AutismKB 2.0

Annotation Detail for NAV1


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Basic Information Top
Gene Symbol:NAV1 ( DKFZp781D0314,FLJ12560,FLJ14203,KIAA1151,MGC14961,POMFIL3,STEERIN1,UNC53H1 )
Gene Full Name: neuron navigator 1
Band: 1q32.1
Quick LinksEntrez ID:89796; OMIM: 611628; Uniprot ID:NAV1_HUMAN; ENSEMBL ID: ENSG00000134369; HGNC ID: 15989
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of NAV1 mRNAincreases expression 19933214
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of NAV1 mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of NAV1 mRNAaffects expression 17562736
D001151 Arsenic Arsenic results in decreased expression of NAV1 mRNAdecreases expression 19654921
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of NAV1 mRNAdecreases expression 20064835
D004041 Dietary Fats Dietary Fats results in decreased expression of NAV1 mRNAdecreases expression 18042831
D002117 Calcitriol Calcitriol results in decreased expression of NAV1 mRNAdecreases expression 16002434
D005576 Forskolin Forskolin results in decreased expression of NAV1 mRNAdecreases expression 16751804
D015741 Metribolone Metribolone results in decreased expression of NAV1 mRNAdecreases expression 16751804
C041786 palm oil palm oil results in decreased expression of NAV1 mRNAdecreases expression 18042831
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of NAV1 mRNAincreases expression 17555868
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of NAV1 mRNAincreases expression 19933214
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0411752688 15322242 14514962
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0120127859 20464547
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.853712494
MESH:D000236 Adenoma Benzo(a)pyrene 6.856695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5716835633
MESH:D018246 Adrenocortical Adenoma Arsenic 5.4317306315
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2519183758
MESH:D020261 Arsenic Poisoning Arsenic 2.9018414634 12569548 16251483 16835338
MESH:D001161 Arteriosclerosis Dietary Fats 4.0615238619
MESH:D050197 Atherosclerosis Arsenic 3.3319371607 12928151
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.2411289319 1440618
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9620146248 17474063
MESH:D001943 Breast Neoplasms Calcitriol 1.9611237771
MESH:D001943 Breast Neoplasms Dietary Fats 1.9620435547
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9620435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9116835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.6617687452 15504454
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.693581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.693084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 4.6916507464 17306315
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.737296757
MESH:D002294 Carcinoma, Squamous Cell Arsenic 7.8117687452 15504454 18922899
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.8120419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 7.8111237771
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.2118640142
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4418670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Arsenic 3.5415738583 17938729 19152805
MESH:D002340 Carotid Artery Diseases Arsenic 4.4316973168 18022660
MESH:D002386 Cataract Acetaminophen 2.6610977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.857505956
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2916835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.2519486331 9022650
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1512621046 8697196 16354765 15340226 15668235
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.9712868966 2524372 11298694 14531868 18759878 11906362 8156756 8970840
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.643621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.3318289764 8291058 18692083 9653073 9022650 16192314 6679447 9328219 6482804 11289319 18648102 7440962 1440618
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.3319923254 11461765 15619225 19085960 12392966 19739265 18713872 17522070 12594235 18071297 12153990 11287661 14986274 17906064 19420014 12705907 16227642 16081117 10774834 11743745 14550746 15968718 10663392 16177239 16485898 11739529 19164858 11421492 11834606 12958197 19370779 16781746 17562736 14725611 16393943 10915739 2444490 19416960 11529661 16109766 12540782
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.3320420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:D050171 Dyslipidemias Dietary Fats 3.5518367378
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1218230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 4.0915138306
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1510568697 9294722
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.473581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.4716530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005234 Fatty Liver Dietary Fats 3.3819551842 17967931 19004024 18296743
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.246705139
MESH:D005355 Fibrosis Dietary Fats 9.2218296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.2220067830
MESH:D005534 Foot Diseases Arsenic 5.786392382
MESH:D005756 Gastritis Acetaminophen 3.8916983495
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.197505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.6720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6710048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.676705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0715340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.268697196 16354765 15340226 16959395 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.8116870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7321332399
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.5917050553
MESH:D006949 Hyperlipidemias Dietary Fats 3.7621332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.1115034207
MESH:D006973 Hypertension Arsenic 5.3916076760 9931084 11953799
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.3918850075 18670907
MESH:D006987 Hypesthesia Arsenic 5.7816093927
MESH:D007249 Inflammation Dietary Fats 5.1420412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.1412200463 12878042
MESH:D007333 Insulin Resistance Dietary Fats 3.1918457598 11836018
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.248074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4816580747
MESH:D007642 Keratosis Arsenic 5.1816930632 12749816
MESH:D007674 Kidney Diseases Acetaminophen 2.2712587719 15629191
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.086582329
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.6417339181
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9518296743
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.2815034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008107 Liver Diseases Acetaminophen 4.1719460945 16610002 19784758 12587719 19014921 11587558 12969438 16611625
MESH:D008107 Liver Diseases Arsenic 4.1711134558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3717185352 16871587
MESH:D008113 Liver Neoplasms Arsenic 7.7116368122
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.7121137059 20195826
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.7116984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.01598648 6587162 1399818 3712494
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.0112151625
MESH:D008175 Lung Neoplasms Arsenic 3.4819168569 17306315 17976673
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.4818569708 18520028 20464547 17053015 18816296 6695378 20064080 20135361 20869020
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4811884234 19555203
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3016381670
MESH:D017202 Myocardial Ischemia Arsenic 9.3815371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.3812213967
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.523581430
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2311141357
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3714600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.676679447
MESH:D009436 Neural Tube Defects Arsenic 7.6716620997
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9918514411
MESH:D020078 Neurogenic Inflammation Arsenic 4.5217056641
MESH:D009765 Obesity Dietary Fats 2.3119632207 21332399 18674790 17217161 18457598 20518802 11836018 20132043 16723640
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.556482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.243988306
MESH:D010051 Ovarian Neoplasms Arsenic 2.7817306315
MESH:D010146 Pain Acetaminophen 2.5016870215
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.667296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.3416093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.1815371236 16905509 6392382
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.696228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3811222880 11399792 11896295 11118676
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.9715572423
MESH:D011471 Prostatic Neoplasms Arsenic 2.6016140617
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.6017292933
MESH:D011471 Prostatic Neoplasms Calcitriol 2.6018247401 16644109 16289102 12479363 15754350
MESH:D011507 Proteinuria Arsenic 4.1521343184
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.483692021
MESH:D012871 Skin Diseases Arsenic 2.7817938729 17050553 18709164 15952646 16759981 19834688 16353154 17548696 17453740 6392382 16702368
MESH:D012878 Skin Neoplasms Arsenic 9.7917976673 19538983 15504454 16251483 17050553 17029826
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.7919755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.7916192470
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.991399818 6582329 6587162 7505956 3712494
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.638074119
MESH:D001749 Urinary Bladder Neoplasms Arsenic 8.6311144890 17306315 17976673 19322015 19429237 15987713 18640142
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.6317053015
MESH:D014581 Urticaria Acetaminophen 3.1210982225
MESH:D014652 Vascular Diseases Arsenic 4.9317056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
MESH:D015430 Weight Gain Dietary Fats 3.8616723640
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA31451
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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