AutismKB 2.0

Annotation Detail for P4HA2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:P4HA2 ( - )
Gene Full Name: prolyl 4-hydroxylase, alpha polypeptide II
Band: 5q31.1
Quick LinksEntrez ID:8974; OMIM: 600608; Uniprot ID:P4HA2_HUMAN; ENSEMBL ID: ENSG00000072682; HGNC ID: 8547
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00330Arginine and proline metabolism
hsa01100Metabolic pathways
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2025Polyarthritis
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of P4HA2 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of P4HA2 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of P4HA2 mRNAaffects expression 17562736
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of P4HA2 mRNAaffects expression 17484886
D016572 Cyclosporine Cyclosporine results in increased expression of P4HA2 mRNAincreases expression 20106945
C014347 decitabine decitabine results in increased expression of P4HA2 mRNAincreases expression 19194470
D002945 Cisplatin P4HA2 protein results in decreased susceptibility to Cisplatindecreases response to substance 16734730
D004041 Dietary Fats Dietary Fats results in decreased expression of P4HA2 mRNAdecreases expression 18042831
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of P4HA2 mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in increased expression of P4HA2 mRNAincreases expression 19619570
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of P4HA2 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of P4HA2 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of P4HA2 mRNAaffects cotreatment|increases expression 17942748
C022838 nickel chloride nickel chloride results in increased expression of P4HA2 mRNAincreases expression 12839937
C030110 oxaliplatin oxaliplatin results in decreased expression of P4HA2 mRNAdecreases expression 17762391
C041786 palm oil palm oil results in decreased expression of P4HA2 mRNAdecreases expression 18042831
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of P4HA2 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of P4HA2 mRNAincreases expression 19482888
D011374 Progesterone Progesterone affects the expression of P4HA2 mRNAaffects expression 17251523
D013629 Tamoxifen Tamoxifen affects the expression of P4HA2 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of P4HA2 mRNAdecreases expression 16443690
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of P4HA2 mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of P4HA2 mRNAincreases expression 19619570
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of P4HA2 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of P4HA2 mRNAincreases expression 17942748
D014212 Tretinoin Tretinoin results in increased expression of P4HA2 mRNAincreases expression 17138961
D002762 Cholecalciferol Cholecalciferol results in increased expression of P4HA2 mRNAincreases expression 17170073
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.4914745880
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 8.096195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.0915322242 11752688 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.8917505938
MESH:D058186 Acute Kidney Injury Cisplatin 3.9012690470 17670903 15814532
MESH:D000230 Adenocarcinoma Cisplatin 7.0111798837 17638652
MESH:D000230 Adenocarcinoma Estradiol 7.0111473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.0114692618
MESH:D018248 Adenoma, Liver Cell Phenobarbital 9.8817620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.8816835633
MESH:D000505 Alopecia Tretinoin 3.5615955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8911748828
MESH:D000799 Angioedema Acetaminophen 3.7910982225
MESH:D001161 Arteriosclerosis Dietary Fats 9.7015238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.7011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.0715885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.0716412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2516292516
MESH:D001249 Asthma Tretinoin 2.3216456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001327 Autoimmune Diseases Cholecalciferol 4.9716142846
MESH:D001471 Barrett Esophagus Tretinoin 4.3416935849
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.7312125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.7316197459 16206674
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7215746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.8314601052
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.2817868700
MESH:D001930 Brain Injuries Progesterone 4.1915665606 15380490 15845082
MESH:D001943 Breast Neoplasms Cisplatin 4.6919526202 18382427
MESH:D001943 Breast Neoplasms decitabine 4.6919208741 18320071
MESH:D001943 Breast Neoplasms Dietary Fats 4.6920435547
MESH:D001943 Breast Neoplasms Estradiol 4.6916675129 12948864 18497071 17289903 19861407 14630087 17018787 17261762
MESH:D001943 Breast Neoplasms Progesterone 4.6915562024 17614352 16175315
MESH:D001943 Breast Neoplasms Tamoxifen 4.6917242785 16202921 21138602 19142967 17440819 11161223 16273361 19011961 21152245 18984771 19189212 19289846 19066611 15565566 17893378 18855134 18997820 20005174 19115204 18629630 20390343 15668708 17049068 18425577 18821012 20135344 19221464 18351453 19059307 19084267 19288272 19155303 19244106 20544844 19189210 16818667 19410462 18815881 19200415 20859285 16873071 19103187 17261762 19487384 20065188
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.6920435547
MESH:D001943 Breast Neoplasms Tretinoin 4.6916443354 16166294 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.5316813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.4016111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.723786805 15700767 10355542 16124888 16097048 15721981 16050911 15673190 16192424 16011737 18705752 16227642
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7416835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.4419066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.1016168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 19.7516705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 19.7516705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 19.753084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 19.7518788625
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 19.7517982673
MESH:D006528 Carcinoma, Hepatocellular Estradiol 19.7516924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 19.7517173139 6705139 20935162 20007298 1701930
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 19.7516924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 19.751917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 3.0112023789 16685392
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 7.5317066447 6189445 18337622
MESH:D002294 Carcinoma, Squamous Cell decitabine 7.5319215824
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.5316051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.5517572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3316120746 18670907 18850075
MESH:D002386 Cataract Acetaminophen 7.1010977129
MESH:D002386 Cataract Tretinoin 7.1017460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 10.876135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.8712371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 10.8718566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.194080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.5316129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1016835633
MESH:D002779 Cholestasis Cyclosporine 7.6119486331
MESH:D002779 Cholestasis Ethinyl Estradiol 7.6117681005 17333356 16105132 11677210 17110522 15861022 16919318
MESH:D002822 Choriocarcinoma Tretinoin 5.1016461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.678697196 15668235 15340226 16354765 12621046
MESH:D002972 Cleft Palate Tretinoin 5.679407595
MESH:D003092 Colitis Tretinoin 3.6417035595
MESH:D003110 Colonic Neoplasms decitabine 4.1717616700
MESH:D003110 Colonic Neoplasms oxaliplatin 4.1716024531 16510598 16004971
MESH:D015179 Colorectal Neoplasms Cisplatin 3.6315273666
MESH:D015179 Colorectal Neoplasms decitabine 3.6318981723
MESH:D015179 Colorectal Neoplasms oxaliplatin 3.6317255274 17695437 17401013 18509181 17594712 18448328
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0017141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4315322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.438800419 17551590 9211117 16925845 14991402 10589399 9664655 9125849 9224671 9142499
MESH:D003490 Cyanosis 2,4-dinitrotoluene 10.6818551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 10.6818551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.3019031437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6517107852
MESH:D003928 Diabetic Nephropathies Estradiol 8.6519279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.6519279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.4317187935
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 11.7921346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 11.7918551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 11.7914986274 10663392 12392966 19164858 16227642 12705907 19416960 2444490 18071297 15619225 16177239 10915739 10774834 11287661 11834606 17906064 16781746 12594235 14725611 11743745 19085960 16393943 19739265 12153990 11421492 17562736 16081117 18713872 17522070 19370779 16109766 19420014 11461765 12540782 15968718 16485898 12958197 19923254 14550746 11739529 11529661
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 11.7917522070 7120509 7440962 15998439 21278145 16177239 10915739 15027814 2869522 19085960 15968718 7179309 4309450 19336974 9327722 11566570 10092053 6623471 6884620 3786805 3732212 16227642
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.7920420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0419426721
MESH:D004362 Drug Toxicity Cisplatin 8.0119839026 12649298 15033597 12231392
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.0111462148
MESH:D050171 Dyslipidemias Dietary Fats 3.4018367378
MESH:D004421 Dystonia Phenobarbital 3.941851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.3211000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.7615322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 11.7618230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 14.9612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 14.9617692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 14.9619031437
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.0619294695
MESH:D016889 Endometrial Neoplasms Estradiol 12.1711473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Tamoxifen 12.1717893378 19155303 16202921 20544844
MESH:D016889 Endometrial Neoplasms Tretinoin 12.1716569247
