858 16485898 10774834 16227642 11461765 12958197 11529661 11421492 12594235 16081117 14550746 14725611 12153990 16781746 12540782 16177239 11739529 17522070 11743745 19923254 17906064 16109766 19416960 19370779 12392966 15968718 19420014 2444490 10915739 16393943 15619225 11834606 11287661 14986274 18071297 10663392
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.1620420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.7119426721
MESH:D004362 Drug Toxicity Cisplatin 7.2412231392 15033597 19839026 12649298
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.2411462148
MESH:D004487 Edema pirinixic acid 13.6912083418
MESH:D004487 Edema resveratrol 13.698985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 13.6912711302 11000095
MESH:D004487 Edema Tetradecanoylphorbol Acetate 13.6916716910 15177302 7812673 9599246 11698051 8273558 8113982
MESH:D004489 Edema, Cardiac 3,4,5,3',4'-pentachlorobiphenyl 18.8517686920
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 18.8515322242 18230668 16714409
MESH:D004489 Edema, Cardiac Tretinoin 18.8518230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 8.2015138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 8.2017872969
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.3116402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 11.0315700306 16804899
MESH:D016889 Endometrial Neoplasms Estradiol 11.0318566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Tretinoin 11.0316569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.6910568697 9294722
MESH:D019446 Endotoxemia Lipopolysaccharides 4.0215328337 17637181 15821434
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.4817923197
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 6.7316530937
MESH:D004938 Esophageal Neoplasms Cisplatin 6.7317638652 15464296 16481741 15173087 16785472
MESH:D004938 Esophageal Neoplasms Zinc 6.7316543248
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.9011564622
MESH:D005124 Eye Abnormalities Tretinoin 7.909664655 16938888
MESH:D005234 Fatty Liver Cyclosporine 6.4419224547
MESH:D005234 Fatty Liver pirinixic acid 6.4420131406 19236843
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.4216611131 16534752 15751030 16002989 16513791
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.0811858732
MESH:D005334 Fever Lipopolysaccharides 3.6911852909 9205823
MESH:D005355 Fibrosis Cyclosporine 12.5712639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 12.5720067830
MESH:D005355 Fibrosis Tretinoin 12.5717994277
MESH:D005756 Gastritis Acetaminophen 9.8716983495
MESH:D005756 Gastritis Zinc 9.8717241300
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.5516973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.9116417039
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.5716452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.848708960
MESH:D005909 Glioblastoma Tretinoin 2.7617312396
MESH:D005922 Glomerulonephritis, IGA deoxynivalenol 4.7115173396 16524712
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2110696789
MESH:D006130 Growth Disorders Zinc 3.7217217573
MESH:D006258 Head and Neck Neoplasms Cisplatin 7.0515102660 15464296
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.0516096774
MESH:D034381 Hearing Loss Cisplatin 3.9819898482
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.7716084493
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.1115464296
MESH:D006330 Heart Defects, Congenital 2,3,7,8-tetrachlorodibenzofuran 18.8811294989
MESH:D006330 Heart Defects, Congenital 3,4,5,3',4'-pentachlorobiphenyl 18.8817686920 20471113
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 18.8820471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 18.8810048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 18.889664655 14991402
MESH:D006333 Heart Failure pirinixic acid 6.3620558911
MESH:D006333 Heart Failure Zinc 6.3617162251
MESH:D006335 Heart Injuries Zinc 5.3817074742
MESH:D016481 Helicobacter Infections Zinc 4.1817241300
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.0415720958
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.0516366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0011000095
MESH:D006527 Hepatolenticular Degeneration Zinc 10.0817276780
