AutismKB 2.0

Annotation Detail for IER3


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Basic Information Top
Gene Symbol:IER3 ( DIF-2,DIF2,GLY96,IEX-1,IEX-1L,IEX1,PRG1 )
Gene Full Name: immediate early response 3
Band: 6p21.33
Quick LinksEntrez ID:8870; OMIM: 602996; Uniprot ID:IEX1_HUMAN; ENSEMBL ID: ENSG00000137331; HGNC ID: 5392
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1800Lupus vulgaris
1807Autoimmune disease
1860Brain tumor
2106Pancreas cancer
2146Lupus erythematosus
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of IER3 mRNAincreases expression 19933214
C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of IER3 mRNA]affects expression|affects reaction 19414516
C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of IER3 mRNA]affects expression|affects reaction 19414516
C010914 2,4-diaminotoluene 2,4-diaminotoluene results in increased expression of IER3 mRNAincreases expression 20713471
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of IER3 mRNAaffects expression 21346803
C013813 4-anisidine 4-anisidine results in increased expression of IER3 mRNAincreases expression 12929121
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of IER3 mRNAdecreases expression 12419474
D000082 Acetaminophen Acetaminophen affects the expression of IER3 mRNAaffects expression 17562736
D000242 Cyclic AMP 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of IER3 mRNA]affects expression|affects reaction 19414516
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of IER3 proteinaffects expression 20106945
D001151 Arsenic Arsenic results in decreased expression of IER3 mRNAdecreases expression 16835338
C015001 arsenite [arsenite co-treated with Benzo(a)pyrene] results in increased expression of IER3 mRNAaffects cotreatment|increases expression 15894712
C015001 arsenite arsenite results in decreased expression of IER3 mRNAdecreases expression 15894712
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of IER3 mRNAincreases expression 18687144
D001205 Ascorbic Acid [Quercetin co-treated with Ascorbic Acid] results in increased expression of IER3 mRNAaffects cotreatment|increases expression 17639512
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of IER3 mRNAincreases expression 20106945
20064835
D001564 Benzo(a)pyrene [arsenite co-treated with Benzo(a)pyrene] results in increased expression of IER3 mRNAaffects cotreatment|increases expression 15894712
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of IER3 mRNAincreases expression 20713471
15894712
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of IER3 mRNAaffects expression 20382639
C006780 bisphenol A bisphenol A affects the expression of IER3 mRNAaffects expression 20170705
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of IER3 mRNAdecreases expression 12419474
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of IER3 mRNAincreases expression 15336504
D019256 Cadmium Chloride Cadmium Chloride results in decreased expression of IER3 mRNAdecreases expression 12760830
D002330 Carmustine Carmustine results in decreased expression of IER3 mRNAdecreases expression 15980968
D003345 Corticosterone Corticosterone results in decreased expression of IER3 mRNAdecreases expression 15755911
D003513 Cycloheximide [hydroxytamoxifen co-treated with Cycloheximide] results in increased expression of IER3 mRNAaffects cotreatment|increases expression 16849584
D016572 Cyclosporine Cyclosporine results in increased expression of IER3 mRNAincreases expression 20106945
D003609 Dactinomycin Dactinomycin inhibits the reaction [hydroxytamoxifen results in increased expression of IER3 mRNA]decreases reaction|increases expression 16849584
C014347 decitabine [decitabine co-treated with TNF protein] promotes the reaction [GTF2H1 protein binds to IER3 promoter]affects binding|affects cotreatment|increases reaction 19117987
C014347 decitabine decitabine promotes the reaction [NFKB1 protein binds to IER3 promoter]affects binding|increases reaction 19117987
C014347 decitabine decitabine promotes the reaction [RELA protein binds to IER3 promoter]affects binding|increases reaction 19117987
C014347 decitabine decitabine results in increased expression of IER3 mRNAincreases expression 19117987
C014347 decitabine TNF protein promotes the reaction [decitabine promotes the reaction [NFKB1 protein binds to IER3 promoter]]affects binding|increases reaction 19117987
C014347 decitabine TNF protein promotes the reaction [decitabine promotes the reaction [RELA protein binds to IER3 promoter]]affects binding|increases reaction 19117987
C014347 decitabine TNF protein promotes the reaction [decitabine results in increased expression of IER3 mRNA]increases expression|increases reaction 19117987
D004041 Dietary Fats Dietary Fats results in decreased expression of IER3 mRNAdecreases expression 18042831
D004041 Dietary Fats Dietary Fats results in increased expression of IER3 mRNAincreases expression 18042831
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of IER3 mRNAincreases expression 16636312
15289156
D002117 Calcitriol Calcitriol results in decreased expression of IER3 mRNAdecreases expression 16002434
D004391 Dust Dust results in increased expression of IER3 mRNAincreases expression 17805423
D004958 Estradiol Estradiol affects the expression of IER3 mRNAaffects expression 15913882
D004958 Estradiol Estradiol inhibits the reaction [hydroxytamoxifen results in increased expression of IER3 mRNA]decreases reaction|increases expression 16849584
D004958 Estradiol Estradiol results in decreased expression of IER3 mRNAdecreases expression 15223131
D004958 Estradiol Estradiol results in increased expression of IER3 mRNAincreases expression 20106945
D004958 Estradiol Estradiol affects the expression of IER3 mRNAaffects expression 15598610
D004958 Estradiol Estradiol results in increased expression of IER3 mRNAincreases expression 15289156
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of IER3 mRNAaffects expression 20170705
