AutismKB 2.0

Annotation Detail for CDK5R1


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Basic Information Top
Gene Symbol:CDK5R1 ( CDK5P35,CDK5R,MGC33831,NCK5A,p23,p25,p35,p35nck5a )
Gene Full Name: cyclin-dependent kinase 5, regulatory subunit 1 (p35)
Band: 17q11.2
Quick LinksEntrez ID:8851; OMIM: 603460; Uniprot ID:CD5R1_HUMAN; ENSEMBL ID: ENSG00000176749; HGNC ID: 1775
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05010Alzheimer's disease
Pathway IDPathway Name
Axon guidance
Pathway IDPathway Name
200182Trk receptor signaling mediated by the MAPK pathway
200077Glucocorticoid receptor regulatory network
200114Lissencephaly gene (LIS1) in neuronal migration and development
200051Reelin signaling pathway
No data
Pathway IDPathway Name
500077CRMPs in Sema3A signaling
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1740Alzheimer's disease
1831Prostate cancer
2001Mental retardation
2035Brain disease
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CDK5R1 mRNAaffects expression 16483693
D003913 Dextroamphetamine Dextroamphetamine results in increased cleavage of CDK5R1 proteinincreases cleavage 18991853
D003913 Dextroamphetamine Dextroamphetamine results in increased expression of CDK5R1 proteinincreases expression 18991853
C015001 arsenite arsenite metabolite results in increased cleavage of CDK5R1 proteinincreases cleavage 18242949
C015001 arsenite arsenite metabolite results in increased expression of CDK5R1 mRNAincreases expression 18242949
C015001 arsenite arsenite metabolite results in increased expression of CDK5R1 proteinincreases expression 18242949
C015001 arsenite calpeptin inhibits the reaction [arsenite metabolite results in increased cleavage of CDK5R1 protein]decreases reaction|increases cleavage 18242949
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of CDK5R1 mRNAincreases expression 19146932
D002118 Calcium Calcium results in increased cleavage of CDK5R1 proteinincreases cleavage 18242949
D002118 Calcium calpeptin inhibits the reaction [Calcium results in increased cleavage of CDK5R1 protein]decreases reaction|increases cleavage 18242949
C071482 calpeptin calpeptin inhibits the reaction [arsenite metabolite results in increased cleavage of CDK5R1 protein]decreases reaction|increases cleavage 18242949
C071482 calpeptin calpeptin inhibits the reaction [Calcium results in increased cleavage of CDK5R1 protein]decreases reaction|increases cleavage 18242949
D003024 Clozapine Clozapine results in increased expression of CDK5R1 mRNAincreases expression 17266109
D004317 Doxorubicin Doxorubicin affects the expression of CDK5R1 mRNAaffects expression 15205334
D005472 Fluorouracil Fluorouracil affects the expression of CDK5R1 mRNAaffects expression 15205334
D017313 Fenretinide Fenretinide results in decreased expression of CDK5R1 mRNAdecreases expression 16570282
D007657 Ketone Bodies Ketone Bodies results in decreased expression of CDK5R1 mRNAdecreases expression 16807920
D008628 Mercury Mercury results in increased expression of CDK5R1 mRNAincreases expression 16823088
D008770 Methylnitrosourea Methylnitrosourea results in increased cleavage of CDK5R1 proteinincreases cleavage 17069801
D010622 Phencyclidine Phencyclidine results in increased expression of CDK5R1 mRNAincreases expression 17266109
D020849 Raloxifene [Raloxifene co-treated with ESR2 protein] results in decreased expression of CDK5R1 mRNAaffects cotreatment|decreases expression 19059307
D018038 Sodium Selenite Sodium Selenite results in increased expression of CDK5R1 mRNAincreases expression 16705456
D013629 Tamoxifen [Tamoxifen co-treated with ESR2 protein] results in decreased expression of CDK5R1 mRNAaffects cotreatment|decreases expression 19059307
D024505 Tocopherols Tocopherols results in increased expression of CDK5R1 mRNAincreases expression 17654050
D014212 Tretinoin Tretinoin results in increased expression of CDK5R1 mRNAincreases expression 17045167
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.4914745880
MESH:D000138 Acidosis Ammonium Chloride 3.5018287403
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 13.4220464547 20127859
