AutismKB 2.0

Annotation Detail for PER3


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Basic Information Top
Gene Symbol:PER3 ( GIG13 )
Gene Full Name: period homolog 3 (Drosophila)
Band: 1p36.23
Quick LinksEntrez ID:8863; OMIM: 603427; Uniprot ID:PER3_HUMAN; ENSEMBL ID: ENSG00000049246; HGNC ID: 8847
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04710Circadian rhythm - mammal
No data
No data
Pathway IDPathway Name
P00015Circadian clock system
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1870Drug abuse
2045Bipolar disorder
2051Leukemia
Desease Name
bipolar disorder
delayed sleep phase syndrome.
AGING
CHEMDEPENDENCY
PSYCH
NEUROLOGICAL
diurnal preference
sleep disorders
heroin abuse
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C026137 3-hydroxyacetanilide 3-hydroxyacetanilide results in decreased expression of PER3 mRNAdecreases expression 18544908
D000082 Acetaminophen Acetaminophen results in decreased expression of PER3 mRNAdecreases expression 18544908
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PER3 mRNAaffects expression 16483693
C055494 caffeic acid phenethyl ester [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PER3 mRNAaffects cotreatment|decreases expression 20360939
D016572 Cyclosporine Cyclosporine results in decreased expression of PER3 mRNAdecreases expression 20106945
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PER3 mRNAaffects cotreatment|decreases expression 20360939
C023036 perfluorooctanoic acid perfluorooctanoic acid results in decreased expression of PER3 mRNAdecreases expression 17560707
C006253 pirinixic acid pirinixic acid results in increased expression of PER3 mRNAincreases expression 17426115
D012643 Selenium Selenium results in decreased expression of PER3 mRNAdecreases expression 19244175
C002979 selenomethylselenocysteine selenomethylselenocysteine results in increased expression of PER3 mRNAincreases expression 19122877
D018038 Sodium Selenite Sodium Selenite results in decreased expression of PER3 mRNAdecreases expression 18175754
D014810 Vitamin E Vitamin E results in decreased expression of PER3 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.7118287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.2318653653
MESH:D000236 Adenoma Diethylnitrosamine 2.9110737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.6117162532 17620307 18056438 19052882 16434500 19061943
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.6116434500
MESH:D000799 Angioedema Acetaminophen 4.0210982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2619483382
MESH:D001943 Breast Neoplasms marker/mechanism 20625127
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.7317474063
MESH:D001943 Breast Neoplasms selenomethylselenocysteine 2.7318855134
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.0716050911
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.903084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 2.9019418558 19919837 20101231 16540662 18056438 16569478 20432363 20514400 19107877 16698587 20512989 19208518 18785209 10672840 17761372 16288022 20524982 17173139 19519916 20214788 17162532 20727157 18506893 18393292 16779866 3084413 19335982 17055752 18691550 16502159 10737359 16935385 18665156 19171122 18494052 17138121 19383236 19052882 20935162 18210153 11831363 19701751 20084675 19539802 21159647 16830150 16807293 16878318 17428255 17978847 18971187 18978308 20007298 16328049 3581430 18788625 16681979 19822196 19394651
MESH:D002386 Cataract Acetaminophen 2.6410977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.8512371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 6.8517174075 2727394 7505956 21159647
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.7819052882
MESH:D002779 Cholestasis Cyclosporine 8.0319486331
MESH:D002779 Cholestasis pirinixic acid 8.0319176532
MESH:D019457 Chromosome Breakage Sodium Selenite 4.8915894690
MESH:D003092 Colitis Selenium 3.9217936198
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9219769572
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4718249437
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.8716285004
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2120387270
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.2416227642 14550746 16177239 11739529 11461765 11743745 12705907 16485898 15968718 18713872 16081117 19420014 16109766 17906064 17522070 12153990 19416960 11287661 12958197 16393943 14986274 19739265 11834606 11529661 19085960 12594235 12392966 17562736 16781746 12540782 18071297 19923254 11421492 2444490 10774834 10915739 14725611 10663392 15619225 19370779 19164858
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 9.2419107877
MESH:D056486 Drug-Induced Liver Injury Selenium 9.2415131321
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 9.2415131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2719426721
MESH:C538011 Eales disease Vitamin E 4.889068938
MESH:D004487 Edema perfluorooctanoic acid 7.3412083418 17259670
MESH:D004487 Edema pirinixic acid 7.3412083418
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2916302075
MESH:D005234 Fatty Liver Cyclosporine 13.7019224547
MESH:D005234 Fatty Liver Diethylnitrosamine 13.7020387270 21071580
MESH:D005234 Fatty Liver pirinixic acid 13.7019236843 20131406
MESH:D005355 Fibrosis Cyclosporine 3.2812168785 12639820
MESH:D005756 Gastritis Acetaminophen 3.8516983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.378708960