C070081 fulvestrant fulvestrant inhibits the reaction [hydroxytamoxifen results in increased expression of IER3 mRNA]decreases reaction|increases expression 16849584
D019833 Genistein Genistein results in increased expression of IER3 mRNAincreases expression 15289156
D006861 Hydrogen Peroxide Hydrogen Peroxide results in decreased expression of IER3 mRNAdecreases expression 12419474
D006861 Hydrogen Peroxide Hydrogen Peroxide results in increased expression of IER3increases expression 18687144
C475919 hydroxytamoxifen Dactinomycin inhibits the reaction [hydroxytamoxifen results in increased expression of IER3 mRNA]decreases reaction|increases expression 16849584
C475919 hydroxytamoxifen ESR2 protein inhibits the reaction [hydroxytamoxifen results in increased expression of IER3 mRNA]decreases reaction|increases expression 16849584
C475919 hydroxytamoxifen Estradiol inhibits the reaction [hydroxytamoxifen results in increased expression of IER3 mRNA]decreases reaction|increases expression 16849584
C475919 hydroxytamoxifen fulvestrant inhibits the reaction [hydroxytamoxifen results in increased expression of IER3 mRNA]decreases reaction|increases expression 16849584
C475919 hydroxytamoxifen [hydroxytamoxifen co-treated with Cycloheximide] results in increased expression of IER3 mRNAaffects cotreatment|increases expression 16849584
C475919 hydroxytamoxifen hydroxytamoxifen results in increased expression of IER3 mRNAincreases expression 16849584
C475919 hydroxytamoxifen hydroxytamoxifen results in increased expression of IER3 proteinincreases expression 16849584
D006918 Hydroxyurea Hydroxyurea results in increased expression of IER3 mRNAincreases expression 12929121
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of IER3 mRNAincreases expression 20713471
D008770 Methylnitrosourea Methylnitrosourea results in increased expression of IER3 mRNAincreases expression 17412507
C016599 mono-(2-ethylhexyl)phthalate mono-(2-ethylhexyl)phthalate results in increased expression of IER3 mRNAincreases expression 16809437
D009151 Mustard Gas Mustard Gas affects the expression of IER3 mRNAaffects expression 15651846
D017239 Paclitaxel Paclitaxel results in increased expression of IER3 mRNAincreases expression 12929121
C041786 palm oil palm oil results in decreased expression of IER3 mRNAdecreases expression 18042831
C041786 palm oil palm oil results in increased expression of IER3 mRNAincreases expression 18042831
C023036 perfluorooctanoic acid perfluorooctanoic acid results in decreased expression of IER3 mRNAdecreases expression 16221955
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of IER3 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of IER3 mRNAdecreases expression 19270015
D010634 Phenobarbital Phenobarbital results in increased expression of IER3 mRNAincreases expression 19482888
D010656 Phenylephrine IER3 protein results in decreased susceptibility to Phenylephrinedecreases response to substance 11934837
D010656 Phenylephrine Phenylephrine affects the localization of IER3 proteinaffects localization 11934837
D011794 Quercetin [Quercetin co-treated with Ascorbic Acid] results in increased expression of IER3 mRNAaffects cotreatment|increases expression 17639512
D020849 Raloxifene ESR2 protein affects the reaction [Raloxifene results in decreased expression of IER3 mRNA]affects reaction|decreases expression 14699072
D020849 Raloxifene Raloxifene affects the expression of IER3 mRNAaffects expression 14699072
D012643 Selenium Selenium results in increased expression of IER3 mRNAincreases expression 17293063
C017947 sodium arsenite sodium arsenite results in increased expression of IER3 mRNAincreases expression 12760830
C016104 sodium bichromate sodium bichromate results in decreased expression of IER3 mRNAdecreases expression 12760830
D013629 Tamoxifen Tamoxifen affects the expression of IER3 mRNAaffects expression 14699072
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of IER3 mRNAincreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of IER3 mRNAincreases expression 19933214
18691609
18172886
14728982
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of IER3 mRNAincreases expression 16054898
C081489 valsartan valsartan inhibits the reaction [AGT protein results in increased expression of IER3 mRNA]decreases reaction|increases expression 19225232
D002762 Cholecalciferol Cholecalciferol results in decreased expression of IER3 mRNAdecreases expression 16508948
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 3.9814745880
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 6.466195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 6.4611752688 15322242 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.3817505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 11.6520464547 20127859
MESH:D000230 Adenocarcinoma Estradiol 11.6511473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 11.6514692618
MESH:D000230 Adenocarcinoma Genistein 11.6511473722
MESH:D000230 Adenocarcinoma Methylnitrosourea 11.6515688392 15113128
MESH:D000236 Adenoma Benzo(a)pyrene 5.726695378
MESH:D000236 Adenoma Methylcholanthrene 5.7210545420 6695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 8.2417620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.2416835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.1315276417
MESH:D018246 Adrenocortical Adenoma Arsenic 11.9017306315
MESH:D018246 Adrenocortical Adenoma sodium arsenite 11.9016712894 17306315
MESH:D000419 Albuminuria Raloxifene 4.0717308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.4015800139
MESH:D000686 Amyloidosis Diethylstilbestrol 3.9515469931
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 3.7410965797
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.4611748828
MESH:D000743 Anemia, Hemolytic Quercetin 3.7417084956
MESH:D000799 Angioedema Acetaminophen 3.2810982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.5319183758