MESH:D006527 Hepatolenticular Degeneration Zinc Sulfate 10.0817063115
MESH:D006529 Hepatomegaly pirinixic acid 7.0318467677 19772884 19176532 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.0312621046 15340226 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.6415709030
MESH:D006561 Herpes Simplex resveratrol 3.8016876885
MESH:D006689 Hodgkin Disease Cisplatin 3.2916200630 16170182
MESH:D019584 Hot Flashes Estradiol 3.3717088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.6616959395 15340226 8697196 16354765 18606429
MESH:D006930 Hyperalgesia Acetaminophen 6.6316870215
MESH:D006930 Hyperalgesia Tretinoin 6.6316870215
MESH:D006937 Hypercholesterolemia resveratrol 3.6717188708
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.2016778211
MESH:D006943 Hyperglycemia pirinixic acid 2.8520558911
MESH:D006949 Hyperlipidemias resveratrol 3.6816873680
MESH:D006965 Hyperplasia Diethylstilbestrol 4.0614722030 12960047
MESH:D006973 Hypertension Cyclosporine 4.4310903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.4318850075 18670907
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 3.9717488730
MESH:D007021 Hypospadias Diethylstilbestrol 4.2116002989
MESH:D007022 Hypotension Zinc Sulfate 4.127265320
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.2717600658
MESH:D007246 Infertility Diethylstilbestrol 3.9915036965
MESH:D007248 Infertility, Male vinclozolin 2.7916467254
MESH:D007249 Inflammation Lipopolysaccharides 10.3317963957 12878042 17255318 9205823 17237260
MESH:D007249 Inflammation resveratrol 10.3316366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 10.3312878042 12200463
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 10.337812673 7562506 15177302 11698051 8273558
MESH:D007251 Influenza, Human resveratrol 4.1616624496
MESH:D007333 Insulin Resistance bisphenol A 10.8616393666
MESH:D007333 Insulin Resistance Estradiol 10.8616627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 10.8616306350
MESH:D007410 Intestinal Diseases Tretinoin 3.4017994277
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.2817255318
MESH:D007511 Ischemia Zinc 4.2616584753
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.8016580747
MESH:D007569 Jaw Abnormalities Tretinoin 8.8017551590 15992940
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.0515604871
MESH:D017492 Keratosis, Seborrheic alitretinoin 5.2616144296
MESH:D007673 Kidney Cortex Necrosis Cisplatin 4.7515464296
MESH:D007674 Kidney Diseases Acetaminophen 16.6815629191 12587719
MESH:D007674 Kidney Diseases Cisplatin 16.6818289764 15190930 12649298 19839026 12231392
MESH:D007674 Kidney Diseases Cyclosporine 16.688314463 18776723 10903974
MESH:D007674 Kidney Diseases Estradiol 16.6815618244
MESH:D007674 Kidney Diseases Zinc 16.6816960431
MESH:D007676 Kidney Failure, Chronic Zinc 4.0816518626
MESH:D007680 Kidney Neoplasms Cyclosporine 10.6512371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 10.6515003126 14681315 16762066
MESH:D007680 Kidney Neoplasms Estradiol 10.6515610895
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.4111231351
MESH:D007859 Learning Disorders Diethylstilbestrol 3.6917184923
MESH:D016773 Leishmaniasis, Cutaneous Zinc Sulfate 3.9615237267
MESH:D007938 Leukemia Tretinoin 2.5817143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.3616482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0119850784 17596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 6.9316087638
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 6.9317368321 12679006 17712046 17361223 17107899 17506722 19642359 19225113 9834237 16766008 17649720 19029980 16891316 17301526 19035177 16935935 17217047 19075265 17339181 15748426 16331271 16823087 16140955 16788101 17294898
MESH:D007970 Leukopenia Lipopolysaccharides 4.3215821434
MESH:D007984 Leydig Cell Tumor vinclozolin 4.3516417039
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.049224671
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.1414659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 6.1412878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.1415474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.1412878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.1418397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 3.9119460945 11587558 16611625 19784758 12969438 19014921 12587719 16610002