MESH:D006330 Heart Defects, Congenital Vitamin E 3.0416080930
MESH:D006333 Heart Failure pirinixic acid 7.1720558911
MESH:D006333 Heart Failure Selenium 7.1717162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5815720958
MESH:D006529 Hepatomegaly perfluorooctanoic acid 9.173609246
MESH:D006529 Hepatomegaly pirinixic acid 9.1716221962 18467677 19772884 19176532
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7316490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.1514716179
MESH:D006930 Hyperalgesia Acetaminophen 8.1516870215
MESH:D006930 Hyperalgesia perfluorooctanoic acid 8.1512083418
MESH:D006943 Hyperglycemia pirinixic acid 3.2920558911
MESH:D006973 Hypertension Cyclosporine 2.1310903974
MESH:D007249 Inflammation Diethylnitrosamine 5.5218785209
MESH:D007249 Inflammation perfluorooctanoic acid 5.5212083418
MESH:D007251 Influenza, Human Selenium 11.5516624496
MESH:D007251 Influenza, Human Vitamin E 11.5516624496
MESH:D007333 Insulin Resistance pirinixic acid 7.5416306350
MESH:D007333 Insulin Resistance Sodium Selenite 7.5414714311
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 4.6910783313
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6215604871
MESH:D007674 Kidney Diseases Acetaminophen 14.9712587719 15629191
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 14.9715369732
MESH:D007674 Kidney Diseases Cyclosporine 14.978314463 10903974 18776723
MESH:D007674 Kidney Diseases Vitamin E 14.9712488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.9916518626
MESH:D007680 Kidney Neoplasms Cyclosporine 2.8212371664
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive marker/mechanism 16999817
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 4.0616766008
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 5.388812269
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8820032147 18665156 18522880 18407596 19638242
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.4115474484
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.4116169303
MESH:D008107 Liver Diseases Acetaminophen 3.9919460945 16610002 12969438 16611625 19014921 19784758 11587558 12587719
MESH:D008107 Liver Diseases Diethylnitrosamine 3.9917034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3416871587 17185352
MESH:D008113 Liver Neoplasms Diethylnitrosamine 7.7220137499 19499222 19254457 19642983 2862719 18978307 12771043 20434301 18644402 19427195 20583210 19090486 20101389 9163691 19996281 21278145 19294768 20452335 12112319 19551842 19426721 20118626 19690152 10737359 18977376 19638242 18754104 19833225 19255062 19073162 15175105 2422723 18648771 19850985 19812893 16942905 21167192 20492335 19256749 20405173 20501860 15885732 21071580 21047994
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 7.7214757943 18709148
MESH:D008113 Liver Neoplasms pirinixic acid 7.7216377806 15890375 20007298
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 2.699362446 18544905 19519916 18164116 16842330 19126423 18282651 17942915 19009564 3124819 19539802 21159647 16267830 2563599 18253720 17174075 18308698 18079962 17854601 19004024 18093689 18775883
MESH:D008171 Lung Diseases Vitamin E 3.2516863852
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.5320512841 20970405 21163286 6695378
MESH:D008175 Lung Neoplasms Vitamin E 2.5311062179
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.1814737004
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.8615318939
MESH:D008325 Mammary Neoplasms, Experimental selenomethylselenocysteine 6.8615318939
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7119513568
MESH:D008654 Mesothelioma Selenium 2.8315107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9616801185
MESH:D009135 Muscular Diseases pirinixic acid 3.6416239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1819151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0316411023
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.609029167 3581430
MESH:D009369 Neoplasms pirinixic acid 1.9917405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3818481113 19348381
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.4918514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.4920387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2920387270
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 5.099802331
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D010146 Pain Acetaminophen 2.4816870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4516540662
MESH:D010954 Plasmacytoma Selenium 5.0615087411
MESH:D011230 Precancerous Conditions Cyclosporine 9.2712371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.272563599
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 4.5517132714
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.3218760546
MESH:D011471 Prostatic Neoplasms Vitamin E 3.3215084515
MESH:D011565 Psoriasis Cyclosporine 2.2616882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4319058328
MESH:D012871 Skin Diseases Vitamin E 2.4618709164
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D020521 Stroke Vitamin E 3.6116517955
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.077505956
MESH:D014581 Urticaria Acetaminophen 3.0910982225
MESH:D014605 Uveitis Cyclosporine 4.161336536
MESH:D014985 Xerophthalmia Cyclosporine 4.6217120751
Pathway ID Pathway Name
KEGG:04710 Circadian rhythm - mammal
Pharmacogenomics Knowledge Base Top
Drug Bank Top

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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