AutismKB 2.0

Annotation Detail for PROM1


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Basic Information Top
Gene Symbol:PROM1 ( AC133,CD133,CORD12,MCDR2,PROML1,RP41,STGD4 )
Gene Full Name: prominin 1
Band: 4p15.32
Quick LinksEntrez ID:8842; OMIM: 604365; Uniprot ID:PROM1_HUMAN; ENSEMBL ID: ENSG00000007062; HGNC ID: 9454
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1734Muscular dystrophy
1934Cancer
2178Retinal disease
No data
Desease Name
Self-rated health
Desease Name
Cone-rod dystrophy 12
Stargardt disease 4
Macular dystrophy, retinal, 2
Retinitis pigmentosa-41
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PROM1 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of PROM1 mRNAincreases expression 18648102
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PROM1 mRNAaffects expression 16483693
D001374 Azacitidine Azacitidine results in increased expression of PROM1 mRNAincreases expression 18037191
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PROM1 mRNAaffects cotreatment|increases expression 18164116
C055494 caffeic acid phenethyl ester [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of PROM1 mRNAaffects cotreatment|increases expression 20360939
C014347 decitabine [decitabine affects the methylation of PROM1 promoter] which affects the expression of PROM1 mRNAaffects expression|affects methylation 18679414
C014347 decitabine [decitabine affects the methylation of PROM1 promoter] which affects the expression of PROM1 proteinaffects expression|affects methylation 18829568
C014347 decitabine [[decitabine co-treated with Valproic Acid] affects the methylation of PROM1 promoter] which affects the expression of PROM1 mRNAaffects cotreatment|affects expression|affects methylation 18679414
D003997 Dicarbethoxydihydrocollidine Dicarbethoxydihydrocollidine results in increased expression of PROM1 proteinincreases expression 17585168
C121718 dicyclanil dicyclanil results in increased expression of PROM1 mRNAincreases expression 15664270
D004041 Dietary Fats Dietary Fats results in increased expression of PROM1 mRNAincreases expression 18042831
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PROM1 mRNAaffects cotreatment|increases expression 18164116
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of PROM1 mRNAaffects cotreatment|increases expression 20360939
D004054 Diethylstilbestrol Diethylstilbestrol results in decreased expression of PROM1 mRNAdecreases expression 15171707
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of PROM1 mRNAincreases expression 15289156
D004128 Dimethylnitrosamine Dimethylnitrosamine results in decreased expression of PROM1 mRNAdecreases expression 17547211
D004958 Estradiol Estradiol affects the expression of PROM1 mRNAaffects expression 15598610
D004958 Estradiol Estradiol results in increased expression of PROM1 mRNAincreases expression 15289156
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PROM1 mRNAincreases expression 17351261
17557909
D015073 2-Acetylaminofluorene 2-Acetylaminofluorene results in increased expression of PROM1 mRNAincreases expression 17187413
D005472 Fluorouracil Fluorouracil results in increased expression of PROM1 proteinincreases expression 15352031
D005472 Fluorouracil PROM1 protein affects the susceptibility to Fluorouracilaffects response to substance 15352031
D019833 Genistein Genistein results in increased expression of PROM1 mRNAincreases expression 15289156
C010176 halofuginone halofuginone results in increased expression of PROM1 mRNAincreases expression 17180598
C051890 irinotecan irinotecan metabolite results in decreased expression of PROM1 mRNAdecreases expression 15956246
C051890 irinotecan irinotecan results in decreased expression of PROM1 mRNAdecreases expression 15956246
D010100 Oxygen Oxygen deficiency results in increased expression of PROM1 proteinincreases expression 18985161
D010100 Oxygen Oxygen inhibits the reaction [Oxygen deficiency results in increased expression of PROM1 protein]decreases reaction|increases expression 18985161
C041786 palm oil palm oil results in increased expression of PROM1 mRNAincreases expression 18042831
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of PROM1 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital affects the expression of PROM1 mRNAaffects expression 19136022
D010634 Phenobarbital Phenobarbital results in increased expression of PROM1 mRNAincreases expression 19482888
19270015
