AutismKB 2.0

Annotation Detail for SPHK1


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Basic Information Top
Gene Symbol:SPHK1 ( SPHK )
Gene Full Name: sphingosine kinase 1
Band: 17q25.2
Quick LinksEntrez ID:8877; OMIM: 603730; Uniprot ID:SPHK1_HUMAN; ENSEMBL ID: ENSG00000176170; HGNC ID: 11240
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00600Sphingolipid metabolism
hsa04020Calcium signaling pathway
hsa01100Metabolic pathways
hsa04370VEGF signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
Pathway IDPathway Name
Metabolism of proteins
Metabolism of lipids and lipoproteins
Pathway IDPathway Name
200003Fc-epsilon receptor I signaling in mast cells
200127PDGFR-beta signaling pathway
200071S1P1 pathway
Pathway IDPathway Name
P00056VEGF signaling pathway
P00005Angiogenesis
Pathway IDPathway Name
500536Association of TriC/CCT with target proteins during biosynthesis
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of SPHK1 mRNAincreases expression 19933214
D000082 Acetaminophen Acetaminophen affects the expression of SPHK1 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SPHK1 mRNAaffects expression 16483693
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of SPHK1 mRNAincreases expression 18687144
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of SPHK1 mRNAaffects expression 20382639
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of SPHK1 mRNAincreases expression 15336504
C055494 caffeic acid phenethyl ester [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of SPHK1 mRNAaffects cotreatment|decreases expression 20360939
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of SPHK1 mRNAincreases expression 17341687
D002518 Ceramides Ceramides results in decreased activity of SPHK1 proteindecreases activity 16281067
C014347 decitabine decitabine results in increased expression of SPHK1 mRNAincreases expression 19194470
D003907 Dexamethasone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SPHK1 mRNAaffects cotreatment|increases expression 16054899
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of SPHK1 mRNAaffects cotreatment|decreases expression 20360939
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of SPHK1 mRNAincreases expression 17351261
C411675 F 12509A F 12509A results in decreased expression of SPHK1 proteindecreases expression 16281067
D015056 1-Methyl-3-isobutylxanthine [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SPHK1 mRNAaffects cotreatment|increases expression 16054899
D008770 Methylnitrosourea Methylnitrosourea results in increased expression of SPHK1 mRNAincreases expression 17412507
D015735 Mifepristone Mifepristone inhibits the reaction [Progesterone results in increased expression of SPHK1 mRNA]decreases reaction|increases expression 17164439
C053238 onapristone onapristone inhibits the reaction [Progesterone results in increased expression of SPHK1 mRNA]decreases reaction|increases expression 17164439
C053238 onapristone onapristone results in decreased expression of SPHK1 mRNAdecreases expression 17164439
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of SPHK1 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of SPHK1 mRNAincreases expression 16985257
D011374 Progesterone Mifepristone inhibits the reaction [Progesterone results in increased expression of SPHK1 mRNA]decreases reaction|increases expression 17164439
D011374 Progesterone onapristone inhibits the reaction [Progesterone results in increased expression of SPHK1 mRNA]decreases reaction|increases expression 17164439
D011374 Progesterone Progesterone results in increased expression of SPHK1 mRNAincreases expression 17164439
C059514 resveratrol resveratrol results in increased expression of SPHK1 mRNAincreases expression 16624241
C089730 rosiglitazone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SPHK1 mRNAaffects cotreatment|increases expression 16054899
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of SPHK1 mRNAincreases expression 19933214
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of SPHK1 mRNAincreases expression 16960034
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.7011752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.4118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7917505938
MESH:D058186 Acute Kidney Injury resveratrol 3.7116538975
MESH:D055371 Acute Lung Injury pirinixic acid 2.9718653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.4714692618
MESH:D000230 Adenocarcinoma Methylnitrosourea 4.4715688392 15113128
MESH:D000236 Adenoma Diethylnitrosamine 6.596695378 10737359
MESH:D000236 Adenoma resveratrol 6.5915688382
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 16.3918056438 17620307 17162532 16434500 19052882 19061943
MESH:D018248 Adenoma, Liver Cell pirinixic acid 16.3916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 16.3916835633
MESH:D000544 Alzheimer Disease resveratrol 4.4216162502 16183991
MESH:D000544 Alzheimer Disease rosiglitazone 4.4219621015
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8111748828
MESH:D000799 Angioedema Acetaminophen 3.6910982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.3111256880
