AutismKB 2.0

Annotation Detail for KYNU


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Basic Information Top
Gene Symbol:KYNU ( - )
Gene Full Name: kynureninase (L-kynurenine hydrolase)
Band: 2q22.2
Quick LinksEntrez ID:8942; OMIM: 605197; Uniprot ID:KYNU_HUMAN; ENSEMBL ID: ENSG00000115919; HGNC ID: 6469
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
NADSYN-PWYNAD biosynthesis II (from tryptophan)
PWY-5651tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde
TRYPTOPHAN-DEGRADATION-1tryptophan degradation III (eukaryotic)
Pathway IDPathway Name
hsa00380Tryptophan metabolism
hsa01100Metabolic pathways
Pathway IDPathway Name
Metabolism of amino acids and derivatives
No data
No data
Pathway IDPathway Name
500887Tryptophan catabolism
Related Diseases/Disorders Top
No data
No data
Desease Name
CARDIOVASCULAR
hypertension
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of KYNU mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of KYNU mRNAaffects expression 17562736
C006632 arsenic trioxide arsenic trioxide results in increased expression of KYNU mRNAincreases expression 15761015
D019324 beta-Naphthoflavone beta-Naphthoflavone results in increased expression of KYNU mRNAincreases expression 19737606
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of KYNU mRNAaffects cotreatment|decreases expression 18164116
D002104 Cadmium Cadmium results in increased expression of KYNU mRNAincreases expression 21172416
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of KYNU mRNAaffects expression 12734012
C030123 coumarin coumarin results in decreased expression of KYNU mRNAdecreases expression 18480146
D003474 Curcumin Curcumin results in increased expression of KYNU mRNAincreases expression 18421014
D016572 Cyclosporine Cyclosporine results in increased expression of KYNU mRNAincreases expression 20106945
C017160 cypermethrin cypermethrin results in decreased activity of KYNU proteindecreases activity 7175100
D019259 Lamivudine [Zidovudine co-treated with Lamivudine] results in increased expression of KYNU mRNAaffects cotreatment|increases expression 15784690
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of KYNU mRNAaffects cotreatment|decreases expression 18164116
D004178 Diquat Diquat results in increased expression of KYNU mRNAincreases expression 21172416
D005047 Etoposide KYNU protein affects the susceptibility to Etoposideaffects response to substance 16217747
C017690 fenvalerate fenvalerate results in decreased activity of KYNU proteindecreases activity 7175102
D005419 Flavonoids Flavonoids results in decreased expression of KYNU mRNAdecreases expression 18035473
D007657 Ketone Bodies Ketone Bodies results in decreased expression of KYNU mRNAdecreases expression 16807920
D008701 Methapyrilene Methapyrilene results in decreased expression of KYNU mRNAdecreases expression 16393664
D008724 Methomyl Methomyl results in decreased activity of KYNU proteindecreases activity 7175100
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of KYNU mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of KYNU mRNAdecreases expression 19482888
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of KYNU mRNAaffects binding|decreases expression|increases activity 19710929
D017378 Quinolinic Acid KYNU protein results in increased chemical synthesis of Quinolinic Acidincreases chemical synthesis 16365156
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of KYNU mRNAaffects binding|decreases expression 16214954
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of KYNU mRNAdecreases expression 18796159
D014212 Tretinoin Tretinoin results in increased expression of KYNU mRNAincreases expression 16249480
D015215 Zidovudine [Zidovudine co-treated with Lamivudine] results in increased expression of KYNU mRNAaffects cotreatment|increases expression 15784690
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 7.666195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.6611752688 14514962 15322242
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.649612607
MESH:D055371 Acute Lung Injury pirinixic acid 2.9418653653
MESH:D000230 Adenocarcinoma arsenic trioxide 2.2411798837 19825857
MESH:D000236 Adenoma beta-Naphthoflavone 6.5219389873
MESH:D000236 Adenoma Diethylnitrosamine 6.526695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 23.2717620307 19052882 18056438 19061943 16434500 17162532
MESH:D018248 Adenoma, Liver Cell Phenobarbital 23.2717620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 23.2716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 23.2716835633
MESH:D000382 Agricultural Workers' Diseases cypermethrin 4.7316487989
MESH:D019973 Alcohol-Related Disorders Curcumin 4.8917887948
MESH:D000505 Alopecia Tretinoin 3.4615955085
MESH:D000544 Alzheimer Disease Curcumin 2.5815590663
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7811748828
MESH:D000799 Angioedema Acetaminophen 3.6510982225
MESH:D001169 Arthritis, Experimental Tretinoin 2.9616412693
MESH:D001172 Arthritis, Rheumatoid Curcumin 4.5816807698
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.5816292516
MESH:D001249 Asthma Tretinoin 2.2916456186