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PROM1 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid affects the expression of PROM1 mRNAaffects expression 19136022
C006253 pirinixic acid pirinixic acid results in decreased expression of PROM1 mRNAdecreases expression 17426115
D012402 Rotenone Rotenone results in increased expression of PROM1 proteinincreases expression 18985161
D014635 Valproic Acid [[decitabine co-treated with Valproic Acid] affects the methylation of PROM1 promoter] which affects the expression of PROM1 mRNAaffects cotreatment|affects expression|affects methylation 18679414
D014635 Valproic Acid [Valproic Acid affects the methylation of PROM1 promoter] which affects the expression of PROM1 mRNAaffects expression|affects methylation 18679414
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 7.836195326
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 7.838875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.7419490988
MESH:D000138 Acidosis Ammonium Chloride 3.3518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7317505938
MESH:D055371 Acute Lung Injury Oxygen 8.5816759491
MESH:D055371 Acute Lung Injury pirinixic acid 8.5818653653
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 12.9716033868
MESH:D000230 Adenocarcinoma Estradiol 12.9711473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 12.9714692618
MESH:D000230 Adenocarcinoma Fluorouracil 12.9717638652
MESH:D000230 Adenocarcinoma Genistein 12.9711473722
MESH:D000236 Adenoma 2-Acetylaminofluorene 19.7710737359
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 19.773712494
MESH:D000236 Adenoma beta-Naphthoflavone 19.7719389873
MESH:D000236 Adenoma Diethylnitrosamine 19.776695378 10737359
MESH:D000236 Adenoma Dimethylnitrosamine 19.7719555203
MESH:D002759 Adenoma, Bile Duct 2-Acetylaminofluorene 5.806705139
MESH:D018248 Adenoma, Liver Cell dicyclanil 23.2017162532
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 23.2019061943 17162532 17620307 19052882 18056438 16434500
MESH:D018248 Adenoma, Liver Cell Phenobarbital 23.2017620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 23.2016434500
MESH:D000550 Amblyopia Valproic Acid 5.0217688650
MESH:D000686 Amyloidosis Diethylstilbestrol 4.2815469931
MESH:D000740 Anemia Fluorouracil 3.5317963324 15504547 16511603
MESH:D000860 Anoxia Oxygen 4.8420872349
MESH:D001008 Anxiety Disorders Valproic Acid 3.4117497229
MESH:D001161 Arteriosclerosis Dietary Fats 9.2215238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.2211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5415885639
MESH:D050197 Atherosclerosis Oxygen 3.6816391483
MESH:D001321 Autistic Disorder Valproic Acid 2.0215238991 17688650 19460635 17157402 18316065 16609825 17507914 18775368 18396377 18177632 18985861 18940202 20603192 19232924 18558336
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.811440618 11289319
MESH:D001714 Bipolar Disorder Valproic Acid 2.9720046352 17594078
MESH:D001778 Blood Coagulation Disorders pirinixic acid 2.9619483382
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.278888407
MESH:D001943 Breast Neoplasms decitabine 4.5619208741 18320071
MESH:D001943 Breast Neoplasms Dietary Fats 4.5620435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 4.5617474063
MESH:D001943 Breast Neoplasms Diethylstilbestrol 4.5617129689 15324884
MESH:D001943 Breast Neoplasms Estradiol 4.5618497071 12948864 14630087 17289903 17261762 17018787 19861407 16675129
MESH:D001943 Breast Neoplasms Fluorouracil 4.5619217205 16557594 15136595 16110121 16595493 18608205 18357371
MESH:D001943 Breast Neoplasms Genistein 4.5616873071 16541309 17200150
MESH:D001943 Breast Neoplasms Oxygen 4.5617263869
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2516111702
MESH:D002276 Carcinoid Tumor Fluorouracil 4.4616051944
MESH:D002277 Carcinoma Dimethylnitrosamine 8.0919555203
MESH:D002277 Carcinoma Fluorouracil 8.0917121937
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 22.2616705839
MESH:D006528 Carcinoma, Hepatocellular 2-Acetylaminofluorene 22.263581430 6705139 10737359 3084413 17761372
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 22.263581430 7296757
MESH:D006528 Carcinoma, Hepatocellular dicyclanil 22.2617162532