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 3.6317460149
MESH:D020261 Arsenic Poisoning marker/mechanism 16835338
MESH:D020261 Arsenic Poisoning Arsenic 2.6912569548 16835338 16251483 18414634
MESH:D001161 Arteriosclerosis Dietary Fats 8.1115238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 8.1111256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.3015885639
MESH:D001249 Asthma Mustard Gas 2.5210378619
MESH:D001260 Ataxia Telangiectasia Quercetin 4.4215336622
MESH:D050197 Atherosclerosis Arsenic 5.7912928151 19371607
MESH:D050197 Atherosclerosis Methylcholanthrene 5.7911922910
MESH:D001284 Atrophy fulvestrant 4.3211514358
MESH:D001321 Autistic Disorder Acetaminophen 1.4918445737
MESH:D001327 Autoimmune Diseases Cholecalciferol 9.2616142846
MESH:D001327 Autoimmune Diseases Quercetin 9.2619761891
MESH:D001768 Blister Mustard Gas 4.6019167455
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.5512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.2215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.3915746008
MESH:D019046 Bone Marrow Neoplasms Dactinomycin 4.9714601052
MESH:D001859 Bone Neoplasms Paclitaxel 4.0515867366
MESH:D001862 Bone Resorption bisphenol A 3.3711985600
MESH:D001919 Bradycardia Phenylephrine 3.9915306635
MESH:D001930 Brain Injuries Raloxifene 3.9316580743
MESH:D001932 Brain Neoplasms Carmustine 3.9116187019
MESH:D001943 Breast Neoplasms 2,4-diaminotoluene 17.8911921183
MESH:D001943 Breast Neoplasms Ascorbic Acid 17.8916443354
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 17.8917474063 20146248
MESH:D001943 Breast Neoplasms bisphenol A 17.8917123778
MESH:D001943 Breast Neoplasms Calcitriol 17.8911237771
MESH:D001943 Breast Neoplasms decitabine 17.8919208741 18320071
MESH:D001943 Breast Neoplasms Dietary Fats 17.8920435547
MESH:D001943 Breast Neoplasms Diethylstilbestrol 17.8915324884 17129689
MESH:D001943 Breast Neoplasms Estradiol 17.8918497071 12948864 17261762 17289903 16675129 17018787 19861407 14630087
MESH:D001943 Breast Neoplasms fulvestrant 17.8918984771
MESH:D001943 Breast Neoplasms Genistein 17.8916541309 16873071 17200150
MESH:D001943 Breast Neoplasms Methylcholanthrene 17.8917474063
MESH:D001943 Breast Neoplasms Methylnitrosourea 17.8916253758 14633655 11306469
MESH:D001943 Breast Neoplasms Paclitaxel 17.8918223236 15136595 11325840 16244791 16115903 18323546 18234424 16273361
MESH:D001943 Breast Neoplasms Quercetin 17.8918628248
MESH:D001943 Breast Neoplasms Raloxifene 17.8917261762 16912660 17595753 15758505 17952589 17893378 16837676 15572757 17242785 17440819 17049068 15775269
MESH:D001943 Breast Neoplasms Tamoxifen 17.8919288272 19221464 17049068 19189212 17261762 19142967 20390343 15565566 19487384 18984771 19059307 19155303 16873071 18629630 17242785 20005174 19410462 11161223 20859285 19115204 16273361 19011961 18425577 19084267 21138602 18815881 18997820 18855134 18821012 20135344 21152245 15668708 20065188 17893378 17440819 19189210 19103187 18351453 19289846 16202921 19200415 20544844 19066611 16818667 19244106
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 17.8920435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.6015286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.4117687719 10378619
MESH:D002105 Cadmium Poisoning Quercetin 4.9816962696
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.9116111702
MESH:D002277 Carcinoma Methylcholanthrene 6.8610545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 6.8616835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.2617687452 15504454
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 3.9619066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 26.2416705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 26.243084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 26.2421507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Arsenic 26.2417306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 26.2416924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Estradiol 26.2416924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 26.2416924424
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 26.2416313753
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 26.2420935162 17173139 6705139 20007298 1701930
MESH:D006528 Carcinoma, Hepatocellular Quercetin 26.2419519916 12508355
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 26.2415276417 17306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 26.2416924424
MESH:D002278 Carcinoma in Situ bisphenol A 4.4317123778
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.4117234771
MESH:D002294 Carcinoma, Squamous Cell Arsenic 12.2118922899 15504454 17687452
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 12.2120419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 12.2111237771
MESH:D002294 Carcinoma, Squamous Cell decitabine 12.2119215824
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 12.2118572023
MESH:D002295 Carcinoma, Transitional Cell Arsenic 13.1218640142
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 13.1217572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 13.1217572228
MESH:D006332 Cardiomegaly Phenylephrine 13.6511179087 17287366 17124262 16170337 15728586 11754973
MESH:D006332 Cardiomegaly Quercetin 13.6519794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 13.6518670907 18850075 16120746
MESH:D006332 Cardiomegaly valsartan 13.6519597038
MESH:D009202 Cardiomyopathies valsartan 4.0616247790
MESH:D002318 Cardiovascular Diseases Arsenic 18.5417938729 15738583 19152805
MESH:D002318 Cardiovascular Diseases Genistein 18.5416332659
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 18.5416936243
MESH:D002318 Cardiovascular Diseases Raloxifene 18.5415775269
MESH:D002318 Cardiovascular Diseases valsartan 18.5411230374
MESH:D002340 Carotid Artery Diseases Arsenic 3.8418022660 16973168
MESH:D002386 Cataract Acetaminophen 6.3910977129
MESH:D002386 Cataract Methylnitrosourea 6.3912484553
