AutismKB 2.0

Annotation Detail for CCKBR


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Basic Information Top
Gene Symbol:CCKBR ( CCK-B,CCK2R,GASR )
Gene Full Name: cholecystokinin B receptor
Band: 11p15.4
Quick LinksEntrez ID:887; OMIM: 118445; Uniprot ID:GASR_HUMAN; ENSEMBL ID: ENSG00000110148; HGNC ID: 1571
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
hsa04020Calcium signaling pathway
hsa04971Gastric acid secretion
Pathway IDPathway Name
Signaling by GPCR
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1709Parkinson disease
1836Panic disorder
1934Cancer
Desease Name
Parkinson's disease
NEUROLOGICAL
hallucinations
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of CCKBR mRNAdecreases expression 16788091
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CCKBR mRNAaffects expression 16483693
D000661 Amphetamine CCKBR protein affects the susceptibility to Amphetamineaffects response to substance 16916582
11702094
11403953
D001058 Apomorphine CCKBR protein affects the susceptibility to Apomorphineaffects response to substance 11702094
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CCKBR mRNAaffects cotreatment|increases expression 18164116
C006780 bisphenol A bisphenol A results in increased expression of CCKBR mRNAincreases expression 15223131
C006780 bisphenol A ESR1 protein affects the reaction [bisphenol A results in increased expression of CCKBR mRNA]affects reaction|increases expression 15223131
D002713 Chlorine Chlorine results in decreased expression of CCKBR mRNAdecreases expression 18636392
D002713 Chlorine [Ozone co-treated with Chlorine] results in increased expression of CCKBR mRNAaffects cotreatment|increases expression 18636392
D003024 Clozapine Clozapine results in increased expression of CCKBR mRNAincreases expression 17266109
D003042 Cocaine CCKBR protein results in increased susceptibility to Cocaineincreases response to substance 11403953
D003993 Dibutyl Phthalate Dibutyl Phthalate results in decreased expression of CCKBR mRNAdecreases expression 15620428
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CCKBR mRNAaffects cotreatment|increases expression 18164116
D004958 Estradiol ESR1 protein affects the reaction [Estradiol results in increased expression of CCKBR mRNA]affects reaction|increases expression 15223131
D004958 Estradiol Estradiol results in increased expression of CCKBR mRNAincreases expression 15223131
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of CCKBR geneincreases mutagenesis 16495775
C058121 L 365260 L 365260 binds to and results in decreased activity of CCKBR proteinaffects binding|decreases activity 15623601
D009020 Morphine CCKBR protein affects the susceptibility to Morphineaffects response to substance 11403953
D010126 Ozone [Ozone co-treated with Chlorine] results in increased expression of CCKBR mRNAaffects cotreatment|increases expression 18636392
D010269 Paraquat Paraquat results in decreased expression of CCKBR mRNAdecreases expression 17077588
D010622 Phencyclidine Phencyclidine results in increased expression of CCKBR mRNAincreases expression 17266109
D010852 Picrotoxin Picrotoxin results in increased expression of CCKBR mRNAincreases expression 15170462
C009250 sevoflurane sevoflurane affects the expression of CCKBR mRNAaffects expression 15967596
D013469 Sulpiride CCKBR protein affects the susceptibility to Sulpirideaffects response to substance 11403953
C104428 YF 476 YF 476 binds to and results in decreased activity of CCKBR proteinaffects binding|decreases activity 15940630
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.4318287403
MESH:D055371 Acute Lung Injury Chlorine 4.2020601635
MESH:D000230 Adenocarcinoma Estradiol 2.0711473722
MESH:D000236 Adenoma beta-Naphthoflavone 10.9119389873
MESH:D000236 Adenoma Diethylnitrosamine 10.9110737359 6695378
MESH:D000236 Adenoma Ethylnitrosourea 10.916695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 3.7716434500 19052882 17162532 17620307 18056438 19061943
MESH:D000380 Agranulocytosis Clozapine 4.9216160616 14617031 12649775
MESH:D000382 Agricultural Workers' Diseases Paraquat 3.6411874814
MESH:D000544 Alzheimer Disease Ozone 2.4115513908
MESH:D019969 Amphetamine-Related Disorders Amphetamine 5.9316459022 15010207 18475255 16916582
MESH:D000855 Anorexia Amphetamine 4.8916101753 12183048 12005258 16084549
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5315570426
MESH:D001249 Asthma Ozone 2.6017854713 16373670
MESH:D001862 Bone Resorption bisphenol A 3.7411985600
MESH:D001927 Brain Diseases Ethylnitrosourea 4.7614991843
MESH:D002545 Brain Ischemia Morphine 5.0119211983
MESH:D001932 Brain Neoplasms Ethylnitrosourea 4.1715144691 16651633 16436596 16357521 18412241
