AutismKB 2.0

Annotation Detail for TIMELESS


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Basic Information Top
Gene Symbol:TIMELESS ( FLJ12640,FLJ20714,TIM,TIM1,hTIM )
Gene Full Name: timeless homolog (Drosophila)
Band: 12q13.3
Quick LinksEntrez ID:8914; OMIM: 603887; Uniprot ID:TIM_HUMAN; ENSEMBL ID: ENSG00000111602; HGNC ID: 11813
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200068Circadian rhythm pathway
No data
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Related Diseases/Disorders Top
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Desease Name
rheumatoid arthritis
Asthma
IMMUNE
atopy
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of TIMELESS mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of TIMELESS mRNAaffects expression 17562736
C006632 arsenic trioxide arsenic trioxide results in decreased expression of TIMELESS mRNAdecreases expression 20458559
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of TIMELESS mRNAincreases expression 20713471
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of TIMELESS mRNAaffects expression 17484886
D016572 Cyclosporine Cyclosporine results in decreased expression of TIMELESS mRNAdecreases expression 20106945
D004958 Estradiol Estradiol results in increased expression of TIMELESS mRNAincreases expression 15223131
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of TIMELESS mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TIMELESS mRNAaffects cotreatment|increases expression 17942748
D005472 Fluorouracil TIMELESS protein affects the susceptibility to Fluorouracilaffects response to substance 15548681
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of TIMELESS mRNAincreases expression 17616710
D010634 Phenobarbital Phenobarbital affects the expression of TIMELESS mRNAaffects expression 19136022
C006253 pirinixic acid pirinixic acid affects the expression of TIMELESS mRNAaffects expression 19136022
C006253 pirinixic acid pirinixic acid results in increased expression of TIMELESS mRNAincreases expression 17950772
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in increased expression of TIMELESS mRNA]increases expression|increases reaction 17950772
C006253 pirinixic acid pirinixic acid results in increased expression of TIMELESS mRNAincreases expression 12832660
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TIMELESS mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 8.696195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.6911752688 14514962 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0817505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.2018653653
MESH:D000230 Adenocarcinoma arsenic trioxide 13.7619825857 11798837
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 13.7620464547 20127859
MESH:D000230 Adenocarcinoma Estradiol 13.7611473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 13.7614692618
MESH:D000230 Adenocarcinoma Fluorouracil 13.7617638652
MESH:D000236 Adenoma Benzo(a)pyrene 2.706695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 18.0017620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 18.0016434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 18.0016835633
MESH:D000740 Anemia Fluorouracil 8.9415504547 16511603 17963324
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.9411748828
MESH:D000799 Angioedema Acetaminophen 3.9810982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1819183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7115885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 15.7716206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 15.7719483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 15.7712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9417474063 20146248
MESH:D001943 Breast Neoplasms Estradiol 1.9417261762 12948864 17018787 18497071 16675129 14630087 17289903 19861407
MESH:D001943 Breast Neoplasms Fluorouracil 1.9416557594 18608205 16595493 18357371 19217205 16110121 15136595
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9420435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.4211589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5816111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.8816097048 3786805 18705752 16192424 16050911 15673190 16124888 10355542 16011737 15721981 15700767 16227642
MESH:D002276 Carcinoid Tumor Fluorouracil 4.8016051944
MESH:D002277 Carcinoma Fluorouracil 8.4017121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.4016835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 14.3016705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 14.303084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 14.3016217749 11135700 15073043 14691202 15553829
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 14.3018788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 14.3016924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 14.3017088986 17045692 17971768 16332177 18930000 16799960
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 14.306705139 1701930 20935162 20007298 17173139
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.0119014326
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.0518695887
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.1912490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.7120419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.7116757204 17066447 18986760 16280240
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4118850075 18670907 16120746
MESH:D002386 Cataract Acetaminophen 2.6310977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.476135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.4712371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 11.4718566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.364080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2316835633
MESH:D002779 Cholestasis Cyclosporine 13.7019486331
MESH:D002779 Cholestasis Ethinyl Estradiol 13.7015861022 11677210 17333356 17681005 17110522 16105132 16919318
MESH:D002779 Cholestasis pirinixic acid 13.7019176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1315340226 8697196 15668235 16354765 12621046
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2417725105 18772588 17018589 16510598 17016597 15001691 17172411 17169374 16340194 17287894
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.5620501625
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.5616391804 18383874 15289873 17094418 16524972 16331619 18448328 17594712 20501625 17016601 18802399 17401013 17255274 18288408 14970324 15148649 17695437 17454858 16282729 18509181 18949393 16303861
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1314669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 4.2812609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.4910525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4920055451 15322242 10048152
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.1218551238