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 22.2619383236 17978847 19919837 19208518 16540662 19822196 3581430 17761372 20524982 19171122 17055752 18506893 18978308 16288022 18691550 16935385 18785209 19539802 19107877 20214788 20084675 20007298 19519916 3084413 11831363 17138121 16878318 17173139 16681979 21159647 19394651 16569478 20935162 16328049 20512989 10672840 16698587 20727157 20101231 18393292 19335982 19052882 17162532 19701751 18788625 16502159 17428255 16779866 20514400 18210153 10737359 18056438 19418558 16807293 16830150 18665156 20432363 18971187 18494052
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 22.2616924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Estradiol 22.2616924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 22.2617088986 17045692 17971768 16332177 18930000 16799960
MESH:D006528 Carcinoma, Hepatocellular Genistein 22.2616924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 22.2617173139 1701930 20007298 20935162 6705139
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.177296757
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 6.1718695887
MESH:D002294 Carcinoma, Squamous Cell decitabine 7.3219215824
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 7.3216033868
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 7.3218986760 16757204 16280240 17066447
MESH:D002318 Cardiovascular Diseases Genistein 3.1616332659
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 10.367505956
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 10.3621159647 17174075 7505956 2727394
MESH:D002471 Cell Transformation, Neoplastic Estradiol 10.3618566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.044080065
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6320734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.5119052882
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 12.489022650 19486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.4811677210 17681005 15861022 16919318 17333356 16105132 17110522
MESH:D002779 Cholestasis pirinixic acid 12.4819176532
MESH:D003110 Colonic Neoplasms decitabine 8.0117616700
MESH:D003110 Colonic Neoplasms Fluorouracil 8.0116340194 17018589 15001691 17169374 17725105 17287894 16510598 17172411 18772588 17016597
MESH:D003110 Colonic Neoplasms Genistein 8.0117182828
MESH:D003110 Colonic Neoplasms irinotecan 8.0117287894 17725105
MESH:D015179 Colorectal Neoplasms marker/mechanism 18829568
MESH:D015179 Colorectal Neoplasms Azacitidine 4.6919934284
MESH:D015179 Colorectal Neoplasms decitabine 4.6918981723
MESH:D015179 Colorectal Neoplasms Fluorouracil 4.6915289873 17094418 18509181 17255274 18802399 16391804 17695437 18949393 15148649 18448328 16331619 18288408 14970324 17016601 17401013 16282729 18383874 17594712 16524972 20501625 16303861 17454858
MESH:D015179 Colorectal Neoplasms irinotecan 4.6917454858 18259882 16303861 17159606 15273666 18509181 16391804
OMIM:612657 CONE-ROD DYSTROPHY 12 marker/mechanism
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.8817688650 16575769 8888407
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.3512952375 16002989
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.8118551238
MESH:D007644 Darier Disease Fluorouracil 4.5816733453
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.618156756 2524372 8970840 14531868 11298694 11906362 18759878 12868966
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3318249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.302952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.3420387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.3416647724
MESH:D003928 Diabetic Nephropathies Estradiol 3.2419279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 11.3518551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 11.3518692083 6482804 18289764 9328219 9022650 1440618 16192314 11289319 18648102 7440962 9653073 6679447 8291058
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 11.3519107877
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 11.358172417
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 11.351733752 19641884
MESH:D050171 Dyslipidemias Dietary Fats 3.3018367378
MESH:D004417 Dyspnea Oxygen 4.6220016425
MESH:D004421 Dystonia Phenobarbital 9.781851702
MESH:D004421 Dystonia Valproic Acid 9.781851702
MESH:D004487 Edema pirinixic acid 2.3012083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 2.9912538720
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.9019294695
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 11.1916402032
MESH:D004714 Endometrial Hyperplasia Genistein 11.1916402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 11.7316804899 15700306
MESH:D016889 Endometrial Neoplasms Estradiol 11.7319148513 18566989 11473722
