AutismKB 2.0

Annotation Detail for ALDH1A2


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Basic Information Top
Gene Symbol:ALDH1A2 ( MGC26444,RALDH(II),RALDH2,RALDH2-T )
Gene Full Name: aldehyde dehydrogenase 1 family, member A2
Band: 15q21.3
Quick LinksEntrez ID:8854; OMIM: 603687; Uniprot ID:AL1A2_HUMAN; ENSEMBL ID: ENSG00000128918; HGNC ID: 15472
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-2501fatty acid alpha-oxidation
Pathway IDPathway Name
hsa00830Retinol metabolism
hsa01100Metabolic pathways
No data
No data
Pathway IDPathway Name
P043725-Hydroxytryptamine degredation
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
CARDIOVASCULAR
hypertension
neural tube defects
DEVELOPMENTAL
Desease Name
Hypertension
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C003585 22-hydroxycholesterol 22-hydroxycholesterol promotes the reaction [SREBF1 protein binds to ALDH1A2 promoter]affects binding|increases reaction 16763553
C003585 22-hydroxycholesterol 22-hydroxycholesterol results in increased expression of ALDH1A2 mRNAincreases expression 16763553
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of ALDH1A2 mRNAdecreases expression 18648102
C035132 4-phenylbenzoic acid 4-phenylbenzoic acid results in decreased activity of ALDH1A2 proteindecreases activity 12547725
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ALDH1A2 mRNAaffects expression 16483693
C015001 arsenite arsenite results in decreased expression of ALDH1A2 mRNAdecreases expression 18929588
C015001 arsenite TRP53 protein affects the reaction [arsenite results in decreased expression of ALDH1A2 mRNA]affects reaction|decreases expression 18929588
D001629 Bezafibrate Bezafibrate results in increased expression of ALDH1A2 mRNAincreases expression 17118139
C055494 caffeic acid phenethyl ester [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of ALDH1A2 mRNAaffects cotreatment|decreases expression 20360939
D002791 Cholesterol, Dietary Cholesterol, Dietary inhibits the reaction [Pravastatin results in decreased expression of ALDH1A2 mRNA]decreases expression|decreases reaction 16763553
D002791 Cholesterol, Dietary Cholesterol, Dietary metabolite results in increased expression of ALDH1A2 mRNAincreases expression 16763553
D002794 Choline Choline affects the expression of ALDH1A2 mRNAaffects expression 17616785
D003840 Deoxycholic Acid [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of ALDH1A2 mRNAaffects cotreatment|increases expression 16556975
D004041 Dietary Fats Dietary Fats results in increased expression of ALDH1A2 mRNAincreases expression 18042831
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of ALDH1A2 mRNAaffects cotreatment|decreases expression 20360939
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ALDH1A2 mRNAincreases expression 15834898
D011345 Fenofibrate Fenofibrate results in increased expression of ALDH1A2 mRNAincreases expression 17118139
C030691 gluconic acid [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of ALDH1A2 mRNAaffects cotreatment|increases expression 16556975
C007350 nitrofen nitrofen results in decreased activity of ALDH1A2 proteindecreases activity 12547725
C002491 N,N'-bis(dichloroacetyl)-1,8-octamethylenediamine N,N'-bis(dichloroacetyl)-1,8-octamethylenediamine results in decreased activity of ALDH1A2 proteindecreases activity 12547725
C041786 palm oil palm oil results in increased expression of ALDH1A2 mRNAincreases expression 18042831
D010269 Paraquat Paraquat affects the expression of ALDH1A2 mRNAaffects expression 15206577
D017035 Pravastatin Cholesterol, Dietary inhibits the reaction [Pravastatin results in decreased expression of ALDH1A2 mRNA]decreases expression|decreases reaction 16763553
D017035 Pravastatin Pravastatin results in decreased expression of ALDH1A2 mRNAdecreases expression 16763553
D011374 Progesterone Progesterone affects the expression of ALDH1A2 mRNAaffects expression 17251523
C406527 R 115866 R 115866 results in increased expression of ALDH1A2 proteinincreases expression 17047027
D012172 Retinaldehyde ALDH1A2 protein results in increased metabolism of Retinaldehydeincreases metabolic processing 16982809
D012172 Retinaldehyde ALDH1A2 protein results in increased oxidation of Retinaldehydeincreases oxidation 17473173
C089730 rosiglitazone rosiglitazone results in increased expression of ALDH1A2 mRNAincreases expression 16982809
C111788 SB 210661 SB 210661 results in decreased activity of ALDH1A2 proteindecreases activity 12547725
C423915 TO-901317 TO-901317 promotes the reaction [SREBF1 protein binds to ALDH1A2 promoter]affects binding|increases reaction 16763553
C423915 TO-901317 TO-901317 results in increased expression of ALDH1A2 mRNAincreases expression 16763553
D014212 Tretinoin ALDH1A2 protein mutant form inhibits the reaction [Tretinoin results in increased expression of TSHZ1 mRNA]decreases reaction|increases expression 17035100
D014212 Tretinoin ALDH1A2 protein results in increased chemical synthesis of Tretinoinincreases chemical synthesis 16166285
D014212 Tretinoin [PPARG protein results in increased expression of ALDH1A2 protein] which results in increased chemical synthesis of Tretinoinincreases chemical synthesis|increases expression 16982809
D014212 Tretinoin ALDH1A2 affects the chemical synthesis of Tretinoinaffects chemical synthesis 15652703
D014212 Tretinoin ALDH1A2 protein affects the chemical synthesis of Tretinoinaffects chemical synthesis 15069081
D014212 Tretinoin ALDH1A2 protein results in increased chemical synthesis of Tretinoinincreases chemical synthesis 16368932
D014212 Tretinoin ALDH1A2 protein results in increased chemical synthesis of Tretinoinincreases chemical synthesis 12547725
16818722
17473173
16982809
10862743
C025643 vinclozolin vinclozolin affects the expression of ALDH1A2 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.3118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6917505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.7514692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.203712494
MESH:D000236 Adenoma Diethylnitrosamine 6.2010737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 3.6516434500 17620307 17162532 19061943 18056438 19052882
MESH:D000382 Agricultural Workers' Diseases Paraquat 3.5211874814
MESH:D000505 Alopecia Tretinoin 3.4215955085
MESH:D000544 Alzheimer Disease Cholesterol, Dietary 4.8120157255
MESH:D000544 Alzheimer Disease rosiglitazone 4.8119621015
MESH:D001008 Anxiety Disorders vinclozolin 3.4519015723
MESH:D001161 Arteriosclerosis Cholesterol, Dietary 15.8015552841
MESH:D001161 Arteriosclerosis Dietary Fats 15.8015238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 15.8011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.7115885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.7116412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2116292516
MESH:D001249 Asthma Tretinoin 2.2716456186
MESH:D001321 Autistic Disorder Choline 3.3716818868
MESH:D001471 Barrett Esophagus Tretinoin 4.1716935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.771440618 11289319
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.3916206674 16197459
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.0917868700
MESH:D001930 Brain Injuries Progesterone 4.0215665606 15845082 15380490
MESH:D001943 Breast Neoplasms Dietary Fats 1.9320435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9317474063
MESH:D001943 Breast Neoplasms Progesterone 1.9316175315 15562024 17614352
MESH:D001943 Breast Neoplasms Tretinoin 1.9316873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.3416813970
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.9116168501
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.357296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.3516681979 18506893 19383236 19519916 19107877 21159647 10737359 19171122 18691550 17138121 19919837 19335982 17162532 17428255 17055752 11831363 20101231 20084675 18056438 19701751 10672840 20007298 18494052 16288022 18665156 19394651 18978308 16779866 20432363 19539802 20512989 16698587 19208518 17978847 18971187 20935162 19418558 19822196 20214788 16540662 3084413 18785209 16935385 16830150 20514400 3581430 18210153 17173139 19052882 16807293 16569478 20524982 16328049 20727157 16502159 18393292 18788625 16878318 17761372
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.351917145
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.567296757
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.2216096774 16051514
MESH:D002386 Cataract Tretinoin 2.9517460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 6.147505956
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 6.142727394 7505956 17174075 21159647