MESH:D007644 Darier Disease Fluorouracil 4.9116733453
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.1815213294
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4618249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.4819279558
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.1321346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.1316485898 14550746 11421492 12540782 19370779 11739529 15968718 18713872 19164858 14986274 16393943 16177239 10774834 17906064 15619225 10915739 12594235 19739265 12392966 11529661 17522070 18071297 19420014 11287661 2444490 16109766 17562736 16227642 19923254 11834606 16081117 16781746 14725611 12958197 19416960 10663392 11743745 11461765 12153990 19085960 12705907
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 9.137179309 3786805 10092053 9327722 6884620 15998439 15027814 19336974 2869522 6623471 3732212 10915739 4309450 7120509 16227642 16177239 15968718 19085960 17522070 11566570 7440962 21278145
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.1320420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8211462148
MESH:D004421 Dystonia Phenobarbital 4.091851702
MESH:D004487 Edema pirinixic acid 6.8112083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.8111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0418230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2812538720
MESH:D016889 Endometrial Neoplasms Estradiol 3.0311473722 18566989 19148513
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.109294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.213659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.003922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.9320417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.616401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.367750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.143659116
MESH:D004938 Esophageal Neoplasms arsenic trioxide 10.6012903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 10.6016530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 10.6017638652 16481741 16785472 16337965 15173087
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 10.6015878914 16704527 15150132 15623463 16805852 16510608 15547733 15264214 15547721
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0711564622
MESH:D005234 Fatty Liver arsenic trioxide 25.5715073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 25.5717595544 12631006 12795759 16239168 15959796 61145 19224547 16045604
MESH:D005234 Fatty Liver Cyclosporine 25.5719224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 25.5715345470
MESH:D005234 Fatty Liver pirinixic acid 25.5719236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D005355 Fibrosis Carbon Tetrachloride 15.3418705752
MESH:D005355 Fibrosis Cyclosporine 15.3412639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 15.3420067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.3616904648
MESH:D005756 Gastritis Acetaminophen 3.8116983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.348708960
MESH:D005910 Glioma Fluorouracil 2.9016145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.4418337622 15162350 15102660
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.5820471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.5810048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.5820558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.6919110552 19900420
MESH:D006529 Hepatomegaly Phenobarbital 15.0116109766
MESH:D006529 Hepatomegaly pirinixic acid 15.0118467677 16221962 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 15.0116120746 15340226 12621046
MESH:D006558 Herpes Genitalis Estradiol 5.1715709030
MESH:D019584 Hot Flashes Estradiol 3.8917088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1816354765 15340226 16959395 8697196 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.7616870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6516899240
MESH:D006943 Hyperglycemia pirinixic acid 3.2620558911
MESH:D006973 Hypertension Cyclosporine 5.0410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0418670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1915338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9116945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5417937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8912878042 12200463
MESH:D007333 Insulin Resistance Estradiol 7.3716393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 7.3716306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4216580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5815604871
MESH:D007674 Kidney Diseases Acetaminophen 10.2412587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 10.2418776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 10.2415618244
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 18.3416705839
MESH:D007680 Kidney Neoplasms Cyclosporine 18.3412371664
MESH:D007680 Kidney Neoplasms Estradiol 18.3415610895
MESH:D007680 Kidney Neoplasms Fluorouracil 18.3416985049
MESH:D007938 Leukemia arsenic trioxide 2.8715070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.8812560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.4216972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.4914633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.8419077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1520471514 16968895 17050201 19850784 16467208
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.2612679006 17107899 15213294 15748426 16891316 16330433 9834237 12712474 16112521 16331271 19642359 17712046 11468182 15336539 17649720 15622746 19225113 17217047 19035177 12018890 19075265 17869043 16823087 16966277 11161223
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.4516882451
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.7817157831 16943688 17334410 16221502 11903743 17174718 16239168 11408273 21278145
MESH:D008103 Liver Cirrhosis Phenobarbital 6.7821047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 4.9917565644 17944888 18277467 17557913 15893842 17721639 14620537 16097048 12666154 15673190 16248980 17805973 15052691 17631135 14512876 10355542 18395914 18263696 18472094 14716833 17698563 17708605 17922224 15730626 18054572 17640975 16638106 16027843 14716496 12445421 12389079 18187930 15650968 14724832 17823541 18156304 15931870 18429990 17481882 18412020 16136751 15876570 15370692 15959796 16116963 12667390 18006644 17525996 18317297 17976157 12445418 18251166 12649538 12741479 14748882 18420326 15925388 17900296 18472332 12546737 17869086 12609069 16015684 18395095 15996030 15818738 16033810 17761835 18166357 15057751 18705752 18418968 12898905 18481824 17714472 13678700 18205269 11481614 18339082 17766677 12586293 20821823 15338365 15123356 18210741 12632514 16011737 18376398 15362042 12958196 12632512 16192424 18279442
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.9914659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.9915474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.9912878042