MESH:D000230 Adenocarcinoma Doxorubicin 13.4217418594
MESH:D000230 Adenocarcinoma Fenretinide 13.4210697514
MESH:D000230 Adenocarcinoma Fluorouracil 13.4217638652
MESH:D000230 Adenocarcinoma Methylnitrosourea 13.4215688392 15113128
MESH:D000236 Adenoma Benzo(a)pyrene 2.616695378
MESH:D000380 Agranulocytosis Clozapine 4.9912649775 14617031 16160616
MESH:D000419 Albuminuria Doxorubicin 11.2521441931
MESH:D000419 Albuminuria Raloxifene 11.2517451421 17308373
MESH:D000505 Alopecia Tretinoin 3.5615955085
MESH:D000544 Alzheimer Disease Raloxifene 2.5315800139
MESH:D000740 Anemia Fluorouracil 3.6516511603 15504547 17963324
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0119183758
MESH:D001169 Arthritis, Experimental Tretinoin 3.0416412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2516292516
MESH:D001249 Asthma Tretinoin 2.3216456186
MESH:D001321 Autistic Disorder Mercury 2.7917497416
MESH:D001327 Autoimmune Diseases Mercury 4.8116634805
MESH:D001471 Barrett Esophagus Tretinoin 4.3416935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.5516197459 16206674
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.6414601052
MESH:D001930 Brain Injuries Raloxifene 4.4116580743
MESH:D001932 Brain Neoplasms Doxorubicin 8.9217150277
MESH:D001932 Brain Neoplasms Fenretinide 8.9216187019
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 4.6920146248 17474063
MESH:D001943 Breast Neoplasms Doxorubicin 4.6915939500 18382427 16264153 11325840 15567936 15692762 17426702 17369602 18695136 15993339 19526202 17983394 16322301 18234424 16595493 16826403 15136595 15634643 15668708 16935488 18628466 16115903 16096432 15994142
MESH:D001943 Breast Neoplasms Fenretinide 4.6916601279
MESH:D001943 Breast Neoplasms Fluorouracil 4.6916557594 16595493 18357371 15136595 18608205 19217205 16110121
MESH:D001943 Breast Neoplasms Methylnitrosourea 4.6916253758 14633655 11306469
MESH:D001943 Breast Neoplasms Raloxifene 4.6917595753 17440819 16912660 16837676 15572757 17049068 17261762 17242785 17952589 15775269 17893378 15758505
MESH:D001943 Breast Neoplasms Tamoxifen 4.6920135344 17261762 19084267 18815881 15668708 19200415 19142967 19189210 19155303 21152245 18629630 19288272 20544844 20390343 19011961 19115204 11161223 19189212 16273361 15565566 19103187 20859285 16202921 19221464 18821012 17893378 16873071 19066611 18855134 17049068 18984771 20005174 19244106 18425577 19410462 19059307 18997820 16818667 19487384 19289846 21138602 17440819 17242785 18351453 20065188
MESH:D001943 Breast Neoplasms Tretinoin 4.6916443354 16166294 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.5316813970
MESH:D002276 Carcinoid Tumor Doxorubicin 12.1716051944
MESH:D002276 Carcinoid Tumor Fluorouracil 12.1716051944
MESH:D002277 Carcinoma Fluorouracil 3.5117121937
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.4419066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.1016168501
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 8.7918059187 16234567 16023760 17876044
MESH:D006528 Carcinoma, Hepatocellular Fenretinide 8.7916270382 17159502
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 8.7916332177 17088986 17045692 17971768 16799960 18930000
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 8.7916924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 8.791917145
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 6.5716201981 1485588
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 6.5718695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 14.1520419170
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 14.156189445
MESH:D002294 Carcinoma, Squamous Cell Fenretinide 14.1516274795
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 14.1517066447 18986760 16757204 16280240
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 14.1516051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 9.3017572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 9.3017572228
