AutismKB 2.0

Annotation Detail for HDAC3


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Basic Information Top
Gene Symbol:HDAC3 ( HD3,RPD3,RPD3-2 )
Gene Full Name: histone deacetylase 3
Band: 5q31.3
Quick LinksEntrez ID:8841; OMIM: 605166; Uniprot ID:HDAC3_HUMAN; ENSEMBL ID: ENSG00000171720; HGNC ID: 4854
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Signalling by NGF
Metabolism of lipids and lipoproteins
Pathway IDPathway Name
200171Validated targets of C-MYC transcriptional repression
200070Signaling events mediated by HDAC Class I
200019Signaling events mediated by HDAC Class II
200142Retinoic acid receptors-mediated signaling
200191Regulation of retinoblastoma protein
Pathway IDPathway Name
P00057Wnt signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of HDAC3 mRNAdecreases expression 18648102
C016601 4-hydroxytamoxifen 4-hydroxytamoxifen promotes the reaction [HDAC3 protein binds to TFF1 promoter]affects binding|increases reaction 19858209
D000643 Ammonium Chloride Ammonium Chloride affects the expression of HDAC3 mRNAaffects expression 16483693
C005961 bis(tri-n-butyltin)oxide bis(tri-n-butyltin)oxide results in decreased expression of HDAC3 mRNAdecreases expression 17553608
D002087 Butyrates Butyrates results in decreased activity of HDAC3 proteindecreases activity 15930892
D002220 Carbamazepine Carbamazepine results in decreased activity of HDAC3 proteindecreases activity 15850602
D003474 Curcumin Curcumin results in decreased expression of HDAC3 proteindecreases expression 17927689
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of HDAC3 mRNAdecreases expression 17475347
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of HDAC3 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HDAC3 mRNAaffects cotreatment|increases expression 17942748
D005839 Gentamicins Gentamicins results in increased expression of HDAC3 proteinincreases expression 19141081
C013598 methoxyacetic acid methoxyacetic acid results in decreased activity of HDAC3 proteindecreases activity 15103026
D009151 Mustard Gas Mustard Gas results in increased expression of HDAC3 mRNAincreases expression 15674844
C059514 resveratrol resveratrol results in increased expression of HDAC3 mRNAincreases expression 15767336
C017947 sodium arsenite sodium arsenite results in decreased expression of HDAC3 mRNAdecreases expression 19822182
D018038 Sodium Selenite Sodium Selenite results in decreased expression of HDAC3 proteindecreases expression 18676679
C021751 tanshinone tanshinone results in increased expression of HDAC3 mRNAincreases expression 15849732
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HDAC3 mRNAaffects cotreatment|increases expression 17942748
C067071 trapoxin B trapoxin B results in decreased activity of HDAC3 proteindecreases activity 15930892
D014212 Tretinoin Tretinoin results in decreased expression of HDAC3 mRNAdecreases expression 17218384
D014212 Tretinoin Tretinoin affects the reaction [HDAC3 protein binds to NR2C1 promoter]affects binding|affects reaction 17389641
C012589 trichostatin A trichostatin A results in decreased activity of HDAC3 proteindecreases activity 15930892
15103026
C012589 trichostatin A trichostatin A results in decreased expression of HDAC3 proteindecreases expression 18676679
D014635 Valproic Acid Valproic Acid results in decreased activity of HDAC3 proteindecreases activity 15103026
C111237 vorinostat vorinostat results in decreased activity of HDAC3 proteindecreases activity 15930892
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Carbamazepine 19.568986270
MESH:D000014 Abnormalities, Drug-Induced methoxyacetic acid 19.563652986 12805644 1761404 1761407 15959878
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 19.5615322242 11752688 14514962
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 19.568875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.8319490988
MESH:D000138 Acidosis Ammonium Chloride 3.4518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.8417505938
MESH:D058186 Acute Kidney Injury Gentamicins 8.7611274264
MESH:D058186 Acute Kidney Injury resveratrol 8.7616538975
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.7914692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.633712494
MESH:D000236 Adenoma resveratrol 6.6315688382
