AutismKB 2.0

Annotation Detail for DLEU2


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Basic Information Top
Gene Symbol:DLEU2 ( 1B4,BCMSUN,DLB2,LEU2,MGC88287,NCRNA00022,RFP2OS,TRIM13OS )
Gene Full Name: deleted in lymphocytic leukemia 2 (non-protein coding)
Band: 13q14.2
Quick LinksEntrez ID:8847; OMIM: 605766; Uniprot ID:; ENSEMBL ID: ; HGNC ID: 13748
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of DLEU2 mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of DLEU2 mRNAdecreases expression 20713471
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of DLEU2 mRNAdecreases expression 19150397
D003513 Cycloheximide [Cycloheximide co-treated with Estradiol] results in increased expression of DLEU2 mRNAaffects cotreatment|increases expression 15072547
D003513 Cycloheximide Cycloheximide results in increased expression of DLEU2 mRNAincreases expression 15072547
D004317 Doxorubicin DLEU2 protein affects the susceptibility to Doxorubicinaffects response to substance 16217747
D004958 Estradiol [Cycloheximide co-treated with Estradiol] results in increased expression of DLEU2 mRNAaffects cotreatment|increases expression 15072547
D004958 Estradiol Estradiol results in increased expression of DLEU2 mRNAincreases expression 15072547
C070081 fulvestrant fulvestrant results in increased expression of DLEU2 mRNAincreases expression 15072547
C475919 hydroxytamoxifen hydroxytamoxifen results in increased expression of DLEU2 mRNAincreases expression 15072547
D010126 Ozone Ozone results in decreased expression of DLEU2 mRNAdecreases expression 17460151
D020849 Raloxifene Raloxifene results in decreased expression of DLEU2 mRNAdecreases expression 19429434
C496197 trans-10,cis-12-conjugated linoleic acid trans-10,cis-12-conjugated linoleic acid results in decreased expression of DLEU2 mRNAdecreases expression 17951470
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.2920127859 20464547
MESH:D000230 Adenocarcinoma Doxorubicin 7.2917418594
MESH:D000230 Adenocarcinoma Estradiol 7.2911473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.736695378
MESH:D000419 Albuminuria Doxorubicin 12.0121441931
MESH:D000419 Albuminuria Raloxifene 12.0117308373 17451421
MESH:D000544 Alzheimer Disease Ozone 4.4715513908
MESH:D000544 Alzheimer Disease Raloxifene 4.4715800139
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2519183758
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5815570426
MESH:D001249 Asthma Ozone 2.6717854713 16373670
MESH:D001284 Atrophy fulvestrant 5.0111514358
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.9214601052
MESH:D001930 Brain Injuries Raloxifene 4.6516580743
MESH:D001932 Brain Neoplasms Doxorubicin 3.9417150277
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.4020146248 17474063
MESH:D001943 Breast Neoplasms Doxorubicin 2.4016264153 15993339 15939500 18382427 16096432 15567936 19526202 15692762 18695136 15994142 15136595 16595493 18628466 11325840 17369602 17426702 17983394 16935488 16115903 15634643 15668708 16322301 18234424 16826403
MESH:D001943 Breast Neoplasms Estradiol 2.4014630087 18497071 17289903 16675129 12948864 19861407 17261762 17018787
MESH:D001943 Breast Neoplasms fulvestrant 2.4018984771
MESH:D001943 Breast Neoplasms Raloxifene 2.4015758505 17242785 16912660 17440819 17893378 17049068 17261762 16837676 15775269 17595753 15572757 17952589
MESH:D016535 Bronchial Hyperreactivity Ozone 3.7917626835 16777450 19059883 18315731 14754758 18417511 15516495
MESH:D002100 Cachexia Ozone 4.9316183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.6616111702
MESH:D002276 Carcinoid Tumor Doxorubicin 5.0316051944
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.683084413
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 4.6818059187 17876044 16234567 16023760
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.6816924424
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.221485588 16201981
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.8120419170
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 4.816189445
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 4.2017572228
MESH:D009202 Cardiomyopathies Doxorubicin 3.6217924179 15792986 16952015 17382496 16278810 16651473 17974986 15811867 16455267 17519947 17928571 15505089 16612575 16242529 16269455 17308081 18627295 17329180 16109756 17007740 17351982 16364871 17131338 16731534 15476868
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.9817334414 16243910
MESH:D002318 Cardiovascular Diseases Raloxifene 3.5415775269
MESH:D002386 Cataract Acetaminophen 2.6610977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.9620889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.9618566989
MESH:D003072 Cognition Disorders Raloxifene 4.7915800139
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.1418259882 18802399
MESH:D003865 Depressive Disorder, Major Raloxifene 4.2917474826
MESH:D003928 Diabetic Nephropathies Estradiol 9.4319279558
MESH:D003928 Diabetic Nephropathies Raloxifene 9.4317451421 15920148 17308373
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.0110915739 11743745 11529661 2444490 12540782 19923254 11287661 16393943 19739265 17562736 14550746 18713872 16109766 19420014 16227642 19164858 19416960 16485898 11461765 12594235 10774834 12392966 16081117 10663392 11834606 15619225 12705907 19370779 16781746 12153990 15968718 11739529 12958197 17522070 19085960 14986274 14725611 17906064 16177239 18071297 11421492
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 4.0117416283
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D004362 Drug Toxicity Doxorubicin 3.7718602426
MESH:D004487 Edema Raloxifene 3.4715860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 4.1615845917
MESH:D016889 Endometrial Neoplasms Doxorubicin 7.8317359293
MESH:D016889 Endometrial Neoplasms Estradiol 7.8318566989 11473722 19148513
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.3718037988
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.4620426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.4616530937
MESH:D005234 Fatty Liver Raloxifene 3.7617473493