MESH:D050197 Atherosclerosis Cadmium 6.6815687053
MESH:D050197 Atherosclerosis Curcumin 6.6818704882
MESH:D001321 Autistic Disorder Acetaminophen 2.6518445737
MESH:D001321 Autistic Disorder Quinolinic Acid 2.6516139734
MESH:D001327 Autoimmune Diseases Curcumin 4.3019761891
MESH:D001471 Barrett Esophagus Tretinoin 4.2216935849
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 20.5216206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 20.5219483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 20.5212125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 20.5216206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6415746008
MESH:D019046 Bone Marrow Neoplasms Etoposide 4.9714601052
MESH:D002545 Brain Ischemia Curcumin 4.1416770732
MESH:D001932 Brain Neoplasms Curcumin 3.7717596214
MESH:D001943 Breast Neoplasms Curcumin 2.2916243823 18593918 18462866 19250217
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2917474063
MESH:D001943 Breast Neoplasms Etoposide 2.2916322251
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.2920435547
MESH:D001943 Breast Neoplasms Tretinoin 2.2916166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.4016813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.1511589617
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.5916227642 3786805 15700767 10355542 15721981 16050911 15673190 16011737 18705752 16124888 16192424 16097048
MESH:D002277 Carcinoma Curcumin 7.7818593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.7816835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.9716168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 13.6016705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 13.603084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 13.6015073043 14691202 15553829 16217749 11135700
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 13.6018788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 13.6016540662 16569478 19822196 16878318 10737359 17055752 20101231 16502159 20935162 16328049 20084675 17138121 16807293 18506893 18665156 19208518 19539802 16681979 16779866 19919837 17162532 18788625 20512989 17761372 18978308 16288022 16830150 18494052 21159647 17173139 19418558 10672840 19107877 20514400 19335982 19171122 16698587 18691550 18056438 20214788 19394651 16935385 20007298 20432363 19383236 17978847 18785209 20727157 3581430 18393292 19519916 18210153 20524982 19052882 17428255 19701751 18971187 3084413 11831363
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 13.6017173139 6705139 1701930 20007298 20935162
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 13.601917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.9118414057
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.6819014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.9512490120
MESH:D002294 Carcinoma, Squamous Cell Curcumin 4.6418462866
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.6416096774 16051514
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2618670907 18850075 16120746
MESH:D002386 Cataract Acetaminophen 6.8610977129
MESH:D002386 Cataract Tretinoin 6.8617460283
MESH:D002471 Cell Transformation, Neoplastic Cadmium 10.5217332340
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.5212371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 10.5221159647 7505956 17174075 2727394
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.064080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.4016129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.7919052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.7916835633
MESH:D002779 Cholestasis Cyclosporine 7.2919486331
MESH:D002779 Cholestasis pirinixic acid 7.2919176532
MESH:D002822 Choriocarcinoma Tretinoin 4.9716461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.5012621046 15340226 15668235 8697196 16354765
MESH:D002972 Cleft Palate Tretinoin 5.509407595
MESH:D003092 Colitis Curcumin 9.0118200517 16782535 16804969
MESH:D003092 Colitis Tretinoin 9.0117035595
MESH:D003103 Coloboma Curcumin 4.3818809619
MESH:D003110 Colonic Neoplasms Curcumin 2.4719359593 16340194
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9017141729 14669216
MESH:D016510 Corneal Neovascularization Curcumin 4.7118497527
MESH:D023903 Coronary Restenosis arsenic trioxide 4.0012609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.6410525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.6420055451 15322242 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.648800419 17551590 9664655 10589399 9224671 16925845 14991402 9142499 9211117 9125849
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.8318551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.9215213294
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3418249437
MESH:D003924 Diabetes Mellitus, Type 2 coumarin 9.8919647726
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 9.8918403477
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 9.8920387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 9.8917107852
MESH:D003928 Diabetic Nephropathies Curcumin 3.8518204486