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 21.2320889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 21.2312371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 21.2318566989
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 21.2316192471
MESH:D002471 Cell Transformation, Neoplastic Methylnitrosourea 21.232727394 7505956
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 21.2319524636 20056578
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.714080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.6916835633
MESH:D002779 Cholestasis Cyclosporine 6.3819486331
MESH:D002779 Cholestasis Ethinyl Estradiol 6.3816919318 17333356 17681005 15861022 16105132 17110522 11677210
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.8516354765 8697196 12621046 15340226 15668235
MESH:D003072 Cognition Disorders Raloxifene 4.0715800139
MESH:D003092 Colitis Selenium 3.2417936198
MESH:D003110 Colonic Neoplasms arsenite 7.2015037631
MESH:D003110 Colonic Neoplasms decitabine 7.2017616700
MESH:D003110 Colonic Neoplasms Genistein 7.2017182828
MESH:D003110 Colonic Neoplasms Quercetin 7.2019056647 11134977 16640504 19440933 15741050 17148506 17191121
MESH:D015179 Colorectal Neoplasms decitabine 3.2018981723
MESH:D015179 Colorectal Neoplasms Paclitaxel 3.2018802399
MESH:D015179 Colorectal Neoplasms Quercetin 3.2018852136 18095365
MESH:D003139 Common Cold Ascorbic Acid 4.9117323712
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.5914669216 17141729
MESH:D003324 Coronary Artery Disease valsartan 3.6717719468
MESH:D003384 Coxsackievirus Infections valsartan 5.2820392896
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2320055451 10048152 15322242
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.0312952375 16002989
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.4718551238
MESH:D003711 Demyelinating Diseases Tamoxifen 3.8219031437
MESH:D003865 Depressive Disorder, Major Raloxifene 3.6917474826
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 7.3419496084
MESH:D003921 Diabetes Mellitus, Experimental valsartan 7.3411508273
MESH:D003924 Diabetes Mellitus, Type 2 Ascorbic Acid 6.2216506275
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 6.2216647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.2217107852
MESH:D003928 Diabetic Nephropathies Estradiol 17.6219279558
MESH:D003928 Diabetic Nephropathies Raloxifene 17.6217308373 17451421 15920148
MESH:D003928 Diabetic Nephropathies Tamoxifen 17.6219279558
MESH:D003928 Diabetic Nephropathies valsartan 17.6211427623 18630688
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 7.2921346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 7.2919923254 12705907 2444490 16081117 16485898 12958197 12153990 19085960 10774834 19416960 15619225 14986274 19370779 16177239 12594235 17906064 19164858 12540782 18713872 12392966 19420014 19739265 10663392 16781746 17562736 11461765 16393943 15968718 11743745 10915739 11529661 11287661 11739529 11834606 14550746 17522070 16227642 14725611 16109766 11421492 18071297
MESH:D056486 Drug-Induced Liver Injury Selenium 7.2915131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 7.2920420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.5319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.3411462148
MESH:D050171 Dyslipidemias Dietary Fats 3.0418367378
MESH:D004421 Dystonia Phenobarbital 3.491851702
MESH:C538011 Eales disease Ascorbic Acid 4.919068938
MESH:D004487 Edema Mustard Gas 12.469260866 11428647 11428631 11402378
MESH:D004487 Edema perfluorooctanoic acid 12.4612083418 17259670
MESH:D004487 Edema Raloxifene 12.4615860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 12.4612711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.3315322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 17.6115138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 17.6112538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 17.6115845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 17.6119031437
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.5519294695
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 10.0416402032
MESH:D004714 Endometrial Hyperplasia Genistein 10.0416402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 14.6715700306 16804899
MESH:D016889 Endometrial Neoplasms Estradiol 14.6719148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Genistein 14.6711473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 14.6719155303 20544844 17893378 16202921
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.5410568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.573659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.313922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.5820417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.076401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 3.717750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.463659116
MESH:D004890 Erythema Mustard Gas 4.609357497
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.2420426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 6.2416530937
MESH:D004938 Esophageal Neoplasms Paclitaxel 6.2416481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.5911564622
MESH:D005234 Fatty Liver arsenite 24.2918296743
MESH:D005234 Fatty Liver Cyclosporine 24.2919224547
MESH:D005234 Fatty Liver Dietary Fats 24.2917967931 19004024 18296743 19551842
MESH:D005234 Fatty Liver Ethinyl Estradiol 24.2915345470
MESH:D005234 Fatty Liver Raloxifene 24.2917473493
MESH:D005234 Fatty Liver Tamoxifen 24.2914986274 19224547
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 7.0216534752 16513791 15751030 16611131 16002989
MESH:D052776 Female Urogenital Diseases Tamoxifen 7.0216709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.9111858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 3.9714745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.6319069698
MESH:D005354 Fibrosarcoma Methylcholanthrene 10.3714633661 10962813
MESH:D005354 Fibrosarcoma Methylnitrosourea 10.3711555667