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.2716835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.5915276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.8017306315 16712894
MESH:D019973 Alcohol-Related Disorders Curcumin 4.9817887948
MESH:D000505 Alopecia Tretinoin 3.5315955085
MESH:D000544 Alzheimer Disease Curcumin 4.3615590663
MESH:D000544 Alzheimer Disease resveratrol 4.3616162502 16183991
MESH:D000550 Amblyopia Valproic Acid 5.1317688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8511748828
MESH:D001008 Anxiety Disorders Valproic Acid 3.4817497229
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.3611256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 11.8815885639
MESH:D001169 Arthritis, Experimental resveratrol 11.8817115116
MESH:D001169 Arthritis, Experimental Tretinoin 11.8816412693
MESH:D001172 Arthritis, Rheumatoid Curcumin 4.6516807698
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.6516292516
MESH:D001249 Asthma Mustard Gas 4.8710378619
MESH:D001249 Asthma Tretinoin 4.8716456186
MESH:D050197 Atherosclerosis Curcumin 6.7018704882
MESH:D050197 Atherosclerosis resveratrol 6.7016873680 17967414
MESH:D001321 Autistic Disorder Valproic Acid 2.0118177632 18985861 18940202 15238991 19460635 20603192 18775368 18558336 18396377 17507914 17688650 18316065 19232924 16609825 17157402
MESH:D001327 Autoimmune Diseases Curcumin 4.3819761891
MESH:D001471 Barrett Esophagus Tretinoin 4.2916935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.9111289319 1440618
MESH:D001714 Bipolar Disorder Carbamazepine 7.3620046352 17594078
MESH:D001714 Bipolar Disorder Valproic Acid 7.3620046352 17594078
MESH:D001768 Blister Mustard Gas 5.0519167455
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.6012125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.6016206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.7915746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.798888407
MESH:D002545 Brain Ischemia Curcumin 9.9616770732
MESH:D002545 Brain Ischemia resveratrol 9.9617600658
MESH:D001932 Brain Neoplasms Curcumin 3.8417596214
MESH:D001943 Breast Neoplasms Curcumin 2.9318462866 18593918 16243823 19250217
MESH:D001943 Breast Neoplasms resveratrol 2.9317651959 16393696 17534123
MESH:D001943 Breast Neoplasms tanshinone 2.9319885617 15849732
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.9320435547
MESH:D001943 Breast Neoplasms Tretinoin 2.9316166294 16443354 16873071
MESH:D001943 Breast Neoplasms vorinostat 2.9316144943
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.0515286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.8717687719 10378619
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.4816813970
MESH:D002277 Carcinoma Curcumin 7.9918593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.9916835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.0516168501
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.467296757 3581430
MESH:D006528 Carcinoma, Hepatocellular resveratrol 6.4616227395 19321006
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 6.4615276417 17306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 6.461917145
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.4816675471
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.9418414057
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.627296757
MESH:D002294 Carcinoma, Squamous Cell Curcumin 10.5818462866
MESH:D002294 Carcinoma, Squamous Cell resveratrol 10.5816227395
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 10.5818572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 10.5816096774 16051514
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3116120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases resveratrol 3.4015458977
MESH:D002386 Cataract Tretinoin 3.0317460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 6.497505956
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 6.4919524636 20056578
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.4816129372
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6720734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0716835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 7.5919486331 9022650
MESH:D002779 Cholestasis Ethinyl Estradiol 7.5917681005 17333356 16919318 16105132 17110522 11677210 15861022
MESH:D002822 Choriocarcinoma Tretinoin 5.0516461808
