AutismKB 2.0

Annotation Detail for GYG2


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Basic Information Top
Gene Symbol:GYG2 ( GN-2,GN2 )
Gene Full Name: glycogenin 2
Band: Xp22.33
Quick LinksEntrez ID:8908; OMIM: 300198; Uniprot ID:GLYG2_HUMAN; ENSEMBL ID: ENSG00000056998; HGNC ID: 4700
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-5067glycogen biosynthesis II (from UDP-D-Glucose)
No data
Pathway IDPathway Name
Metabolism of carbohydrates
No data
No data
Pathway IDPathway Name
500680Glycogen breakdown (glycogenolysis)
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of GYG2 mRNAdecreases expression 15336504
D016572 Cyclosporine Cyclosporine results in decreased expression of GYG2 mRNAdecreases expression 20106945
D005472 Fluorouracil TP53 protein affects the reaction [Fluorouracil results in decreased expression of GYG2 mRNA]affects reaction|decreases expression 15016801
D014635 Valproic Acid Valproic Acid results in increased expression of GYG2 mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 4.118875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.3519490988
MESH:D000230 Adenocarcinoma Fluorouracil 2.5017638652
MESH:D000550 Amblyopia Valproic Acid 5.9617688650
MESH:D000740 Anemia Fluorouracil 4.1115504547 16511603 17963324
MESH:D001008 Anxiety Disorders Valproic Acid 3.9017497229
MESH:D001321 Autistic Disorder Valproic Acid 1.9815238991 18316065 18985861 17507914 18558336 19232924 18940202 19460635 17688650 17157402 18396377 16609825 18775368 18177632 20603192
MESH:D001714 Bipolar Disorder Valproic Acid 3.2420046352 17594078
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.638888407
MESH:D001943 Breast Neoplasms Fluorouracil 2.4319217205 18357371 15136595 16110121 16557594 16595493 18608205
MESH:D002276 Carcinoid Tumor Fluorouracil 5.3916051944
MESH:D002277 Carcinoma Fluorouracil 3.8917121937
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 2.1216332177 17088986 17045692 17971768 18930000 16799960
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.1718695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 2.5818986760 16757204 16280240 17066447
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.7912371664
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.8220734317
MESH:D002779 Cholestasis Cyclosporine 3.2119486331
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2817725105 17169374 16510598 17287894 15001691 17172411 18772588 17016597 16340194 17018589
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0016303861 16524972 18949393 17695437 18288408 18802399 17016601 17401013 18509181 15148649 17094418 16282729 17594712 17454858 15289873 16331619 18448328 18383874 17255274 20501625 14970324 16391804
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.9117688650 8888407 16575769
MESH:D007644 Darier Disease Fluorouracil 5.4216733453
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 2.251733752 19641884
MESH:D004421 Dystonia Valproic Acid 4.511851702
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.7117275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.6416628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.1120417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.966426943 6254150 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.867750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.693659116
MESH:D004938 Esophageal Neoplasms Fluorouracil 2.5216337965 16481741 15173087 17638652 16785472
MESH:D005234 Fatty Liver Cyclosporine 9.2019224547
MESH:D005234 Fatty Liver Valproic Acid 9.2019224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 5.6116575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.648888407 18558336
MESH:D005355 Fibrosis Cyclosporine 3.7012168785 12639820
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.858708960
MESH:D005910 Glioma Fluorouracil 2.9916145905
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.6415102660 15162350 18337622
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 5.0515720958
MESH:D006849 Hydrocephalus Valproic Acid 5.5017688650
MESH:D006973 Hypertension Cyclosporine 2.2110903974
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.1615604871
MESH:D007674 Kidney Diseases Cyclosporine 2.5418776723 10903974 8314463
MESH:D007680 Kidney Neoplasms Cyclosporine 8.5612371664
MESH:D007680 Kidney Neoplasms Fluorouracil 8.5616985049
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.2016294345 17596541
MESH:D008113 Liver Neoplasms Fluorouracil 2.6017045692 16603448 15113037 18383874
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.9817228818
MESH:D008175 Lung Neoplasms Fluorouracil 2.0115246190
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.4215086387
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.5116801185
MESH:D008881 Migraine Disorders Valproic Acid 3.4718803445 18765137
MESH:D009062 Mouth Neoplasms Fluorouracil 3.9418986760 16757204
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.458888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.3517596541
MESH:D009369 Neoplasms Fluorouracil 2.7716928823 18600527 18239605
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.1617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.6518481113 19348381
MESH:D009436 Neural Tube Defects Valproic Acid 3.3716359493 8888407
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.6916436463
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7715113037 16929163 16500647 19003803
MESH:D011230 Precancerous Conditions Cyclosporine 3.5912371664
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.4620603192
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.3518626508 19082440
MESH:D019310 Pseudolymphoma Valproic Acid 5.2612752131 11422049
MESH:D011565 Psoriasis Cyclosporine 2.3316882103
MESH:D012004 Rectal Neoplasms Fluorouracil 4.3815538739 18722050 16160472 18286688
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.6419155313
MESH:D012559 Schizophrenia Valproic Acid 2.1019110320 15737665
MESH:D012640 Seizures Valproic Acid 2.991511512 16876388 14763951 11738929 11044598 15475178 3137016 17978042
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 2.848532709
MESH:D016135 Spinal Dysraphism Valproic Acid 4.0919490988
MESH:D013226 Status Epilepticus Valproic Acid 5.2612833885
MESH:D013274 Stomach Neoplasms Fluorouracil 2.0018396642 17498489 16424979 19084572 19015929 17522103 16951190 15786421 18567086 17172411
MESH:D014062 Tongue Neoplasms Fluorouracil 4.3816280240
MESH:D014178 Translocation, Genetic Valproic Acid 5.9617262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 5.153119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.208888407
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.2716803524
MESH:D014605 Uveitis Cyclosporine 4.711336536
MESH:D014985 Xerophthalmia Cyclosporine 5.1617120751
Pathway ID Pathway Name
REACT:474 Metabolism of carbohydrates
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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