MESH:D001169 Arthritis, Experimental Dexamethasone 11.8017659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 11.8015885639
MESH:D001169 Arthritis, Experimental resveratrol 11.8017115116
MESH:D050197 Atherosclerosis resveratrol 3.1816873680 17967414
MESH:D001321 Autistic Disorder Acetaminophen 1.4318445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.3119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.3112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6715746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.1917868700
MESH:D001930 Brain Injuries Progesterone 4.1115665606 15845082 15380490
MESH:D002545 Brain Ischemia resveratrol 4.1317600658
MESH:D001943 Breast Neoplasms decitabine 2.8919208741 18320071
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.8917474063
MESH:D001943 Breast Neoplasms Methylnitrosourea 2.8911306469 14633655 16253758
MESH:D001943 Breast Neoplasms Progesterone 2.8915562024 17614352 16175315
MESH:D001943 Breast Neoplasms resveratrol 2.8917651959 16393696 17534123
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.8920435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.6316227642 16124888 15673190 10355542 16011737 16192424 3786805 18705752 16050911 15721981 16097048 15700767
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6816835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.373084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.3718788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.3720514400 19822196 10672840 19394651 16698587 3581430 16681979 17978847 16328049 19335982 16502159 17138121 17055752 20007298 19539802 19171122 20101231 17428255 16878318 21159647 18393292 16779866 18665156 18506893 18056438 20524982 20432363 11831363 19418558 19519916 19919837 16288022 19208518 20084675 17761372 17173139 20512989 16540662 19107877 16830150 17162532 20935162 18494052 18785209 18971187 16807293 3084413 16935385 20214788 18691550 19701751 18978308 19052882 18210153 10737359 19383236 16569478 20727157 18788625
MESH:D006528 Carcinoma, Hepatocellular resveratrol 6.3716227395 19321006
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.4416675471
MESH:D002294 Carcinoma, Squamous Cell decitabine 4.7719215824
MESH:D002294 Carcinoma, Squamous Cell resveratrol 4.7716227395
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2816120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases resveratrol 3.3715458977
MESH:D002386 Cataract Acetaminophen 7.2610977129
MESH:D002386 Cataract Methylnitrosourea 7.2612484553
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10.7220889678
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 10.7217174075 21159647 7505956 2727394
MESH:D002471 Cell Transformation, Neoplastic Methylnitrosourea 10.722727394 7505956
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.8919052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.8916835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.3711677210 16105132 17681005 17110522 16919318 15861022 17333356
MESH:D002779 Cholestasis pirinixic acid 7.3719176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0416354765 15668235 8697196 15340226 12621046
MESH:D003092 Colitis resveratrol 3.9816474422
MESH:D003110 Colonic Neoplasms decitabine 5.7717616700
MESH:D003110 Colonic Neoplasms Dexamethasone 5.7715824018
MESH:D003110 Colonic Neoplasms resveratrol 5.7716338953
MESH:D015179 Colorectal Neoplasms decitabine 2.6818981723
MESH:D015179 Colorectal Neoplasms resveratrol 2.6816550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9314669216 17141729
MESH:D003327 Coronary Disease resveratrol 3.6616507316
MESH:D019465 Craniofacial Abnormalities Dexamethasone 2.5717728286
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5720055451 15322242 10048152
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.2612438553
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3618249437
MESH:D003920 Diabetes Mellitus rosiglitazone 4.1717446233
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.6416873680
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.9420387270
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 6.9412642470
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.9417107852
MESH:D003928 Diabetic Nephropathies resveratrol 3.8316286809
MESH:D003929 Diabetic Neuropathies Progesterone 4.3417187935
MESH:D003967 Diarrhea Dexamethasone 3.557237001
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.5710774834 19739265 19420014 19370779 15968718 11287661 16177239 10915739 14986274 10663392 17522070 11743745 19085960 12392966 17906064 16485898 16081117 12594235 16109766 11529661 11834606 19164858 11421492 14725611 12958197 19416960 15619225 16393943 16227642 11739529 18713872 12153990 11461765 12705907 16781746 12540782 19923254 2444490 18071297 14550746 17562736
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 8.5721278145 7440962 10092053 6623471 15027814 7179309 17522070 15968718 2869522 19085960 10915739 16177239 4309450 16227642 3732212 11566570 15998439 3786805 6884620 9327722 19336974 7120509
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 8.5719107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.5720420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9519426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6511462148