MESH:D009202 Cardiomyopathies Doxorubicin 3.4817351982 17007740 17974986 17382496 15792986 16612575 16952015 17519947 16651473 15476868 15811867 16455267 17928571 17924179 18627295 16242529 16278810 17308081 16731534 16364871 17329180 17131338 16269455 15505089 16109756
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 6.1116243910 17334414
MESH:D002311 Cardiomyopathy, Dilated Mercury 6.1110334427
MESH:D002318 Cardiovascular Diseases Raloxifene 3.4015775269
MESH:D002386 Cataract Methylnitrosourea 7.6112484553
MESH:D002386 Cataract Tretinoin 7.6117460283
MESH:D002471 Cell Transformation, Neoplastic Methylnitrosourea 3.752727394 7505956
MESH:D018290 Cervical Intraepithelial Neoplasia Fenretinide 12.7716154183
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 12.7716129372
MESH:D002822 Choriocarcinoma Tretinoin 5.1016461808
MESH:D019457 Chromosome Breakage Sodium Selenite 4.6915894690
MESH:D002972 Cleft Palate Tretinoin 2.649407595
MESH:D003072 Cognition Disorders Clozapine 11.4717123785
MESH:D003072 Cognition Disorders Raloxifene 11.4715800139
MESH:D003092 Colitis Tretinoin 3.6417035595
MESH:D003110 Colonic Neoplasms arsenite 3.9215037631
MESH:D003110 Colonic Neoplasms Fluorouracil 3.9216510598 17725105 16340194 18772588 17018589 15001691 17016597 17169374 17172411 17287894
MESH:D015179 Colorectal Neoplasms Doxorubicin 3.5618259882 18802399
MESH:D015179 Colorectal Neoplasms Fenretinide 3.5617273769
MESH:D015179 Colorectal Neoplasms Fluorouracil 3.5618802399 17255274 16524972 14970324 18448328 16391804 17695437 17094418 20501625 17401013 17454858 18383874 15148649 18949393 17594712 17016601 15289873 16303861 18509181 18288408 16331619 16282729
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.8210589399 9211117 17551590 9142499 8800419 9224671 14991402 16925845 9664655 9125849
MESH:D007644 Darier Disease Fluorouracil 4.7316733453
MESH:D003711 Demyelinating Diseases Tamoxifen 4.3019031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.1017474826
MESH:D017449 Dermatitis, Allergic Contact Mercury 3.7316823706
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.7216285004
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 2.9616402076
MESH:D003928 Diabetic Nephropathies Raloxifene 8.8417451421 17308373 15920148
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.8419279558
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.5015331141
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 4.0817416283
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 4.0815131321
MESH:D004362 Drug Toxicity Doxorubicin 3.6218602426
MESH:D050171 Dyslipidemias Clozapine 4.1316402076
MESH:D004487 Edema Raloxifene 3.2815860553
MESH:D004489 Edema, Cardiac Tretinoin 4.4118230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 9.0315845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.0319031437
MESH:D016889 Endometrial Neoplasms Doxorubicin 12.2417359293
MESH:D016889 Endometrial Neoplasms Tamoxifen 12.2417893378 16202921 20544844 19155303
MESH:D016889 Endometrial Neoplasms Tretinoin 12.2416569247
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.1018037988
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.4316530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.4315173087 16337965 17638652 16481741 16785472
MESH:D005124 Eye Abnormalities Tretinoin 3.539664655 16938888
MESH:D005234 Fatty Liver arsenite 12.9318296743
MESH:D005234 Fatty Liver Raloxifene 12.9317473493
MESH:D005234 Fatty Liver Tamoxifen 12.9314986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1916709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.4714745880
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 11.2419069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 11.2419069698
MESH:D005354 Fibrosarcoma Methylnitrosourea 5.1711555667
MESH:D005355 Fibrosis arsenite 8.8218296743
MESH:D005355 Fibrosis Tretinoin 8.8217994277
MESH:D005909 Glioblastoma Doxorubicin 11.7617150277
MESH:D005909 Glioblastoma Fenretinide 11.7616187019
MESH:D005909 Glioblastoma Tretinoin 11.7617312396
MESH:D005910 Glioma Fluorouracil 6.2916145905
MESH:D005910 Glioma Methylnitrosourea 6.299825942