MESH:D001943 Breast Neoplasms bisphenol A 1.9217123778
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9217474063
MESH:D001943 Breast Neoplasms Estradiol 1.9217289903 19861407 17261762 18497071 12948864 17018787 16675129 14630087
MESH:D016535 Bronchial Hyperreactivity Ozone 3.5715516495 16777450 17626835 18417511 14754758 19059883 18315731
MESH:D002100 Cachexia Ozone 4.6116183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.3316111702
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 2.9316681979 20935162 18788625 16830150 17162532 16540662 16328049 17428255 20727157 19822196 19052882 20007298 20432363 16698587 19208518 19383236 10672840 19107877 18210153 3581430 17055752 19335982 18971187 16779866 20514400 18978308 10737359 21159647 18056438 11831363 3084413 19539802 18665156 19701751 16878318 18393292 16502159 17138121 19919837 17173139 19418558 20524982 18494052 19394651 17761372 17978847 18691550 19171122 20214788 20084675 16569478 18785209 20101231 19519916 20512989 16807293 16935385 18506893 16288022
MESH:D006528 Carcinoma, Hepatocellular Estradiol 2.9316924424
MESH:D002278 Carcinoma in Situ bisphenol A 4.8617123778
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 10.7917174075 2727394 21159647 7505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 10.7918566989
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 10.7916003739
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 5.8617160924
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.5719052882
MESH:D019970 Cocaine-Related Disorders Cocaine 5.5819606084
MESH:D003072 Cognition Disorders Clozapine 4.8317123785
MESH:D003456 Cryptorchidism Dibutyl Phthalate 5.3216037377
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 4.5916402076
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.5920387270
MESH:D003928 Diabetic Nephropathies Estradiol 3.3019279558
MESH:D003967 Diarrhea Morphine 4.392540324
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.4315331141
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 2.0319107877
MESH:D050171 Dyslipidemias Clozapine 4.0916402076
MESH:D004417 Dyspnea Chlorine 4.5020016425
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 5.8618357618
MESH:D016889 Endometrial Neoplasms Estradiol 2.9011473722 18566989 19148513
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9916302075
MESH:D005221 Fatigue Amphetamine 5.4719890266
MESH:D005234 Fatty Liver Diethylnitrosamine 3.0720387270 21071580
MESH:D005739 Gas Poisoning Chlorine 4.8820016425
MESH:D005909 Glioblastoma Ethylnitrosourea 3.7516436596
MESH:D005910 Glioma Ethylnitrosourea 3.4416651633 18412241 16357521
MESH:D005911 Gliosis Paraquat 5.0411124998
MESH:D006558 Herpes Genitalis Estradiol 4.9015709030
MESH:D019584 Hot Flashes Estradiol 3.6217088409
MESH:D006948 Hyperkinesis Amphetamine 11.361977408 14960337
MESH:D006948 Hyperkinesis Clozapine 11.3616046005
MESH:D007248 Infertility, Male Paraquat 3.164850670
MESH:D007249 Inflammation Diethylnitrosamine 2.3118785209
MESH:D007333 Insulin Resistance bisphenol A 7.1516393666
MESH:D007333 Insulin Resistance Estradiol 7.1516393666 16627594
MESH:D007674 Kidney Diseases Estradiol 2.5115618244
MESH:D007680 Kidney Neoplasms Estradiol 7.3615610895
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 7.3617379185
MESH:D007859 Learning Disorders sevoflurane 4.6419212262
MESH:D008064 Lipidoses Clozapine 3.8717567588
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.7518665156 19638242 18407596 18522880 20032147
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 1.6714716833 14659978
MESH:D008107 Liver Diseases Diethylnitrosamine 2.0717034775
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 4.6119389873 21295105
MESH:D008113 Liver Neoplasms Diethylnitrosamine 4.6119090486 19642983 19551842 19833225 19850985 19255062 18977376 19996281 15175105 16942905 18754104 9163691 20501860 19427195 20101389 20583210 19812893 18978307 19294768 2862719 2422723 19073162 20434301 21047994 15885732 19256749 18644402 20118626 19254457 21167192 18648771 21071580 10737359 19499222 19638242 21278145 20492335 20137499 12771043 12112319 20405173 20452335 19426721 19690152
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 5.8618164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 5.8618164116 18775883 18253720 19539802 17942915 18544905 18079962 19009564 18308698 19004024 19126423 17854601 19519916 16267830 21159647 17174075 18093689 2563599 18282651 9362446 16842330 3124819
MESH:D008171 Lung Diseases Ozone 3.2919066396 8266340
MESH:D055370 Lung Injury Ozone 3.7220417186
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.5220970405 21163286 6695378 20512841
