AutismKB 2.0

Annotation Detail for SKAP2


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Basic Information Top
Gene Symbol:SKAP2 ( MGC10411,MGC33304,PRAP,RA70,SAPS,SCAP2,SKAP-HOM,SKAP55R )
Gene Full Name: src kinase associated phosphoprotein 2
Band: 7p15.2
Quick LinksEntrez ID:8935; OMIM: 605215; Uniprot ID:SKAP2_HUMAN; ENSEMBL ID: ENSG00000005020; HGNC ID: 15687
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Interactions of the immunoglobulin superfamily (IgSF) member proteins
Cell junction organization
No data
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Related Diseases/Disorders Top
No data
Desease IDDesease Name
1943Adenocarcinoma
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of SKAP2 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SKAP2 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of SKAP2 mRNAdecreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SKAP2 mRNAdecreases expression 20018196
D016572 Cyclosporine Cyclosporine results in decreased expression of SKAP2 mRNAdecreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of SKAP2 mRNAdecreases expression 18042831
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of SKAP2 mRNAincreases expression 15289156
D004958 Estradiol Estradiol results in increased expression of SKAP2 mRNAincreases expression 15289156
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of SKAP2 mRNAincreases expression 17475347
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of SKAP2 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of SKAP2 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SKAP2 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of SKAP2 mRNAincreases expression 17557909
D019833 Genistein Genistein results in increased expression of SKAP2 mRNAincreases expression 15289156
D007657 Ketone Bodies Ketone Bodies results in decreased expression of SKAP2 mRNAdecreases expression 16807920
C041786 palm oil palm oil results in decreased expression of SKAP2 mRNAdecreases expression 18042831
C006253 pirinixic acid pirinixic acid results in decreased expression of SKAP2 mRNAdecreases expression 17426115
D013629 Tamoxifen Tamoxifen affects the expression of SKAP2 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of SKAP2 mRNAincreases expression 20106945
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SKAP2 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of SKAP2 mRNAincreases expression 16960034
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of SKAP2 mRNAincreases expression 16960034
D014050 Toluene Toluene results in increased expression of SKAP2 mRNAincreases expression 17584516
D014415 Tunicamycin Tunicamycin results in decreased expression of SKAP2 mRNAdecreases expression 17127020
D014635 Valproic Acid Valproic Acid results in increased expression of SKAP2 mRNAincreases expression 19101580
C025643 vinclozolin vinclozolin affects the expression of SKAP2 mRNAaffects expression 19015723
D014810 Vitamin E Vitamin E results in decreased expression of SKAP2 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.4714745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.0311752688 14514962 15322242
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 8.038875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.8419490988
MESH:D000138 Acidosis Ammonium Chloride 3.4718287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.8617505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.0318653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 9.9820127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 9.9811473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.9814692618
MESH:D000230 Adenocarcinoma Genistein 9.9811473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.606695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.6216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.6216835633
MESH:D000550 Amblyopia Valproic Acid 5.1517688650
MESH:D000686 Amyloidosis Diethylstilbestrol 4.3915469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8711748828
MESH:D000799 Angioedema Acetaminophen 3.7610982225
MESH:D001008 Anxiety Disorders Valproic Acid 8.6217497229
MESH:D001008 Anxiety Disorders vinclozolin 8.6219015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9919183758
MESH:D001161 Arteriosclerosis Dietary Fats 9.6215238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.6211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6115885639
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8518177632 18940202 15238991 19460635 18558336 17688650 20603192 19232924 18775368 18396377 16609825 17507914 18985861 18316065 17157402
MESH:D001714 Bipolar Disorder Valproic Acid 3.0320046352 17594078
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.4919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.4912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.8315746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.838888407
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 3.7220146248 17474063
MESH:D001943 Breast Neoplasms Dietary Fats 3.7220435547
MESH:D001943 Breast Neoplasms Diethylstilbestrol 3.7217129689 15324884
MESH:D001943 Breast Neoplasms Estradiol 3.7216675129 12948864 14630087 17289903 18497071 19861407 17018787 17261762
MESH:D001943 Breast Neoplasms Genistein 3.7217200150 16541309 16873071
MESH:D001943 Breast Neoplasms Tamoxifen 3.7215668708 16818667 18815881 19142967 19115204 19059307 19155303 18351453 19200415 16873071 15565566 17242785 19011961 20390343 17440819 19103187 19084267 19410462 18629630 18855134 19189210 21138602 19189212 18425577 20859285 16202921 20544844 20135344 19221464 18984771 21152245 18821012 17893378 18997820 17049068 20005174 19289846 19487384 20065188 17261762 19288272 19066611 16273361 11161223 19244106