MESH:D008107 Liver Diseases Lindane 3.911715830
MESH:D017114 Liver Failure, Acute Acetaminophen 2.9116871587 17185352
MESH:D008113 Liver Neoplasms Aflatoxin B1 19.512125692 9163691 18177683 15890375
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 19.5120195826 21137059
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 19.5121295105 19389873
MESH:D008113 Liver Neoplasms Diethylstilbestrol 19.5116712894 15890375
MESH:D008113 Liver Neoplasms pirinixic acid 19.5116377806 20007298 15890375
MESH:D008113 Liver Neoplasms resveratrol 19.5119812893 20405173 19073162 19321006
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 19.5116984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 12.218603461
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 12.2118164116
MESH:D008114 Liver Neoplasms, Experimental Hexachlorobenzene 12.211423854
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 12.2112151625
MESH:D055370 Lung Injury Asbestos, Crocidolite 8.0717365036
MESH:D055370 Lung Injury Lipopolysaccharides 8.0721114838
MESH:D008175 Lung Neoplasms Aflatoxin B1 9.8514755239
MESH:D008175 Lung Neoplasms alitretinoin 9.8516413115
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 9.8518569708 17053015 20064080 20464547 20135361 18520028 18816296 6695378 20869020
MESH:D008175 Lung Neoplasms Cisplatin 9.8517225452 11798837 6189445
MESH:D008175 Lung Neoplasms Isotretinoin 9.8515899809
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 9.8511884234 19555203
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 9.8511807781
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.7715166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.2015700306
MESH:D016393 Lymphoma, B-Cell resveratrol 3.9517088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.5614749477
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.1316002989
MESH:D015674 Mammary Neoplasms, Animal resveratrol 3.8715688416
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 12.3116891317 11408345 17203775 11807958
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 12.318985016 11606380
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 12.318985016
MESH:D008325 Mammary Neoplasms, Experimental Zinc 12.3112773700
MESH:D020149 Manganese Poisoning Estradiol 4.0919453300
MESH:D008527 Medulloblastoma Tretinoin 2.6317453147
MESH:D008545 Melanoma Cisplatin 6.7416248763 12393984 17761969 18176117 17023156 18505091 11135225 16432458 15577323 16809738 12374674 12883367 18332650
MESH:D008545 Melanoma Isotretinoin 6.7417237267
MESH:D008545 Melanoma resveratrol 6.7417992120
MESH:D008545 Melanoma Tretinoin 6.7416752155
MESH:D018328 Melanoma, Amelanotic Cisplatin 4.3915990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2019513568
MESH:D008591 Meningomyelocele Tretinoin 4.0516940565
MESH:D008654 Mesothelioma Asbestos, Crocidolite 5.9716966607 18303189 16166281
MESH:D008654 Mesothelioma Cisplatin 5.9717638057
MESH:D008659 Metabolic Diseases resveratrol 4.0417112576
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.4016801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.9016381670
MESH:D009101 Multiple Myeloma resveratrol 3.2017935668 16490592 14749477 17049120 16267019 17164350
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.4917962980
MESH:D009135 Muscular Diseases pirinixic acid 3.1416239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.8617596541
MESH:D009203 Myocardial Infarction pirinixic acid 5.1819151258
MESH:D009203 Myocardial Infarction resveratrol 5.1816525036 16317513 16456233 17015251 17188708 17125593
MESH:D017202 Myocardial Ischemia resveratrol 8.0117015251 17125593
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.0112213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.2816810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.2816411023
MESH:D009205 Myocarditis resveratrol 4.3817322642
MESH:D009290 Narcolepsy marker/mechanism 17521418
MESH:D009369 Neoplasms alitretinoin 21.0316946489
MESH:D009369 Neoplasms Benzo(a)pyrene 21.0311141357
MESH:D009369 Neoplasms Cisplatin 21.0316773208