MESH:D016889 Endometrial Neoplasms Genistein 11.7311473722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 10.103659116
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 10.1017275665 3659116
MESH:D004828 Epilepsies, Partial Phenobarbital 9.2711558140 3922381
MESH:D004828 Epilepsies, Partial Valproic Acid 9.273922381 16628512
MESH:D004827 Epilepsy Phenobarbital 6.3120417680
MESH:D004827 Epilepsy Valproic Acid 6.3120417680 18234410
MESH:D004832 Epilepsy, Absence Phenobarbital 8.286401628
MESH:D004832 Epilepsy, Absence Valproic Acid 8.286254150 7562514 6426943
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 10.617750514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 10.617750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 9.783659116
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 9.783659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9016302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.033581430
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 7.0317016578
MESH:D004938 Esophageal Neoplasms Fluorouracil 7.0316337965 16785472 16481741 17638652 15173087
MESH:D005234 Fatty Liver Dietary Fats 22.6319004024 17967931 18296743 19551842
MESH:D005234 Fatty Liver Diethylnitrosamine 22.6320387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 22.6315345470
MESH:D005234 Fatty Liver pirinixic acid 22.6319236843 20131406
MESH:D005234 Fatty Liver Valproic Acid 22.6314986274 19224547
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.5316611131 16513791 16002989 15751030 16534752
MESH:D005315 Fetal Diseases Valproic Acid 4.6716575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.938888407 18558336
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.816705139
MESH:D005355 Fibrosis Dietary Fats 3.3218296743
MESH:D005739 Gas Poisoning Oxygen 5.0120016425
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.7416452187
MESH:D005909 Glioblastoma marker/mechanism 18679414 18829568 19718438
MESH:D005909 Glioblastoma Genistein 3.1316598420
MESH:D005910 Glioma Fluorouracil 2.7916145905
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.847505956
MESH:D006258 Head and Neck Neoplasms decitabine 7.4419215824
MESH:D006258 Head and Neck Neoplasms Fluorouracil 7.4415102660 18337622 15162350
MESH:D006333 Heart Failure pirinixic acid 2.4120558911
MESH:D006390 Hemangioendothelioma 2-Acetylaminofluorene 5.106705139
MESH:D006394 Hemangiosarcoma 2-Acetylaminofluorene 4.226705139
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.316705139
MESH:D006529 Hepatomegaly Phenobarbital 7.7916109766
MESH:D006529 Hepatomegaly pirinixic acid 7.7919176532 16221962 18467677 19772884
MESH:D006558 Herpes Genitalis Estradiol 4.8215709030
MESH:D019584 Hot Flashes Estradiol 3.5417088409
MESH:D006849 Hydrocephalus Valproic Acid 4.6617688650
MESH:D006937 Hypercholesterolemia Dietary Fats 3.4021332399
MESH:D006943 Hyperglycemia pirinixic acid 3.0020558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.4221332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 17.2815034207
MESH:D006965 Hyperplasia Diethylstilbestrol 17.2812960047 14722030
MESH:D006965 Hyperplasia halofuginone 17.2811874485
MESH:D007021 Hypospadias Diethylstilbestrol 10.5516002989
MESH:D007021 Hypospadias Ethinyl Estradiol 10.5516945680 16569931
MESH:D007246 Infertility Diethylstilbestrol 4.1515036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2712013081
MESH:D007248 Infertility, Male decitabine 6.2617581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.2617937319
MESH:D007249 Inflammation Dietary Fats 4.7520412841
MESH:D007249 Inflammation Diethylnitrosamine 4.7518785209
MESH:D007333 Insulin Resistance Dietary Fats 11.5118457598 11836018
MESH:D007333 Insulin Resistance Estradiol 11.5116393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 11.5116306350
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 4.4010783313
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.819022650 8074119
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 5.9815369732
MESH:D007674 Kidney Diseases Estradiol 5.9815618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 21.5316705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 21.536582329
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 21.5314681315 15003126 16762066
MESH:D007680 Kidney Neoplasms Estradiol 21.5315610895
MESH:D007680 Kidney Neoplasms Fluorouracil 21.5316985049
MESH:D007859 Learning Disorders Diethylstilbestrol 3.8617184923