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 14.5121346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 14.5111739529 11461765 19370779 16781746 17562736 16177239 11743745 11287661 15619225 16081117 12705907 10915739 10663392 19416960 16393943 17906064 18713872 17522070 11529661 19164858 12392966 2444490 12540782 19085960 19420014 14725611 10774834 19739265 12153990 16109766 14550746 18071297 16485898 11421492 19923254 15968718 12594235 12958197 11834606 16227642 14986274
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 14.516884620 9327722 19336974 7179309 3732212 7440962 11566570 2869522 3786805 17522070 10092053 21278145 15998439 19085960 6623471 10915739 7120509 16227642 15027814 16177239 4309450 15968718
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 14.5119107877
MESH:D056486 Drug-Induced Liver Injury Diquat 14.5118445702 18164269
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 14.5120420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9119426721
MESH:D004362 Drug Toxicity Lamivudine 13.0615040536
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 13.0611462148
MESH:D004362 Drug Toxicity Zidovudine 13.0615040536
MESH:D004381 Duodenal Ulcer Curcumin 3.8717351913
MESH:D004417 Dyspnea cypermethrin 5.2016487989
MESH:D004421 Dystonia Phenobarbital 3.831851702
MESH:D004487 Edema pirinixic acid 5.9712083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.9712711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.3015322242 18230668 16714409
MESH:D004489 Edema, Cardiac Tretinoin 11.3018230668
MESH:D020803 Encephalitis, Herpes Simplex Quinolinic Acid 6.6117174341
MESH:D016889 Endometrial Neoplasms Tretinoin 2.9816569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.869294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.923659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.6811558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.7920417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.386401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.067750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.833659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9216302075
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.2612903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.3711564622
MESH:D005124 Eye Abnormalities Tretinoin 8.3716938888 9664655
MESH:D005234 Fatty Liver arsenic trioxide 34.3215073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 34.3212795759 61145 12631006 16045604 15959796 16239168 19224547 17595544
MESH:D005234 Fatty Liver Curcumin 34.3219297423
MESH:D005234 Fatty Liver Cyclosporine 34.3219224547
MESH:D005234 Fatty Liver Diethylnitrosamine 34.3221071580 20387270
MESH:D005234 Fatty Liver pirinixic acid 34.3219236843 20131406
MESH:D005234 Fatty Liver Zidovudine 34.3218299183
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2711858732
MESH:D005355 Fibrosis Carbon Tetrachloride 25.7218705752
MESH:D005355 Fibrosis Curcumin 25.7218705752
MESH:D005355 Fibrosis Cyclosporine 25.7212168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 25.7220067830
MESH:D005355 Fibrosis Tretinoin 25.7217994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.0816904648
MESH:D005756 Gastritis Acetaminophen 10.8116983495
MESH:D005756 Gastritis Diquat 10.8115046732
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.5018462866
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.038708960
MESH:D005909 Glioblastoma Curcumin 6.8817596214
MESH:D005909 Glioblastoma Tretinoin 6.8817312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4010696789
MESH:D006258 Head and Neck Neoplasms Curcumin 7.4718829502 18462866
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.4716096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.9716084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.2010048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 6.2014991402 9664655
MESH:D006333 Heart Failure pirinixic acid 2.4220558911
MESH:D006402 Hematologic Diseases Zidovudine 4.5312579204
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2315720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1611000095
MESH:D006505 Hepatitis Carbon Tetrachloride 9.2219110552 19900420
MESH:D006505 Hepatitis cypermethrin 9.2216487989
MESH:D006509 Hepatitis B Lamivudine 4.9317703166
MESH:D019694 Hepatitis B, Chronic Lamivudine 4.9315274664 16476009 12044531 15631357 15309715
MESH:D006529 Hepatomegaly fenvalerate 19.1815602828
MESH:D006529 Hepatomegaly Phenobarbital 19.1816109766
MESH:D006529 Hepatomegaly pirinixic acid 19.1819772884 16221962 18467677 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 19.1815340226 16120746 12621046
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.8517701891
MESH:D006561 Herpes Simplex Etoposide 4.3710809021
MESH:D015658 HIV Infections Lamivudine 6.7311141242 9296927 20032539 17530837
MESH:D015658 HIV Infections Zidovudine 6.7320032539 11141242 11698656 11363243 17358032
MESH:D006689 Hodgkin Disease Etoposide 3.7117606976 18180244 16200630 15147373 16135485
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8518606429 16354765 16959395 15340226 8697196