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.3416129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.4819052882
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 7.2619486331 9022650
MESH:D002779 Cholestasis Ethinyl Estradiol 7.2617110522 15861022 11677210 16105132 17333356 16919318 17681005
MESH:D002822 Choriocarcinoma Tretinoin 4.9116461808
MESH:D002972 Cleft Palate Tretinoin 2.579407595
MESH:D003092 Colitis Tretinoin 3.4617035595
MESH:D003110 Colonic Neoplasms arsenite 4.2915037631
MESH:D003110 Colonic Neoplasms Deoxycholic Acid 4.2916213893
MESH:D019465 Craniofacial Abnormalities nitrofen 3.0611405365
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.068800419 9224671 14991402 9211117 10589399 16925845 9125849 9142499 9664655 17551590
MESH:D003456 Cryptorchidism vinclozolin 4.1114966744
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.5711906362 18759878 8970840 8156756 11298694 12868966 14531868 2524372
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.263621924 2952479
MESH:D002658 Developmental Disabilities Choline 4.5116818868
MESH:D003920 Diabetes Mellitus rosiglitazone 4.0917446233
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.4820387270
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 4.4812642470
MESH:D003929 Diabetic Neuropathies Progesterone 4.2517187935
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 3.649653073 7440962 6482804 16192314 9022650 9328219 6679447 1440618 8291058 18289764 18648102 18692083 11289319
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 3.6419107877
MESH:D050171 Dyslipidemias Dietary Fats 8.3718367378
MESH:D050171 Dyslipidemias Fenofibrate 8.3716707586
MESH:D004487 Edema rosiglitazone 3.4412083418
MESH:D004489 Edema, Cardiac Tretinoin 4.2218230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.2512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 8.2517692515
MESH:D016889 Endometrial Neoplasms Fenofibrate 7.2916569247
MESH:D016889 Endometrial Neoplasms Tretinoin 7.2916569247
MESH:D004715 Endometriosis Progesterone 3.5516134523
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.8716302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.053581430
MESH:D005124 Eye Abnormalities Tretinoin 3.409664655 16938888
MESH:D005234 Fatty Liver arsenite 22.3318296743
MESH:D005234 Fatty Liver Dietary Fats 22.3319004024 17967931 19551842 18296743
MESH:D005234 Fatty Liver Diethylnitrosamine 22.3320387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 22.3315345470
MESH:D005234 Fatty Liver rosiglitazone 22.3319196556
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.776705139
MESH:D005355 Fibrosis arsenite 13.5218296743
MESH:D005355 Fibrosis Dietary Fats 13.5218296743
MESH:D005355 Fibrosis Tretinoin 13.5217994277
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.6916973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.0516417039
MESH:D005909 Glioblastoma Tretinoin 2.8517312396
MESH:D005911 Gliosis Paraquat 4.9111124998
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.817505956
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.0216096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.9116084493
MESH:D006330 Heart Defects, Congenital nitrofen 6.8016080930
MESH:D006330 Heart Defects, Congenital Tretinoin 6.8014991402 9664655
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.286705139
MESH:D006548 Hernia, Diaphragmatic 4-phenylbenzoic acid 13.4012547725
MESH:D006548 Hernia, Diaphragmatic nitrofen 13.4010693666 9473106 12021965 17618886 9859898 12759764 15578192 12904592 11584395 16292651 15088113 16863852 11076806 9698600 17245593 7576705 11057544 18958481 7760232 9476886 15185205 12746050 11329586 9575882 10370016 17270546 12194112 15764645 8863223 10898224 12407540 7520565 15793718 11051153 11685700 10359170 15756563 10541330 12547725 11409163 10370017 18280291 11588001 10646786 16473863 16720372 16080930 12505043 10898222 18280292 15136996 15707848 16490937
MESH:D006548 Hernia, Diaphragmatic N,N'-bis(dichloroacetyl)-1,8-octamethylenediamine 13.4012547725
MESH:D006548 Hernia, Diaphragmatic SB 210661 13.4012547725
MESH:D006930 Hyperalgesia rosiglitazone 7.4412083418
MESH:D006930 Hyperalgesia Tretinoin 7.4416870215
MESH:D006937 Hypercholesterolemia Cholesterol, Dietary 14.4410876104
MESH:D006937 Hypercholesterolemia Dietary Fats 14.4421332399