MESH:D006258 Head and Neck Neoplasms Doxorubicin 12.7215692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 12.7215162350 18337622 15102660
MESH:D006258 Head and Neck Neoplasms Tretinoin 12.7216096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.1016084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.5420471113
MESH:D006330 Heart Defects, Congenital Tretinoin 6.549664655 14991402
MESH:D006331 Heart Diseases Doxorubicin 7.6917875725 16144979 16879835 16244371 14766674 16330681 18006777 17888722 16244372 16707910 16495754 18674790 12587719
MESH:D006331 Heart Diseases Raloxifene 7.6911110106
MESH:D006333 Heart Failure Doxorubicin 3.3017481944
MESH:D006394 Hemangiosarcoma Doxorubicin 3.8415692506
MESH:D006689 Hodgkin Disease Doxorubicin 3.3515147373 18501091 17606976
MESH:D006930 Hyperalgesia Tretinoin 3.1616870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.5016778211
MESH:D006948 Hyperkinesis Clozapine 4.8516046005
MESH:D006973 Hypertension Raloxifene 2.8415787275 17577099
MESH:D007248 Infertility, Male Methylnitrosourea 3.757193160
MESH:D007249 Inflammation Tamoxifen 2.3219457130
MESH:D007333 Insulin Resistance Sodium Selenite 3.2314714311
MESH:D007410 Intestinal Diseases Tretinoin 3.7017994277
MESH:D007569 Jaw Abnormalities Tretinoin 3.8417551590 15992940
MESH:D007674 Kidney Diseases Doxorubicin 6.4315699352 15369732 16775033
MESH:D007674 Kidney Diseases Mercury 6.4317934191
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.0916707910
MESH:D007680 Kidney Neoplasms Fluorouracil 7.3216985049
MESH:D007680 Kidney Neoplasms Tamoxifen 7.3218625569
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 4.9916316344
MESH:D007889 Leiomyoma Raloxifene 4.4316973256
MESH:D007938 Leukemia Tretinoin 2.7417143497
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.1016085563
MESH:D007951 Leukemia, Myeloid Tretinoin 3.6416482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0719850784 17596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.119834237 12679006 17361223 17649720 16823087 17506722 17294898 16788101 17107899 19029980 19075265 16140955 16891316 17339181 17712046 16935935 19225113 17301526 17217047 19642359 16766008 19035177 16331271 15748426 17368321
MESH:D007972 Leukoplakia, Oral Fenretinide 5.9916707609
MESH:D017880 Limb Deformities, Congenital Methylnitrosourea 8.3015526292
MESH:D017880 Limb Deformities, Congenital Tretinoin 8.309224671
MESH:D008064 Lipidoses Clozapine 7.9217567588
MESH:D008064 Lipidoses Tamoxifen 7.9217567588 15342952
MESH:D008103 Liver Cirrhosis arsenite 3.3818296743
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 3.5316595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.5318564211
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.5316248980 18397230
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.3221137059 20195826
MESH:D008113 Liver Neoplasms Fluorouracil 7.3218383874 17045692 16603448 15113037
MESH:D008113 Liver Neoplasms Tamoxifen 7.3216684651
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 2.9717085340 16842330
MESH:D038061 Lower Extremity Deformities, Congenital Methylnitrosourea 5.4016080182
MESH:D008175 Lung Neoplasms arsenite 8.4716809336
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 8.4720869020 20464547 20064080 18520028 18816296 17053015 18569708 6695378 20135361
MESH:D008175 Lung Neoplasms Doxorubicin 8.4717418594 6189445
MESH:D008175 Lung Neoplasms Fluorouracil 8.4715246190
MESH:D008175 Lung Neoplasms Methylnitrosourea 8.4718062963
MESH:D008175 Lung Neoplasms Tamoxifen 8.4718625569
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.7315086387
MESH:D008223 Lymphoma Doxorubicin 7.7816098063
MESH:D008223 Lymphoma Methylnitrosourea 7.7811418001 16257854
MESH:D016393 Lymphoma, B-Cell Methylnitrosourea 10.2414633661
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 10.2414737004
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.7317654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.5015621674
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.7019428831
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 18.4315458769
MESH:D008325 Mammary Neoplasms, Experimental Fenretinide 18.4310697514
