AutismKB 2.0

Annotation Detail for LDB1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:LDB1 ( CLIM2,NLI )
Gene Full Name: LIM domain binding 1
Band: 10q24.32
Quick LinksEntrez ID:8861; OMIM: 603451; Uniprot ID:LDB1_HUMAN; ENSEMBL ID: ENSG00000198728; HGNC ID: 6532
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LDB1 mRNAaffects cotreatment|increases expression 17942748
D007657 Ketone Bodies Ketone Bodies results in decreased expression of LDB1 mRNAdecreases expression 16807920
D009151 Mustard Gas Mustard Gas results in decreased expression of LDB1 mRNAdecreases expression 15674843
D013467 Sulindac Sulindac results in increased expression of LDB1 mRNAincreases expression 11906190
D013629 Tamoxifen Tamoxifen results in decreased expression of LDB1 mRNAdecreases expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LDB1 mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Sulindac 14.8214745880
MESH:D000008 Abdominal Neoplasms Tamoxifen 14.8214745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3115322242 11752688 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.4617505938
MESH:D058186 Acute Kidney Injury Sulindac 4.647897758
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.8114692618
MESH:D000230 Adenocarcinoma Sulindac 4.8111910360
MESH:D000236 Adenoma Sulindac 3.9410223192
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.8416835633
MESH:D011125 Adenomatous Polyposis Coli Sulindac 4.9017611924 11874996 16460482 11535846 15623613 19003578 12394442
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2511748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8415885639
MESH:D001249 Asthma Mustard Gas 2.7810378619
MESH:D001768 Blister Mustard Gas 5.6219167455
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.3115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9515746008
MESH:D001913 Bowen's Disease Sulindac 5.8711207687
MESH:D001943 Breast Neoplasms Sulindac 1.9516642371
MESH:D001943 Breast Neoplasms Tamoxifen 1.9517440819 19115204 20859285 21138602 18425577 18815881 19066611 19142967 20065188 20544844 19289846 18855134 19244106 19084267 19200415 15668708 19288272 19189210 16273361 16202921 21152245 19011961 19059307 18629630 19103187 19221464 18997820 11161223 17242785 18351453 16873071 17893378 18984771 19189212 16818667 19410462 20005174 15565566 19155303 20135344 18821012 20390343 17261762 19487384 17049068
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9520435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.6215286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.5017687719 10378619
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0516835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.9219066611
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 1.8516924424
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.9217572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5218850075 18670907 16120746
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4516835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.1015861022 16919318 17110522 17681005 17333356 16105132 11677210
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2115340226 12621046 8697196 16354765 15668235
MESH:D003110 Colonic Neoplasms Sulindac 2.9612458338 12902858
MESH:D015179 Colorectal Neoplasms Sulindac 2.6911197048 18059344 10666051 11076880
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003711 Demyelinating Diseases Tamoxifen 4.7819031437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.7619279558
MESH:D003930 Diabetic Retinopathy Sulindac 5.5617621415 12861449
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.6020420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9911462148
MESH:D004487 Edema Mustard Gas 7.9411428631 9260866 11428647 11402378
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.9412711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.4215322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.2412538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.2419031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.2417893378 19155303 20544844 16202921
MESH:D004715 Endometriosis Sulindac 10.2215652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 10.229294722 10568697
MESH:D004890 Erythema Mustard Gas 5.629357497
MESH:D004938 Esophageal Neoplasms Sulindac 3.1912235107
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2411564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.7915345470
MESH:D005234 Fatty Liver Tamoxifen 8.7919224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.4116709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8711858732
MESH:D018221 Fibromatosis, Abdominal Sulindac 14.5514745880
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 14.5514745880
MESH:D018222 Fibromatosis, Aggressive Sulindac 13.2319069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 13.2319069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3620067830
MESH:D005764 Gastroesophageal Reflux Sulindac 5.3911910360
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.1210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4710048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6611000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.3115340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.578697196 16354765 15340226 16959395 18606429
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0018670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 4.2316945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.8112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6817937319
MESH:D007249 Inflammation Mustard Gas 13.2511428647 9357497 9260866 11428631 17524151 11402378 11428620 16001271 8975870
MESH:D007249 Inflammation Sulindac 13.253291741
MESH:D007249 Inflammation Tamoxifen 13.2519457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 13.2512878042 12200463
MESH:D007414 Intestinal Neoplasms Sulindac 4.9412584176 12351151 10223192 12663524 10213222 12628509
MESH:D007417 Intestinal Polyps Sulindac 5.3411245490 12394442
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6616580747
MESH:D007680 Kidney Neoplasms Tamoxifen 3.3118625569
MESH:D008064 Lipidoses Tamoxifen 3.3715342952 17567588
MESH:D008105 Liver Cirrhosis, Biliary Sulindac 4.4012468960
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.3618564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3612878042
MESH:D008107 Liver Diseases Sulindac 3.0916867024 14986274
MESH:D008113 Liver Neoplasms Tamoxifen 4.7216684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.7216984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2812151625
MESH:D008171 Lung Diseases Mustard Gas 3.6518702808 18161513
MESH:D008175 Lung Neoplasms Mustard Gas 5.133148597 8781369
MESH:D008175 Lung Neoplasms Sulindac 5.1319359593 15713900
MESH:D008175 Lung Neoplasms Tamoxifen 5.1318625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 5.1319555203 11884234
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.2219428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.8111731420 19196723 14580682 16827153 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 5.0719453300
MESH:D008545 Melanoma Sulindac 3.7516642371
MESH:D008545 Melanoma Tamoxifen 3.7512393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.6415990972
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2712213967
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6519393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.6019410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.5219189210 19200415 19196722
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5914600291
MESH:D019636 Neurodegenerative Diseases Sulindac 4.5417266991 16850258
MESH:D009503 Neutropenia Mustard Gas 4.327688884 16761898
MESH:D010146 Pain Sulindac 4.053291741
MESH:D010190 Pancreatic Neoplasms Sulindac 3.4411504793 16820089
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.0411578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.7712520081
MESH:D011041 Poisoning Mustard Gas 4.1515727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.9418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.6511399792 11222880 11896295 11118676
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.1015067354
MESH:D011537 Pruritus Ethinyl Estradiol 11.1115861022 16919318
MESH:D011537 Pruritus Mustard Gas 11.1118058305
MESH:D011658 Pulmonary Fibrosis Mustard Gas 3.0217720292 17620002 17266442 17894541 10334151
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2218990726
MESH:D012871 Skin Diseases Mustard Gas 2.7812880345 16961503 15451306
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1716192470
MESH:D013088 Spermatocele Ethinyl Estradiol 13.3616709447
MESH:D013088 Spermatocele Tamoxifen 13.3616709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.5019457130
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4415669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.4212697716
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 2.4516712894 8653321 17572228
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 10.9714692618
MESH:D014594 Uterine Neoplasms Sulindac 10.9718645019
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.1212125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8715869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.7715886252
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved