AutismKB 2.0

Annotation Detail for AP1G2


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Basic Information Top
Gene Symbol:AP1G2 ( G2AD )
Gene Full Name: adaptor-related protein complex 1, gamma 2 subunit
Band: 14q11.2
Quick LinksEntrez ID:8906; OMIM: 603534; Uniprot ID:AP1G2_HUMAN; ENSEMBL ID: ENSG00000213983; HGNC ID: 556
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D004390 Chlorpyrifos Chlorpyrifos affects the expression of AP1G2 mRNAaffects expression 17452286
D003907 Dexamethasone Dexamethasone results in increased expression of AP1G2 mRNAincreases expression 12782123
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of AP1G2 mRNAaffects binding|increases activity|increases expression 19710929
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of AP1G2 mRNAincreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.4714514962 15322242 11752688
MESH:D055371 Acute Lung Injury pirinixic acid 3.5818653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 12.1016434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 12.1016835633
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 4.9717119214 16611668 11874814
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.3411748828
MESH:D001169 Arthritis, Experimental Dexamethasone 3.7617659584
MESH:D001778 Blood Coagulation Disorders pirinixic acid 10.2219483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 10.2212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.5115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 3.0015746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6720435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.1216835633
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5618850075 18670907 16120746
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.5316835633
MESH:D002779 Cholestasis pirinixic acid 3.1219176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.248697196 12621046 15340226 15668235 16354765
MESH:D003110 Colonic Neoplasms Dexamethasone 2.5415824018
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.4314669216 17141729
MESH:D019465 Craniofacial Abnormalities Dexamethasone 2.7017728286
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.7010048152 20055451 15322242
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.9612438553
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5718249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7417107852
MESH:D003967 Diarrhea Dexamethasone 4.207237001
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.6220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0511462148
MESH:D004485 Eczema Dexamethasone 4.9712438553
MESH:D004487 Edema Dexamethasone 14.0219703484
MESH:D004487 Edema pirinixic acid 14.0212083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 14.0211000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.6218230668 16714409 15322242
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.4210568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.3111564622
MESH:D005234 Fatty Liver pirinixic acid 3.1920131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 4.0211858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.5120067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.3210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.5111294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.7620558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.7611000095
MESH:D006529 Hepatomegaly pirinixic acid 10.1916221962 19176532 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 10.1915340226 16120746 12621046
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 3.187520565
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.7718606429 15340226 16354765 16959395 8697196
MESH:D006943 Hyperglycemia pirinixic acid 3.5820558911
MESH:D006973 Hypertension Dexamethasone 5.6617042910
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.6618850075 18670907
MESH:D007249 Inflammation Dexamethasone 5.6811099482 8960868
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.6812878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.8716306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.7616580747
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 3.6516718785
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.6515474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.6512878042
MESH:D008107 Liver Diseases Chlorpyrifos 3.1415991261
MESH:D008113 Liver Neoplasms pirinixic acid 4.6520007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.6516984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.3312151625
MESH:D008175 Lung Neoplasms Dexamethasone 2.5315824018 11195469
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.5319555203 11884234
MESH:D009101 Multiple Myeloma Dexamethasone 3.7816118317 15744524 15867202
MESH:D009135 Muscular Diseases pirinixic acid 4.0716239165
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 3.749809623
MESH:D009203 Myocardial Infarction pirinixic acid 2.2719151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.3412213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2516411023
MESH:D009369 Neoplasms pirinixic acid 2.1117405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.7214600291
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 4.4215081274
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.9712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.0718163543
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.7421297632
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.8211399792 11118676 11222880 11896295
MESH:D015427 Reperfusion Injury pirinixic acid 2.5519058328
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 4.4818379247 11700416
MESH:D012135 Respiratory Sounds Chlorpyrifos 5.1917119214 16611668 11874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.3518990726
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 5.6117119214 16611668
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 6.816418539
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.2016192470
MESH:D013272 Stomach Diseases Dexamethasone 4.9515472012
MESH:D013276 Stomach Ulcer Dexamethasone 3.9115138204
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.6212697716
MESH:D014605 Uveitis Dexamethasone 5.541336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.3212125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.9715886252
Pathway ID Pathway Name
KEGG:04142 Lysosome
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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