MESH:D009369 Neoplasms Diethylstilbestrol 21.0315313581
MESH:D009369 Neoplasms Lindane 21.0316818664 12807735
MESH:D009369 Neoplasms pirinixic acid 21.0317405874
MESH:D009369 Neoplasms Tretinoin 21.0316946489 16594593
MESH:D009374 Neoplasms, Experimental resveratrol 3.638985016
MESH:D009389 Neovascularization, Pathologic Estradiol 3.3517289903
MESH:D009395 Nephritis, Interstitial Cisplatin 4.1115464296
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.0517954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.9719348381 18481113
MESH:D009421 Nervous System Malformations bisphenol A 26.8911399458 16427766
MESH:D009421 Nervous System Malformations Diethylstilbestrol 26.8911399458
MESH:D009421 Nervous System Malformations Estradiol 26.8911399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 26.8914600291
MESH:D009421 Nervous System Malformations Tretinoin 26.899125849
MESH:D009436 Neural Tube Defects Tretinoin 2.819142499
MESH:D009447 Neuroblastoma Cisplatin 6.768761367
MESH:D009447 Neuroblastoma Isotretinoin 6.7617368321
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.3318514411
MESH:D019636 Neurodegenerative Diseases resveratrol 7.3317652729
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.328761367
MESH:D020078 Neurogenic Inflammation resveratrol 4.0517929310
MESH:D009765 Obesity pirinixic acid 1.7220558911
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 3.9117513867
MESH:D010049 Ovarian Diseases bisphenol A 4.6111985600
MESH:D010051 Ovarian Neoplasms Cisplatin 7.176897625 15464296 19769630 17225452
MESH:D010051 Ovarian Neoplasms Estradiol 7.1719401270
MESH:D010051 Ovarian Neoplasms Tretinoin 7.1716936753
MESH:D010146 Pain Acetaminophen 5.5816870215
MESH:D010146 Pain Tretinoin 5.5816870215
MESH:D010190 Pancreatic Neoplasms Cisplatin 7.9119003803
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 7.9115976015
MESH:D010190 Pancreatic Neoplasms Tretinoin 7.9115976015
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 3.9218404319 12065085 18922899 8330346
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8612520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 3.9515464296
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.7814722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.3015687265 16977796
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.5210923243
MESH:D010997 Pleural Neoplasms Cisplatin 4.9517638057
MESH:D011014 Pneumonia Lipopolysaccharides 4.1711605937 12224865
MESH:D017499 Porokeratosis alitretinoin 5.6116144296
MESH:D017119 Porphyria Cutanea Tarda Hexachlorobenzene 9.909918132
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 9.9018163543
MESH:D011230 Precancerous Conditions Cyclosporine 2.9012371664
MESH:D011225 Pre-Eclampsia Zinc 3.8817114810
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 32.9310548101
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 32.9317184923
MESH:D011297 Prenatal Exposure Delayed Effects Isotretinoin 32.9318769834
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 32.9316679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 32.9311222880 11118676 11399792 11896295
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 32.9319015723 18220299 18042343
MESH:D011469 Prostatic Diseases vinclozolin 4.5518220299
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.4015572423
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 9.4220887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.4220887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.8017292933
MESH:D011471 Prostatic Neoplasms bisphenol A 2.8016740699
MESH:D011471 Prostatic Neoplasms Calcitriol 2.8012479363 18247401 16289102 15754350 16644109
MESH:D011471 Prostatic Neoplasms Clorgyline 2.8019691856
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.8017136230 15046698 15846301
MESH:D011471 Prostatic Neoplasms Estradiol 2.8016740699
MESH:D011471 Prostatic Neoplasms Lindane 2.8014688026 12661182
MESH:D011471 Prostatic Neoplasms resveratrol 2.8017636462 17718901 17675339 15767336 16731767 17804756
MESH:D011471 Prostatic Neoplasms Zinc 2.8016700911 16517595 12429649 16606632
MESH:D011472 Prostatitis vinclozolin 4.5518629315
MESH:D011507 Proteinuria Tretinoin 3.2616636307