MESH:D007938 Leukemia Azacitidine 10.0519148494
MESH:D007938 Leukemia decitabine 10.0518980019 19235587
MESH:D007938 Leukemia Genistein 10.0518980019 17468513
MESH:D007951 Leukemia, Myeloid Azacitidine 9.2719077051
MESH:D007951 Leukemia, Myeloid decitabine 9.2717236224 18454857 19117987
MESH:D015470 Leukemia, Myeloid, Acute Azacitidine 6.0417596541 18720364
MESH:D015470 Leukemia, Myeloid, Acute decitabine 6.0418206229 18704418 18460780 19387464 19010910 17679729
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 6.0417596541 16294345
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.2518055864
MESH:D054429 Leukemia, Myelomonocytic, Juvenile Azacitidine 4.9919299654
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 3.8616766008
MESH:D008103 Liver Cirrhosis Dietary Fats 14.8718296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 14.8718522880 20032147 18407596 18665156 19638242
MESH:D008103 Liver Cirrhosis halofuginone 14.8717180598
MESH:D008103 Liver Cirrhosis Phenobarbital 14.8721047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.079327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Dicarbethoxydihydrocollidine 8.4116015684
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 8.4116009107 15138612 17036385 15161499 17201889 15864749 15383259 15942678 17203207 14659978 15763062 15339415 15099470 12925901 17719030 17881167 14726149 15733078 15798949 15842777 15369754 18237412 14643895 16270385 15744066 15479170 16627068 18371158 15492853 18672772 15793283 17348192 18629640 12918455 15591649 17640959 16603200 16570917 15504291 15723089 18364076 17196135 16169303 15298665 15081153 16544323 18095165 15366600 17198567 15067225 15571005 17465448 18239293 16042886 15577212 15086199 18567088 14709902 17534399 18210741 18637143 17432682 14568256 17666798 17724770
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.4114716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 8.4117823541
MESH:D008106 Liver Cirrhosis, Experimental halofuginone 8.4112175628 18458672 14739098 11172339 16489207
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 8.4115474484
MESH:D008107 Liver Diseases Diethylnitrosamine 3.9217034775
MESH:D008107 Liver Diseases Phenobarbital 3.9219363144
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 4.2217457977
MESH:D008113 Liver Neoplasms 2-Acetylaminofluorene 28.6118001218 11376686 10672840 14678523 16273603 10737359
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 28.6121295105 19389873
MESH:D008113 Liver Neoplasms dicyclanil 28.6120118626
MESH:D008113 Liver Neoplasms Diethylnitrosamine 28.6119090486 19073162 2422723 19294768 21047994 16942905 15885732 19833225 19551842 19812893 19642983 18648771 21071580 20452335 21167192 18754104 20118626 20137499 20405173 21278145 20492335 19427195 10737359 19254457 19850985 20101389 2862719 19638242 19256749 18977376 20583210 18644402 9163691 19690152 18978307 12112319 19996281 15175105 20501860 12771043 19255062 19426721 20434301 19499222
MESH:D008113 Liver Neoplasms Diethylstilbestrol 28.6116712894 15890375
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 28.613113478 15890375
MESH:D008113 Liver Neoplasms Fluorouracil 28.6116603448 17045692 18383874 15113037
MESH:D008113 Liver Neoplasms Phenobarbital 28.6115975961 19073162 8742319 21047994 19482888 19812893
MESH:D008113 Liver Neoplasms pirinixic acid 28.6116377806 15890375 20007298
MESH:D008114 Liver Neoplasms, Experimental 2-Acetylaminofluorene 21.706150874 1399818 534488
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 21.70598648 6587162 3712494 1399818
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 21.7018164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 21.7019519916 18079962 17854601 18775883 21159647 18093689 3124819 18544905 17174075 19126423 18308698 19539802 9362446 16842330 17942915 19004024 16267830 2563599 18164116 18253720 18282651 19009564
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 21.7015603536 1848544 6150874
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 21.702563599 1399818 18308698 17172636 6150874
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.0517228818
MESH:D055370 Lung Injury Oxygen 4.3018339021
MESH:D008175 Lung Neoplasms 2-Acetylaminofluorene 6.3511376686
MESH:D008175 Lung Neoplasms Azacitidine 6.3521224363
MESH:D008175 Lung Neoplasms Diethylnitrosamine 6.3521163286 20512841 6695378 20970405
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 6.3511884234 19555203 16061637