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.7220435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.3816111702
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.8416050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7316835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.4219066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.723084413
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 8.7215948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Estradiol 8.7216924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 8.7216924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 8.7216924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0320419170
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.5317572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3218850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Genistein 3.2416332659
MESH:D002386 Cataract Acetaminophen 2.5310977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10.7820889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.7812371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 10.7818566989
MESH:D002547 Cerebral Palsy Toluene 5.769294310
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6820734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0816835633
MESH:D002779 Cholestasis Cyclosporine 12.9619486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.9617110522 16105132 15861022 17681005 11677210 16919318 17333356
MESH:D002779 Cholestasis pirinixic acid 12.9619176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0716354765 8697196 12621046 15340226 15668235
MESH:D003110 Colonic Neoplasms Genistein 2.2717182828
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.3710048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Toluene 5.379294310
MESH:D019465 Craniofacial Abnormalities Valproic Acid 5.3716575769 8888407 17688650
MESH:D019465 Craniofacial Abnormalities Vitamin E 5.3719769572
MESH:D003456 Cryptorchidism Diethylstilbestrol 11.0812952375 16002989
MESH:D003456 Cryptorchidism vinclozolin 11.0814966744
MESH:D003643 Death Toluene 5.596431079
MESH:D003711 Demyelinating Diseases Tamoxifen 4.2819031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3818249437
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.2616647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2617107852
MESH:D003928 Diabetic Nephropathies Estradiol 8.5819279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.5819279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 5.9916393943 11287661 2444490 19416960 14550746 12705907 19085960 11834606 19923254 10663392 17562736 14725611 15968718 18071297 12958197 17522070 11529661 17906064 11421492 18713872 12594235 12153990 12392966 19739265 11743745 16227642 19164858 11461765 19370779 14986274 11739529 10915739 12540782 16781746 19420014 16485898 16109766 15619225 16081117 10774834 16177239
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 5.9920420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 5.991733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6911462148
MESH:D050171 Dyslipidemias Dietary Fats 3.3918367378
MESH:D004421 Dystonia Valproic Acid 3.961851702
MESH:C538011 Eales disease Vitamin E 4.629068938
MESH:D004487 Edema pirinixic acid 6.2712083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.2711000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8216714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.6612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.6619031437
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 11.6116402032
MESH:D004714 Endometrial Hyperplasia Genistein 11.6116402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 17.3215700306 16804899
MESH:D016889 Endometrial Neoplasms Estradiol 17.3219148513 18566989 11473722
MESH:D016889 Endometrial Neoplasms Genistein 17.3211473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 17.3216202921 19155303 20544844 17893378
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.9410568697 9294722
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.0717275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 3.843922381 16628512
MESH:D004827 Epilepsy Valproic Acid 2.8920417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.517562514 6426943 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.217750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.983659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.2720426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.2716530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9511564622
MESH:D005234 Fatty Liver Cyclosporine 29.6619224547
MESH:D005234 Fatty Liver Dietary Fats 29.6618296743 19004024 17967931 19551842
MESH:D005234 Fatty Liver Ethinyl Estradiol 29.6615345470
MESH:D005234 Fatty Liver pirinixic acid 29.6619236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 29.6614986274 19224547
MESH:D005234 Fatty Liver Valproic Acid 29.6614986274 19224547
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 8.0316534752 16513791 16611131 16002989 15751030
MESH:D052776 Female Urogenital Diseases Tamoxifen 8.0316709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3711858732
MESH:D005315 Fetal Diseases Valproic Acid 4.8116575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.048888407 18558336
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.4414745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.1019069698
MESH:D005355 Fibrosis Cyclosporine 14.2212639820 12168785
MESH:D005355 Fibrosis Dietary Fats 14.2218296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 14.2220067830
MESH:D005756 Gastritis Acetaminophen 3.5916983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.8516973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.2216417039