MESH:D008107 Liver Diseases Acetaminophen 6.6011587558 16611625 19014921 12587719 19784758 19460945 12969438 16610002
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.6017285989 16246199 15720792 16964402 15830285
MESH:D008107 Liver Diseases Phenobarbital 6.6019363144
MESH:D017093 Liver Failure Carbon Tetrachloride 4.2715123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.6717185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.6716899240 14706259
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 26.547678174
MESH:D008113 Liver Neoplasms arsenic trioxide 26.5414682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 26.5421137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 26.5419294768
MESH:D008113 Liver Neoplasms Fluorouracil 26.5418383874 16603448 15113037 17045692
MESH:D008113 Liver Neoplasms Phenobarbital 26.5415975961 21047994 19482888 8742319 19812893 19073162
MESH:D008113 Liver Neoplasms pirinixic acid 26.5420007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 26.5416984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 19.192876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 19.1920377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 19.1915583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 19.196150874 1399818 2563599 18308698 17172636
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 19.1912151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4115213294
MESH:D008175 Lung Neoplasms arsenic trioxide 4.9119825857 11798837
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.9117053015 6695378 18520028 20064080 18816296 20869020 18569708 20464547 20135361
MESH:D008175 Lung Neoplasms Fluorouracil 4.9115246190
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.9119555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.9115086387
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.6111408345 16891317 17203775 11807958
MESH:D020149 Manganese Poisoning Estradiol 4.6219453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6719513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9216801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.7416381670
MESH:D009062 Mouth Neoplasms Fluorouracil 8.7416757204 18986760
MESH:D009101 Multiple Myeloma arsenic trioxide 3.1615949261 11468182 14977855 19549372 19417148
MESH:D009135 Muscular Diseases pirinixic acid 3.6116239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.8118349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.1816105982 16882451
MESH:D009203 Myocardial Infarction pirinixic acid 2.1719151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.4616810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.4616411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.5917484760
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.9818551238 7678174
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.0516624393
MESH:D009369 Neoplasms Benzo(a)pyrene 8.4411141357
MESH:D009369 Neoplasms Fluorouracil 8.4416928823 18600527 18239605
MESH:D009369 Neoplasms pirinixic acid 8.4417405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8517289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3619348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 9.7816427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.7814600291
MESH:D009436 Neural Tube Defects arsenic trioxide 3.1710525206
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9418514411
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.4916436463
MESH:D009765 Obesity pirinixic acid 1.8320558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.5116049721
MESH:D010018 Osteomalacia Phenobarbital 4.4817016548
MESH:D010051 Ovarian Neoplasms arsenic trioxide 4.9016624393 12452020 19769630
MESH:D010051 Ovarian Neoplasms Estradiol 4.9019401270
MESH:D010146 Pain Acetaminophen 2.4616870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 8.8115580305
MESH:D010190 Pancreatic Neoplasms Fluorouracil 8.8116500647 16929163 19003803 15113037
MESH:D010190 Pancreatic Neoplasms Phenobarbital 8.8116965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7711578682
MESH:D010235 Paraganglioma arsenic trioxide 4.2519927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011230 Precancerous Conditions Cyclosporine 9.2112371664
MESH:D011230 Precancerous Conditions Phenobarbital 9.212563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3111222880 11896295 11118676 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9720887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.0519131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0517292933
MESH:D011471 Prostatic Neoplasms Estradiol 2.0516740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.0518626508 19082440
MESH:D011537 Pruritus Ethinyl Estradiol 3.4315861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 4.6312752131
MESH:D011565 Psoriasis Cyclosporine 2.2516882103
MESH:D012004 Rectal Neoplasms Fluorouracil 4.0818722050 16160472 15538739 18286688
MESH:D015427 Reperfusion Injury pirinixic acid 2.4219058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.0516646077
MESH:D012640 Seizures 2,6-dinitrotoluene 6.1118551238
MESH:D012640 Seizures Phenobarbital 6.1111442880 16876388 3137016 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 4.946407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.5910029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.5916192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0816709447
MESH:D013274 Stomach Neoplasms arsenic trioxide 4.8017007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.8020155912 2093021
MESH:D013274 Stomach Neoplasms Fluorouracil 4.8018567086 16424979 19015929 17172411 16951190 18396642 19084572 17522103 15786421 17498489
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 4.8012958204 17575124
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.4319014326
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.431399818
MESH:D013978 Tibial Fractures Estradiol 4.8219048282
MESH:D014062 Tongue Neoplasms Fluorouracil 4.0616280240
MESH:D016171 Torsades de Pointes arsenic trioxide 4.0815213294
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.4616049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.4611780464 20435036 12845720 12973940
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.4617053015
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.4310091137
MESH:D014581 Urticaria Acetaminophen 3.0610982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 3.9516803524
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3914692618
MESH:D014605 Uveitis Cyclosporine 4.121336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6214671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
MESH:D014985 Xerophthalmia Cyclosporine 4.5817120751
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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