AutismKB 2.0

Annotation Detail for HIST1H2BJ


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Basic Information Top
Gene Symbol:HIST1H2BJ ( H2B/r,H2BFR )
Gene Full Name: histone cluster 1, H2bj
Band: 6p22.1
Quick LinksEntrez ID:8970; OMIM: NA; Uniprot ID:H2B1J_HUMAN; ENSEMBL ID: ENSG00000124635; HGNC ID: 4761
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05322Systemic lupus erythematosus
Pathway IDPathway Name
Chromosome Maintenance
No data
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
HEMATOLOGICAL
serum markers of iron status
PSYCH
schizophrenia
Desease Name
Serum markers of iron status
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of HIST1H2BJ mRNAincreases expression 18648102
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of HIST1H2BJ mRNAincreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of HIST1H2BJ mRNAdecreases expression 17944540
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of HIST1H2BJ mRNAincreases expression 20382639
C006780 bisphenol A bisphenol A results in increased expression of HIST1H2BJ mRNAincreases expression 16029874
D020366 Methylmethacrylate Methylmethacrylate results in increased expression of HIST1H2BJ mRNAincreases expression 16916219
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0520127859 20464547
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 7.223712494
MESH:D000236 Adenoma Benzo(a)pyrene 7.226695378
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.5619183758
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.631440618 11289319
MESH:D001862 Bone Resorption bisphenol A 4.2411985600
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.1420146248 17474063
MESH:D001943 Breast Neoplasms bisphenol A 2.1417123778
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 1.773581430 7296757
MESH:D002278 Carcinoma in Situ bisphenol A 5.5317123778
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.817296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1320419170
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.437505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.4320889678
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.4119486331 9022650
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.288970840 18759878 11906362 8156756 14531868 12868966 2524372 11298694
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.893621924 2952479
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 2.0318692083 9022650 18289764 6679447 18648102 1440618 8291058 9653073 7440962 16192314 11289319 6482804 9328219
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.623581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.6220426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.6216530937
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.636705139
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.447505956
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8220471113
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.956705139
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.4215034207
MESH:D007333 Insulin Resistance bisphenol A 3.5016393666
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.639022650 8074119
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.276582329
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.4015034207 9327722
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 2.1420195826 21137059
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.733712494 598648 6587162 1399818
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.5720464547 17053015 18816296 18520028 18569708 20869020 6695378 20135361 20064080
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4616381670
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.583581430
MESH:D009369 Neoplasms Benzo(a)pyrene 2.3111141357
MESH:D009421 Nervous System Malformations bisphenol A 4.4111399458 16427766
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.136679447
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.776482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.633988306
MESH:D010049 Ovarian Diseases bisphenol A 5.5311985600
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.977296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 5.086228378
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 4.4910548101
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.5820887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1517292933
MESH:D011471 Prostatic Neoplasms bisphenol A 3.1516740699
MESH:D011629 Puberty, Precocious bisphenol A 5.3310548101
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.643692021
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.5110029692 19755658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D019966 Substance-Related Disorders bisphenol A 4.5216045194 16684133
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.151399818 6582329 3712494 6587162 7505956
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.358074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.3517053015
MESH:D014591 Uterine Diseases bisphenol A 5.6214652134
Pathway ID Pathway Name
REACT:22172 Chromosome Maintenance
REACT:27271 Meiotic Recombination
REACT:27235 Meiotic Recombination (mouse)
KEGG:05322 Systemic lupus erythematosus
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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