MESH:D004485 Eczema Dexamethasone 4.3112438553
MESH:D004487 Edema Dexamethasone 20.1919703484
MESH:D004487 Edema pirinixic acid 20.1912083418
MESH:D004487 Edema resveratrol 20.198985016
MESH:D004487 Edema rosiglitazone 20.1912083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 20.1912711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7518230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 14.5312538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 14.5317692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 14.5317872969
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.9619294695
MESH:D004715 Endometriosis Mifepristone 14.5616134523
MESH:D004715 Endometriosis Progesterone 14.5616134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 14.5610568697 9294722
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.7017923197
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9716302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.0420426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9011564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 23.1816045604 12631006 15959796 61145 16239168 19224547 17595544 12795759
MESH:D005234 Fatty Liver Diethylnitrosamine 23.1821071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 23.1815345470
MESH:D005234 Fatty Liver pirinixic acid 23.1820131406 19236843
MESH:D005234 Fatty Liver rosiglitazone 23.1819196556
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3111858732
MESH:D005354 Fibrosarcoma Methylnitrosourea 5.0811555667
MESH:D005355 Fibrosis Carbon Tetrachloride 8.1018705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.1020067830
MESH:D005756 Gastritis Acetaminophen 3.5216983495
MESH:D005910 Glioma Methylnitrosourea 3.509825942
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4410696789
MESH:D006258 Head and Neck Neoplasms decitabine 3.3919215824
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.2511294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.4420558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2011000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.4519900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 7.7619772884 16221962 19176532 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.7615340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 3.027520565
MESH:D006561 Herpes Simplex resveratrol 4.0316876885
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8916354765 8697196 15340226 18606429 16959395
MESH:D006930 Hyperalgesia Acetaminophen 7.4816870215
MESH:D006930 Hyperalgesia rosiglitazone 7.4812083418
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3816899240
MESH:D006937 Hypercholesterolemia resveratrol 3.8717188708
MESH:D006943 Hyperglycemia pirinixic acid 3.0520558911
MESH:D006949 Hyperlipidemias resveratrol 3.8916873680
MESH:D006973 Hypertension Dexamethasone 5.0617042910
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0618670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9415338365
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.1717488730
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6616569931 16945680
MESH:D007077 Ileal Diseases 1-Methyl-3-isobutylxanthine 5.2918306037
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 10.9815869954
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 10.9817600658
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3212013081
MESH:D007248 Infertility, Male decitabine 10.7617581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 10.7617937319
MESH:D007248 Infertility, Male Methylnitrosourea 10.767193160
MESH:D007249 Inflammation Dexamethasone 18.968960868 11099482
MESH:D007249 Inflammation Diethylnitrosamine 18.9618785209
MESH:D007249 Inflammation Progesterone 18.9615869954
MESH:D007249 Inflammation resveratrol 18.9616366677
MESH:D007249 Inflammation rosiglitazone 18.9612083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 18.9612200463 12878042
MESH:D007251 Influenza, Human resveratrol 4.3916624496
MESH:D007333 Insulin Resistance pirinixic acid 7.1816306350
MESH:D007333 Insulin Resistance rosiglitazone 7.1816306350
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 4.4510783313
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2016580747
MESH:D007579 Jejunal Diseases 1-Methyl-3-isobutylxanthine 5.2918306037
MESH:D007674 Kidney Diseases Acetaminophen 5.9515629191 12587719
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 5.9515369732
MESH:D007938 Leukemia decitabine 3.0019235587 18980019
MESH:D007951 Leukemia, Myeloid decitabine 3.8617236224 18454857 19117987
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.3518460780 19010910 17679729 18206229 18704418 19387464
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.3118055864
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 7.7516766008
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 7.7516087638
MESH:D017880 Limb Deformities, Congenital Methylnitrosourea 4.0915526292
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.3316239168 17157831 11408273 16943688 11903743 21278145 16221502 17174718 17334410