MESH:D005355 Fibrosis arsenite 27.5118296743
MESH:D005355 Fibrosis Cyclosporine 27.5112639820 12168785
MESH:D005355 Fibrosis Dietary Fats 27.5118296743
MESH:D005355 Fibrosis Quercetin 27.5119474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 27.5120067830
MESH:D005355 Fibrosis valsartan 27.5116893502
MESH:D005534 Foot Diseases Arsenic 4.996392382
MESH:D005756 Gastritis Acetaminophen 3.1116983495
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 10.9616452187
MESH:D005833 Genital Neoplasms, Female sodium arsenite 10.9616452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.668708960
MESH:D005909 Glioblastoma Carmustine 9.8616187019
MESH:D005909 Glioblastoma Genistein 9.8616598420
MESH:D005909 Glioblastoma Quercetin 9.8619804834
MESH:D005910 Glioma Methylnitrosourea 5.609825942
MESH:D005910 Glioma Quercetin 5.6017643826
MESH:D015432 Glomerulonephritis, Membranoproliferative valsartan 5.0116928621
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.0310696789
MESH:D006258 Head and Neck Neoplasms decitabine 3.1019215824
MESH:D006330 Heart Defects, Congenital Ascorbic Acid 9.3516080930
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 9.3520471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 9.3510048152 11294989
MESH:D006331 Heart Diseases Raloxifene 3.1411110106
MESH:D006333 Heart Failure Selenium 6.3817162251
MESH:D006333 Heart Failure valsartan 6.3819027736
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.8615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.8411000095
MESH:D006529 Hepatomegaly perfluorooctanoic acid 11.413609246
MESH:D006529 Hepatomegaly Phenobarbital 11.4116109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 11.4112621046 15340226 16120746
MESH:D006548 Hernia, Diaphragmatic Ascorbic Acid 3.2516490937 16863852
MESH:D006558 Herpes Genitalis Estradiol 4.4615709030
MESH:D006689 Hodgkin Disease sodium arsenite 2.7012676792
MESH:D019584 Hot Flashes Estradiol 3.1917088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.4815340226 16959395 8697196 16354765 18606429
MESH:D006930 Hyperalgesia Acetaminophen 6.3916870215
MESH:D006930 Hyperalgesia perfluorooctanoic acid 6.3912083418
MESH:D006937 Hypercholesterolemia Dietary Fats 3.1021332399
MESH:D006943 Hyperglycemia Quercetin 3.5518262572 11834736
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 3.9717050553
MESH:D006949 Hyperlipidemias Dietary Fats 3.1121332399
MESH:D006965 Hyperplasia Diethylstilbestrol 3.8912960047 14722030
MESH:D006973 Hypertension Arsenic 21.2216076760 11953799 9931084
MESH:D006973 Hypertension Cyclosporine 21.2210903974
MESH:D006973 Hypertension Phenylephrine 21.228949925 12717712
MESH:D006973 Hypertension Quercetin 21.2218356687
MESH:D006973 Hypertension Raloxifene 21.2217577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 21.2218850075 18670907
MESH:D006973 Hypertension valsartan 21.2218344623 10903974 20102058 12850387 11427623 18390891 16475468 12692753
MESH:D006974 Hypertension, Malignant valsartan 5.8411560862
MESH:D006984 Hypertrophy Phenylephrine 4.0512791704 18502941
MESH:D006987 Hypesthesia Arsenic 4.9916093927
MESH:D007021 Hypospadias Diethylstilbestrol 9.4416002989
MESH:D007021 Hypospadias Ethinyl Estradiol 9.4416569931 16945680
MESH:D007246 Infertility Diethylstilbestrol 3.8315036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 2.9512013081
MESH:D007248 Infertility, Male decitabine 17.0417581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 17.0417937319
MESH:D007248 Infertility, Male fulvestrant 17.0411514358
MESH:D007248 Infertility, Male Methylnitrosourea 17.047193160
MESH:D007248 Infertility, Male sodium arsenite 17.0412646999 15346721
MESH:D007249 Inflammation Dietary Fats 12.5120412841
MESH:D007249 Inflammation Mustard Gas 12.518975870 11428647 11428620 11402378 17524151 9357497 9260866 16001271 11428631
MESH:D007249 Inflammation perfluorooctanoic acid 12.5112083418
MESH:D007249 Inflammation Tamoxifen 12.5119457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 12.5112878042 12200463
MESH:D007251 Influenza, Human Quercetin 9.1816624496
MESH:D007251 Influenza, Human Selenium 9.1816624496
MESH:D007333 Insulin Resistance bisphenol A 10.1716393666
MESH:D007333 Insulin Resistance Dietary Fats 10.1718457598 11836018
MESH:D007333 Insulin Resistance Estradiol 10.1716627594 16393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 2.8416580747
MESH:D007627 Keloid Quercetin 4.4117086741
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.8715604871
MESH:D007642 Keratosis Arsenic 4.4312749816 16930632
MESH:D007674 Kidney Diseases Acetaminophen 23.5915629191 12587719
MESH:D007674 Kidney Diseases Cadmium Chloride 23.5916962696
MESH:D007674 Kidney Diseases Cyclosporine 23.5918776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 23.5915618244
MESH:D007674 Kidney Diseases Quercetin 23.5916962696
MESH:D007674 Kidney Diseases sodium arsenite 23.5920008137
MESH:D007674 Kidney Diseases valsartan 23.5912164870 10903974 16893502
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 8.3716518626
MESH:D007676 Kidney Failure, Chronic Selenium 8.3716518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 18.5216705839
MESH:D007680 Kidney Neoplasms Cyclosporine 18.5212371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 18.5215003126 14681315 16762066
MESH:D007680 Kidney Neoplasms Estradiol 18.5215610895
MESH:D007680 Kidney Neoplasms Tamoxifen 18.5218625569
MESH:D007859 Learning Disorders Diethylstilbestrol 3.5217184923
MESH:D007889 Leiomyoma Raloxifene 3.9816973256
MESH:D007938 Leukemia decitabine 8.8018980019 19235587
MESH:D007938 Leukemia Genistein 8.8018980019 17468513
MESH:D007938 Leukemia Quercetin 8.8017468513
MESH:D007951 Leukemia, Myeloid decitabine 8.3918454857 19117987 17236224
MESH:D007951 Leukemia, Myeloid Hydroxyurea 8.3916532439
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.2719010910 19387464 18460780 18704418 17679729 18206229
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 4.8918055864