MESH:C536081 Hydroxykynureninuria marker/mechanism
MESH:D006930 Hyperalgesia Acetaminophen 7.1316870215
MESH:D006930 Hyperalgesia Tretinoin 7.1316870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3416899240
MESH:D006937 Hypercholesterolemia Curcumin 3.8818704882
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.3816778211
MESH:D006943 Hyperglycemia pirinixic acid 3.0220558911
MESH:D006973 Hypertension Cyclosporine 4.7010903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.7018670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9015338365
MESH:D007248 Infertility, Male Diquat 4.174850670
MESH:D007249 Inflammation marker/mechanism 16365156
MESH:D007249 Inflammation Curcumin 11.1618403477 16956363 17151092
MESH:D007249 Inflammation Diethylnitrosamine 11.1618785209
MESH:D007249 Inflammation Flavonoids 11.1617296493
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.1612878042 12200463
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.1318200517 18596194
MESH:D007299 Insect Bites and Stings cypermethrin 5.7815189238
MESH:D007333 Insulin Resistance pirinixic acid 2.5116306350
MESH:D007410 Intestinal Diseases Tretinoin 3.5817994277
MESH:D007414 Intestinal Neoplasms Curcumin 4.0510783313
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.3616580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.3615992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2515604871
MESH:D007674 Kidney Diseases Acetaminophen 9.4715629191 12587719
MESH:D007674 Kidney Diseases Cadmium 9.4716226777 16322080 16962696
MESH:D007674 Kidney Diseases Cyclosporine 9.4718776723 10903974 8314463
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 11.5816705839
MESH:D007680 Kidney Neoplasms Cyclosporine 11.5812371664
MESH:D007680 Kidney Neoplasms Zidovudine 11.5812579204
MESH:D007889 Leiomyoma Curcumin 4.3918555241
MESH:D007938 Leukemia arsenic trioxide 9.9815070760
MESH:D007938 Leukemia Curcumin 9.9818462866
MESH:D007938 Leukemia Tretinoin 9.9817143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 15.3217077332 12560223
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 15.3216106398
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 15.3220370541
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.1116972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.2914633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 8.9019077051
MESH:D007951 Leukemia, Myeloid Tretinoin 8.9016482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.7616467208 16968895 19850784 20471514 17050201
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.7619850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 7.2215336539 19035177 12679006 19075265 17869043 12712474 11161223 17217047 15622746 15213294 16330433 19642359 16966277 16112521 19225113 17107899 16331271 16891316 12018890 11468182 15748426 17649720 9834237 17712046 16823087
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.2217217047 17294898 17368321 19642359 17301526 16766008 19225113 17107899 19029980 16823087 16935935 19035177 17649720 15748426 16140955 16891316 17506722 19075265 12679006 16331271 16788101 9834237 17339181 17712046 17361223
MESH:D015458 Leukemia, T-Cell arsenic trioxide 11.1016882451
MESH:D015458 Leukemia, T-Cell Curcumin 11.1016106398
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.179224671
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 10.4216943688 16239168 11903743 21278145 11408273 16221502 17157831 17334410 17174718
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 10.4218665156 19638242 20032147 18407596 18522880
MESH:D008103 Liver Cirrhosis Phenobarbital 10.4221047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.4716248980 17631135 15925388 18317297 17761835 18279442 12898905 18339082 16638106 15893842 15818738 12958196 18006644 15650968 17557913 15057751 14620537 15052691 17922224 18705752 12546737 18395095 12445418 20821823 14716496 17565644 18210741 17640975 18412020 14716833 17869086 12586293 12666154 12445421 17823541 12667390 15730626 18277467 14512876 17766677 15370692 17900296 17805973 17721639 18376398 13678700 12649538 12632512 18251166 15876570 15338365 14724832 15931870 12609069 18472094 16027843 17708605 18156304 12632514 18420326 17481882 17944888 17714472 15362042 18395914 17976157 18054572 17525996 16136751 15996030 12389079 18481824 15673190 16192424 17698563 18263696 16015684 16033810 18472332 18166357 10355542 18187930 11481614 14748882 18429990 12741479 15959796 18418968 16011737 16097048 15123356 18205269 16116963
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 6.4718006644 18705752 17355460
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.4715474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.4712878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.4716248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 15.2312969438 16610002 19014921 19460945 19784758 11587558 16611625 12587719
MESH:D008107 Liver Diseases Carbon Tetrachloride 15.2315720792 16246199 17285989 15830285 16964402
MESH:D008107 Liver Diseases Curcumin 15.2316956363
MESH:D008107 Liver Diseases cypermethrin 15.2315991261
