AutismKB 2.0

Annotation Detail for WASF1


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Basic Information Top
Gene Symbol:WASF1 ( FLJ31482,KIAA0269,SCAR1,WAVE,WAVE1 )
Gene Full Name: WAS protein family, member 1
Band: 6q21
Quick LinksEntrez ID:8936; OMIM: 605035; Uniprot ID:WASF1_HUMAN; ENSEMBL ID: ENSG00000112290; HGNC ID: 12732
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05131Shigellosis
hsa05100Bacterial invasion of epithelial cells
hsa04520Adherens junction
hsa04810Regulation of actin cytoskeleton
hsa04666Fc gamma R-mediated phagocytosis
No data
Pathway IDPathway Name
200027E2F transcription factor network
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2177Wiskott-Aldrich syndrome
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of WASF1 mRNAaffects expression 17562736
C008493 methylselenic acid methylselenic acid affects the expression of WASF1 mRNAaffects expression 14617803
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of WASF1 mRNAaffects binding|decreases expression|increases activity 19710929
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.6418653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.2216434500
MESH:D000799 Angioedema Acetaminophen 4.7110982225
MESH:D001321 Autistic Disorder Acetaminophen 1.3918445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.6319483382
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.413084413
MESH:D002386 Cataract Acetaminophen 2.8110977129
MESH:D002779 Cholestasis pirinixic acid 3.1519176532
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5918249437
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6815619225 12705907 16177239 16081117 17562736 14550746 12594235 11743745 12958197 10915739 19085960 10663392 2444490 11739529 19164858 11287661 16485898 19416960 19420014 19739265 19923254 16781746 10774834 18071297 16393943 17522070 14986274 16109766 19370779 12153990 11834606 15968718 16227642 11421492 12392966 18713872 17906064 14725611 11461765 11529661 12540782
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.9619426721
MESH:D004487 Edema pirinixic acid 2.9612083418
MESH:D005234 Fatty Liver pirinixic acid 3.2520131406 19236843
MESH:D005756 Gastritis Acetaminophen 4.5416983495
MESH:D006333 Heart Failure pirinixic acid 2.7820558911
MESH:D006529 Hepatomegaly pirinixic acid 3.6418467677 19772884 19176532 16221962
MESH:D006930 Hyperalgesia Acetaminophen 3.0616870215
MESH:D006943 Hyperglycemia pirinixic acid 3.6320558911
MESH:D007333 Insulin Resistance pirinixic acid 2.9016306350
MESH:D007674 Kidney Diseases Acetaminophen 2.4215629191 12587719
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 1.7112969438 19014921 16611625 16610002 19460945 19784758 12587719 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.6817185352 16871587
MESH:D008113 Liver Neoplasms pirinixic acid 1.9415890375 16377806 20007298
MESH:D008546 Melanoma, Experimental Acetaminophen 4.2219513568
MESH:D009135 Muscular Diseases pirinixic acid 4.1616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2919151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2916411023
MESH:D009369 Neoplasms pirinixic acid 2.1217405874
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.2618514411
MESH:D009765 Obesity pirinixic acid 1.8920558911
MESH:D010146 Pain Acetaminophen 2.7716870215
MESH:D011471 Prostatic Neoplasms methylselenic acid 3.8216205645
MESH:D015427 Reperfusion Injury pirinixic acid 2.5619058328
MESH:D014581 Urticaria Acetaminophen 3.5010982225
Pathway ID Pathway Name
KEGG:04520 Adherens junction
KEGG:05100 Bacterial invasion of epithelial cells
KEGG:04666 Fc gamma R-mediated phagocytosis
KEGG:04810 Regulation of actin cytoskeleton
KEGG:05131 Shigellosis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA37343
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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