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.1717339181
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 4.678812269
MESH:D017880 Limb Deformities, Congenital Methylnitrosourea 3.7915526292
MESH:D008064 Lipidoses Tamoxifen 2.7515342952 17567588
MESH:D008080 Liposarcoma Paclitaxel 4.3117353645
MESH:D008103 Liver Cirrhosis arsenite 9.1818296743
MESH:D008103 Liver Cirrhosis Dietary Fats 9.1818296743
MESH:D008103 Liver Cirrhosis Phenobarbital 9.1821047994
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 7.5314716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 7.5317823541
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 7.5312741479
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 7.5318564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 7.5312878042
MESH:D008106 Liver Cirrhosis, Experimental valsartan 7.5315619341 16872305 15504291
MESH:D008107 Liver Diseases Acetaminophen 5.5012969438 12587719 19460945 16611625 19014921 11587558 19784758 16610002
MESH:D008107 Liver Diseases Arsenic 5.5011134558
MESH:D008107 Liver Diseases Phenobarbital 5.5019363144
MESH:D017114 Liver Failure, Acute Acetaminophen 2.7516871587 17185352
MESH:D008113 Liver Neoplasms Aflatoxin B1 29.0015890375 2125692 18177683 9163691
MESH:D008113 Liver Neoplasms Arsenic 29.0016368122
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 29.0020195826 21137059
MESH:D008113 Liver Neoplasms Diethylstilbestrol 29.0016712894 15890375
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 29.0014757943 18709148
MESH:D008113 Liver Neoplasms Phenobarbital 29.0015975961 19812893 19073162 21047994 19482888 8742319
MESH:D008113 Liver Neoplasms Quercetin 29.0018980244
MESH:D008113 Liver Neoplasms sodium arsenite 29.0015276417 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 29.0016684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 29.0016984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 18.638603461
MESH:D008114 Liver Neoplasms, Experimental Ascorbic Acid 18.6318544905
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 18.631399818 598648
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 18.632563599 1399818 18308698 17172636 6150874
MESH:D008114 Liver Neoplasms, Experimental Quercetin 18.6319519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 18.6312151625
MESH:D038061 Lower Extremity Deformities, Congenital Methylnitrosourea 4.9216080182
MESH:D008171 Lung Diseases Ascorbic Acid 10.2316863852
MESH:D008171 Lung Diseases Mustard Gas 10.2318161513 18702808
MESH:D008171 Lung Diseases sodium arsenite 10.2319095001
MESH:D055370 Lung Injury Asbestos, Crocidolite 3.4917365036
MESH:D008175 Lung Neoplasms Aflatoxin B1 20.7714755239
MESH:D008175 Lung Neoplasms Arsenic 20.7717306315 19168569 17976673
MESH:D008175 Lung Neoplasms arsenite 20.7716809336
MESH:D008175 Lung Neoplasms Ascorbic Acid 20.7716401635
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 20.7720064080 18816296 20869020 20464547 17053015 18569708 6695378 20135361 18520028
MESH:D008175 Lung Neoplasms Methylcholanthrene 20.7715390079 17909032 1399818 11893704 16337739 20512841 20970405 21163286 9230183 6695378 7750092 10545420 16271038
MESH:D008175 Lung Neoplasms Methylnitrosourea 20.7718062963
MESH:D008175 Lung Neoplasms Mustard Gas 20.773148597 8781369
MESH:D008175 Lung Neoplasms Quercetin 20.7716280456
MESH:D008175 Lung Neoplasms sodium arsenite 20.7716712894 19931552 17306315 15276417 17077188
MESH:D008175 Lung Neoplasms Tamoxifen 20.7718625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 20.7719555203 11884234
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.5915166399
MESH:D008223 Lymphoma decitabine 10.3419470736
MESH:D008223 Lymphoma Diethylstilbestrol 10.3415700306
MESH:D008223 Lymphoma Methylnitrosourea 10.3416257854 11418001
MESH:D016393 Lymphoma, B-Cell Methylnitrosourea 4.2614633661
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 3.6414749477
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 4.9516002989
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.2119428831
MESH:D008325 Mammary Neoplasms, Experimental 2,4-diaminotoluene 22.7711921183
MESH:D008325 Mammary Neoplasms, Experimental Corticosterone 22.7712807724
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 22.7717203775 11807958 11408345 16891317
MESH:D008325 Mammary Neoplasms, Experimental Genistein 22.7714578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Methylnitrosourea 22.7710767621 17131329 15313902 12931682 15113128 14999141 16619500 10838139 11807958 15688392 11751437 19196723 16827153 17020996 16944150 16051031 14633655
MESH:D008325 Mammary Neoplasms, Experimental Selenium 22.7715318939
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 22.7711731420 16827153 14580682 19196722 19196723
MESH:D020149 Manganese Poisoning Estradiol 10.7619453300
MESH:D020149 Manganese Poisoning Tamoxifen 10.7619453300
MESH:D008545 Melanoma Carmustine 8.4112393984
MESH:D008545 Melanoma decitabine 8.4117785578 16505122
MESH:D008545 Melanoma Paclitaxel 8.4116342250 12025231 12040289
MESH:D008545 Melanoma sodium arsenite 8.4116487513 19082730
MESH:D008545 Melanoma Tamoxifen 8.4112393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.6315990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.0219513568
MESH:D008654 Mesothelioma Asbestos, Crocidolite 5.4918303189 16966607 16166281
MESH:D008654 Mesothelioma Selenium 5.4915107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.2216801185
MESH:D020326 Migraine without Aura Cyclic AMP 4.6311304026
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 4.9915863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.7616381670
MESH:D009101 Multiple Myeloma decitabine 9.8918172295
MESH:D009101 Multiple Myeloma Paclitaxel 9.8914749477
MESH:D009101 Multiple Myeloma Raloxifene 9.8916497877
MESH:D009190 Myelodysplastic Syndromes decitabine 3.0419010910 16882708 19157545 18608210
MESH:D009203 Myocardial Infarction Genistein 5.1117141266
