AutismKB 2.0

Annotation Detail for TOP3B


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Basic Information Top
Gene Symbol:TOP3B ( FLJ39376 )
Gene Full Name: topoisomerase (DNA) III beta
Band: 22q11.22
Quick LinksEntrez ID:8940; OMIM: 603582; Uniprot ID:TOP3B_HUMAN; ENSEMBL ID: ENSG00000100038; HGNC ID: 11993
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03440Homologous recombination
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of TOP3B mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of TOP3B mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of TOP3B mRNAincreases expression 18648102
D003913 Dextroamphetamine Dextroamphetamine results in decreased expression of TOP3B mRNAdecreases expression 12558987
D001241 Aspirin Aspirin results in increased expression of TOP3B mRNAincreases expression 11906190
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of TOP3B mRNAdecreases expression 20106945
D008770 Methylnitrosourea Methylnitrosourea results in decreased expression of TOP3B mRNAdecreases expression 16616109
D018038 Sodium Selenite Sodium Selenite results in decreased expression of TOP3B mRNAdecreases expression 18175754
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TOP3B mRNAincreases expression 19465110
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1314514962 15322242 11752688
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.8120127859 20464547
MESH:D000230 Adenocarcinoma Methylnitrosourea 4.8115113128 15688392
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.963712494
MESH:D000236 Adenoma Benzo(a)pyrene 6.966695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6616835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3319183758
MESH:D055963 Asthma, Aspirin-Induced Aspirin 4.8720485159 12372130
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.341440618 11289319
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D001932 Brain Neoplasms Aspirin 4.6115481559
MESH:D001943 Breast Neoplasms Aspirin 2.0415161893
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0420146248 17474063
MESH:D001943 Breast Neoplasms Methylnitrosourea 2.0414633655 11306469 16253758
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0420435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.7116705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.7116705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.713581430 7296757
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.767296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1020419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4716120746 18670907 18850075
MESH:D002386 Cataract Methylnitrosourea 4.1012484553
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 12.126135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 12.127505956
MESH:D002471 Cell Transformation, Neoplastic Methylnitrosourea 12.122727394 7505956
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3416835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.3019486331 9022650
MESH:D019457 Chromosome Breakage Sodium Selenite 5.0115894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.188697196 12621046 16354765 15340226 15668235
MESH:D003110 Colonic Neoplasms Aspirin 3.0112411196
MESH:D015179 Colorectal Neoplasms Aspirin 2.7517047198
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.7718551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.7718551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.0618759878 8156756 2524372 12868966 11298694 8970840 11906362 14531868
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.712952479 3621924
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9616285004
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.5921346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.5921346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 12.5918289764 16192314 9653073 9328219 18692083 1440618 11289319 7440962 9022650 6679447 6482804 18648102 8291058
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 12.5915131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.5920420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:D004487 Edema Aspirin 7.7417259670
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.7412711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2218230668 15322242 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.219294722 10568697
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.513581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5116530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.346705139
MESH:D005354 Fibrosarcoma Methylnitrosourea 5.5211555667
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.2120067830
MESH:D005909 Glioblastoma Aspirin 4.0812870263
MESH:D005910 Glioma Methylnitrosourea 3.639825942
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.267505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006261 Headache Aspirin 5.2815240983
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.7720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.7710048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.756705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1515340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3615340226 8697196 16959395 16354765 18606429
MESH:D012001 Hyperacusis Aspirin 6.0815240983
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2015034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9718850075 18670907
MESH:D007248 Infertility, Male Methylnitrosourea 3.927193160
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9512200463 12878042
MESH:D007333 Insulin Resistance Sodium Selenite 3.4014714311
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.348074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.4216705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 13.4216705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 13.426582329
MESH:D017880 Limb Deformities, Congenital Methylnitrosourea 4.3515526292
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.319327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.757678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.7521137059 20195826
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.7516984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.496135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.49598648 1399818 3712494 6587162
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.4912151625
MESH:D038061 Lower Extremity Deformities, Congenital Methylnitrosourea 5.7216080182
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.5818816296 17053015 18569708 20869020 20135361 18520028 6695378 20064080 20464547
MESH:D008175 Lung Neoplasms Methylnitrosourea 3.5818062963
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5811884234 19555203
MESH:D008223 Lymphoma Methylnitrosourea 4.1516257854 11418001
MESH:D016393 Lymphoma, B-Cell Methylnitrosourea 11.2014633661
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 11.2014737004
MESH:D008325 Mammary Neoplasms, Experimental Methylnitrosourea 3.7016944150 10838139 14999141 19196723 15688392 16619500 16827153 11807958 17131329 10767621 12931682 15113128 14633655 15313902 17020996 16051031 11751437
MESH:D008881 Migraine Disorders Aspirin 4.2115240983
MESH:D009041 Motion Sickness Dextroamphetamine 5.841613127
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3516381670
MESH:D009203 Myocardial Infarction Aspirin 3.6312692751
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D009325 Nausea Aspirin 5.5315240983
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.3218551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.3218551238 7678174
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.543581430
MESH:D009369 Neoplasms Benzo(a)pyrene 5.6211141357
MESH:D009369 Neoplasms Methylnitrosourea 5.6215533788
MESH:D009374 Neoplasms, Experimental Methylnitrosourea 4.7312696579
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4514600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.046679447
MESH:D009442 Neurilemmoma Methylnitrosourea 5.7711555667
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 16.2316049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 16.2316049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 16.236482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.343988306
MESH:D010003 Osteoarthritis Aspirin 4.177009135
MESH:D010146 Pain Aspirin 4.026363464 6995502
MESH:D010190 Pancreatic Neoplasms Methylnitrosourea 3.4216965848
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.747296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D010438 Peptic Ulcer Hemorrhage Aspirin 5.8211156591
MESH:D020795 Photophobia Aspirin 6.0815240983
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.796228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4811399792 11896295 11222880 11118676
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.6417292933
MESH:D011471 Prostatic Neoplasms Methylnitrosourea 2.6415682402 12376480
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.6418760546
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 9.623692021
MESH:D012162 Retinal Degeneration Methylnitrosourea 9.6218172121 18155124
MESH:D012175 Retinoblastoma Methylnitrosourea 5.7711555667
MESH:D012220 Rhinitis Aspirin 4.5712372130
MESH:D012640 Seizures 2,4-dinitrotoluene 6.3218551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.3218551238
MESH:D012851 Sinus Thrombosis, Intracranial Aspirin 5.5212269725
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.7619755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7616192470
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.722093021 20155912
MESH:D013274 Stomach Neoplasms Methylnitrosourea 2.7218593901 15930296 16257854
MESH:D020521 Stroke Aspirin 4.5416403987
MESH:D013927 Thrombosis Aspirin 4.7017672075
MESH:D013953 Thymus Neoplasms Methylnitrosourea 5.5211418001
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.991399818 7505956 6582329 3712494 6587162
MESH:D013964 Thyroid Neoplasms Methylnitrosourea 7.993078959 7505956
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 12.4916049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 12.4916049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 12.498074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 12.4917053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.9610091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.9610091137
MESH:D014581 Urticaria Aspirin 4.6610982225 20485159
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
Pathway ID Pathway Name
KEGG:03440 Homologous recombination
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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