AutismKB 2.0

Annotation Detail for NAV3


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Basic Information Top
Gene Symbol:NAV3 ( KIAA0938,POMFIL1,STEERIN3,unc53H3 )
Gene Full Name: neuron navigator 3
Band: 12q21.2
Quick LinksEntrez ID:89795; OMIM: 611629; Uniprot ID:NAV3_HUMAN; ENSEMBL ID: ENSG00000067798; HGNC ID: 15998
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C006632 arsenic trioxide arsenic trioxide results in decreased expression of NAV3 mRNAdecreases expression 15761015
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of NAV3 mRNAincreases expression 18687144
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of NAV3 mRNAdecreases expression 20382639
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of NAV3 mRNAincreases expression 15336504
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of NAV3 mRNAaffects expression 17484886
D002117 Calcitriol Calcitriol results in increased expression of NAV3 mRNAincreases expression 16002434
D008628 Mercury Mercury results in increased expression of NAV3 mRNAincreases expression 16823088
D017239 Paclitaxel NAV3 protein affects the susceptibility to Paclitaxelaffects response to substance 16217747
D014810 Vitamin E Vitamin E results in decreased expression of NAV3 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3319825857 11798837
MESH:D001321 Autistic Disorder Mercury 2.7717497416
MESH:D001327 Autoimmune Diseases Mercury 5.1316634805
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 3.8816206674
MESH:D001859 Bone Neoplasms Paclitaxel 4.7915867366
MESH:D001943 Breast Neoplasms Calcitriol 2.5311237771
MESH:D001943 Breast Neoplasms Paclitaxel 2.5316244791 18223236 18323546 18234424 16273361 16115903 11325840 15136595
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5511589617
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 10.8115721981 3786805 15700767 16192424 15673190 18705752 16227642 16124888 10355542 16050911 16097048 16011737
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 10.8116050911
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.8516217749 14691202 11135700 15553829 15073043
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.8518788625
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 4.8516313753
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.1919014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3112490120
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 2.6711237771
MESH:D002311 Cardiomyopathy, Dilated Mercury 3.5110334427
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.8620889678
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.7520501625
MESH:D015179 Colorectal Neoplasms Paclitaxel 2.7518802399
MESH:D023903 Coronary Restenosis arsenic trioxide 4.4212609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.7610525206
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.7619769572
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.3215213294
MESH:D017449 Dermatitis, Allergic Contact Mercury 4.0516823706
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 2.0919085960 11566570 16227642 6884620 3786805 3732212 17522070 15027814 10915739 7179309 16177239 10092053 4309450 6623471 15968718 15998439 2869522 7120509 21278145 9327722 7440962 19336974
MESH:C538011 Eales disease Vitamin E 5.029068938
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 4.1715138306
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.6020426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 7.6012903497
MESH:D004938 Esophageal Neoplasms Paclitaxel 7.6016481741
MESH:D005234 Fatty Liver arsenic trioxide 8.5615073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.5612631006 16045604 12795759 61145 16239168 19224547 15959796 17595544
MESH:D005355 Fibrosis Carbon Tetrachloride 3.7118705752
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5016904648
MESH:D006330 Heart Defects, Congenital Vitamin E 3.0816080930
MESH:D006505 Hepatitis Carbon Tetrachloride 3.8319110552 19900420
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7616863852 16490937
MESH:D019584 Hot Flashes Vitamin E 4.2914716179
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.8216899240
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3515338365
MESH:D007251 Influenza, Human Vitamin E 4.5316624496
MESH:D007674 Kidney Diseases Mercury 6.8317934191
MESH:D007674 Kidney Diseases Vitamin E 6.8312488133
MESH:D007938 Leukemia arsenic trioxide 2.9215070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0017077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5916972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5814633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.9719077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1617050201 16968895 19850784 20471514 16467208
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3412679006 12018890 19642359 17107899 17869043 11468182 16823087 17217047 19225113 15336539 16891316 16112521 9834237 16330433 17712046 15622746 15213294 16331271 12712474 15748426 16966277 11161223 19035177 17649720 19075265
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5916882451
MESH:D008080 Liposarcoma Paclitaxel 5.0417353645
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9117174718 17157831 16221502 16943688 11408273 11903743 21278145 17334410 16239168
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.5818420326 16638106 15362042 12649538 20821823 18006644 18418968 14620537 18205269 17761835 12445421 15818738 18317297 15925388 16192424 15730626 14724832 15052691 18395095 17698563 17714472 17805973 18166357 17823541 15876570 12389079 15893842 15338365 15057751 17922224 17525996 14748882 17557913 15370692 17565644 14512876 18263696 15931870 17640975 16097048 12609069 17481882 18481824 18472094 18705752 16033810 12741479 18277467 16027843 17900296 18279442 17708605 12546737 14716496 18395914 16136751 14716833 15673190 17766677 12632514 12898905 12445418 15959796 16248980 12632512 18472332 16011737 18210741 18156304 16015684 15650968 18054572 18412020 12666154 18429990 17869086 11481614 12667390 13678700 16116963 18251166 18187930 17976157 15123356 17721639 12958196 17944888 15996030 12586293 17631135 18376398 10355542 18339082
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.5816169303
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1215830285 16246199 16964402 15720792 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 4.4215123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.8814706259 16899240
MESH:D008113 Liver Neoplasms arsenic trioxide 4.8514682389
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.8519294768
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 6.3920377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.3915583823 12014681
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5115213294
MESH:D008171 Lung Diseases Vitamin E 3.3116863852
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.2817365036
MESH:D008175 Lung Neoplasms arsenic trioxide 2.5911798837 19825857
MESH:D008175 Lung Neoplasms Vitamin E 2.5911062179
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 4.2614749477
MESH:D008545 Melanoma Paclitaxel 2.6116342250 12025231 12040289
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.2518303189 16966607 16166281
MESH:D009101 Multiple Myeloma arsenic trioxide 7.9811468182 19417148 14977855 15949261 19549372
MESH:D009101 Multiple Myeloma Paclitaxel 7.9814749477
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.9918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2516105982 16882451
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2016624393
MESH:D009362 Neoplasm Metastasis Paclitaxel 3.3215867366
MESH:D009436 Neural Tube Defects arsenic trioxide 3.2410525206
MESH:D010014 Osteolysis Paclitaxel 5.2615867366
MESH:D010051 Ovarian Neoplasms arsenic trioxide 5.3019769630 16624393 12452020
MESH:D010051 Ovarian Neoplasms Paclitaxel 5.3011161223
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.5815580305
MESH:D010235 Paraganglioma arsenic trioxide 4.3819927285
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 5.1510923243
MESH:D011470 Prostatic Hyperplasia Calcitriol 5.0615572423
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.1019131511
MESH:D011471 Prostatic Neoplasms Calcitriol 2.1016289102 18247401 12479363 15754350 16644109
MESH:D011471 Prostatic Neoplasms Paclitaxel 2.1017136230 16729912 16356831 17172428
MESH:D011471 Prostatic Neoplasms Vitamin E 2.1015084515
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.0917365031 15814490 17322281 17975199
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2016646077
MESH:D012871 Skin Diseases Vitamin E 2.4818709164
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 2.778532709
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.7417007042
MESH:D013274 Stomach Neoplasms Paclitaxel 2.7418506536 18396642
MESH:D020521 Stroke Vitamin E 3.6816517955
MESH:D024801 Tauopathies Paclitaxel 5.1016930453
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.2419014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.2415213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 2.5512845720 20435036 12973940 11780464
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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