MESH:D004715 Endometriosis Progesterone 8.7316134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.7310568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.043659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.823922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.8620417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.486401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.197750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.963659116
MESH:D004938 Esophageal Neoplasms Cisplatin 2.7616785472 16481741 17638652 15464296 15173087
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.6711564622
MESH:D005124 Eye Abnormalities Tretinoin 8.679664655 16938888
MESH:D005234 Fatty Liver Carbon Tetrachloride 23.9912631006 17595544 12795759 61145 16045604 16239168 15959796 19224547
MESH:D005234 Fatty Liver Cyclosporine 23.9919224547
MESH:D005234 Fatty Liver Dietary Fats 23.9917967931 19004024 19551842 18296743
MESH:D005234 Fatty Liver Ethinyl Estradiol 23.9915345470
MESH:D005234 Fatty Liver Tamoxifen 23.9914986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1916709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3911858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.4714745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.1219069698
MESH:D005355 Fibrosis Carbon Tetrachloride 27.0718705752
MESH:D005355 Fibrosis Cyclosporine 27.0712168785 12639820
MESH:D005355 Fibrosis Dietary Fats 27.0718296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 27.0720067830
MESH:D005355 Fibrosis Tretinoin 27.0717994277
MESH:D005756 Gastritis Acetaminophen 3.6216983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.168708960
MESH:D005909 Glioblastoma Tretinoin 2.9617312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5410696789
MESH:D006258 Head and Neck Neoplasms Cisplatin 12.7615464296 15102660
MESH:D006258 Head and Neck Neoplasms decitabine 12.7619215824
MESH:D006258 Head and Neck Neoplasms Tretinoin 12.7616096774
MESH:D034381 Hearing Loss Cisplatin 4.2419898482
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.1016084493
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.3615464296
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.4210048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 6.4214991402 9664655
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2711000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.5319110552 19900420
MESH:D006529 Hepatomegaly Phenobarbital 8.2316109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.2312621046 15340226 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.9815709030
MESH:D006689 Hodgkin Disease Cisplatin 3.5416200630 16170182
MESH:D019584 Hot Flashes Estradiol 3.7017088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9916959395 16354765 8697196 15340226 18606429
MESH:D006930 Hyperalgesia Acetaminophen 12.8416870215
MESH:D006930 Hyperalgesia oxaliplatin 12.8417418472
MESH:D006930 Hyperalgesia Tretinoin 12.8416870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.4716899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.5321332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.5016778211
MESH:D006949 Hyperlipidemias Dietary Fats 3.5521332399
MESH:D006973 Hypertension Cyclosporine 4.8610903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.8618670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.0215338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7516945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.3415869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4012013081
MESH:D007248 Infertility, Male decitabine 6.5717581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.5717937319
MESH:D007249 Inflammation Dietary Fats 11.6720412841
MESH:D007249 Inflammation Progesterone 11.6715869954
MESH:D007249 Inflammation Tamoxifen 11.6719457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.6712200463 12878042
MESH:D007333 Insulin Resistance Dietary Fats 7.2211836018 18457598
MESH:D007333 Insulin Resistance Estradiol 7.2216393666 16627594
MESH:D007410 Intestinal Diseases Tretinoin 3.7017994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.7316580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.7317551590 15992940
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3915604871
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.0815464296
MESH:D007674 Kidney Diseases Acetaminophen 14.1215629191 12587719
MESH:D007674 Kidney Diseases Cisplatin 14.1212649298 12231392 18289764 15190930 19839026
MESH:D007674 Kidney Diseases Cyclosporine 14.128314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 14.1215618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 22.7316705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 22.7316705839
MESH:D007680 Kidney Neoplasms Cyclosporine 22.7312371664
MESH:D007680 Kidney Neoplasms Estradiol 22.7315610895
MESH:D007680 Kidney Neoplasms Tamoxifen 22.7318625569
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.7411231351
MESH:D007938 Leukemia decitabine 6.3219235587 18980019
MESH:D007938 Leukemia Tretinoin 6.3217143497
MESH:D007951 Leukemia, Myeloid decitabine 9.3618454857 19117987 17236224
MESH:D007951 Leukemia, Myeloid Tretinoin 9.3619285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute decitabine 3.9317679729 19010910 18460780 19387464 18704418 18206229
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.9319850784 16294345 17596541
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.4118055864
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.1119075265 16823087 16140955 19029980 19642359 16935935 19035177 17506722 17217047 16766008 17107899 19225113 16891316 17368321 17712046 17649720 9834237 17301526 17339181 15748426 17294898 12679006 17361223 16788101 16331271