MESH:D008175 Lung Neoplasms Fluorouracil 6.3515246190
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.5815086387
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.9415166399
MESH:D008223 Lymphoma decitabine 7.2419470736
MESH:D008223 Lymphoma Diethylstilbestrol 7.2415700306
OMIM:608051 MACULAR DYSTROPHY, RETINAL, 2 marker/mechanism
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.3016002989
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.6411408345 11807958 16891317 17203775
MESH:D008325 Mammary Neoplasms, Experimental Genistein 5.6414578162 12929590
MESH:D020149 Manganese Poisoning Estradiol 4.2719453300
MESH:D008545 Melanoma decitabine 2.2216505122 17785578
MESH:D008881 Migraine Disorders Valproic Acid 3.0418765137 18803445
MESH:D009006 Monosomy Azacitidine 5.8719299654
MESH:D009062 Mouth Neoplasms Fluorouracil 3.4716757204 18986760
MESH:D052016 Mucositis irinotecan 4.8017159606
MESH:D009101 Multiple Myeloma Azacitidine 7.2018443271 19549372
MESH:D009101 Multiple Myeloma decitabine 7.2018172295
MESH:D009135 Muscular Diseases pirinixic acid 3.3016239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.848888407
MESH:D009190 Myelodysplastic Syndromes Azacitidine 11.7817611569 18720364 17596541 19805378
MESH:D009190 Myelodysplastic Syndromes decitabine 11.7818608210 19010910 16882708 19157545
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 11.7817596541
MESH:D009203 Myocardial Infarction Genistein 5.3917141266
MESH:D009203 Myocardial Infarction pirinixic acid 5.3919151258
MESH:D015428 Myocardial Reperfusion Injury Estradiol 13.2516810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 13.2517141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 13.2516411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.2617484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.6518551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 9.063581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 9.063581430 9029167
MESH:D009362 Neoplasm Metastasis irinotecan 9.0618259882
MESH:D009369 Neoplasms decitabine 11.0419470736 19116145 17925555
MESH:D009369 Neoplasms Diethylstilbestrol 11.0415313581
MESH:D009369 Neoplasms Fluorouracil 11.0418239605 18600527 16928823
MESH:D009369 Neoplasms pirinixic acid 11.0417405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5217289903
MESH:D009410 Nerve Degeneration Rotenone 3.7217356569 15790535 18619942
MESH:D009421 Nervous System Malformations Diethylstilbestrol 15.3211399458
MESH:D009421 Nervous System Malformations Estradiol 15.3211399458 16427766
MESH:D009421 Nervous System Malformations Genistein 15.3216427766
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 6.806679447
MESH:D009436 Neural Tube Defects Valproic Acid 6.8016359493 8888407
MESH:D009447 Neuroblastoma irinotecan 3.378761367
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.1720387270
MESH:D017599 Neuroectodermal Tumors irinotecan 4.528761367
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9020387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.3016436463
MESH:D009765 Obesity Dietary Fats 4.2518674790 20518802 21332399 19632207 20132043 18457598 16723640 11836018 17217161
MESH:D009765 Obesity pirinixic acid 4.2520558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.2716049721 12819281
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 8.276482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.813988306
MESH:D010018 Osteomalacia Phenobarbital 4.1517016548
MESH:D010024 Osteoporosis Genistein 3.1319401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.8916169203
MESH:D010051 Ovarian Neoplasms decitabine 7.5519331143 19259094
MESH:D010051 Ovarian Neoplasms Estradiol 7.5519401270
MESH:D010051 Ovarian Neoplasms Genistein 7.5519005980
MESH:D010190 Pancreatic Neoplasms decitabine 11.7219294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 11.7216540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 11.7215113037 19003803 16929163 16500647
MESH:D010190 Pancreatic Neoplasms Phenobarbital 11.7216965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4911578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.287296757
MESH:D010300 Parkinson Disease Rotenone 2.9011535288 18619942 11445065 16140633 15451049 19232380 16412576 19114014 18191903
MESH:D020734 Parkinsonian Disorders Rotenone 3.8915927086 15795934 18197244 15574749
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.266228378
