AutismKB 2.0

Annotation Detail for BTRC


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Basic Information Top
Gene Symbol:BTRC ( BETA-TRCP,FBW1A,FBXW1,FBXW1A,FWD1,MGC4643,bTrCP,bTrCP1,betaTrCP )
Gene Full Name: beta-transducin repeat containing
Band: 10q24.32
Quick LinksEntrez ID:8945; OMIM: 603482; Uniprot ID:FBW1A_HUMAN; ENSEMBL ID: ENSG00000166167; HGNC ID: 1144
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04710Circadian rhythm - mammal
hsa04310Wnt signaling pathway
hsa05131Shigellosis
hsa04120Ubiquitin mediated proteolysis
hsa04114Oocyte meiosis
hsa04340Hedgehog signaling pathway
Pathway IDPathway Name
Signaling by Wnt
Cell Cycle, Mitotic
Signaling in Immune system
HIV Infection
Pathway IDPathway Name
200037Alternative NF-kappaB pathway
200070Signaling events mediated by HDAC Class I
200017Atypical NF-kappaB pathway
200013Notch signaling pathway
200080mTOR signaling pathway
200087PLK1 signaling events
200064Canonical Wnt signaling pathway
200106Regulation of Wnt-mediated beta catenin signaling and target gene transcription
200147Hedgehog signaling events mediated by Gli proteins
200026Canonical NF-kappaB pathway
200052Presenilin action in Notch and Wnt signaling
Pathway IDPathway Name
P00025Hedgehog signaling pathway
P00057Wnt signaling pathway
Pathway IDPathway Name
500761Vpu mediated degradation of CD4
500393SCF-beta-TrCP mediated degradation of Emi1
500310Degradation of beta-catenin by the destruction complex
500490Interleukin-1 signaling
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1770Melanoma
1831Prostate cancer
1832Congenital abnormality
1841Stomach cancer
2066Lung cancer
Desease Name
CANCER
hepatocellular carcinoma
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D011374 Progesterone Progesterone results in increased expression of BTRC mRNAincreases expression 17170212
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 6.7517868700
MESH:D001930 Brain Injuries Progesterone 5.1715845082 15665606 15380490
MESH:D001943 Breast Neoplasms Progesterone 2.4016175315 15562024 17614352
MESH:D003929 Diabetic Neuropathies Progesterone 5.4017187935
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 4.5617692515
MESH:D004715 Endometriosis Progesterone 4.3416134523
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 5.3115869954
MESH:D007249 Inflammation Progesterone 2.8315869954
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 3.1811408345 17203775
MESH:D010051 Ovarian Neoplasms Progesterone 2.6416525653 17393432
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9918045962
MESH:D013119 Spinal Cord Injuries Progesterone 5.3715862959 16503802
Pathway ID Pathway Name
REACT:152 Cell Cycle, Mitotic
REACT:24941 Circadian Clock
REACT:24972 Circadian Clock (mouse)
KEGG:04710 Circadian rhythm - mammal
KEGG:04340 Hedgehog signaling pathway
REACT:6185 HIV Infection
KEGG:04114 Oocyte meiosis
KEGG:05131 Shigellosis
REACT:11045 Signaling by Wnt
REACT:6900 Signaling in Immune system
KEGG:04120 Ubiquitin mediated proteolysis
KEGG:04310 Wnt signaling pathway
Pharmacogenomics Knowledge Base Top
Drug Bank Top

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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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