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.7819069698
MESH:D005756 Gastritis Acetaminophen 3.8916983495
MESH:D005909 Glioblastoma Doxorubicin 3.4317150277
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.6215692506
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7220471113
MESH:D006331 Heart Diseases Doxorubicin 8.1612587719 18674790 18006777 16707910 14766674 16244371 17888722 16330681 16244372 17875725 16144979 16495754 16879835
MESH:D006331 Heart Diseases Raloxifene 8.1611110106
MESH:D006333 Heart Failure Doxorubicin 3.4217481944
MESH:D006394 Hemangiosarcoma Doxorubicin 4.0415692506
MESH:D006558 Herpes Genitalis Estradiol 5.2515709030
MESH:D006689 Hodgkin Disease Doxorubicin 3.5318501091 15147373 17606976
MESH:D019584 Hot Flashes Estradiol 3.9717088409
MESH:D006930 Hyperalgesia Acetaminophen 2.8116870215
MESH:D006973 Hypertension Raloxifene 2.9115787275 17577099
MESH:D007248 Infertility, Male fulvestrant 3.8411514358
MESH:D007333 Insulin Resistance Estradiol 3.0516627594 16393666
MESH:D007674 Kidney Diseases Acetaminophen 10.5215629191 12587719
MESH:D007674 Kidney Diseases Doxorubicin 10.5215699352 15369732 16775033
MESH:D007674 Kidney Diseases Estradiol 10.5215618244
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.2916707910
MESH:D007680 Kidney Neoplasms Estradiol 3.0915610895
MESH:D007889 Leiomyoma Raloxifene 4.6516973256
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.3716085563
MESH:D015470 Leukemia, Myeloid, Acute marker/mechanism 21441929
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 2.6316595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.6314659978 14716833
MESH:D008107 Liver Diseases Acetaminophen 1.6619784758 16610002 19460945 11587558 12969438 12587719 19014921 16611625
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3717185352 16871587
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 2.0821137059 20195826
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 3.1017085340 16842330
MESH:D008171 Lung Diseases Ozone 3.478266340 19066396
MESH:D055370 Lung Injury Ozone 4.0220417186
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.5920869020 20464547 20135361 18816296 18520028 18569708 6695378 20064080 17053015
MESH:D008175 Lung Neoplasms Doxorubicin 3.5917418594 6189445
MESH:D008175 Lung Neoplasms Ozone 3.598597069 7614698
MESH:D008223 Lymphoma Doxorubicin 3.5616098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.9117654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.7415621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 6.4115458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.4111807958 16891317 11408345 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.7019453300
MESH:D008545 Melanoma Doxorubicin 2.3016827129
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D008654 Mesothelioma Doxorubicin 3.1117638057
MESH:D008679 Metaplasia Ozone 5.3210496685
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.6415792986
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.7715863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3016381670
MESH:D052016 Mucositis Doxorubicin 4.9817415656
MESH:D009101 Multiple Myeloma Raloxifene 3.5316497877
MESH:D009203 Myocardial Infarction Doxorubicin 3.0015857846 19429709
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.3916810080
MESH:D009232 Myxoma Raloxifene 5.7716343187
MESH:D009362 Neoplasm Metastasis Doxorubicin 3.0018259882
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2311141357
MESH:D009389 Neovascularization, Pathologic Estradiol 3.9317289903
MESH:D009401 Nephrosis Doxorubicin 4.9416636307 16899518
MESH:D009404 Nephrotic Syndrome Doxorubicin 4.1215640375 16889571
MESH:D009421 Nervous System Malformations Estradiol 3.8116427766 11399458
MESH:D009447 Neuroblastoma Doxorubicin 3.3315555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9918514411
MESH:D010024 Osteoporosis Raloxifene 3.4715775268 17882678 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.3817823083 17893378 15579764 15758505
MESH:D012516 Osteosarcoma Doxorubicin 4.2315930896
MESH:D010051 Ovarian Neoplasms Estradiol 2.2519401270
MESH:D010146 Pain Acetaminophen 2.5016870215
MESH:D010538 Peritonitis Ozone 4.3116369182
MESH:D003557 Phyllodes Tumor Doxorubicin 5.3717983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.3717638057
MESH:D011014 Pneumonia Ozone 4.5918007984 18929643 18381685
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0220887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0717292933
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.0716888761 18437689 15749863 15897917 16868541 16729912
MESH:D011471 Prostatic Neoplasms Estradiol 2.0716740699
MESH:D011471 Prostatic Neoplasms Raloxifene 2.0715731164 16220300 16536755
MESH:D011693 Purpura Raloxifene 5.7715770314
MESH:D051437 Renal Insufficiency Doxorubicin 4.4017922066
MESH:D012509 Sarcoma Doxorubicin 4.1218313854 17203757 15625365 17710206 16767912 15675481
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.4014601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.9817846226
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 6.0119755658 10029692
MESH:D012878 Skin Neoplasms Doxorubicin 6.0115692506
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.7417203757 15625365 16767912
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D020521 Stroke Raloxifene 3.9316837676
MESH:D013964 Thyroid Neoplasms Doxorubicin 3.4717909728 16010429
MESH:D013978 Tibial Fractures Estradiol 14.4519048282
MESH:D013978 Tibial Fractures Raloxifene 14.4519048282
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.6917053015
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 8.6917653716
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 8.6917572228
MESH:D014581 Urticaria Acetaminophen 3.1210982225
MESH:D054556 Venous Thromboembolism Raloxifene 5.4316837676
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.4017638931 17678736 16364871 17334414
MESH:D014846 Vulvar Neoplasms Raloxifene 5.7716343187
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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