MESH:D008175 Lung Neoplasms Ethylnitrosourea 3.5217703301 16271038 6695378 16019985
MESH:D008175 Lung Neoplasms Ozone 3.528597069 7614698
MESH:D008223 Lymphoma Ethylnitrosourea 3.8515790496
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 4.9215375218
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.0217203775 11807958 16891317 11408345
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 6.0210838139 18041768 10767621
MESH:D020149 Manganese Poisoning Estradiol 4.3519453300
MESH:D008569 Memory Disorders sevoflurane 4.6219212262
MESH:D008579 Meningioma Ethylnitrosourea 5.8617943659
MESH:D001523 Mental Disorders Clozapine 8.5016856516
MESH:D001523 Mental Disorders Sulpiride 8.5016856516
MESH:D024821 Metabolic Syndrome X Clozapine 4.3019142101
MESH:D008679 Metaplasia Ozone 4.9810496685
MESH:D009203 Myocardial Infarction Cocaine 3.9318072171
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.1816810080
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.529029167 3581430
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 4.2716707424
MESH:D009389 Neovascularization, Pathologic Estradiol 3.6017289903
MESH:D009410 Nerve Degeneration Paraquat 3.6116893418
MESH:D009421 Nervous System Malformations bisphenol A 9.3211399458 16427766
MESH:D009421 Nervous System Malformations Estradiol 9.3211399458 16427766
MESH:D009442 Neurilemmoma Ethylnitrosourea 5.2816651423 16003739 17160924
MESH:D019636 Neurodegenerative Diseases Amphetamine 8.4715183010
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.4720387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9920387270
MESH:D009765 Obesity Clozapine 2.9918515891 19142110
MESH:D009837 Oligodendroglioma Ethylnitrosourea 5.8617160924
MESH:D010049 Ovarian Diseases bisphenol A 4.8611985600
MESH:D010051 Ovarian Neoplasms Estradiol 2.1819401270
MESH:D010146 Pain Morphine 4.0816273134 6776300 15275824 15215642 18699797 20225289
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.3816540662
MESH:D010300 Parkinson Disease Apomorphine 6.2010900399 18328768
MESH:D010300 Parkinson Disease Paraquat 6.2011445065 16510128 15451049 11124998 16140633 15824117 12911755 11181820
MESH:D010302 Parkinson Disease, Secondary Paraquat 4.3016190885
MESH:D010538 Peritonitis Ozone 4.0016369182
MESH:D011014 Pneumonia Ozone 10.6318007984 18929643 18381685
MESH:D011014 Pneumonia Paraquat 10.6312504350
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.442563599
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 3.8210548101
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 10.1520887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 10.1520887781
MESH:D011471 Prostatic Neoplasms bisphenol A 3.3116740699
MESH:D011471 Prostatic Neoplasms Estradiol 3.3116740699
MESH:D011618 Psychotic Disorders Clozapine 9.0515331141
MESH:D011618 Psychotic Disorders Cocaine 9.0516134406
MESH:D011629 Puberty, Precocious bisphenol A 4.6510548101
MESH:D011658 Pulmonary Fibrosis Paraquat 2.8616324872 17997886
MESH:D015427 Reperfusion Injury Morphine 4.0719211983
MESH:D012120 Respiration Disorders Chlorine 5.0818579056
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 3.7811700416
MESH:D012135 Respiratory Sounds Paraquat 3.9311874814
MESH:D012162 Retinal Degeneration Paraquat 3.7716458197
MESH:D012559 Schizophrenia Clozapine 2.7220168265 20521326 18806925 20521320 17667964 11763009 11151749 18855531 19369910 20452607 16141801 20107430 17726453 17123785 20580759
MESH:D012640 Seizures Cocaine 6.6610454489
MESH:D012640 Seizures Picrotoxin 6.668635557 8954991
MESH:D019956 Stereotypic Movement Disorder Amphetamine 6.291977408
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.4018456281
MESH:D013274 Stomach Neoplasms YF 476 3.4015940630
MESH:D019966 Substance-Related Disorders bisphenol A 3.8516684133 16045194
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 5.0315790496
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 2.887505956
MESH:D013978 Tibial Fractures Estradiol 4.5619048282
MESH:D014591 Uterine Diseases bisphenol A 4.8814652134
MESH:D015430 Weight Gain Clozapine 4.3620521320 16141801 20564506 20107430 16402076 17502770
MESH:D015431 Weight Loss Clozapine 4.9517933447
Pathway ID Pathway Name
KEGG:04020 Calcium signaling pathway
KEGG:04971 Gastric acid secretion
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26143
    • No data
    Releated disease ID Related disease Name
    PA443890Diabetes Mellitus, Type 2
    Releated drug ID Related drug Name
    PA452604xenobiotics
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00183 agonist Pentagastrin Diagnostic aid;gastric function
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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