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.269224671
MESH:D008064 Lipidoses Tamoxifen 3.1115342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 10.8211903743 17157831 21278145 16943688 11408273 17334410 17174718 16239168 16221502
MESH:D008103 Liver Cirrhosis Dietary Fats 10.8218296743
MESH:D008103 Liver Cirrhosis Phenobarbital 10.8221047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.6418205269 15052691 18472332 17766677 17721639 15959796 12649538 17565644 12586293 14716833 18251166 18263696 18279442 16027843 15673190 11481614 12741479 16011737 18376398 12609069 14748882 17640975 15818738 18395095 16638106 12445421 17698563 12958196 18339082 18481824 15338365 20821823 18395914 16015684 17761835 16116963 17805973 15876570 12389079 17976157 18412020 15893842 16136751 14512876 18472094 15370692 16248980 18418968 15362042 12667390 18277467 13678700 17708605 18705752 15931870 17525996 17869086 16033810 18006644 15057751 18210741 18187930 17557913 17944888 17922224 16192424 15123356 12632512 12898905 18317297 12546737 18420326 17481882 17631135 10355542 17900296 15996030 16097048 15730626 18054572 17714472 12666154 14716496 17823541 14620537 18156304 12632514 12445418 15925388 14724832 18429990 15650968 18166357
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.6414716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 6.6418564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.6412878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.6418397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 6.3816611625 12969438 16610002 19460945 11587558 19014921 19784758 12587719
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.3815720792 16246199 17285989 15830285 16964402
MESH:D008107 Liver Diseases Phenobarbital 6.3819363144
MESH:D017093 Liver Failure Carbon Tetrachloride 4.1015123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.2116871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.2114706259 16899240
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 13.977678174
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 13.9719294768
MESH:D008113 Liver Neoplasms Phenobarbital 13.9719073162 19812893 8742319 21047994 19482888 15975961
MESH:D008113 Liver Neoplasms Tamoxifen 13.9716684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.9716984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 13.762876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 13.7612014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 13.7618308698 6150874 2563599 1399818 17172636
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 13.7612151625
MESH:D008175 Lung Neoplasms Cisplatin 3.4011798837 17225452 6189445
MESH:D008175 Lung Neoplasms Tamoxifen 3.4018625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4019555203 11884234
MESH:D008223 Lymphoma decitabine 3.3719470736
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.7019428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 9.7211408345 11807958 17203775 16891317
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 9.7217203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 9.7219196722 16827153 14580682 19196723 11731420
MESH:D020149 Manganese Poisoning Estradiol 12.4619453300
MESH:D020149 Manganese Poisoning Tamoxifen 12.4619453300
MESH:D008527 Medulloblastoma Tretinoin 2.7617453147
MESH:D008545 Melanoma Cisplatin 7.2316809738 17023156 11135225 17761969 12393984 18505091 12374674 18332650 15577323 12883367 18176117 16248763 16432458
MESH:D008545 Melanoma decitabine 7.2316505122 17785578
MESH:D008545 Melanoma Tamoxifen 7.2319393235 12393984
MESH:D008545 Melanoma Tretinoin 7.2316752155
MESH:D018328 Melanoma, Amelanotic Cisplatin 11.3115990972
MESH:D018328 Melanoma, Amelanotic Tamoxifen 11.3115990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5019513568
MESH:D008591 Meningomyelocele Tretinoin 4.3616940565
MESH:D008654 Mesothelioma Cisplatin 3.2217638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7316801185
MESH:D009101 Multiple Myeloma decitabine 3.3018172295
MESH:D009190 Myelodysplastic Syndromes decitabine 7.3518608210 19010910 16882708 19157545
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.3517596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9612213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.2316810080
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.4117484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.1418551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.1418551238 7678174
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5219393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4919410462
MESH:D009369 Neoplasms Cisplatin 8.2116773208
MESH:D009369 Neoplasms decitabine 8.2119116145 19470736 17925555
MESH:D009369 Neoplasms Tretinoin 8.2116594593 16946489
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.9419189210 19200415 19196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.6717289903
MESH:D009395 Nephritis, Interstitial Cisplatin 4.4415464296
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2319348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 15.9616427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.9614600291
MESH:D009421 Nervous System Malformations Tretinoin 15.969125849
MESH:D009436 Neural Tube Defects Tretinoin 3.019142499
MESH:D009447 Neuroblastoma Cisplatin 3.418761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8118514411
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.648761367