MESH:D019457 Chromosome Breakage Sodium Selenite 4.6415894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.6115668235 8697196 12621046 15340226 16354765
MESH:D002972 Cleft Palate Tretinoin 5.619407595
MESH:D003092 Colitis Curcumin 15.4718200517 16804969 16782535
MESH:D003092 Colitis resveratrol 15.4716474422
MESH:D003092 Colitis Tretinoin 15.4717035595
MESH:D003103 Coloboma Curcumin 4.4518809619
MESH:D003110 Colonic Neoplasms Butyrates 5.9215936596
MESH:D003110 Colonic Neoplasms Curcumin 5.9216340194 19359593
MESH:D003110 Colonic Neoplasms resveratrol 5.9216338953
MESH:D015179 Colorectal Neoplasms resveratrol 2.2216550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9617141729 14669216
MESH:D016510 Corneal Neovascularization Curcumin 4.7918497527
MESH:D003327 Coronary Disease resveratrol 3.6816507316
MESH:D019465 Craniofacial Abnormalities Carbamazepine 5.359014606
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.3510048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 5.358800419 10589399 9125849 16925845 14991402 17551590 9664655 9211117 9142499 9224671
MESH:D019465 Craniofacial Abnormalities Valproic Acid 5.358888407 17688650 16575769
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.7011906362 12868966 8156756 14531868 8970840 11298694 18759878 2524372
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.393621924 2952479
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.6816285004
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.6816873680
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 4.3218403477
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3217107852
MESH:D003928 Diabetic Nephropathies Curcumin 8.9218204486
MESH:D003928 Diabetic Nephropathies resveratrol 8.9216286809
MESH:D003967 Diarrhea vorinostat 4.3920479100
OMIM:607208 DRAVET SYNDROME Carbamazepine 5.3411748493
MESH:D004342 Drug Hypersensitivity Carbamazepine 4.3416538176 20216337 16538175 15057820
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 11.6918648102 18289764 9653073 18692083 16192314 7440962 9022650 8291058 11289319 9328219 1440618 6482804 6679447
MESH:D056486 Drug-Induced Liver Injury Carbamazepine 11.6917465707
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 11.6915131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.6920420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 11.691733752 19641884
MESH:D004362 Drug Toxicity Carbamazepine 13.4920216337
MESH:D004362 Drug Toxicity Gentamicins 13.4915033597 11033412
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 13.4911462148
MESH:D004381 Duodenal Ulcer Curcumin 3.9417351913
MESH:D004421 Dystonia Valproic Acid 3.941851702
MESH:D004487 Edema Mustard Gas 10.969260866 11428647 11428631 11402378
MESH:D004487 Edema resveratrol 10.968985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.9612711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.5915322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 11.5918230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Carbamazepine 14.9017654737
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 14.9012538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 14.9017872969
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 5.5319294695
MESH:D016889 Endometrial Neoplasms 4-hydroxytamoxifen 7.5919148513
MESH:D016889 Endometrial Neoplasms Tretinoin 7.5916569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.929294722 10568697
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.7417923197
MESH:D004816 Epidermal Necrolysis, Toxic Carbamazepine 5.1516538176 20485159 19915237 18855540 16415921
MESH:D004831 Epilepsies, Myoclonic Carbamazepine 10.8317275665
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 10.833659116 17275665
MESH:D004828 Epilepsies, Partial Carbamazepine 10.0317116037 15008574 16628512
MESH:D004828 Epilepsies, Partial Valproic Acid 10.033922381 16628512
MESH:D004827 Epilepsy Carbamazepine 6.889014606 17178248 17465707 18234410 19700373 7988514 19439326 821787 19620853 20417680
MESH:D004827 Epilepsy Valproic Acid 6.8820417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.496426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Carbamazepine 11.347750514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 11.347750514
MESH:D004830 Epilepsy, Tonic-Clonic Carbamazepine 10.5215276670 3659116
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 10.523659116
MESH:D004890 Erythema Mustard Gas 5.059357497