MESH:D006937 Hypercholesterolemia Pravastatin 14.4417188708
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.3316778211
MESH:D006949 Hyperlipidemias Dietary Fats 3.3921332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.7015034207
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5716945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.1615869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2312013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 10.3017937319
MESH:D007248 Infertility, Male Paraquat 10.304850670
MESH:D007248 Infertility, Male vinclozolin 10.3016467254
MESH:D007249 Inflammation Dietary Fats 10.9620412841
MESH:D007249 Inflammation Diethylnitrosamine 10.9618785209
MESH:D007249 Inflammation Progesterone 10.9615869954
MESH:D007249 Inflammation rosiglitazone 10.9612083418
MESH:D007333 Insulin Resistance Dietary Fats 7.1518457598 11836018
MESH:D007333 Insulin Resistance rosiglitazone 7.1516306350
MESH:D007410 Intestinal Diseases Tretinoin 3.5317994277
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 4.3710783313
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.778074119 9022650
MESH:D007569 Jaw Abnormalities Tretinoin 3.6815992940 17551590
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 3.4115369732
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 2.776582329
MESH:D007938 Leukemia Tretinoin 2.6517143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.4819285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0419850784 17596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 7.3916766008
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.3919075265 17506722 17301526 16140955 17649720 19029980 16891316 17217047 16935935 19225113 17361223 12679006 17294898 17712046 16788101 16766008 16823087 17368321 19642359 17339181 19035177 16331271 17107899 15748426 9834237
MESH:D007984 Leydig Cell Tumor vinclozolin 4.4816417039
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.139224671
MESH:D008103 Liver Cirrhosis arsenite 10.3218296743
MESH:D008103 Liver Cirrhosis Dietary Fats 10.3218296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 10.3218665156 20032147 18407596 19638242 18522880
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.0415034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Fenofibrate 4.8915474484
MESH:D008106 Liver Cirrhosis, Experimental Retinaldehyde 4.8916248980
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 4.8915980055 17347453
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 4.8918397230 16248980
MESH:D008107 Liver Diseases Diethylnitrosamine 2.0417034775
MESH:D008113 Liver Neoplasms Diethylnitrosamine 4.6619812893 19427195 19294768 12112319 18644402 20137499 18977376 19426721 18754104 21047994 20452335 19256749 19254457 16942905 19551842 12771043 18648771 19690152 21167192 19073162 19850985 10737359 15175105 19833225 20501860 19996281 2422723 19638242 20101389 20583210 20118626 19499222 2862719 19255062 20434301 20405173 18978307 9163691 19090486 20492335 15885732 21278145 21071580 19642983
MESH:D008113 Liver Neoplasms Fenofibrate 4.6618978307
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 13.00598648 1399818 3712494 6587162
MESH:D008114 Liver Neoplasms, Experimental Deoxycholic Acid 13.006150874
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 13.0018544905 19519916 18775883 18253720 19009564 19126423 19539802 17942915 18079962 18093689 16267830 18282651 17174075 3124819 19004024 18164116 16842330 17854601 2563599 18308698 21159647 9362446
MESH:D008114 Liver Neoplasms, Experimental Fenofibrate 13.0018253720 18775883
MESH:D008171 Lung Diseases nitrofen 4.259859898 17245593 16863852 9614859
MESH:D008175 Lung Neoplasms arsenite 2.5916809336
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.5920512841 21163286 6695378 20970405
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 5.8511408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 5.8516827153
MESH:D008527 Medulloblastoma Tretinoin 2.6917453147
MESH:D008545 Melanoma Tretinoin 1.9116752155
MESH:D008591 Meningomyelocele marker/mechanism 16237707
MESH:D008591 Meningomyelocele Tretinoin 4.1816940565
MESH:D024821 Metabolic Syndrome X rosiglitazone 4.1817261469
MESH:D009135 Muscular Diseases Bezafibrate 5.1816239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.9417596541
