AutismKB 2.0

Annotation Detail for CCNF


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:CCNF ( FBX1,FBXO1 )
Gene Full Name: cyclin F
Band: 16p13.3
Quick LinksEntrez ID:899; OMIM: 600227; Uniprot ID:CCNF_HUMAN; ENSEMBL ID: ENSG00000162063; HGNC ID: 1591
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of CCNF mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CCNF mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of CCNF mRNAincreases expression 17530438
D001554 Benzene Benzene results in increased expression of CCNF mRNAincreases expression 15122651
15120971
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CCNF mRNAdecreases expression 19150397
20382639
D002084 Butylated Hydroxytoluene Butylated Hydroxytoluene results in increased expression of CCNF mRNAincreases expression 12867420
D002084 Butylated Hydroxytoluene [Butylated Hydroxytoluene results in increased expression of FOXM1 mRNA] which results in increased expression of CCNF mRNAincreases expression 12867420
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of CCNF mRNAincreases expression 15003993
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of CCNF proteinaffects expression 16092975
C057862 cyanoginosin LR cyanoginosin LR results in decreased expression of CCNF mRNAdecreases expression 17654400
C014347 decitabine decitabine results in decreased expression of CCNF mRNAdecreases expression 19363521
C014347 decitabine TP53 protein affects the reaction [decitabine results in decreased expression of CCNF mRNA]affects reaction|decreases expression 19363521
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of CCNF mRNAincreases expression 17854601
D004052 Diethylnitrosamine RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of CCNF mRNA]decreases reaction|increases expression 17854601
D004137 Dinitrochlorobenzene Dinitrochlorobenzene results in increased expression of CCNF mRNAincreases expression 18242016
D004391 Dust Dust results in decreased expression of CCNF mRNAdecreases expression 17805423
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of CCNF mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CCNF mRNAaffects cotreatment|increases expression 17942748
D005472 Fluorouracil CCNF affects the susceptibility to Fluorouracilaffects response to substance 15067352
C051890 irinotecan irinotecan metabolite results in decreased expression of CCNF mRNAdecreases expression 15956246
C051890 irinotecan irinotecan results in decreased expression of CCNF mRNAdecreases expression 15956246
D009151 Mustard Gas Mustard Gas results in increased expression of CCNF mRNAincreases expression 15674843
D010081 Oxazolone Oxazolone results in increased expression of CCNF mRNAincreases expression 18242016
C006253 pirinixic acid pirinixic acid results in increased expression of CCNF mRNAincreases expression 18445702
D011794 Quercetin Quercetin results in decreased expression of CCNF mRNAdecreases expression 14715546
C064116 S-(1,1,2,2-tetrafluoroethyl)cysteine S-(1,1,2,2-tetrafluoroethyl)cysteine results in decreased expression of CCNF mRNAdecreases expression 16678137
C017947 sodium arsenite sodium arsenite results in increased expression of CCNF mRNAincreases expression 12016162
C017947 sodium arsenite sodium arsenite results in decreased expression of CCNF mRNAdecreases expression 17998272
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CCNF mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CCNF mRNAincreases expression 15667827
D014051 Toluene 2,4-Diisocyanate Toluene 2,4-Diisocyanate results in increased expression of CCNF mRNAincreases expression 18242016
D019772 Topotecan CCNF protein affects the susceptibility to Topotecanaffects response to substance 16217747
C034028 vanadyl sulfate vanadyl sulfate results in decreased expression of CCNF mRNAdecreases expression 16330358
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.6415322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.3518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7317505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.9218653653
MESH:D000230 Adenocarcinoma arsenic trioxide 6.7711798837 19825857
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.7714692618
MESH:D000230 Adenocarcinoma Fluorouracil 6.7717638652
MESH:D000236 Adenoma Diethylnitrosamine 2.7310737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 16.0519061943 19052882 17162532 17620307 18056438 16434500
MESH:D018248 Adenoma, Liver Cell pirinixic acid 16.0516434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 16.0516835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.4915276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.6917306315 16712894
MESH:D000740 Anemia Fluorouracil 8.0716511603 17963324 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.0711748828
MESH:D000741 Anemia, Aplastic Benzene 4.2111369114 17661222 14761424
MESH:D000743 Anemia, Hemolytic Quercetin 4.0517084956
MESH:D000799 Angioedema Acetaminophen 3.6310982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2611256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5415885639
MESH:D001249 Asthma Mustard Gas 5.1910378619
MESH:D001249 Asthma Toluene 2,4-Diisocyanate 5.197684630 6091945 15590891 11742282 10934080 17015710 19187332 16792590 15590890 170078 16210060 20032816 12684321 15855793 18394133 8156442 10797510 11467998 12585506 11077013 12762349 3040596 6091946