MESH:D004916 Erythromelalgia Carbamazepine 5.6119549232
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.083581430
MESH:D005076 Exanthema Carbamazepine 5.3620485159
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.5611564622
MESH:D005124 Eye Abnormalities Tretinoin 8.569664655 16938888
MESH:D005221 Fatigue vorinostat 5.4920479100
MESH:D005234 Fatty Liver Curcumin 12.6019297423
MESH:D005234 Fatty Liver Ethinyl Estradiol 12.6015345470
MESH:D005234 Fatty Liver Valproic Acid 12.6019224547 14986274
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3511858732
MESH:D005315 Fetal Diseases Valproic Acid 4.7816575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.028888407 18558336
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.916705139
MESH:D005355 Fibrosis Curcumin 14.2018705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 14.2020067830
MESH:D005355 Fibrosis Tretinoin 14.2017994277
MESH:D005532 Foot Deformities, Congenital methoxyacetic acid 5.613652986
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.5818462866
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.5716452187
MESH:D005909 Glioblastoma Curcumin 11.6117596214
MESH:D005909 Glioblastoma Tretinoin 11.6117312396
MESH:D005909 Glioblastoma trichostatin A 11.6118801729
MESH:D005910 Glioma tanshinone 3.9816955220
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.937505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4910696789
MESH:D006258 Head and Neck Neoplasms Curcumin 7.6518462866 18829502
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.6516096774
MESH:D034381 Hearing Loss Gentamicins 4.7919130971 15968427 18024279 17868369
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.0516084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.3411294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 6.349664655 14991402
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2311000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.416705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.7815340226 12621046 16120746
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.9317701891
MESH:D006561 Herpes Simplex resveratrol 4.0716876885
MESH:D006689 Hodgkin Disease sodium arsenite 3.0612676792
MESH:D006849 Hydrocephalus Valproic Acid 4.7617688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.948697196 18606429 15340226 16354765 16959395
MESH:D006930 Hyperalgesia Tretinoin 3.1216870215
MESH:D053565 Hypercalciuria Gentamicins 5.6017652376
MESH:D006937 Hypercholesterolemia Curcumin 9.0518704882
MESH:D006937 Hypercholesterolemia resveratrol 9.0517188708
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.4616778211
MESH:D020138 Hyperhomocysteinemia Carbamazepine 4.6310459572
MESH:D006949 Hyperlipidemias resveratrol 3.9216873680
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 10.7615034207
MESH:D006965 Hyperplasia Carbamazepine 10.7618773962
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8718850075 18670907
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 10.3917488730
MESH:D017379 Hypertrophy, Left Ventricular tanshinone 10.3919662366
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7016569931 16945680
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.5417600658
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3612013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.4017937319
MESH:D007248 Infertility, Male sodium arsenite 6.4012646999 15346721
MESH:D007249 Inflammation Curcumin 11.5416956363 18403477 17151092
MESH:D007249 Inflammation Mustard Gas 11.5416001271 11428620 11428631 17524151 9357497 9260866 11402378 8975870 11428647
MESH:D007249 Inflammation resveratrol 11.5416366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.5412200463 12878042
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.1618596194 18200517
MESH:D007251 Influenza, Human resveratrol 4.4416624496
MESH:D007333 Insulin Resistance Sodium Selenite 3.2014714311
MESH:D007410 Intestinal Diseases Tretinoin 3.6617994277
MESH:D007414 Intestinal Neoplasms Curcumin 4.1210783313
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.919022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.5916580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.5917551590 15992940
MESH:D007673 Kidney Cortex Necrosis Gentamicins 5.6218842672
MESH:D007674 Kidney Diseases Gentamicins 6.3519349640 17934191 18289764