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.3318665156 20032147 18407596 19638242 18522880
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.5418210741 18263696 18277467 18395095 18187930 14716833 12546737 12649538 18279442 16116963 15925388 16033810 17805973 15650968 18412020 18481824 17640975 17481882 15362042 17922224 17698563 16011737 15818738 12741479 17761835 17944888 17766677 15931870 17557913 12445418 12389079 18054572 16192424 16136751 12666154 20821823 15370692 15959796 14512876 18317297 18418968 12609069 17708605 15996030 18156304 16097048 17823541 17976157 12632514 17869086 15673190 15052691 15730626 17900296 15876570 17565644 18395914 18705752 16248980 18166357 10355542 16638106 12667390 18472094 18429990 12958196 14748882 12586293 14716496 15057751 16015684 11481614 12445421 18420326 12898905 14724832 17714472 15893842 16027843 12632512 18251166 18205269 18376398 15338365 18472332 17631135 17525996 14620537 18006644 15123356 13678700 17721639 18339082
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 6.5416718785
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.5415474484
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 6.5417347453 15980055
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.5412878042
MESH:D008107 Liver Diseases Acetaminophen 6.2416611625 12969438 19460945 19784758 16610002 12587719 19014921 11587558
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.2416964402 16246199 17285989 15720792 15830285
MESH:D008107 Liver Diseases Diethylnitrosamine 6.2417034775
MESH:D017093 Liver Failure Carbon Tetrachloride 4.0115123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.9616871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.9616899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 13.6219294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 13.6219256749 19551842 19427195 19426721 20492335 20101389 9163691 19690152 21278145 20452335 16942905 19090486 10737359 18648771 12112319 15885732 19499222 20434301 12771043 2422723 19073162 18644402 20137499 2862719 19833225 21167192 19255062 19294768 20405173 19254457 20583210 18978307 21047994 18754104 19996281 15175105 19638242 21071580 20501860 20118626 18977376 19850985 19642983 19812893
MESH:D008113 Liver Neoplasms pirinixic acid 13.6215890375 20007298 16377806
MESH:D008113 Liver Neoplasms resveratrol 13.6219073162 20405173 19812893 19321006
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.6216984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 9.2512014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 9.259362446 3124819 18544905 18775883 19539802 18093689 18079962 18164116 16842330 18282651 19004024 18253720 21159647 19126423 16267830 19519916 19009564 17942915 17854601 2563599 18308698 17174075
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.2512151625
MESH:D038061 Lower Extremity Deformities, Congenital Methylnitrosourea 5.3116080182
MESH:D055370 Lung Injury Asbestos, Crocidolite 3.8717365036
MESH:D008175 Lung Neoplasms Dexamethasone 4.7515824018 11195469
MESH:D008175 Lung Neoplasms Diethylnitrosamine 4.7520970405 6695378 21163286 20512841
MESH:D008175 Lung Neoplasms Methylnitrosourea 4.7518062963
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.7519555203 11884234
MESH:D008223 Lymphoma decitabine 7.5719470736
MESH:D008223 Lymphoma Methylnitrosourea 7.5716257854 11418001
MESH:D016393 Lymphoma, B-Cell Methylnitrosourea 10.0614633661
MESH:D016393 Lymphoma, B-Cell resveratrol 10.0617088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.7514749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.0915688416
MESH:D008325 Mammary Neoplasms, Experimental Methylnitrosourea 13.5815313902 17131329 14999141 12931682 16944150 16619500 15688392 16827153 11751437 10767621 11807958 19196723 15113128 14633655 17020996 16051031 10838139
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 13.5811408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 13.5811606380 8985016
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 13.5816827153
MESH:D008545 Melanoma decitabine 3.4917785578 16505122
MESH:D008545 Melanoma resveratrol 3.4917992120
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4219513568
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.1218303189 16966607 16166281
MESH:D008659 Metabolic Diseases resveratrol 4.2417112576
MESH:D024821 Metabolic Syndrome X rosiglitazone 4.2517261469
MESH:D009101 Multiple Myeloma decitabine 11.6118172295
MESH:D009101 Multiple Myeloma Dexamethasone 11.6116118317 15744524 15867202
MESH:D009101 Multiple Myeloma resveratrol 11.6117049120 17164350 16267019 16490592 14749477 17935668
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.7217962980
MESH:D009135 Muscular Diseases pirinixic acid 3.3616239165
MESH:D009190 Myelodysplastic Syndromes decitabine 7.3618608210 19010910 19157545 16882708
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 7.369809623
MESH:D009203 Myocardial Infarction pirinixic acid 5.5319151258
MESH:D009203 Myocardial Infarction resveratrol 5.5317125593 16317513 16456233 17188708 17015251 16525036
MESH:D017202 Myocardial Ischemia resveratrol 8.6117125593 17015251