MESH:D001260 Ataxia Telangiectasia Quercetin 4.7715336622
MESH:D001321 Autistic Disorder Acetaminophen 1.4418445737
MESH:D001327 Autoimmune Diseases Quercetin 4.2019761891
MESH:D001768 Blister Mustard Gas 4.9519167455
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 14.1816206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 14.1819483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 14.1812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5815340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6315746008
MESH:D001855 Bone Marrow Diseases Benzene 5.0216183116
MESH:D001943 Breast Neoplasms Benzene 3.6411921183 17162533
MESH:D001943 Breast Neoplasms decitabine 3.6418320071 19208741
MESH:D001943 Breast Neoplasms Diethylnitrosamine 3.6417474063
MESH:D001943 Breast Neoplasms Fluorouracil 3.6419217205 16595493 16110121 15136595 18357371 16557594 18608205
MESH:D001943 Breast Neoplasms Quercetin 3.6418628248
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.6420435547
MESH:D001943 Breast Neoplasms Toluene 2,4-Diisocyanate 3.6411921183
MESH:D016535 Bronchial Hyperreactivity Toluene 2,4-Diisocyanate 4.3815590891 8156442 12507178
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.9515286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.7617687719 10378619
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.1311589617
MESH:D002105 Cadmium Poisoning Quercetin 5.3316962696
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.5718705752 16192424 16227642 16050911 15673190 16011737 15700767 16124888 15721981 16097048 10355542 3786805
MESH:D002276 Carcinoid Tumor Fluorouracil 4.4616051944
MESH:D002277 Carcinoma Fluorouracil 7.6417121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.6416835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 13.553084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 13.5515553829 14691202 15073043 16217749 11135700
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 13.5518788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 13.5516779866 16878318 19335982 19208518 16288022 17761372 17138121 18788625 19394651 16502159 17173139 20727157 17978847 18393292 16540662 16328049 21159647 19052882 3581430 18210153 18506893 20514400 19171122 3084413 20084675 19418558 19822196 16569478 19519916 20101231 11831363 20432363 16830150 18691550 19539802 10672840 18785209 20512989 17428255 18665156 18978308 20214788 19701751 16935385 20935162 19383236 20007298 19919837 16807293 18056438 20524982 17162532 10737359 17055752 19107877 18494052 16681979 16698587 18971187
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 13.5517971768 17045692 17088986 18930000 16799960 16332177
MESH:D006528 Carcinoma, Hepatocellular Quercetin 13.5519519916 12508355
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 13.5515276417 17306315 16507464
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.7517234771
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.6619014326
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.9218695887
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.9312490120
MESH:D002294 Carcinoma, Squamous Cell decitabine 7.2419215824
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 7.2417066447 16280240 16757204 18986760
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 7.2418572023
MESH:D006332 Cardiomegaly Quercetin 6.4219794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.4218670907 16120746 18850075
MESH:D002386 Cataract Acetaminophen 2.4610977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10.3820889678
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 10.3817174075 7505956 21159647 2727394
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 10.3819524636 20056578
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.7419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.7416835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.2317333356 16105132 11677210 15861022 17110522 16919318 17681005
MESH:D002779 Cholestasis pirinixic acid 7.2319176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0216354765 8697196 12621046 15668235 15340226
MESH:D003093 Colitis, Ulcerative Dinitrochlorobenzene 3.7817373747 19159591
MESH:D003110 Colonic Neoplasms decitabine 8.0117616700
MESH:D003110 Colonic Neoplasms Fluorouracil 8.0115001691 17018589 16510598 17172411 17725105 18772588 17169374 17016597 17287894 16340194
MESH:D003110 Colonic Neoplasms irinotecan 8.0117725105 17287894
MESH:D003110 Colonic Neoplasms Quercetin 8.0117191121 19440933 11134977 15741050 19056647 17148506 16640504
MESH:D015179 Colorectal Neoplasms arsenic trioxide 6.2620501625
MESH:D015179 Colorectal Neoplasms decitabine 6.2618981723
MESH:D015179 Colorectal Neoplasms Fluorouracil 6.2615289873 16282729 17255274 17695437 17016601 17454858 16331619 16524972 17094418 18509181 14970324 16303861 18448328 18802399 16391804 17401013 18949393 18383874 18288408 20501625 15148649 17594712
MESH:D015179 Colorectal Neoplasms irinotecan 6.2617159606 16303861 18259882 18509181 16391804 15273666 17454858
MESH:D015179 Colorectal Neoplasms Quercetin 6.2618095365 18852136