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.8616452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.138708960
MESH:D005909 Glioblastoma Genistein 3.2016598420
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5110696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.8420471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.8410048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 10.8416080930
MESH:D006333 Heart Failure pirinixic acid 2.4820558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2511000095
MESH:D006529 Hepatomegaly pirinixic acid 7.9716221962 18467677 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.9712621046 16120746 15340226
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6716863852 16490937
MESH:D006558 Herpes Genitalis Estradiol 4.9515709030
MESH:D019584 Hot Flashes Estradiol 9.7817088409
MESH:D019584 Hot Flashes Vitamin E 9.7814716179
MESH:D006849 Hydrocephalus Valproic Acid 4.7817688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9615340226 18606429 16354765 8697196 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.6316870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.5121332399
MESH:D006943 Hyperglycemia pirinixic acid 3.1020558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.5321332399
MESH:D006965 Hyperplasia Diethylstilbestrol 4.3512960047 14722030
MESH:D006973 Hypertension Cyclosporine 4.8310903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.8318670907 18850075
MESH:D007021 Hypospadias Diethylstilbestrol 10.9516002989
MESH:D007021 Hypospadias Ethinyl Estradiol 10.9516569931 16945680
MESH:D007246 Infertility Diethylstilbestrol 4.2715036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.4617937319
MESH:D007248 Infertility, Male vinclozolin 6.4616467254
MESH:D007249 Inflammation Dietary Fats 8.0120412841
MESH:D007249 Inflammation Tamoxifen 8.0119457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.0112878042 12200463
MESH:D007251 Influenza, Human Vitamin E 4.1316624496
MESH:D007333 Insulin Resistance Dietary Fats 11.9618457598 11836018
MESH:D007333 Insulin Resistance Estradiol 11.9616393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 11.9616306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2516580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3615604871
MESH:D007674 Kidney Diseases Acetaminophen 14.0015629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 14.008314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 14.0015618244
MESH:D007674 Kidney Diseases Vitamin E 14.0012488133
MESH:D007680 Kidney Neoplasms Cyclosporine 17.1612371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 17.1616762066 15003126 14681315
MESH:D007680 Kidney Neoplasms Estradiol 17.1615610895
MESH:D007680 Kidney Neoplasms Tamoxifen 17.1618625569
MESH:D007859 Learning Disorders Diethylstilbestrol 3.9717184923
MESH:D007938 Leukemia Genistein 2.9818980019 17468513
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1417596541 16294345
MESH:D007984 Leydig Cell Tumor vinclozolin 4.6516417039
MESH:D008064 Lipidoses Tamoxifen 3.0915342952 17567588
MESH:D008103 Liver Cirrhosis Dietary Fats 2.8318296743
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.6014659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 8.6017823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 8.6015474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 8.6018564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.6012878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 8.6016169303
MESH:D008107 Liver Diseases Acetaminophen 1.6119460945 12587719 19014921 16611625 12969438 11587558 19784758 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.1616871587 17185352
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 13.8820195826 21137059
MESH:D008113 Liver Neoplasms Diethylstilbestrol 13.8816712894 15890375
MESH:D008113 Liver Neoplasms pirinixic acid 13.8816377806 15890375 20007298
MESH:D008113 Liver Neoplasms Tamoxifen 13.8816684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.8816984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.0512151625
MESH:D008171 Lung Diseases Vitamin E 3.1216863852
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.1817228818
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.7420135361 20464547 6695378 17053015 20064080 18520028 18816296 20869020 18569708
MESH:D008175 Lung Neoplasms Tamoxifen 4.7418625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.7419555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 4.7411062179
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.0615166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.4115700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.4316002989
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.6719428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 9.6517203775 11807958 11408345 16891317
MESH:D008325 Mammary Neoplasms, Experimental Genistein 9.6514578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 9.6511731420 19196722 14580682 16827153 19196723
MESH:D020149 Manganese Poisoning Estradiol 12.3819453300
MESH:D020149 Manganese Poisoning Tamoxifen 12.3819453300
MESH:D008545 Melanoma Tamoxifen 1.8712393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.1015990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4819513568
MESH:D008607 Mental Retardation Toluene 3.629294310
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7116801185
MESH:D008881 Migraine Disorders Valproic Acid 3.1318803445 18765137
MESH:D019957 Motor Skills Disorders Toluene 5.159294310
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1216381670
MESH:D009135 Muscular Diseases pirinixic acid 3.4216239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.948888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.1017596541