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.6112213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.8316411023
MESH:D009205 Myocarditis resveratrol 4.6117322642
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.513581430 9029167
MESH:D009369 Neoplasms decitabine 7.9519470736 17925555 19116145
MESH:D009369 Neoplasms Methylnitrosourea 7.9515533788
MESH:D009369 Neoplasms pirinixic acid 7.9517405874
MESH:D009374 Neoplasms, Experimental Methylnitrosourea 9.0212696579
MESH:D009374 Neoplasms, Experimental resveratrol 9.028985016
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.0714600291
MESH:D009442 Neurilemmoma Methylnitrosourea 5.3311555667
MESH:D019636 Neurodegenerative Diseases Acetaminophen 13.3318514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 13.3320387270
MESH:D019636 Neurodegenerative Diseases resveratrol 13.3317652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.2617929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9720387270
MESH:D009765 Obesity pirinixic acid 1.7820558911
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.1117513867
MESH:D010051 Ovarian Neoplasms decitabine 7.7719331143 19259094
MESH:D010051 Ovarian Neoplasms Mifepristone 7.7716525653
MESH:D010051 Ovarian Neoplasms Progesterone 7.7717393432 16525653
MESH:D010146 Pain Acetaminophen 2.2716870215
MESH:D010190 Pancreatic Neoplasms decitabine 8.4519294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 8.4516540662
MESH:D010190 Pancreatic Neoplasms Methylnitrosourea 8.4516965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5411578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1012520081
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.7410923243
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4118163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.422563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.4621297632
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 9.0816679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.0811118676 11399792 11896295 11222880
MESH:D055728 Primary Myelofibrosis decitabine 4.5817616702
MESH:D011471 Prostatic Neoplasms Methylnitrosourea 3.7812376480 15682402
MESH:D011471 Prostatic Neoplasms resveratrol 3.7817675339 15767336 17636462 16731767 17804756 17718901
MESH:D011537 Pruritus Ethinyl Estradiol 3.1615861022 16919318
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 2.9717365031 17322281 17975199 15814490
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.4316325855
MESH:D015427 Reperfusion Injury pirinixic acid 6.3319058328
MESH:D015427 Reperfusion Injury resveratrol 6.3317520802 16314181 16317513 15827377 17058453
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 3.8718379247 11700416
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6918990726
MESH:D012162 Retinal Degeneration Methylnitrosourea 4.3018155124 18172121
MESH:D012175 Retinoblastoma Methylnitrosourea 5.3311555667
MESH:D012208 Rhabdomyosarcoma decitabine 4.2619155313
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8018045962
MESH:D012878 Skin Neoplasms resveratrol 9.078985016 15837718
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 9.078532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.0716192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.7916709447
MESH:D013119 Spinal Cord Injuries Progesterone 4.1316503802 15862959
MESH:D013272 Stomach Diseases Dexamethasone 4.1715472012
MESH:D013274 Stomach Neoplasms decitabine 3.4419037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.4418456281
MESH:D013274 Stomach Neoplasms Methylnitrosourea 3.4418593901 16257854 15930296
MESH:D013276 Stomach Ulcer Dexamethasone 3.3515138204
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.3516321402
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0215669648
MESH:D013953 Thymus Neoplasms Methylnitrosourea 5.0811418001
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7512697716
MESH:D013964 Thyroid Neoplasms decitabine 11.4617967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 11.467505956
MESH:D013964 Thyroid Neoplasms Methylnitrosourea 11.463078959 7505956
MESH:D014062 Tongue Neoplasms resveratrol 4.0816227395
MESH:D001749 Urinary Bladder Neoplasms decitabine 2.6617616700 19087683
MESH:D014581 Urticaria Acetaminophen 2.8310982225
MESH:D002583 Uterine Cervical Neoplasms resveratrol 3.9717473185
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 9.0114692618
MESH:D014594 Uterine Neoplasms resveratrol 9.0117044934
MESH:D014604 Uveal Neoplasms decitabine 4.7617785578
MESH:D014605 Uveitis Dexamethasone 4.671336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4014671159 15869587
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.1517488730
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1015886252
Pathway ID Pathway Name
KEGG:04020 Calcium signaling pathway
KEGG:04666 Fc gamma R-mediated phagocytosis
KEGG:01100 Metabolic pathways
REACT:22258 Metabolism of lipids and lipoproteins
REACT:17015 Metabolism of proteins
KEGG:00600 Sphingolipid metabolism
KEGG:05152 Tuberculosis
KEGG:04370 VEGF signaling pathway
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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