MESH:D009203 Myocardial Infarction Quercetin 5.1119595682
MESH:D017202 Myocardial Ischemia Arsenic 7.5215371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 7.5212213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 11.7716810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 11.7717141266
MESH:D015428 Myocardial Reperfusion Injury Quercetin 11.7719207477
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 3.9217484760
MESH:D009232 Myxoma Raloxifene 4.9916343187
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.3018551238
MESH:D009362 Neoplasm Metastasis Paclitaxel 5.1315867366
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.1319393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.3119410462
MESH:D009369 Neoplasms Benzo(a)pyrene 15.8511141357
MESH:D009369 Neoplasms decitabine 15.8517925555 19116145 19470736
MESH:D009369 Neoplasms Diethylstilbestrol 15.8515313581
MESH:D009369 Neoplasms Methylnitrosourea 15.8515533788
MESH:D009369 Neoplasms Quercetin 15.8515185748
MESH:D009369 Neoplasms sodium arsenite 15.8511559025
MESH:D009374 Neoplasms, Experimental Methylnitrosourea 7.6112696579
MESH:D009374 Neoplasms, Experimental sodium arsenite 7.6120056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.4319196722 19189210 19200415
MESH:D009389 Neovascularization, Pathologic arsenite 8.3115738583
MESH:D009389 Neovascularization, Pathologic Estradiol 8.3117289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.8717954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.8119348381 18481113
MESH:D009421 Nervous System Malformations bisphenol A 25.1616427766 11399458
MESH:D009421 Nervous System Malformations Diethylstilbestrol 25.1611399458
MESH:D009421 Nervous System Malformations Estradiol 25.1611399458 16427766
MESH:D009421 Nervous System Malformations Genistein 25.1616427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 25.1614600291
MESH:D009436 Neural Tube Defects Arsenic 6.2016620997
MESH:D009436 Neural Tube Defects sodium arsenite 6.2012854658
MESH:D009442 Neurilemmoma Methylnitrosourea 4.9311555667
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.4218514411
MESH:D020078 Neurogenic Inflammation Arsenic 8.9817056641
MESH:D020078 Neurogenic Inflammation Quercetin 8.9817929310
MESH:D009503 Neutropenia Mustard Gas 3.4616761898 7688884
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 4.419802331
MESH:D009765 Obesity Ascorbic Acid 4.3517217161
MESH:D009765 Obesity Dietary Fats 4.3521332399 16723640 17217161 18674790 11836018 20518802 20132043 19632207 18457598
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 2.9512819281 16049721
MESH:D010014 Osteolysis Paclitaxel 4.4215867366
MESH:D010018 Osteomalacia Phenobarbital 3.8117016548
MESH:D010024 Osteoporosis Genistein 6.1319401787
MESH:D010024 Osteoporosis Raloxifene 6.1317882678 15775268 19059307
MESH:D015663 Osteoporosis, Postmenopausal Genistein 13.9316169203
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 13.9319495926
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 13.9315579764 17823083 17893378 15758505
MESH:D010049 Ovarian Diseases bisphenol A 4.4311985600
MESH:D010051 Ovarian Neoplasms Arsenic 19.6917306315
MESH:D010051 Ovarian Neoplasms decitabine 19.6919259094 19331143
MESH:D010051 Ovarian Neoplasms Estradiol 19.6919401270
MESH:D010051 Ovarian Neoplasms Genistein 19.6919005980
MESH:D010051 Ovarian Neoplasms Paclitaxel 19.6911161223
MESH:D010051 Ovarian Neoplasms Quercetin 19.6919005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 19.6915276417 17306315
MESH:D010146 Pain Acetaminophen 1.9616870215
MESH:D010190 Pancreatic Neoplasms decitabine 10.4619294695
MESH:D010190 Pancreatic Neoplasms Methylnitrosourea 10.4616965848
MESH:D010190 Pancreatic Neoplasms Phenobarbital 10.4616965848
MESH:D010190 Pancreatic Neoplasms Quercetin 10.4616965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.1711578682
MESH:D010212 Papilloma Hydrogen Peroxide 3.5512065085
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.6812520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 3.6516093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.4315371236 6392382 16905509
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 4.9311550810
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.6014722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.1315687265 16977796
MESH:D010954 Plasmacytoma Selenium 4.3215087411
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.3510923243
MESH:D011041 Poisoning Mustard Gas 3.2915727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.0318163543
MESH:D011230 Precancerous Conditions Cyclosporine 12.6012371664
MESH:D011230 Precancerous Conditions Phenobarbital 12.602563599
MESH:D011230 Precancerous Conditions Quercetin 12.6019056647
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 18.7310548101
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 18.7317184923
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 18.7317132714
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 18.7311399792 11222880 11118676 11896295
MESH:D055728 Primary Myelofibrosis decitabine 4.1817616702
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.2215572423
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 8.8920887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 8.8920887781
MESH:D011471 Prostatic Neoplasms Arsenic 6.2216140617
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 6.2217292933
MESH:D011471 Prostatic Neoplasms bisphenol A 6.2216740699
MESH:D011471 Prostatic Neoplasms Calcitriol 6.2216289102 18247401 15754350 12479363 16644109
MESH:D011471 Prostatic Neoplasms Cholecalciferol 6.2217024972
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 6.2217136230 15846301 15046698
MESH:D011471 Prostatic Neoplasms Estradiol 6.2216740699
MESH:D011471 Prostatic Neoplasms Genistein 6.2215256057 16925846 15378649
MESH:D011471 Prostatic Neoplasms Methylnitrosourea 6.2215682402 12376480
MESH:D011471 Prostatic Neoplasms Paclitaxel 6.2216729912 17172428 17136230 16356831
MESH:D011471 Prostatic Neoplasms Quercetin 6.2217292933 14715546
MESH:D011471 Prostatic Neoplasms Raloxifene 6.2216220300 16536755 15731164
MESH:D011471 Prostatic Neoplasms sodium arsenite 6.2216039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 6.2215067354
MESH:D011507 Proteinuria Arsenic 8.0421343184
MESH:D011507 Proteinuria valsartan 8.0417664856 12164870 18344623
MESH:D011537 Pruritus Ethinyl Estradiol 7.6815861022 16919318
MESH:D011537 Pruritus Mustard Gas 7.6818058305
MESH:D019310 Pseudolymphoma Phenobarbital 3.9312752131
MESH:D011565 Psoriasis Cyclosporine 2.0116882103
MESH:D011629 Puberty, Precocious bisphenol A 4.2310548101
MESH:D011657 Pulmonary Eosinophilia Ascorbic Acid 4.7614606601
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 8.0515814490 17365031 17322281 17975199
MESH:D011658 Pulmonary Fibrosis Mustard Gas 8.0517266442 10334151 17894541 17620002 17720292
MESH:D011658 Pulmonary Fibrosis valsartan 8.0517241526
MESH:D011693 Purpura Raloxifene 4.9915770314
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.3118990726
MESH:D012162 Retinal Degeneration Methylnitrosourea 3.9918172121 18155124
MESH:D012174 Retinitis Pigmentosa Ascorbic Acid 3.1316849425
MESH:D012175 Retinoblastoma Methylnitrosourea 4.9311555667
MESH:D012208 Rhabdomyosarcoma decitabine 3.8919155313
MESH:D012512 Sarcoma, Ewing's Dactinomycin 4.5514601052
MESH:D012554 Schistosomiasis japonica Quercetin 4.9816862918
MESH:D012640 Seizures 2,4-dinitrotoluene 4.6418551238
MESH:D012640 Seizures Phenobarbital 4.643137016 4039156 16876388 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 4.266407741
MESH:D012852 Sinusitis Phenylephrine 4.157327846
MESH:D012871 Skin Diseases marker/mechanism 16835338
MESH:D012871 Skin Diseases Arsenic 7.0616759981 19834688 17548696 16702368 15952646 18709164 17938729 17050553 16353154 6392382 17453740
MESH:D012871 Skin Diseases Ascorbic Acid 7.0618709164
MESH:D012871 Skin Diseases Mustard Gas 7.0615451306 12880345 16961503
MESH:D012878 Skin Neoplasms Arsenic 18.6915504454 17976673 19538983 17029826 17050553 16251483
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 18.6919755658 10029692
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 18.6912065085
MESH:D012878 Skin Neoplasms sodium arsenite 18.6918572023 19524636
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 18.698532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 18.6916192470
MESH:D013088 Spermatocele Diethylstilbestrol 16.8516002989 16709447
MESH:D013088 Spermatocele Ethinyl Estradiol 16.8516709447
MESH:D013088 Spermatocele Tamoxifen 16.8516709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.4819457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.3612854658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.192093021 20155912
MESH:D013274 Stomach Neoplasms decitabine 4.1919037991
MESH:D013274 Stomach Neoplasms Methylnitrosourea 4.1916257854 18593901 15930296
MESH:D013274 Stomach Neoplasms Paclitaxel 4.1918506536 18396642
MESH:D013276 Stomach Ulcer Ascorbic Acid 3.4118726076
MESH:D020521 Stroke Ascorbic Acid 7.5116403987 16517955
MESH:D020521 Stroke Raloxifene 7.5116837676
MESH:D019966 Substance-Related Disorders bisphenol A 3.4316045194 16684133
MESH:D024801 Tauopathies Paclitaxel 4.2616930453
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.1111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.6815669648
MESH:D013953 Thymus Neoplasms Methylnitrosourea 4.6711418001
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.3312697716
MESH:D013964 Thyroid Neoplasms decitabine 9.6517967635
MESH:D013964 Thyroid Neoplasms Methylnitrosourea 9.657505956 3078959
MESH:D013964 Thyroid Neoplasms Phenobarbital 9.651399818
MESH:D013978 Tibial Fractures Estradiol 11.8219048282
MESH:D013978 Tibial Fractures Raloxifene 11.8219048282
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 28.0516049721
MESH:D001749 Urinary Bladder Neoplasms Arsenic 28.0517976673 19429237 11144890 15987713 19322015 17306315 18640142
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 28.0517053015
MESH:D001749 Urinary Bladder Neoplasms decitabine 28.0519087683 17616700
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 28.0517306315 16452187 16712894
MESH:D001749 Urinary Bladder Neoplasms Quercetin 28.0516720314
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 28.0517572228
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 28.0516452187 11723127 16712894 17306315
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 28.058653321 16712894 17572228
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 3.7610091137
MESH:D014581 Urticaria Acetaminophen 2.4710982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 7.9316175088
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 7.9311813266
MESH:D014591 Uterine Diseases bisphenol A 11.9314652134
MESH:D014591 Uterine Diseases Diethylstilbestrol 11.9314652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 7.7215809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 7.7214692618
MESH:D014604 Uveal Neoplasms decitabine 4.3517785578
MESH:D014605 Uveitis Cyclosporine 3.421336536
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 3.8916513791 16002989
MESH:D014652 Vascular Diseases Arsenic 10.0017056641
MESH:D014652 Vascular Diseases sodium arsenite 10.0017056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.0312125929
MESH:D054556 Venous Thromboembolism Raloxifene 4.6416837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.0414671159 15869587
MESH:D020257 Ventricular Remodeling valsartan 5.1419027736
MESH:D014846 Vulvar Neoplasms Raloxifene 4.9916343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.6815886252
MESH:D015430 Weight Gain Dietary Fats 3.2716723640
MESH:D014985 Xerophthalmia Cyclosporine 3.8717120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29639
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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