MESH:D008107 Liver Diseases Diethylnitrosamine 15.2317034775
MESH:D008107 Liver Diseases Phenobarbital 15.2319363144
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9715123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.8516871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.8514706259 16899240
MESH:D008113 Liver Neoplasms arsenic trioxide 24.7014682389
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 24.7019389873 21295105
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 24.7019294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 24.7020501860 18648771 2422723 21278145 20492335 20101389 19256749 12112319 9163691 15175105 16942905 19812893 20583210 19499222 20434301 19638242 19090486 19294768 19690152 19254457 19996281 12771043 21167192 20137499 21047994 18977376 2862719 20452335 19833225 18644402 10737359 18754104 15885732 19426721 19427195 20405173 19551842 19850985 21071580 19642983 20118626 19255062 19073162 18978307
MESH:D008113 Liver Neoplasms Methapyrilene 24.7015890375
MESH:D008113 Liver Neoplasms Phenobarbital 24.7019812893 19073162 21047994 19482888 8742319 15975961
MESH:D008113 Liver Neoplasms pirinixic acid 24.7020007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 24.7016984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 21.8420377131
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 21.8418164116
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 21.8415583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 21.8419539802 17174075 19004024 17942915 16267830 2563599 18544905 18253720 19009564 19126423 18775883 18164116 18079962 21159647 17854601 18282651 9362446 3124819 18093689 18308698 19519916 16842330
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 21.846150874 18308698 2563599 17172636 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 21.8412151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.2115213294
MESH:D008175 Lung Neoplasms arsenic trioxide 6.3511798837 19825857
MESH:D008175 Lung Neoplasms Curcumin 6.3516243823 19359593 18462866
MESH:D008175 Lung Neoplasms Diethylnitrosamine 6.356695378 20970405 20512841 21163286
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.3519555203 11884234
MESH:D008175 Lung Neoplasms Zidovudine 6.3518800350
MESH:D008223 Lymphoma Curcumin 7.5118462866
MESH:D008223 Lymphoma Etoposide 7.5112854902 12556972
MESH:D016399 Lymphoma, T-Cell Curcumin 4.5016173963
MESH:D008527 Medulloblastoma Tretinoin 2.7117453147
MESH:D008545 Melanoma Curcumin 3.3717885582 18462866
MESH:D008545 Melanoma Tretinoin 3.3716752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3819513568
MESH:D008569 Memory Disorders Curcumin 3.9717263510
MESH:D008591 Meningomyelocele Tretinoin 4.2416940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5916801185
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 5.6517358032
MESH:D009101 Multiple Myeloma arsenic trioxide 6.9919417148 14977855 15949261 19549372 11468182
MESH:D009101 Multiple Myeloma Curcumin 6.9919372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.7317962980
MESH:D009135 Muscular Diseases pirinixic acid 3.3216239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.4818349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.0316882451 16105982
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.0317596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.0719151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8712213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.8016411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.2817484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.6718551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 9.7116624393
MESH:D009361 Neoplasm Invasiveness Curcumin 9.7118495463
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.499029167 3581430
MESH:D009369 Neoplasms fenvalerate 7.892895627
MESH:D009369 Neoplasms pirinixic acid 7.8917405874
MESH:D009369 Neoplasms Tretinoin 7.8916946489 16594593
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.3412497104
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2517954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1218481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.9014600291
MESH:D009421 Nervous System Malformations Tretinoin 8.909125849
MESH:D009423 Nervous System Neoplasms Curcumin 5.4418462866
MESH:D009436 Neural Tube Defects arsenic trioxide 6.8910525206
MESH:D009436 Neural Tube Defects Tretinoin 6.899142499
MESH:D019636 Neurodegenerative Diseases marker/mechanism 16365156
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.6618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.6620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9220387270
MESH:D009765 Obesity Curcumin 4.4419297423
MESH:D009765 Obesity pirinixic acid 4.4420558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.2616049721 12819281
MESH:D010018 Osteomalacia Phenobarbital 4.1717016548
MESH:D010024 Osteoporosis Curcumin 3.3518719352
MESH:D010051 Ovarian Neoplasms arsenic trioxide 7.6012452020 19769630 16624393
MESH:D010051 Ovarian Neoplasms Curcumin 7.6018462866 19020741
MESH:D010051 Ovarian Neoplasms Tretinoin 7.6016936753
