AutismKB 2.0

Annotation Detail for KAT2B


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Basic Information Top
Gene Symbol:KAT2B ( CAF,P,P/CAF,PCAF )
Gene Full Name: K(lysine) acetyltransferase 2B
Band: 3p24.3
Quick LinksEntrez ID:8850; OMIM: 602303; Uniprot ID:KAT2B_HUMAN; ENSEMBL ID: ENSG00000114166; HGNC ID: 8638
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04330Notch signaling pathway
Pathway IDPathway Name
Transcription
Gene Expression
Pathway IDPathway Name
200070Signaling events mediated by HDAC Class I
200002Regulation of nuclear SMAD2/3 signaling
200027E2F transcription factor network
200020Signaling events mediated by HDAC Class III
200142Retinoic acid receptors-mediated signaling
200091FoxO family signaling
200175p53 pathway
200102Regulation of Androgen receptor activity
Pathway IDPathway Name
P00059p53 pathway
Pathway IDPathway Name
500905Notch-HLH transcription pathway
500575RNA Polymerase I Transcription Initiation
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1870Drug abuse
2051Leukemia
2224Rhabdomyosarcoma
No data
No data
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C065180 fluvastatin [zoledronic acid co-treated with fluvastatin] results in increased expression of KAT2B mRNAaffects cotreatment|increases expression 16996129
C009159 rapeseed oil rapeseed oil affects the expression of KAT2B mRNAaffects expression 16177195
C017947 sodium arsenite sodium arsenite results in decreased expression of KAT2B mRNAdecreases expression 19822182
C088658 zoledronic acid [zoledronic acid co-treated with fluvastatin] results in increased expression of KAT2B mRNAaffects cotreatment|increases expression 16996129
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D058186 Acute Kidney Injury zoledronic acid 4.8919715164
MESH:D000210 Acute-Phase Reaction zoledronic acid 6.1120200999
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.4215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.6317306315 16712894
MESH:D001859 Bone Neoplasms zoledronic acid 5.4216778634 16121404 15867366 11697798 17312309 19442620
MESH:D001862 Bone Resorption zoledronic acid 5.1318404659 18496637 15845617 16769263 11869084 8053405
MESH:D001943 Breast Neoplasms zoledronic acid 3.2716096432 18695136
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 2.0116507464 17306315 15276417
MESH:D002289 Carcinoma, Non-Small-Cell Lung zoledronic acid 3.6519233551
MESH:D002292 Carcinoma, Renal Cell zoledronic acid 4.0018507039
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.4618572023
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 3.2520056578 19524636
MESH:D003327 Coronary Disease fluvastatin 5.0416142594
MESH:D005264 Femoral Fractures zoledronic acid 6.4616234978
MESH:D005833 Genital Neoplasms, Female sodium arsenite 5.3116452187
MESH:D006689 Hodgkin Disease sodium arsenite 3.5212676792
MESH:D006930 Hyperalgesia zoledronic acid 4.5716769263
MESH:D006934 Hypercalcemia zoledronic acid 5.4719622757 18089816
MESH:D006996 Hypocalcemia zoledronic acid 6.9212669777
MESH:D007248 Infertility, Male sodium arsenite 3.2415346721 12646999
MESH:D007674 Kidney Diseases sodium arsenite 3.0020008137
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell zoledronic acid 5.1918089816
MESH:D008113 Liver Neoplasms sodium arsenite 2.4816712894 15276417
MESH:D008171 Lung Diseases sodium arsenite 3.4219095001
MESH:D008175 Lung Neoplasms sodium arsenite 1.9017306315 15276417 16712894 19931552 17077188
MESH:D008325 Mammary Neoplasms, Experimental zoledronic acid 3.9517312309
MESH:D008545 Melanoma sodium arsenite 2.0716487513 19082730
MESH:D008654 Mesothelioma zoledronic acid 3.8716675582
MESH:D009101 Multiple Myeloma fluvastatin 9.1016996129
MESH:D009101 Multiple Myeloma zoledronic acid 9.1018089719 16996129 19621390
MESH:D009362 Neoplasm Metastasis zoledronic acid 3.7715867366 17312309 19139120
MESH:D009369 Neoplasms sodium arsenite 2.6611559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 4.2220056578
MESH:D009436 Neural Tube Defects sodium arsenite 3.3812854658
MESH:D010014 Osteolysis zoledronic acid 6.0015867366
MESH:D010024 Osteoporosis zoledronic acid 4.2517882678
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.5317306315 15276417
MESH:D010146 Pain zoledronic acid 4.2716475674
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.5716039940
MESH:D011471 Prostatic Neoplasms zoledronic acid 3.5719103299 12438248
MESH:D012512 Sarcoma, Ewing's zoledronic acid 5.4416121404
MESH:D012878 Skin Neoplasms sodium arsenite 2.8519524636 18572023
MESH:D016135 Spinal Dysraphism sodium arsenite 4.1012854658
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 2.6311723127 16712894 16452187 17306315
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 4.1611813266
MESH:D014652 Vascular Diseases sodium arsenite 5.0617056641
Pathway ID Pathway Name
REACT:71 Gene Expression
KEGG:04330 Notch signaling pathway
REACT:1788 Transcription
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB01992 - Coenzyme A
DB08186 - (3E)-4-(1-METHYL-1H-INDOL-3-YL)BUT-3-EN-2-ONE
DB08290 - N-(3-AMINOPROPYL)-4-METHYL-2-NITROBENZENAMINE
DB08291 - N-(3-AMINOPROPYL)-2-NITROBENZENAMINE
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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