AutismKB 2.0

Annotation Detail for USP13


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Basic Information Top
Gene Symbol:USP13 ( ISOT3,IsoT-3 )
Gene Full Name: ubiquitin specific peptidase 13 (isopeptidase T-3)
Band: 3q26.33
Quick LinksEntrez ID:8975; OMIM: 603591; Uniprot ID:UBP13_HUMAN; ENSEMBL ID: ENSG00000058056; HGNC ID: 12611
Relate to Another Database: SFARIGene; denovo-db
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001151 Arsenic Arsenic results in decreased expression of USP13 mRNAdecreases expression 16835338
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of USP13 mRNAdecreases expression 20064835
C029938 nickel sulfate nickel sulfate results in decreased expression of USP13 mRNAdecreases expression 16780908
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of USP13 mRNAaffects binding|increases activity|increases expression 19710929
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury nickel sulfate 10.7211954676 19131640 16100012 12718980
MESH:D055371 Acute Lung Injury pirinixic acid 10.7218653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0620127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.866695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.1116434500
MESH:D018246 Adrenocortical Adenoma Arsenic 5.9417306315
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.6419183758
MESH:D020261 Arsenic Poisoning marker/mechanism 16835338
MESH:D020261 Arsenic Poisoning Arsenic 2.9516835338 18414634 12569548 16251483
MESH:D050197 Atherosclerosis Arsenic 3.4612928151 19371607
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.5719483382
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9917474063 20146248
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.7817687452 15504454
MESH:D006528 Carcinoma, Hepatocellular Arsenic 2.3217306315 16507464
MESH:D002294 Carcinoma, Squamous Cell Arsenic 5.0217687452 18922899 15504454
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 5.0220419170
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.4718640142
MESH:D002318 Cardiovascular Diseases Arsenic 3.7117938729 19152805 15738583
MESH:D002340 Carotid Artery Diseases Arsenic 4.6818022660 16973168
MESH:D002779 Cholestasis pirinixic acid 3.1219176532
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 4.2211298694 16823706 16780908
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5718249437
MESH:D004487 Edema pirinixic acid 2.9012083418
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0816530937
MESH:D005234 Fatty Liver pirinixic acid 3.1919236843 20131406
MESH:D005534 Foot Diseases Arsenic 6.286392382
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8320471113
MESH:D006333 Heart Failure pirinixic acid 2.7620558911
MESH:D006529 Hepatomegaly pirinixic acid 3.5519772884 18467677 19176532 16221962
MESH:D006943 Hyperglycemia pirinixic acid 3.5820558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.8517050553
MESH:D006973 Hypertension Arsenic 2.999931084 11953799 16076760
MESH:D006987 Hypesthesia Arsenic 6.2816093927
MESH:D007333 Insulin Resistance pirinixic acid 2.8716306350
MESH:D007642 Keratosis Arsenic 5.6216930632 12749816
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.7917339181
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Arsenic 2.6111134558
MESH:D008113 Liver Neoplasms Arsenic 8.1616368122
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 8.1620195826 21137059
MESH:D008113 Liver Neoplasms pirinixic acid 8.1616377806 20007298 15890375
MESH:D008175 Lung Neoplasms Arsenic 2.6317976673 19168569 17306315
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.636695378 17053015 20464547 18520028 20135361 20064080 18816296 18569708 20869020
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.5016381670
MESH:D009135 Muscular Diseases pirinixic acid 4.0716239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2719151258
MESH:D017202 Myocardial Ischemia Arsenic 4.3115371236
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2516411023
MESH:D009369 Neoplasms Benzo(a)pyrene 5.3911141357
MESH:D009369 Neoplasms pirinixic acid 5.3917405874
MESH:D009436 Neural Tube Defects Arsenic 3.6916620997
MESH:D020078 Neurogenic Inflammation Arsenic 4.8417056641
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D010051 Ovarian Neoplasms Arsenic 2.8417306315
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.6816093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.6216905509 6392382 15371236
MESH:D011471 Prostatic Neoplasms Arsenic 3.2216140617
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.2217292933
MESH:D011507 Proteinuria Arsenic 4.4721343184
MESH:D015427 Reperfusion Injury pirinixic acid 2.5519058328
MESH:D012871 Skin Diseases marker/mechanism 16835338
MESH:D012871 Skin Diseases Arsenic 2.8217938729 6392382 15952646 17453740 17050553 16702368 17548696 16353154 19834688 18709164 16759981
MESH:D012878 Skin Neoplasms Arsenic 6.3615504454 17029826 16251483 17976673 17050553 19538983
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 6.3610029692 19755658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D001749 Urinary Bladder Neoplasms Arsenic 5.5917976673 18640142 17306315 19429237 19322015 15987713 11144890
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.5917053015
MESH:D014652 Vascular Diseases Arsenic 5.3717056641
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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