MESH:D009765 Obesity Dietary Fats 2.2717217161 11836018 20518802 16723640 20132043 18457598 21332399 18674790 19632207
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.6912819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.6916049721
MESH:D010018 Osteomalacia Phenobarbital 4.3017016548
MESH:D010051 Ovarian Neoplasms Cisplatin 14.776897625 15464296 17225452 19769630
MESH:D010051 Ovarian Neoplasms decitabine 14.7719259094 19331143
MESH:D010051 Ovarian Neoplasms Estradiol 14.7719401270
MESH:D010051 Ovarian Neoplasms Progesterone 14.7716525653 17393432
MESH:D010051 Ovarian Neoplasms Tretinoin 14.7716936753
MESH:D010146 Pain Acetaminophen 6.4016870215
MESH:D010146 Pain Tretinoin 6.4016870215
MESH:D010190 Pancreatic Neoplasms Cisplatin 12.1819003803
MESH:D010190 Pancreatic Neoplasms decitabine 12.1819294695
MESH:D010190 Pancreatic Neoplasms Phenobarbital 12.1816965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 12.1815976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6211578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1912520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.2415464296
MESH:D010997 Pleural Neoplasms Cisplatin 5.2917638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4918163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.7812371664
MESH:D011230 Precancerous Conditions Phenobarbital 8.782563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.1311222880 11118676 11399792 11896295
MESH:D055728 Primary Myelofibrosis decitabine 4.6617616702
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.8220887781
MESH:D011471 Prostatic Neoplasms Cholecalciferol 2.6917024972
MESH:D011471 Prostatic Neoplasms Estradiol 2.6916740699
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.6915067354
MESH:D011507 Proteinuria Tretinoin 3.5416636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.2516919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 4.4412752131
MESH:D011565 Psoriasis Cyclosporine 2.2116882103
MESH:D011625 Pterygium Tretinoin 4.7316723453
MESH:D051437 Renal Insufficiency Cisplatin 4.3415464296
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7718990726
MESH:D012208 Rhabdomyosarcoma decitabine 10.7419155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 10.7416283617 16116481
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8318045962
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.3614601052
MESH:D012640 Seizures 2,4-dinitrotoluene 9.5418551238
MESH:D012640 Seizures 2,6-dinitrotoluene 9.5418551238
MESH:D012640 Seizures Phenobarbital 9.543137016 11442880 16876388 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 4.766407741
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.4616192470
MESH:D012878 Skin Neoplasms Tretinoin 5.4616467112
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.2915464296
MESH:D013088 Spermatocele Ethinyl Estradiol 11.3716709447
MESH:D013088 Spermatocele Tamoxifen 11.3716709447
MESH:D013119 Spinal Cord Injuries Progesterone 10.6715862959 16503802
MESH:D013119 Spinal Cord Injuries Tamoxifen 10.6719457130
MESH:D013274 Stomach Neoplasms Cisplatin 3.4417522103 18396642 15958060
MESH:D013274 Stomach Neoplasms decitabine 3.4419037991
MESH:D013274 Stomach Neoplasms Tretinoin 3.4417261132
MESH:D013736 Testicular Neoplasms Cisplatin 4.5715464296 17225452
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0915669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8512697716
MESH:D013964 Thyroid Neoplasms decitabine 11.7217967635
MESH:D013964 Thyroid Neoplasms Phenobarbital 11.721399818
MESH:D013964 Thyroid Neoplasms Tretinoin 11.7216026305 17045167
MESH:D013978 Tibial Fractures Estradiol 4.6319048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.7316051514
MESH:D014376 Tuberculosis Tretinoin 3.1916040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 15.5416049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 15.5416049721
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 15.5412973940 15464296 17225452
MESH:D001749 Urinary Bladder Neoplasms decitabine 15.5417616700 19087683
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 15.548653321 17572228 16712894
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 11.7810091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 11.7810091137
MESH:D014581 Urticaria Acetaminophen 2.9110982225
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 9.3716803524
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 9.3716129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2314692618
MESH:D014604 Uveal Neoplasms decitabine 12.6417785578
MESH:D014604 Uveal Neoplasms Tretinoin 12.6416752155
MESH:D014605 Uveitis Cyclosporine 3.931336536
MESH:D014625 Vaginal Neoplasms Cisplatin 4.5515577323
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4814671159 15869587
MESH:D014820 Vitiligo Tretinoin 3.9916761959
MESH:D014839 Vomiting Cisplatin 4.6611897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1915886252
MESH:D015430 Weight Gain Dietary Fats 3.6816723640
MESH:D009396 Wilms Tumor Tretinoin 3.9116287080
MESH:D014985 Xerophthalmia Cyclosporine 4.3917120751
Pathway ID Pathway Name
KEGG:00330 Arginine and proline metabolism
KEGG:01100 Metabolic pathways
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00139 - Ubicoenzyme Anti-Ulcer Agents;Dietary supplement;Micronutrient;Radiation-Protective Agents
DB00172 - L-Proline Dietary supplement;Micronutrient;Non-Essential Amino Acids
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved