AutismKB 2.0

Annotation Detail for ARHGEF7


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Basic Information Top
Gene Symbol:ARHGEF7 ( BETA-PIX,COOL-1,COOL1,DKFZp686C12170,DKFZp761K1021,KIAA0142,KIAA0412,Nbla10314,P50,P50BP,P85,P85COOL1,P85SPR,PAK3,PIXB )
Gene Full Name: Rho guanine nucleotide exchange factor (GEF) 7
Band: 13q34
Quick LinksEntrez ID:8874; OMIM: 605477; Uniprot ID:ARHG7_HUMAN; ENSEMBL ID: ENSG00000102606; HGNC ID: 15607
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04810Regulation of actin cytoskeleton
Pathway IDPathway Name
Signaling by GPCR
Signalling by NGF
Signaling by EGFR
Signaling by Rho GTPases
Pathway IDPathway Name
200146Internalization of ErbB1
200098Class I PI3K signaling events
200166Aurora A signaling
200165Regulation of RAC1 activity
200192Signaling events mediated by focal adhesion kinase
200057CDC42 signaling events
200059Regulation of CDC42 activity
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
HEMATOLOGICAL
serum bilirubin levels
menopause (age at onset)
REPRODUCTION
Desease Name
Serum bilirubin levels
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of ARHGEF7 mRNAaffects expression 17562736
D020106 Acrylamide Acrylamide results in decreased expression of ARHGEF7 mRNAdecreases expression 15749267
D000638 Amiodarone Amiodarone results in increased expression of ARHGEF7 mRNAincreases expression 19774075
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ARHGEF7 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of ARHGEF7 mRNAincreases expression 17879257
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ARHGEF7 mRNAdecreases expression 19150397
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of ARHGEF7 mRNAdecreases expression 15336504
D004041 Dietary Fats Dietary Fats results in increased expression of ARHGEF7 mRNAincreases expression 18042831
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of ARHGEF7 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ARHGEF7 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ARHGEF7 mRNAaffects cotreatment|increases expression 17942748
C041786 palm oil palm oil results in increased expression of ARHGEF7 mRNAincreases expression 18042831
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of ARHGEF7 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of ARHGEF7 mRNAincreases expression 19482888
C006253 pirinixic acid pirinixic acid results in increased expression of ARHGEF7 mRNAincreases expression 18445702
C017947 sodium arsenite sodium arsenite results in increased expression of ARHGEF7 mRNAincreases expression 20308225
D013629 Tamoxifen Tamoxifen affects the expression of ARHGEF7 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ARHGEF7 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ARHGEF7 mRNAincreases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.6114745880
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 8.466195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.4611752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.6118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0017505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.1518653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.2020127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.2014692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.676695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 17.6017620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 17.6016434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 17.6016835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.7615276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.9617306315 16712894
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9711748828
MESH:D000799 Angioedema Acetaminophen 3.9110982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1219183758
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.8318218290 18057881 20041841
MESH:D001161 Arteriosclerosis Dietary Fats 10.0515238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 10.0511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6815885639
MESH:D001281 Atrial Fibrillation Amiodarone 3.9219698954 18651412
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001778 Blood Coagulation Disorders Amiodarone 15.4919483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 15.4919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 15.4912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8515340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7815746008
MESH:D001943 Breast Neoplasms Acrylamide 2.3516253758 18183576
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.3520146248 17474063
MESH:D001943 Breast Neoplasms Dietary Fats 2.3520435547
MESH:D001943 Breast Neoplasms Tamoxifen 2.3519142967 18425577 20544844 20005174 15565566 19103187 19155303 18351453 18629630 17242785 15668708 19289846 19084267 20135344 18855134 11161223 19115204 19059307 16202921 18984771 17893378 18997820 17049068 21138602 19011961 19200415 21152245 17440819 19244106 18821012 18815881 19189210 19487384 16873071 17261762 19221464 20390343 16273361 20859285 19066611 20065188 19288272 16818667 19189212 19410462
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3520435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8216835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.5519066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.603084413
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 6.6020007298 17173139 1701930 6705139 20935162
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 6.6016507464 17306315 15276417
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.6016924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.6220419170
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.6218572023
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.6417572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3818670907 18850075 16120746
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9019225199 15710769
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.1318974383
MESH:D002386 Cataract Acetaminophen 2.6010977129
MESH:D002418 Cattle Diseases Acrylamide 5.5112510666
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.7920889678
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 6.7919524636 20056578