MESH:D010146 Pain Acetaminophen 6.0816870215
MESH:D010146 Pain Tretinoin 6.0816870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 19.6215580305
MESH:D010190 Pancreatic Neoplasms Curcumin 19.6217440100 19401701 19196508
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 19.6216540662
MESH:D010190 Pancreatic Neoplasms Etoposide 19.6219003803
MESH:D010190 Pancreatic Neoplasms Phenobarbital 19.6216965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 19.6215976015
MESH:D010195 Pancreatitis Methomyl 5.1916258382 15767733
MESH:D010235 Paraganglioma arsenic trioxide 3.9819927285
MESH:D010243 Paralysis fenvalerate 5.818952708
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0612520081
MESH:D016491 Peripheral Vascular Diseases Cadmium 5.1915687053
MESH:D011041 Poisoning Methomyl 5.2511800311
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3718163543
MESH:D011230 Precancerous Conditions Cyclosporine 14.3412371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 14.342563599
MESH:D011230 Precancerous Conditions Phenobarbital 14.342563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.0011399792 11222880 11896295 11118676
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.2119131511
MESH:D011471 Prostatic Neoplasms Cadmium 2.2117075824
MESH:D011471 Prostatic Neoplasms Curcumin 2.2118769126 18156803 18226269 15129424 11398177 10851300 12497104
MESH:D011471 Prostatic Neoplasms Etoposide 2.2117172428
MESH:D011507 Proteinuria Tretinoin 3.4316636307
MESH:D019310 Pseudolymphoma Phenobarbital 4.3012752131
MESH:D011565 Psoriasis Cyclosporine 2.1616882103
MESH:D011625 Pterygium Tretinoin 4.6016723453
MESH:D011656 Pulmonary Emphysema Curcumin 4.3619168576
MESH:D015427 Reperfusion Injury pirinixic acid 2.2919058328
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.8518379247 10666014
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6518990726
MESH:D012206 Rhabdomyolysis Lamivudine 5.349296927
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.9216116481 16283617
MESH:D012509 Sarcoma Curcumin 3.9518462866
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 9.8316646077
MESH:D012512 Sarcoma, Ewing's Etoposide 9.8314601052
MESH:D012640 Seizures 2,4-dinitrotoluene 9.3518551238
MESH:D012640 Seizures Methomyl 9.3512660363 11218047
MESH:D012640 Seizures Phenobarbital 9.353137016 4039156 11442880 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.636407741
MESH:D018805 Sepsis Curcumin 3.9218389075
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.2616192470
MESH:D012878 Skin Neoplasms Tretinoin 5.2616467112
MESH:D013274 Stomach Neoplasms arsenic trioxide 4.5917007042
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.5918456281
MESH:D013274 Stomach Neoplasms Tretinoin 4.5917261132
MESH:D013274 Stomach Neoplasms Zidovudine 4.5917696246
MESH:D013276 Stomach Ulcer Curcumin 3.3316631530 19188055
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7112697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 15.9219014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 15.927505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 15.921399818
MESH:D013964 Thyroid Neoplasms Tretinoin 15.9216026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.6216051514
MESH:D016171 Torsades de Pointes arsenic trioxide 3.7715213294
MESH:D014202 Tremor fenvalerate 5.378952708
MESH:D014376 Tuberculosis Tretinoin 3.1116040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 7.9516049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 7.9512973940 20435036 11780464 12845720
MESH:D001749 Urinary Bladder Neoplasms Curcumin 7.9518593936
MESH:D014565 Urogenital Neoplasms Curcumin 5.0718462866
MESH:D014570 Urologic Diseases cypermethrin 5.6716487989
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.1210091137
MESH:D014581 Urticaria Acetaminophen 2.8010982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.5116129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.4216752155
MESH:D014605 Uveitis Cyclosporine 3.791336536
MESH:D014625 Vaginal Neoplasms Zidovudine 4.5712579204
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4012125929
MESH:D014689 Venous Insufficiency coumarin 5.5812708602
MESH:D014820 Vitiligo Tretinoin 3.8716761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0615886252
MESH:D009396 Wilms Tumor Tretinoin 3.8116287080
MESH:D014985 Xerophthalmia Cyclosporine 4.2517120751
Pathway ID Pathway Name
KEGG:01100 Metabolic pathways
REACT:13 Metabolism of amino acids and derivatives
KEGG:00380 Tryptophan metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30258
    • No data
    No data
    Releated drug ID Related drug Name
    PA10090l-glutamine
    PA448055l-alanine
    PA10323l-tryptophan
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00114 - Pyridoxal Phosphate Dietary supplement;Micronutrient;Vitamin B Complex
    DB00160 - Travasol Amino Acid Injection Without Electrolytes Dietary supplement;Micronutrient;Non-Essential Amino Acids
    DB07069 - 3-Hydroxyhippuric acid
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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