AutismKB 2.0

Annotation Detail for ABCC10


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Basic Information Top
Gene Symbol:ABCC10 ( EST182763,MRP7,SIMRP7 )
Gene Full Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 10
Band: 6p21.1
Quick LinksEntrez ID:89845; OMIM: 612509; Uniprot ID:MRP7_HUMAN; ENSEMBL ID: ENSG00000124574; HGNC ID: 52
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased activity of NR1I3 protein] which results in increased expression of ABCC10 mRNAincreases activity|increases expression 15833929
C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene 1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of ABCC10 mRNAincreases expression 15833929
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of ABCC10 mRNAincreases expression 18648102
D015073 2-Acetylaminofluorene 2-Acetylaminofluorene results in increased expression of ABCC10 mRNAincreases expression 12566991
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ABCC10 mRNAincreases expression 20106945
C012589 trichostatin A trichostatin A results in increased expression of ABCC10 mRNAincreases expression 12566991
C025643 vinclozolin vinclozolin affects the expression of ABCC10 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3111752688 14514962 15322242
MESH:D000236 Adenoma 2-Acetylaminofluorene 7.5510737359
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 7.553712494
MESH:D002759 Adenoma, Bile Duct 2-Acetylaminofluorene 6.536705139
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.8416835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2511748828
MESH:D001008 Anxiety Disorders vinclozolin 3.8919015723
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.5411289319 1440618
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.3115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9515746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6720435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0516835633
MESH:D006528 Carcinoma, Hepatocellular 2-Acetylaminofluorene 3.4310737359 3581430 3084413 6705139 17761372
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 3.437296757 3581430
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.807296757
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5218850075 16120746 18670907
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.967505956
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4516835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.389022650 19486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2112621046 8697196 15340226 16354765 15668235
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003456 Cryptorchidism vinclozolin 4.7214966744
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.218970840 18759878 11298694 11906362 12868966 14531868 8156756 2524372
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.842952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 3.949022650 9328219 16192314 18648102 6679447 11289319 1440618 18692083 7440962 9653073 8291058 18289764 6482804
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.9420420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9911462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.4215322242 16714409 18230668
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 6.1619294695
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.339294722 10568697
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.173581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2411564622
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8711858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.546705139
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3620067830
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.4016973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.8216417039
MESH:D005909 Glioblastoma trichostatin A 4.0218801729
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.397505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.1210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4711294989 10048152
MESH:D006390 Hemangioendothelioma 2-Acetylaminofluorene 5.846705139
MESH:D006394 Hemangiosarcoma 2-Acetylaminofluorene 4.736705139
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6611000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.896705139
MESH:D006529 Hepatomegaly 1,4-bis(2-(3,5-dichloropyridyloxy))benzene 10.3316109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 10.3312621046 15340226 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.5716959395 15340226 8697196 18606429 16354765
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.3615034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0018850075 18670907
MESH:D007248 Infertility, Male vinclozolin 3.2416467254
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9912878042 12200463
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.549022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6616580747
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.236582329
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 2.9418206229
MESH:D007984 Leydig Cell Tumor vinclozolin 5.1916417039
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.389327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2512878042
MESH:D008113 Liver Neoplasms 2-Acetylaminofluorene 5.0610672840 10737359 16273603 11376686 14678523 18001218
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 5.0616984957
MESH:D008114 Liver Neoplasms, Experimental 2-Acetylaminofluorene 10.991399818 6150874 534488
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.99598648 3712494 1399818 6587162
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.9912151625
MESH:D008175 Lung Neoplasms 2-Acetylaminofluorene 2.6611376686
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.6611884234 19555203
MESH:D008545 Melanoma trichostatin A 2.8016505122
MESH:D009101 Multiple Myeloma trichostatin A 4.0918172295
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2712213967
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.573581430
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5914600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.106679447
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.724026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.543988306
MESH:D010051 Ovarian Neoplasms trichostatin A 3.2519331143
MESH:D010190 Pancreatic Neoplasms trichostatin A 3.3819294695
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.907296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.7712520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.996228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.9418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 11.0811118676 11399792 11896295 11222880
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 11.0819015723 18220299 18042343
MESH:D055728 Primary Myelofibrosis trichostatin A 5.6717616702
MESH:D011469 Prostatic Diseases vinclozolin 5.4018220299
MESH:D011471 Prostatic Neoplasms trichostatin A 3.9919789329 18798265
MESH:D011472 Prostatitis vinclozolin 5.4018629315
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2218990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.613692021
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1716192470
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.4212697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.126587162 3712494 7505956 6582329 1399818
MESH:D001749 Urinary Bladder Neoplasms 2-Acetylaminofluorene 5.711399818 15867355 15289314
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.718074119
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.1212125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.7715886252
Pathway ID Pathway Name
KEGG:02010 ABC transporters
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24392
    • Releated gene ID Related gene Name
    PA24392ABCC10
    No data
    No data
    Drug Bank Top
    No data
    No data
    Drugbank ID Action Drug Name Description
    DB00091 inhibitor Cyclosporine Antirheumatic Agents;Immunomodulatory Agents;Enzyme Inhibitors;Dermatologic Agents;Immunosuppressive Agents;Antifungal Agents
    DB00203 inhibitor Sildenafil Vasodilator Agents;Phosphodiesterase Inhibitors
    DB00441 substrate Gemcitabine Antineoplastic Agents;Antiviral Agents;Radiation-Sensitizing Agents;Antimetabolites;Enzyme Inhibitors;Immunosuppressive Agents;Antimetabolites, Antineoplastic
    DB00541 inhibitor Vincristine Antineoplastic Agents;Antineoplastic Agents, Phytogenic;Tubulin Modulators
    DB00563 inhibitor Methotrexate Antineoplastic Agents;Antirheumatic Agents;Antimetabolites;Enzyme Inhibitors;Folic Acid Antagonists;Dermatologic Agents;Immunosuppressive Agents;Nucleic Acid Synthesis Inhibitors;Abortifacient Agents, Nonsteroidal;Abortifacient Agents;Antimetabolites, Antineoplastic
    DB00661 inhibitor Tarka Vasodilator Agents;Antiarrhythmic Agents;Calcium Channel Blockers;Anti-Arrhythmia Agents
    DB00694 substrate Daunorubicin Antineoplastic Agents;Antibiotics;Antibiotics, Antineoplastic
    DB00773 inhibitor Etoposide Nucleic Acid Synthesis Inhibitors;Antineoplastic Agents, Phytogenic
    DB00783 inhibitor Triquilar 21 Anticholesteremic Agents;Estrogens;Anti-menopausal Agents
    DB00987 substrate Cytarabine Antineoplastic Agents;Antiviral Agents;Antimetabolites;Immunosuppressive Agents;Antimetabolites, Antineoplastic
    DB00997 inhibitor Doxorubicin Antineoplastic Agents;Antibiotics;Antibiotics, Antineoplastic
    DB01229 inhibitor Paclitaxel Antineoplastic Agents;Antineoplastic Agents, Phytogenic;Tubulin Modulators
    DB01248 substrate Docetaxel Antineoplastic Agents;Radiation-Sensitizing Agents;Antimalarials;Antineoplastic Agents, Phytogenic
    DB04348 inhibitor Taurocholic Acid Cholagogues and Choleretics;Detergents
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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