AutismKB 2.0

Annotation Detail for HERC1


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Basic Information Top
Gene Symbol:HERC1 ( p532,p619 )
Gene Full Name: hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1
Band: 15q22.31
Quick LinksEntrez ID:8925; OMIM: 605109; Uniprot ID:HERC1_HUMAN; ENSEMBL ID: ENSG00000103657; HGNC ID: 4867
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04120Ubiquitin mediated proteolysis
No data
No data
No data
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in decreased expression of HERC1 mRNAdecreases expression 20406850
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of HERC1 mRNAaffects expression 21346803
C006632 arsenic trioxide arsenic trioxide results in increased expression of HERC1 mRNAincreases expression 20458559
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of HERC1 mRNAdecreases expression 20106945
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of HERC1 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of HERC1 mRNAincreases expression 18301758
C017947 sodium arsenite sodium arsenite results in decreased expression of HERC1 mRNAdecreases expression 17879257
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of HERC1 mRNAdecreases expression 18762178
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3114514962 15322242 11752688
MESH:D055371 Acute Lung Injury pirinixic acid 3.4718653653
MESH:D000230 Adenocarcinoma arsenic trioxide 4.5711798837 19825857
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.5720127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.826695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.4916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.4916835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.2215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.4217306315 16712894
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2511748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4919183758
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 17.2516206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 17.2519483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 17.2512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.3115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9515746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8720146248 17474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8720435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.6811589617
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0516835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.8416705839
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.8414691202 15073043 16217749 15553829 11135700
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 4.8416507464 15276417 17306315
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.4019014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.4212490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.8520419170
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.8518572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5218670907 16120746 18850075
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.446135515
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 7.4419524636 20056578
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4516835633
MESH:D002779 Cholestasis pirinixic acid 3.0519176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2116354765 15340226 15668235 8697196 12621046
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3417141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 4.5712609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.5410525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5410048152 15322242 20055451
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.4418551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.4515213294
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5518249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 3.9518551238 21346803
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.9520420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9911462148
MESH:D004487 Edema pirinixic acid 7.6312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.6311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.4216714409 15322242 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.3310568697 9294722
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.6512903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.6516530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2411564622
MESH:D005234 Fatty Liver arsenic trioxide 8.8215073043
MESH:D005234 Fatty Liver pirinixic acid 8.8220131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8711858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3620067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.6416904648
MESH:D005833 Genital Neoplasms, Female sodium arsenite 5.1416452187
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.1210696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.9320471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.9310048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.7120558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6611000095
MESH:D006529 Hepatomegaly pirinixic acid 9.6916221962 18467677 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.6915340226 16120746 12621046
MESH:D006689 Hodgkin Disease sodium arsenite 3.4312676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.5718606429 15340226 16959395 8697196 16354765
MESH:D006943 Hyperglycemia pirinixic acid 3.4920558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0018670907 18850075
MESH:D007248 Infertility, Male sodium arsenite 3.1912646999 15346721
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9912200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.8216306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6616580747
MESH:D007674 Kidney Diseases sodium arsenite 2.9620008137
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.2416705839
MESH:D007938 Leukemia arsenic trioxide 2.9615070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.1212560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.7716972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6614633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.0919077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1816467208 19850784 16968895 20471514 17050201
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.4117712046 11161223 17649720 12018890 12712474 12679006 17107899 16330433 19035177 17869043 19642359 16966277 11468182 19225113 19075265 16331271 16112521 15622746 16891316 15748426 15213294 15336539 9834237 17217047 16823087
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.7316882451
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.2115474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.2112878042
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 19.337678174
MESH:D008113 Liver Neoplasms arsenic trioxide 19.3314682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 19.3321137059 20195826
MESH:D008113 Liver Neoplasms pirinixic acid 19.3315890375 16377806 20007298
MESH:D008113 Liver Neoplasms sodium arsenite 19.3315276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 19.3316984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.882876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 10.8820377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.8812151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5915213294
MESH:D008171 Lung Diseases sodium arsenite 3.3719095001
MESH:D008175 Lung Neoplasms arsenic trioxide 5.0711798837 19825857
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 5.0720064080 20464547 6695378 18816296 20869020 18569708 20135361 17053015 18520028
MESH:D008175 Lung Neoplasms sodium arsenite 5.0716712894 15276417 17306315 17077188 19931552
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 5.0719555203 11884234
MESH:D008545 Melanoma sodium arsenite 2.0616487513 19082730
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4316381670
MESH:D009101 Multiple Myeloma arsenic trioxide 3.3214977855 11468182 15949261 19549372 19417148
MESH:D009135 Muscular Diseases pirinixic acid 3.9216239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.1918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.3016882451 16105982
MESH:D009203 Myocardial Infarction pirinixic acid 2.2519151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2712213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1916411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.327678174 18551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.3416624393
MESH:D009369 Neoplasms Benzo(a)pyrene 9.0111141357
MESH:D009369 Neoplasms pirinixic acid 9.0117405874
MESH:D009369 Neoplasms sodium arsenite 9.0111559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 4.0820056578
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5914600291
MESH:D009436 Neural Tube Defects arsenic trioxide 7.9810525206
MESH:D009436 Neural Tube Defects sodium arsenite 7.9812854658
MESH:D009765 Obesity pirinixic acid 1.8720558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.7416049721
MESH:D010051 Ovarian Neoplasms arsenic trioxide 5.1819769630 12452020 16624393
MESH:D010051 Ovarian Neoplasms sodium arsenite 5.1817306315 15276417
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.6115580305
MESH:D010235 Paraganglioma arsenic trioxide 4.5119927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.7712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.9418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.6511896295 11222880 11399792 11118676
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.4919131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.4917292933
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.4916039940
MESH:D015427 Reperfusion Injury pirinixic acid 2.5219058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2218990726
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.3416646077
MESH:D012640 Seizures 2,6-dinitrotoluene 2.7418551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 10.1519755658 10029692
MESH:D012878 Skin Neoplasms sodium arsenite 10.1518572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 10.1516192470
MESH:D016135 Spinal Dysraphism sodium arsenite 4.0412854658
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.4317007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.4320155912 2093021
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.4212697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.3219014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.4215213294
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 12.7916049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 12.7912973940 12845720 11780464 20435036
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 12.7917053015
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 12.7916712894 11723127 17306315 16452187
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.7810091137
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 4.0711813266
MESH:D014652 Vascular Diseases sodium arsenite 4.8917056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.1212125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.7715886252
Pathway ID Pathway Name
KEGG:04120 Ubiquitin mediated proteolysis
Pharmacogenomics Knowledge Base Top
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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