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.294080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1916835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.8111677210 17110522 16919318 17333356 16105132 15861022 17681005
MESH:D002779 Cholestasis pirinixic acid 7.8119176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1112621046 15340226 16354765 15668235 8697196
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0817141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2510048152 20055451 15322242
MESH:D003711 Demyelinating Diseases Tamoxifen 4.4019031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4418249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6717107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.5019279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.2215968718 12153990 14986274 14550746 19416960 11287661 18071297 12594235 11461765 19420014 16227642 19739265 11834606 18713872 11421492 10663392 17522070 11739529 16781746 11529661 14725611 17906064 12705907 12540782 10774834 11743745 12958197 19164858 2444490 10915739 19370779 16485898 12392966 16393943 16177239 16081117 19085960 15619225 19923254 17562736 16109766
MESH:D056486 Drug-Induced Liver Injury Amiodarone 6.2218218290 15265979
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.2220420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1619426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7811462148
MESH:D050171 Dyslipidemias Dietary Fats 3.4718367378
MESH:D004421 Dystonia Phenobarbital 4.041851702
MESH:D004487 Edema pirinixic acid 6.6312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.6312711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9615322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.0712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.0719031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.0620544844 17893378 16202921 19155303
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.059294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.153659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.933922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.9020417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.576401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.297750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.073659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.3720426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.3716530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0311564622
MESH:D005234 Fatty Liver Amiodarone 24.9914986274
MESH:D005234 Fatty Liver Dietary Fats 24.9919004024 17967931 19551842 18296743
MESH:D005234 Fatty Liver Ethinyl Estradiol 24.9915345470
MESH:D005234 Fatty Liver pirinixic acid 24.9919236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 24.9919224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2516709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5011858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.5814745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.2319069698
MESH:D005355 Fibrosis Dietary Fats 8.7618296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.7620067830
MESH:D005756 Gastritis Acetaminophen 3.7416983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.7316452187
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6610696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.4920471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.4910048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.5520558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3611000095
MESH:D006529 Hepatomegaly Amiodarone 21.0615265979
MESH:D006529 Hepatomegaly Phenobarbital 21.0616109766
MESH:D006529 Hepatomegaly pirinixic acid 21.0616221962 19772884 19176532 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 21.0615340226 16120746 12621046
MESH:D006689 Hodgkin Disease sodium arsenite 3.1812676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.118697196 16354765 16959395 15340226 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.7216870215
MESH:D006937 Hypercholesterolemia Amiodarone 9.268137927 9751232
MESH:D006937 Hypercholesterolemia Dietary Fats 9.2621332399
MESH:D006943 Hyperglycemia pirinixic acid 3.2120558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.6521332399
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9118850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8516569931 16945680
MESH:D007037 Hypothyroidism Amiodarone 4.5617991464 18020914
MESH:D007247 Infertility, Female Acrylamide 10.5011020651
MESH:D007247 Infertility, Female Ethinyl Estradiol 10.5012013081
MESH:D007248 Infertility, Male Acrylamide 11.4812507653 11020651 15749267 15355880
MESH:D007248 Infertility, Male Ethinyl Estradiol 11.4817937319
MESH:D007248 Infertility, Male sodium arsenite 11.4812646999 15346721
MESH:D007249 Inflammation Dietary Fats 8.3620412841
MESH:D007249 Inflammation Tamoxifen 8.3619457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.3612200463 12878042
MESH:D007333 Insulin Resistance Dietary Fats 7.3111836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 7.3116306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3616580747
MESH:D007674 Kidney Diseases Acetaminophen 6.0112587719 15629191
MESH:D007674 Kidney Diseases sodium arsenite 6.0120008137
MESH:D007680 Kidney Neoplasms Tamoxifen 3.0718625569
MESH:D008064 Lipidoses Amiodarone 7.9817567588 15342952
MESH:D008064 Lipidoses Tamoxifen 7.9817567588 15342952
MESH:D008103 Liver Cirrhosis Dietary Fats 6.7118296743
MESH:D008103 Liver Cirrhosis Phenobarbital 6.7121047994
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4015474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.4018564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4012878042
MESH:D008107 Liver Diseases Acetaminophen 3.9512969438 12587719 19014921 19784758 19460945 16610002 16611625 11587558
MESH:D008107 Liver Diseases Phenobarbital 3.9519363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2616871587 17185352
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 18.1320195826 21137059
MESH:D008113 Liver Neoplasms Phenobarbital 18.1319073162 15975961 21047994 8742319 19812893 19482888