MESH:D007674 Kidney Diseases sodium arsenite 6.3520008137
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 2.886582329
MESH:D007683 Kidney Tubular Necrosis, Acute Gentamicins 5.2811231351
MESH:D007889 Leiomyoma Curcumin 4.4718555241
MESH:D016773 Leishmaniasis, Cutaneous Gentamicins 4.3710219319
MESH:D007938 Leukemia Curcumin 6.3118462866
MESH:D007938 Leukemia Tretinoin 6.3117143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 4.1016106398
MESH:D007951 Leukemia, Myeloid Tretinoin 3.6016932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 6.1017596541 16294345 19850784
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 6.1018206229
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 6.1016294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 7.5316087638
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.5317361223 17217047 16788101 17506722 16823087 16935935 17294898 16766008 19035177 15748426 9834237 16140955 17649720 19225113 16891316 17301526 19075265 16331271 19642359 17368321 17107899 19029980 17339181 12679006 17712046
MESH:D015458 Leukemia, T-Cell Curcumin 4.6516106398
MESH:D017880 Limb Deformities, Congenital methoxyacetic acid 8.3912805644 15959878
MESH:D017880 Limb Deformities, Congenital Tretinoin 8.399224671
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.1315034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 3.4518705752 18006644 17355460
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4512878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.4518397230 16248980
MESH:D008107 Liver Diseases Curcumin 2.5916956363
MESH:D008113 Liver Neoplasms resveratrol 7.2319812893 19321006 19073162 20405173
MESH:D008113 Liver Neoplasms sodium arsenite 7.2316712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.2316984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 5.506587162 3712494 598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.5012151625
MESH:D008171 Lung Diseases Mustard Gas 7.3018702808 18161513
MESH:D008171 Lung Diseases sodium arsenite 7.3019095001
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.1617228818
MESH:D008175 Lung Neoplasms Curcumin 4.7718462866 19359593 16243823
MESH:D008175 Lung Neoplasms Mustard Gas 4.773148597 8781369
MESH:D008175 Lung Neoplasms sodium arsenite 4.7716712894 19931552 17306315 17077188 15276417
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.7719555203 11884234
MESH:D008180 Lupus Erythematosus, Systemic Carbamazepine 3.5416628512
MESH:D008223 Lymphoma Curcumin 3.5118462866
MESH:D016393 Lymphoma, B-Cell resveratrol 9.9317088997
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 9.9314737004
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.7814749477
MESH:D016399 Lymphoma, T-Cell Curcumin 4.5816173963
MESH:D016410 Lymphoma, T-Cell, Cutaneous vorinostat 5.5820479100
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.1415688416
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 3.048985016 11606380
MESH:D008527 Medulloblastoma Tretinoin 2.7417453147
MESH:D008545 Melanoma Curcumin 9.6218462866 17885582
MESH:D008545 Melanoma resveratrol 9.6217992120
MESH:D008545 Melanoma sodium arsenite 9.6216487513 19082730
MESH:D008545 Melanoma Tretinoin 9.6216752155
MESH:D008545 Melanoma trichostatin A 9.6216505122
MESH:D008569 Memory Disorders Curcumin 4.0517263510
MESH:D008591 Meningomyelocele Tretinoin 4.3216940565
MESH:D008607 Mental Retardation Carbamazepine 3.699014606
MESH:D008659 Metabolic Diseases resveratrol 4.2717112576
MESH:D008881 Migraine Disorders Valproic Acid 3.1118803445 18765137
MESH:D009101 Multiple Myeloma Curcumin 11.8519372569
MESH:D009101 Multiple Myeloma resveratrol 11.8517049120 16267019 16490592 17935668 17164350 14749477
MESH:D009101 Multiple Myeloma trichostatin A 11.8518172295
MESH:D009134 Muscular Atrophy, Spinal Curcumin 12.0517962980
MESH:D009134 Muscular Atrophy, Spinal resveratrol 12.0517962980
MESH:D009137 Muscular Dystrophy, Animal Gentamicins 6.1718694830
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.928888407
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.1917596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.1917596541
MESH:D009203 Myocardial Infarction resveratrol 2.9817188708 16317513 16525036 16456233 17125593 17015251
MESH:D017202 Myocardial Ischemia resveratrol 8.7217125593 17015251
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.7212213967
MESH:D009205 Myocarditis resveratrol 4.6517322642
MESH:D009224 Myotonia Congenita Carbamazepine 5.3620399394
MESH:D009325 Nausea vorinostat 5.4220479100
MESH:D009361 Neoplasm Invasiveness Curcumin 4.2618495463
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.433581430
MESH:D009369 Neoplasms sodium arsenite 4.9311559025
MESH:D009369 Neoplasms Tretinoin 4.9316946489 16594593
MESH:D009374 Neoplasms, Experimental resveratrol 8.868985016
MESH:D009374 Neoplasms, Experimental sodium arsenite 8.8620056578
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.4312497104
MESH:D009421 Nervous System Malformations Carbamazepine 15.8816990009
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.8814600291
MESH:D009421 Nervous System Malformations Tretinoin 15.889125849
MESH:D009423 Nervous System Neoplasms Curcumin 5.5218462866
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 16.746679447
MESH:D009436 Neural Tube Defects sodium arsenite 16.7412854658
MESH:D009436 Neural Tube Defects Tretinoin 16.749142499
MESH:D009436 Neural Tube Defects Valproic Acid 16.7416359493 8888407
MESH:D019636 Neurodegenerative Diseases resveratrol 3.7217652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.2917929310
MESH:D009503 Neutropenia Mustard Gas 3.8716761898 7688884
MESH:D009765 Obesity Curcumin 2.7219297423
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.326482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.913988306
MESH:D010018 Osteomalacia Carbamazepine 5.3617016548
MESH:D010024 Osteoporosis Curcumin 3.4018719352
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.1517513867
MESH:D010051 Ovarian Neoplasms Curcumin 11.0718462866 19020741
MESH:D010051 Ovarian Neoplasms sodium arsenite 11.0717306315 15276417
MESH:D010051 Ovarian Neoplasms Tretinoin 11.0716936753
MESH:D010051 Ovarian Neoplasms trichostatin A 11.0719331143
MESH:D010146 Pain Carbamazepine 6.8915215642
MESH:D010146 Pain Tretinoin 6.8916870215
MESH:D010190 Pancreatic Neoplasms Curcumin 8.5619196508 17440100 19401701
MESH:D010190 Pancreatic Neoplasms Tretinoin 8.5615976015
MESH:D010190 Pancreatic Neoplasms trichostatin A 8.5619294695
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5811578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.387296757
MESH:D010267 Parapsoriasis Carbamazepine 5.5916538176
OMIM:167400 PAROXYSMAL EXTREME PAIN DISORDER Carbamazepine 5.8217679678 17145499
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1412520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.366228378
MESH:D011041 Poisoning Mustard Gas 3.6915727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4518163543
MESH:D011248 Pregnancy Complications Carbamazepine 5.049014606
MESH:D011297 Prenatal Exposure Delayed Effects Carbamazepine 22.419014606
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 22.4116679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 22.4111118676 11399792 11896295 11222880
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 22.4120603192
MESH:D055728 Primary Myelofibrosis trichostatin A 5.1417616702
MESH:D011471 Prostatic Neoplasms Curcumin 1.9015129424 12497104 11398177 10851300 18226269 18156803 18769126
MESH:D011471 Prostatic Neoplasms resveratrol 1.9017804756 15767336 17636462 16731767 17675339 17718901
MESH:D011471 Prostatic Neoplasms sodium arsenite 1.9016039940
MESH:D011471 Prostatic Neoplasms Sodium Selenite 1.9018760546
MESH:D011471 Prostatic Neoplasms trichostatin A 1.9019789329 18798265
MESH:D011471 Prostatic Neoplasms vorinostat 1.9017218635
MESH:D011507 Proteinuria Gentamicins 9.1915033597
MESH:D011507 Proteinuria Tretinoin 9.1916636307
MESH:D011537 Pruritus Ethinyl Estradiol 9.1615861022 16919318
MESH:D011537 Pruritus Mustard Gas 9.1618058305
MESH:D019310 Pseudolymphoma Carbamazepine 12.249591791 12752131
MESH:D019310 Pseudolymphoma Valproic Acid 12.2412752131 11422049
MESH:D011625 Pterygium Tretinoin 4.6816723453
MESH:D011656 Pulmonary Emphysema Curcumin 4.4319168576
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.8917266442 17720292 17894541 17620002 10334151
MESH:D051437 Renal Insufficiency Gentamicins 4.8815728788 17132701
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.4816325855
MESH:D015427 Reperfusion Injury resveratrol 3.2217520802 16317513 16314181 17058453 15827377
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.9218379247 10666014
