Annotation Detail for EIF2B5
Basic Information
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| Gene Symbol: | EIF2B5 ( CACH,CLE,EIF-2B,EIF2Bepsilon,LVWM ) |
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| Gene Full Name: | eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa |
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| Band: | 3q27.1 |
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| Quick Links | Entrez ID:8893; OMIM: 603945; Uniprot ID:EI2BE_HUMAN; ENSEMBL ID: ENSG00000145191; HGNC ID: 3261 |
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| Relate to Another Database: |
SFARIGene;
denovo-db |
| Pathway ID | Pathway Name |
|---|
| Metabolism of proteins |
| Gene Expression |
| Desease ID | Desease Name |
|---|
| 1832 | Congenital abnormality |
| 1877 | Multiple sclerosis |
| 2011 | Leukoencephalopathy |
| 2088 | Leukodystrophy NOS |
| Desease Name |
|---|
| Ovarioleukodystrophy |
| Leukoencephalopathy with vanishing white matter |
| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| C016403 |
2,4-dinitrotoluene |
2,4-dinitrotoluene affects the expression of EIF2B5 mRNA | affects expression | 21346803
|
| C023514 |
2,6-dinitrotoluene |
2,6-dinitrotoluene affects the expression of EIF2B5 mRNA | affects expression | 21346803
|
| D000643 |
Ammonium Chloride |
Ammonium Chloride affects the expression of EIF2B5 mRNA | affects expression | 16483693
|
| D005576 |
Forskolin |
Forskolin results in increased expression of EIF2B5 mRNA | increases expression | 16751804
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D000138 |
Acidosis |
|
Ammonium Chloride |
4.19 | 18287403 |
| MESH:D006528 |
Carcinoma, Hepatocellular |
|
2,4-dinitrotoluene |
3.10 | 16705839 |
| MESH:D006528 |
Carcinoma, Hepatocellular |
|
2,6-dinitrotoluene |
3.10 | 16705839 |
| MESH:D002471 |
Cell Transformation, Neoplastic |
|
2,6-dinitrotoluene |
3.03 | 6135515 |
| MESH:D003490 |
Cyanosis |
|
2,4-dinitrotoluene |
12.83 | 18551238 |
| MESH:D003490 |
Cyanosis |
|
2,6-dinitrotoluene |
12.83 | 18551238 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
2,4-dinitrotoluene |
4.16 | 21346803 18551238 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
2,6-dinitrotoluene |
4.16 | 21346803 18551238 |
| MESH:D007680 |
Kidney Neoplasms |
|
2,4-dinitrotoluene |
8.53 | 16705839 |
| MESH:D007680 |
Kidney Neoplasms |
|
2,6-dinitrotoluene |
8.53 | 16705839 |
| OMIM:603896 |
LEUKOENCEPHALOPATHY WITH VANISHING WHITE MATTER |
marker/mechanism |
|
| |
| MESH:D008113 |
Liver Neoplasms |
|
2,6-dinitrotoluene |
2.27 | 7678174 |
| MESH:D008114 |
Liver Neoplasms, Experimental |
|
2,6-dinitrotoluene |
2.77 | 2876784 2876786 6135515 |
| MESH:D009336 |
Necrosis |
|
2,4-dinitrotoluene |
12.54 | 18551238 |
| MESH:D009336 |
Necrosis |
|
2,6-dinitrotoluene |
12.54 | 18551238 7678174 |
| MESH:D009784 |
Occupational Diseases |
|
2,4-dinitrotoluene |
10.23 | 16049721 12819281 |
| MESH:D009784 |
Occupational Diseases |
|
2,6-dinitrotoluene |
10.23 | 16049721 |
| MESH:D012640 |
Seizures |
|
2,4-dinitrotoluene |
6.74 | 18551238 |
| MESH:D012640 |
Seizures |
|
2,6-dinitrotoluene |
6.74 | 18551238 |
| MESH:D001749 |
Urinary Bladder Neoplasms |
|
2,4-dinitrotoluene |
5.43 | 16049721 |
| MESH:D001749 |
Urinary Bladder Neoplasms |
|
2,6-dinitrotoluene |
5.43 | 16049721 |
| MESH:D014571 |
Urologic Neoplasms |
|
2,4-dinitrotoluene |
14.19 | 10091137 |
| MESH:D014571 |
Urologic Neoplasms |
|
2,6-dinitrotoluene |
14.19 | 10091137 |
PharmGKB Accession:PA27692
| Releated drug ID |
Related drug Name |
| PA451365 | sirolimus |
Drug Bank