MESH:D008325 Mammary Neoplasms, Experimental Methylnitrosourea 18.4315688392 10767621 14999141 15113128 12931682 11807958 16944150 14633655 10838139 16619500 11751437 17131329 16827153 16051031 15313902 19196723 17020996
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 18.4314580682 19196723 11731420 16827153 19196722
MESH:D008325 Mammary Neoplasms, Experimental Tocopherols 18.4317927505
MESH:D020149 Manganese Poisoning Tamoxifen 4.4919453300
MESH:D008527 Medulloblastoma Tretinoin 2.7617453147
MESH:D008545 Melanoma Doxorubicin 7.2516827129
MESH:D008545 Melanoma Fenretinide 7.2516270382
MESH:D008545 Melanoma Tamoxifen 7.2519393235 12393984
MESH:D008545 Melanoma Tretinoin 7.2516752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.1215990972
MESH:D008591 Meningomyelocele Tretinoin 4.3616940565
MESH:D001523 Mental Disorders Clozapine 3.8916856516
MESH:D008654 Mesothelioma Doxorubicin 6.6917638057
MESH:D008654 Mesothelioma Tocopherols 6.6915878867
MESH:D024821 Metabolic Syndrome X Clozapine 4.3519142101
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.4415792986
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.5015863610
MESH:D009041 Motion Sickness Dextroamphetamine 5.471613127
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 14.1616381670
MESH:D009062 Mouth Neoplasms Fenretinide 14.1616274795
MESH:D009062 Mouth Neoplasms Fluorouracil 14.1616757204 18986760
MESH:D052016 Mucositis Doxorubicin 4.7317415656
MESH:D009101 Multiple Myeloma Raloxifene 3.3916497877
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.0417596541
MESH:D009203 Myocardial Infarction Doxorubicin 2.9215857846 19429709
MESH:D009232 Myxoma Raloxifene 5.5016343187
MESH:D009362 Neoplasm Metastasis Doxorubicin 5.7818259882
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.7819393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4919410462
MESH:D009369 Neoplasms Benzo(a)pyrene 15.4211141357
MESH:D009369 Neoplasms Fenretinide 15.4217353921 15958647
MESH:D009369 Neoplasms Fluorouracil 15.4218600527 18239605 16928823
MESH:D009369 Neoplasms Methylnitrosourea 15.4215533788
MESH:D009369 Neoplasms Tretinoin 15.4216946489 16594593
MESH:D009374 Neoplasms, Experimental Methylnitrosourea 4.4112696579
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.9419189210 19200415 19196722
MESH:D009389 Neovascularization, Pathologic arsenite 4.3515738583
MESH:D009401 Nephrosis Doxorubicin 4.7016636307 16899518
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.9416889571 15640375
MESH:D009421 Nervous System Malformations Tretinoin 3.719125849
MESH:D009436 Neural Tube Defects Tretinoin 3.019142499
MESH:D009442 Neurilemmoma Methylnitrosourea 5.4211555667
MESH:D009447 Neuroblastoma Doxorubicin 3.2315555623
MESH:D009472 Neuronal Ceroid-Lipofuscinoses Fenretinide 5.6216303764
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.3916436463
MESH:D009765 Obesity Clozapine 3.0018515891 19142110
MESH:D010024 Osteoporosis Calcium 7.3917882678
MESH:D010024 Osteoporosis Raloxifene 7.3915775268 17882678 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.1617823083 15758505 17893378 15579764
MESH:D012516 Osteosarcoma Doxorubicin 4.0615930896
MESH:D010051 Ovarian Neoplasms Fenretinide 5.1116133793
MESH:D010051 Ovarian Neoplasms Tretinoin 5.1116936753
MESH:D010146 Pain Tretinoin 2.8516870215
MESH:D010190 Pancreatic Neoplasms Fenretinide 12.2315580305
MESH:D010190 Pancreatic Neoplasms Fluorouracil 12.2316500647 19003803 16929163 15113037
MESH:D010190 Pancreatic Neoplasms Methylnitrosourea 12.2316965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 12.2315976015
MESH:D003557 Phyllodes Tumor Doxorubicin 5.1017983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.1017638057
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9417292933
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.9415897917 18437689 16868541 16729912 16888761 15749863
MESH:D011471 Prostatic Neoplasms Fenretinide 2.9417024972
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.9419082440 18626508
MESH:D011471 Prostatic Neoplasms Methylnitrosourea 2.9415682402 12376480