MESH:D009203 Myocardial Infarction Pravastatin 4.2817188708
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.373581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.373581430 9029167
MESH:D009369 Neoplasms Tretinoin 2.3016594593 16946489
MESH:D009389 Neovascularization, Pathologic arsenite 4.1715738583
MESH:D009410 Nerve Degeneration Paraquat 3.5316893418
MESH:D009421 Nervous System Malformations Tretinoin 3.549125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 6.706679447
MESH:D009436 Neural Tube Defects Tretinoin 6.709142499
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.1420387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.8720387270
MESH:D009765 Obesity Dietary Fats 2.2318457598 19632207 20518802 18674790 16723640 21332399 11836018 20132043 17217161
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.214026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.773988306
MESH:D010051 Ovarian Neoplasms Progesterone 4.6517393432 16525653
MESH:D010051 Ovarian Neoplasms Tretinoin 4.6516936753
MESH:D010146 Pain Tretinoin 2.7116870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 4.9516540662
MESH:D010190 Pancreatic Neoplasms Tretinoin 4.9515976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4611578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.247296757
MESH:D010300 Parkinson Disease Cholesterol, Dietary 5.7119014385
MESH:D010300 Parkinson Disease Paraquat 5.7112911755 16140633 11181820 15451049 11124998 15824117 11445065 16510128
MESH:D010302 Parkinson Disease, Secondary Paraquat 4.1916190885
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.226228378
MESH:D011014 Pneumonia Paraquat 4.2112504350
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.352563599
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 3.6518042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 4.6918220299
MESH:D011471 Prostatic Neoplasms marker/mechanism 16166285
MESH:D011472 Prostatitis vinclozolin 4.6918629315
MESH:D011507 Proteinuria Tretinoin 3.3816636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.0715861022 16919318
MESH:D011625 Pterygium Tretinoin 4.5516723453
MESH:D011658 Pulmonary Fibrosis Paraquat 2.8216324872 17997886
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 3.6811700416
MESH:D012135 Respiratory Sounds Paraquat 3.8211874814
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 8.313692021
MESH:D012162 Retinal Degeneration Paraquat 8.3116458197
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.8716116481 16283617
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7718045962
MESH:D012878 Skin Neoplasms Tretinoin 2.5016467112
MESH:D013088 Spermatocele Ethinyl Estradiol 3.6916709447
MESH:D013119 Spinal Cord Injuries Progesterone 4.0316503802 15862959
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.3618456281
MESH:D013274 Stomach Neoplasms Tretinoin 2.3617261132
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3911994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9515669648
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 10.881399818 6587162 3712494 7505956 6582329
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 10.887505956
MESH:D013964 Thyroid Neoplasms Tretinoin 10.8816026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.5716051514
MESH:D014376 Tuberculosis Tretinoin 3.0816040207
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.198074119
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.4616129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.0614692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.3616752155
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3214671159 15869587
MESH:D014820 Vitiligo Tretinoin 3.8216761959
MESH:D015430 Weight Gain Dietary Fats 3.5316723640
MESH:D009396 Wilms Tumor Tretinoin 3.7616287080
Pathway ID Pathway Name
KEGG:01100 Metabolic pathways
KEGG:00830 Retinol metabolism
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00157 - NADH Dietary supplement;Micronutrient
DB00162 - Z-Mass Pm Vitamin and Mineral Supplement Essential Vitamin;Anti-acne Agents;Vitamins (Vitamin A);Vitamins
DB00755 - Tretinoin Antineoplastic Agents;Keratolytic Agents;Cell Stimulants and Proliferants
DB01907 - Nicotinamide-Adenine-Dinucleotide
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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