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7318990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.293692021
MESH:D012173 Retinitis Gentamicins 6.1718644591
MESH:D012208 Rhabdomyosarcoma Tretinoin 10.5116116481 16283617
MESH:D012208 Rhabdomyosarcoma Valproic Acid 10.5119155313
MESH:D012509 Sarcoma Curcumin 4.0218462866
MESH:D012559 Schizophrenia Valproic Acid 2.0519110320 15737665
MESH:D012640 Seizures Carbamazepine 6.1615946322 16180713 9844417 16938433 9046859 19414003 16876388
MESH:D012640 Seizures Valproic Acid 6.1615475178 1511512 16876388 3137016 11738929 11044598 17978042 14763951
MESH:D018805 Sepsis Curcumin 3.9818389075
MESH:D012871 Skin Diseases Mustard Gas 2.6912880345 16961503 15451306
MESH:D012878 Skin Neoplasms resveratrol 13.1615837718 8985016
MESH:D012878 Skin Neoplasms sodium arsenite 13.1618572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 13.1616192470
MESH:D012878 Skin Neoplasms Tretinoin 13.1616467112
MESH:D012893 Sleep Disorders Carbamazepine 5.0119414003
MESH:D013088 Spermatocele Ethinyl Estradiol 3.8416709447
MESH:D016135 Spinal Dysraphism sodium arsenite 9.2612854658
MESH:D016135 Spinal Dysraphism Valproic Acid 9.2619490988
MESH:D013226 Status Epilepticus Valproic Acid 4.4412833885
MESH:D013262 Stevens-Johnson Syndrome Carbamazepine 5.1019915237 16415921 19694795 18855540 16538176 20485159 15057820
MESH:D013274 Stomach Neoplasms Tretinoin 1.7917261132
MESH:D013276 Stomach Ulcer Curcumin 3.4019188055 16631530
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.3816321402
MESH:D013576 Syndactyly methoxyacetic acid 5.521761407 1761404
MESH:D013733 Testicular Diseases methoxyacetic acid 5.226499806 18486176
MESH:D013921 Thrombocytopenia vorinostat 4.8720479100
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0615669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8012697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 11.613712494 6582329 1399818 6587162 7505956
MESH:D013964 Thyroid Neoplasms Butyrates 11.6117967635
MESH:D013964 Thyroid Neoplasms Tretinoin 11.6116026305 17045167
MESH:D014062 Tongue Neoplasms resveratrol 9.5816227395
MESH:D014062 Tongue Neoplasms Tretinoin 9.5816051514
MESH:D014178 Translocation, Genetic Valproic Acid 5.1317262798
MESH:D014376 Tuberculosis Tretinoin 3.1616040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.413119515
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.148074119
MESH:D001749 Urinary Bladder Neoplasms Curcumin 8.1418593936
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 8.1416712894 11723127 17306315 16452187
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.538888407
MESH:D014565 Urogenital Neoplasms Curcumin 5.1618462866
MESH:D002583 Uterine Cervical Neoplasms resveratrol 15.3217473185
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 15.3211813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 15.3216129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 9.1414692618
MESH:D014594 Uterine Neoplasms resveratrol 9.1417044934
MESH:D014604 Uveal Neoplasms Tretinoin 4.5016752155
MESH:D014652 Vascular Diseases sodium arsenite 4.3217056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4414671159 15869587
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.1917488730
MESH:D015837 Vestibular Diseases Gentamicins 5.4118776599
MESH:D014820 Vitiligo Tretinoin 3.9516761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1415886252
MESH:D009396 Wilms Tumor Tretinoin 3.8716287080
Pathway ID Pathway Name
REACT:15380 Diabetes pathways
REACT:22258 Metabolism of lipids and lipoproteins
REACT:11061 Signalling by NGF
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29228
    • No data
    Releated disease ID Related disease Name
    PA445062Neoplasms
    PA447199Bipolar Disorder
    PA443223Congenital Abnormalities
    PA444065Epilepsy
    PA444354Headache
    PA447230HIV
    PA447004Migraine with Aura
    PA444949Migraine without Aura
    PA447216Schizophrenia
    PA446284Spinal Dysraphism
    PA164925725Toxic liver disease
    Releated drug ID Related drug Name
    PA451846valproic acid
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB02546 antagonist Vorinostat Antineoplastic Agents;Enzyme Inhibitors;Anticarcinogenic Agents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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