MESH:D011565 Psoriasis Cyclosporine 2.0916882103
MESH:D011596 Psychomotor Disorders Isotretinoin 5.5418769834
MESH:D011625 Pterygium Tretinoin 4.4116723453
MESH:D011629 Puberty, Precocious bisphenol A 4.4010548101
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 2.8817975199 17322281 15814490 17365031
MESH:D051437 Renal Insufficiency Cisplatin 4.0415464296
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.1916325855
MESH:D015427 Reperfusion Injury pirinixic acid 5.9319058328
MESH:D015427 Reperfusion Injury resveratrol 5.9315827377 17520802 17058453 16314181 16317513
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.4810835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4718990726
MESH:D012162 Retinal Degeneration Zinc 3.8416584753
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.7516116481 16283617
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.0714601052
MESH:D012640 Seizures Lindane 3.3712842176 7539098 15475178
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 15.9410029692 19755658
MESH:D012878 Skin Neoplasms resveratrol 15.9415837718 8985016
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 15.9416192470
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 15.948985016 12065085 11807781 18404319 8330346
MESH:D012878 Skin Neoplasms Tretinoin 15.9416467112
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 4.9515464296
MESH:D013088 Spermatocele Diethylstilbestrol 4.3216709447 16002989
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.172093021 20155912
MESH:D013274 Stomach Neoplasms Cisplatin 3.1717522103 18396642 15958060
MESH:D013274 Stomach Neoplasms Tretinoin 3.1717261132
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.1516321402
MESH:D019966 Substance-Related Disorders bisphenol A 3.6016684133 16045194
MESH:D013736 Testicular Neoplasms Cisplatin 4.2817225452 15464296
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.8415821434
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5112697716
MESH:D013964 Thyroid Neoplasms Tretinoin 2.7417045167 16026305
MESH:D013978 Tibial Fractures Estradiol 4.3019048282
MESH:D014062 Tongue Neoplasms resveratrol 14.7316227395
MESH:D014062 Tongue Neoplasms Tretinoin 14.7316051514
MESH:D014062 Tongue Neoplasms Zinc 14.7316543248
MESH:D014376 Tuberculosis Tretinoin 2.9916040207
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 7.4917053015
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 7.4912973940 17225452 15464296
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 7.4916452187 17306315 16712894
MESH:D014581 Urticaria Acetaminophen 2.6310982225
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 19.9616803524
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 19.9616175088
MESH:D002583 Uterine Cervical Neoplasms resveratrol 19.9617473185
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 19.9616129372
MESH:D014591 Uterine Diseases bisphenol A 12.5214652134
MESH:D014591 Uterine Diseases Diethylstilbestrol 12.5214652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 8.5815809267 16690809
MESH:D014594 Uterine Neoplasms resveratrol 8.5817044934
MESH:D014604 Uveal Neoplasms Tretinoin 4.2216752155
MESH:D014605 Uveitis Cyclosporine 3.601336536
MESH:D014625 Vaginal Neoplasms Cisplatin 9.8415577323
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 9.8416513791 16002989
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2112125929
MESH:D018487 Ventricular Dysfunction, Left resveratrol 3.9317488730
MESH:D014820 Vitiligo Tretinoin 3.6916761959
MESH:D014839 Vomiting Cisplatin 4.3311897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8615886252
MESH:D009396 Wilms Tumor Tretinoin 3.6516287080
MESH:D014985 Xerophthalmia Cyclosporine 4.0517120751
Pathway ID Pathway Name
KEGG:04910 Insulin signaling pathway
KEGG:04630 Jak-STAT signaling pathway
KEGG:04930 Type II diabetes mellitus
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA128394542
    • No data
    Releated disease ID Related disease Name
    PA443624Carcinoma, Renal Cell
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA164749376interferon alfacon-1
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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