MESH:D009203 Myocardial Infarction Genistein 5.5617141266
MESH:D009203 Myocardial Infarction pirinixic acid 5.5619151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9512213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 13.7716810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 13.7717141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 13.7716411023
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5119393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4919410462
MESH:D009369 Neoplasms Benzo(a)pyrene 7.9911141357
MESH:D009369 Neoplasms Diethylstilbestrol 7.9915313581
MESH:D009369 Neoplasms pirinixic acid 7.9917405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.9219200415 19196722 19189210
MESH:D009389 Neovascularization, Pathologic Estradiol 3.6517289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2118481113 19348381
MESH:D009421 Nervous System Malformations Diethylstilbestrol 22.7511399458
MESH:D009421 Nervous System Malformations Estradiol 22.7516427766 11399458
MESH:D009421 Nervous System Malformations Genistein 22.7516427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 22.7514600291
MESH:D009436 Neural Tube Defects Valproic Acid 3.0716359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8018514411
MESH:D009765 Obesity Dietary Fats 4.3620132043 18674790 11836018 21332399 16723640 19632207 20518802 17217161 18457598
MESH:D009765 Obesity pirinixic acid 4.3620558911
MESH:D010024 Osteoporosis Genistein 3.2019401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.0016169203
MESH:D010051 Ovarian Neoplasms Estradiol 4.8119401270
MESH:D010051 Ovarian Neoplasms Genistein 4.8119005980
MESH:D010146 Pain Acetaminophen 2.3216870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6011578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1712520081
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.0914722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.5815687265 16977796
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4718163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.1412371664
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 22.5517184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 22.5511399792 11118676 11222880 11896295
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 22.5520603192
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 22.5518220299 19015723 18042343
MESH:D011469 Prostatic Diseases vinclozolin 4.8518220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.8020887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8817292933
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 1.8817136230 15846301 15046698
MESH:D011471 Prostatic Neoplasms Estradiol 1.8816740699
MESH:D011471 Prostatic Neoplasms Genistein 1.8816925846 15256057 15378649
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.8815067354
MESH:D011471 Prostatic Neoplasms Vitamin E 1.8815084515
MESH:D011472 Prostatitis vinclozolin 4.8518629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.2316919318 15861022
MESH:D019310 Pseudolymphoma Valproic Acid 4.4611422049 12752131
MESH:D011565 Psoriasis Cyclosporine 2.2016882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.3419058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7518990726
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.0919155313
MESH:D012559 Schizophrenia Valproic Acid 2.0619110320 15737665
MESH:D012640 Seizures Toluene 6.186431079 9294310
MESH:D012640 Seizures Valproic Acid 6.1814763951 11044598 16876388 17978042 1511512 15475178 11738929 3137016
MESH:D012871 Skin Diseases Vitamin E 2.4218709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.3319755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.3316192470
MESH:D013088 Spermatocele Diethylstilbestrol 19.6716709447 16002989
MESH:D013088 Spermatocele Ethinyl Estradiol 19.6716709447
MESH:D013088 Spermatocele Tamoxifen 19.6716709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.9519457130
MESH:D016135 Spinal Dysraphism Valproic Acid 3.7119490988
MESH:D013226 Status Epilepticus Valproic Acid 4.4612833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5520155912 2093021
MESH:D020521 Stroke Vitamin E 3.4516517955
MESH:D013733 Testicular Diseases Toluene 4.8710048760 10514026
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0715669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8212697716
MESH:D013978 Tibial Fractures Estradiol 4.6019048282
MESH:D014178 Translocation, Genetic Valproic Acid 5.1517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.443119515
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.1417053015
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 8.1416452187 17306315 16712894
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.1417572228 16712894 8653321
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.568888407
MESH:D014581 Urticaria Acetaminophen 2.8910982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 3.9516175088
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.0914652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 9.1916690809 15809267
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 9.1914692618
MESH:D014605 Uveitis Cyclosporine 3.901336536
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.3516002989 16513791
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4615869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1715886252
MESH:D015430 Weight Gain Dietary Fats 3.6616723640
MESH:D014985 Xerophthalmia Cyclosporine 4.3617120751
Pathway ID Pathway Name
REACT:20676 Cell junction organization
REACT:23853 Interactions of the immunoglobulin superfamily (IgSF) member proteins
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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