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.9614722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.4615687265 16977796
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.502563599
MESH:D011230 Precancerous Conditions Phenobarbital 8.502563599
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 9.1017184923
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 9.1020603192
MESH:D055728 Primary Myelofibrosis decitabine 4.5217616702
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6920887781
MESH:D011471 Prostatic Neoplasms Azacitidine 1.9018324645
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 1.9017136230 15046698 15846301
MESH:D011471 Prostatic Neoplasms Estradiol 1.9016740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.9018626508 19082440
MESH:D011471 Prostatic Neoplasms Genistein 1.9015256057 15378649 16925846
MESH:D011537 Pruritus Ethinyl Estradiol 3.1015861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 11.4812752131
MESH:D019310 Pseudolymphoma Valproic Acid 11.4811422049 12752131
MESH:D012004 Rectal Neoplasms Fluorouracil 3.8316160472 18286688 15538739 18722050
MESH:D015427 Reperfusion Injury pirinixic acid 2.2919058328
MESH:D012128 Respiratory Distress Syndrome, Adult Oxygen 4.3118339021 17627322
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.223692021
MESH:D012174 Retinitis Pigmentosa marker/mechanism
MESH:D012208 Rhabdomyosarcoma decitabine 10.3219155313
MESH:D012208 Rhabdomyosarcoma Valproic Acid 10.3219155313
MESH:D012559 Schizophrenia Valproic Acid 2.0419110320 15737665
MESH:D012640 Seizures 2,4-dinitrotoluene 9.0218551238
MESH:D012640 Seizures Phenobarbital 9.0211442880 4039156 3137016 16876388
MESH:D012640 Seizures Valproic Acid 9.0211044598 17978042 1511512 11738929 14763951 15475178 3137016 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.616407741
MESH:D012871 Skin Diseases halofuginone 3.4611874485
MESH:D013088 Spermatocele Diethylstilbestrol 11.0116002989 16709447
MESH:D013088 Spermatocele Ethinyl Estradiol 11.0116709447
MESH:D016135 Spinal Dysraphism Valproic Acid 3.6219490988
MESH:D013158 Splenic Diseases Dimethylnitrosamine 5.0612587719
MESH:C535521 Stargardt disease 4 marker/mechanism
MESH:D013226 Status Epilepticus Valproic Acid 4.3312833885
MESH:D013274 Stomach Neoplasms decitabine 6.1919037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 6.1918456281
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 6.1916033868
MESH:D013274 Stomach Neoplasms Fluorouracil 6.1917522103 16951190 16424979 17498489 19015929 18567086 19084572 15786421 18396642 17172411
MESH:D013274 Stomach Neoplasms irinotecan 6.1915723263
MESH:D013398 Sudden Infant Death Oxygen 5.3312563064
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9815669648
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 15.811399818 7505956 6587162 6582329 3712494
MESH:D013964 Thyroid Neoplasms decitabine 15.8117967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 15.817505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 15.811399818
MESH:D013978 Tibial Fractures Estradiol 4.4719048282
MESH:D014062 Tongue Neoplasms Fluorouracil 3.8116280240
MESH:D014178 Translocation, Genetic Valproic Acid 5.0217262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.313119515
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 14.9516049721
MESH:D001749 Urinary Bladder Neoplasms 2-Acetylaminofluorene 14.951399818 15289314 15867355
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 14.958074119
MESH:D001749 Urinary Bladder Neoplasms decitabine 14.9519087683 17616700
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 14.9516712894 16452187 17306315
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.448888407
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.1010091137
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 8.9716175088
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 8.9716803524
MESH:D014591 Uterine Diseases Diethylstilbestrol 4.9614652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 8.8016690809 15809267
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.8014692618
MESH:D014604 Uveal Neoplasms decitabine 4.7017785578
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.2316002989 16513791
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3514671159 15869587
MESH:D015430 Weight Gain Dietary Fats 3.5616723640
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33807
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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