MESH:D008113 Liver Neoplasms pirinixic acid 18.1316377806 15890375 20007298
MESH:D008113 Liver Neoplasms sodium arsenite 18.1315276417 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 18.1316684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 18.1316984957
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 5.8517172636 18308698 1399818 2563599 6150874
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.8512151625
MESH:D008133 Long QT Syndrome Amiodarone 3.6011989578 15350150 17391786
MESH:D008171 Lung Diseases Amiodarone 7.5812587719
MESH:D008171 Lung Diseases sodium arsenite 7.5819095001
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.5418516814
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.8520464547 20064080 17053015 6695378 18816296 18520028 18569708 20869020 20135361
MESH:D008175 Lung Neoplasms sodium arsenite 4.8517306315 17077188 19931552 15276417 16712894
MESH:D008175 Lung Neoplasms Tamoxifen 4.8518625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.8519555203 11884234
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.8119428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.6419196723 14580682 16827153 11731420 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.6119453300
MESH:D008545 Melanoma sodium arsenite 3.3316487513 19082730
MESH:D008545 Melanoma Tamoxifen 3.3319393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.2315990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6119513568
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2116381670
MESH:D009135 Muscular Diseases pirinixic acid 3.5516239165
MESH:D009181 Mycoses Amiodarone 4.9612754197 17974566
MESH:D009203 Myocardial Infarction pirinixic acid 2.1519151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0412213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9716411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.5317484760
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5519393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5219410462
MESH:D009369 Neoplasms Benzo(a)pyrene 8.2811141357
MESH:D009369 Neoplasms pirinixic acid 8.2817405874
MESH:D009369 Neoplasms sodium arsenite 8.2811559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.7120056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.0619200415 19189210 19196722
MESH:D009410 Nerve Degeneration Acrylamide 4.7112387367 12387366 11264303
MESH:D009422 Nervous System Diseases Acrylamide 5.0112164553 12507653
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2514600291
MESH:D009436 Neural Tube Defects sodium arsenite 3.1612854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8918514411
MESH:D009765 Obesity Dietary Fats 4.4518457598 20518802 16723640 17217161 11836018 18674790 20132043 21332399 19632207
MESH:D009765 Obesity pirinixic acid 4.4520558911
MESH:D010018 Osteomalacia Phenobarbital 4.4117016548
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.4417306315 15276417
MESH:D010146 Pain Acetaminophen 2.4116870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5016965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7211578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3112520081
MESH:D010523 Peripheral Nervous System Diseases Acrylamide 5.1411510240
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5918163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.652563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2411399792 11896295 11222880 11118676
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5317292933
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.5316039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.5315067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.3616919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 4.5612752131
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.8612490602 11597910 12832656
MESH:D015427 Reperfusion Injury pirinixic acid 2.4019058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8718990726
MESH:D012640 Seizures Phenobarbital 2.7111442880 3137016 4039156 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.876407741
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.1318724381
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 13.6619755658 10029692
MESH:D012878 Skin Neoplasms sodium arsenite 13.6618572023 19524636
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 13.668532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 13.6616192470
MESH:D013088 Spermatocele Ethinyl Estradiol 11.7716709447
MESH:D013088 Spermatocele Tamoxifen 11.7716709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.0919457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.8212854658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D013276 Stomach Ulcer Amiodarone 3.3418087811
MESH:D013610 Tachycardia Amiodarone 4.3211238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.2219225199
MESH:D013733 Testicular Diseases Acrylamide 5.2815864552
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6511994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1815669648
MESH:D013959 Thyroid Diseases Amiodarone 12.2619731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 12.2612697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.071399818
MESH:D013971 Thyrotoxicosis Amiodarone 4.9019584973 18020914
MESH:D016171 Torsades de Pointes Amiodarone 4.2411989578 17467628
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.3617053015
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 8.3617306315 16712894 16452187 11723127
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.3616712894 17572228 8653321
MESH:D014581 Urticaria Acetaminophen 3.0110982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.7911813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3314692618
MESH:D014652 Vascular Diseases sodium arsenite 4.4717056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5714671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3115886252
MESH:D015430 Weight Gain Dietary Fats 3.7616723640
Pathway ID Pathway Name
KEGG:04810 Regulation of actin cytoskeleton
REACT:9417 Signaling by EGFR
REACT:14797 Signaling by GPCR
REACT:11044 Signaling by Rho GTPases
REACT:11061 Signalling by NGF
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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