MESH:D011471 Prostatic Neoplasms Raloxifene 2.9416536755 16220300 15731164
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.9418760546
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.9415067354
MESH:D011471 Prostatic Neoplasms Tocopherols 2.9412504091
MESH:D011507 Proteinuria Tretinoin 3.5416636307
MESH:D011618 Psychotic Disorders Clozapine 4.1315331141
MESH:D011625 Pterygium Tretinoin 4.7316723453
MESH:D011693 Purpura Raloxifene 5.5015770314
MESH:D012004 Rectal Neoplasms Fluorouracil 3.9518286688 15538739 16160472 18722050
MESH:D051437 Renal Insufficiency Doxorubicin 4.1617922066
MESH:D012162 Retinal Degeneration Fenretinide 9.3216303925
MESH:D012162 Retinal Degeneration Methylnitrosourea 9.3218155124 18172121
MESH:D012175 Retinoblastoma Methylnitrosourea 5.4211555667
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.0416116481 16283617
MESH:D012509 Sarcoma Doxorubicin 3.9317710206 16767912 15625365 17203757 18313854 15675481
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.1816326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.7317846226
MESH:D012559 Schizophrenia Clozapine 2.7316141801 20107430 19369910 20580759 20452607 17726453 11151749 18855531 17123785 11763009 20168265 20521326 18806925 17667964 20521320
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 13.3810029692 19755658
MESH:D012878 Skin Neoplasms Doxorubicin 13.3815692506
MESH:D012878 Skin Neoplasms Fenretinide 13.3816467112
MESH:D012878 Skin Neoplasms Tretinoin 13.3816467112
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.5015625365 17203757 16767912
MESH:D013088 Spermatocele Tamoxifen 4.2416709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.9819457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.7120155912 2093021
MESH:D013274 Stomach Neoplasms Fluorouracil 4.7117498489 15786421 17172411 19084572 18567086 18396642 16951190 17522103 19015929 16424979
MESH:D013274 Stomach Neoplasms Methylnitrosourea 4.7116257854 15930296 18593901
MESH:D013274 Stomach Neoplasms Tretinoin 4.7117261132
MESH:D020521 Stroke Raloxifene 3.7716837676
MESH:D013953 Thymus Neoplasms Methylnitrosourea 5.1711418001
MESH:D013964 Thyroid Neoplasms Doxorubicin 11.8416010429 17909728
MESH:D013964 Thyroid Neoplasms Methylnitrosourea 11.847505956 3078959
MESH:D013964 Thyroid Neoplasms Tretinoin 11.8416026305 17045167
MESH:D013978 Tibial Fractures Raloxifene 5.1519048282
MESH:D014062 Tongue Neoplasms Fluorouracil 9.6316280240
MESH:D014062 Tongue Neoplasms Tretinoin 9.6316051514
MESH:D014376 Tuberculosis Tretinoin 3.1916040207
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 15.5617053015
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 15.5617653716
MESH:D001749 Urinary Bladder Neoplasms Fenretinide 15.5616720286
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 15.5617572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 15.5616712894 8653321 17572228
MESH:D002583 Uterine Cervical Neoplasms Fenretinide 15.6216154183
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 15.6216803524
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 15.6216129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.5516752155
MESH:D054556 Venous Thromboembolism Raloxifene 5.1516837676
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.1616364871 17638931 17334414 17678736
MESH:D014820 Vitiligo Tretinoin 3.9916761959
MESH:D014846 Vulvar Neoplasms Raloxifene 5.5016343187
MESH:D015430 Weight Gain Clozapine 4.4116402076 20107430 20521320 17502770 16141801 20564506
MESH:D015431 Weight Loss Clozapine 5.0217933447
MESH:D009396 Wilms Tumor Tretinoin 3.9116287080
Pathway ID Pathway Name
KEGG:05010 Alzheimer's disease
REACT:18266 Axon guidance
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26311
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA152241909PP2
    PA164743471adenosine triphosphate
    PA449396dopamine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB02052 - Indirubin-3'-Monoxime
    DB07364 - 6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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