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8817141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 3.9812609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.7110525206
MESH:D019465 Craniofacial Abnormalities Benzene 3.7115643154
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.7110048152 15322242 20055451
MESH:D007644 Darier Disease Fluorouracil 4.5816733453
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.9015213294
MESH:D003872 Dermatitis Benzene 4.5615902427
MESH:D017449 Dermatitis, Allergic Contact Dinitrochlorobenzene 7.1315491423
MESH:D017449 Dermatitis, Allergic Contact Toluene 2,4-Diisocyanate 7.1312956900 15491423 18759878
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3318249437
MESH:D003877 Dermatitis, Contact Oxazolone 9.5312811023 15944321
MESH:D003877 Dermatitis, Contact Toluene 2,4-Diisocyanate 9.5317010967
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 8.2119496084
MESH:D003921 Diabetes Mellitus, Experimental vanadyl sulfate 8.2116684804
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.0420387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.0417107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 11.3419164858 11529661 16227642 11739529 16177239 12392966 17522070 16393943 15968718 19370779 15619225 17562736 2444490 14550746 12958197 10663392 12594235 16485898 11421492 11743745 19739265 12540782 11834606 10774834 16081117 19416960 19420014 18071297 16109766 11461765 19085960 12153990 14986274 18713872 11287661 16781746 17906064 12705907 19923254 14725611 10915739
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 11.3419085960 9327722 6623471 16227642 15968718 17522070 15998439 2869522 7440962 10092053 16177239 4309450 11566570 15027814 7120509 10915739 3732212 7179309 3786805 21278145 19336974 6884620
MESH:D056486 Drug-Induced Liver Injury cyanoginosin LR 11.3417654400
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 11.3419107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.3420420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8919426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6111462148
MESH:D004487 Edema Mustard Gas 10.3411428647 11402378 9260866 11428631
MESH:D004487 Edema pirinixic acid 10.3412083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.3411000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6918230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 2.9912538720
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.9019294695
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.8410568697 9294722
MESH:D004802 Eosinophilia Toluene 2,4-Diisocyanate 4.458156442
MESH:D004890 Erythema Mustard Gas 4.959357497
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9016302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.9420426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 6.9412903497
MESH:D004938 Esophageal Neoplasms Fluorouracil 6.9416481741 17638652 16785472 16337965 15173087
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8611564622
MESH:D005128 Eye Diseases Toluene 2,4-Diisocyanate 5.5418447907
MESH:D005234 Fatty Liver arsenic trioxide 22.6315073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 22.6312795759 15959796 19224547 16045604 61145 16239168 12631006 17595544
MESH:D005234 Fatty Liver Diethylnitrosamine 22.6320387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 22.6315345470
MESH:D005234 Fatty Liver pirinixic acid 22.6319236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2511858732
MESH:D005355 Fibrosis Carbon Tetrachloride 13.6118705752
MESH:D005355 Fibrosis Quercetin 13.6119474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.6120067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.0616904648
MESH:D005756 Gastritis Acetaminophen 3.4616983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.4716452187
MESH:D005909 Glioblastoma Quercetin 3.2619804834
MESH:D005910 Glioma Fluorouracil 5.9116145905
MESH:D005910 Glioma Quercetin 5.9117643826
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3810696789
MESH:D006258 Head and Neck Neoplasms decitabine 7.4419215824
MESH:D006258 Head and Neck Neoplasms Fluorouracil 7.4415162350 15102660 18337622
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.2210048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.4120558911
MESH:D006402 Hematologic Diseases Benzene 4.4616183116
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1511000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.3919900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 7.5719176532 16221962 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.5716120746 15340226 12621046
MESH:D006689 Hodgkin Disease sodium arsenite 2.9812676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8318606429 15340226 16959395 16354765 8697196
MESH:D006930 Hyperalgesia Acetaminophen 2.5416870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3216899240
MESH:D006943 Hyperglycemia pirinixic acid 8.6320558911
MESH:D006943 Hyperglycemia Quercetin 8.6311834736 18262572
MESH:D006967 Hypersensitivity Butylated Hydroxytoluene 8.8017604070
MESH:D006967 Hypersensitivity Toluene 2,4-Diisocyanate 8.8011019492 10880147
MESH:D006973 Hypertension Benzene 8.2517940673
MESH:D006973 Hypertension Quercetin 8.2518356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.2518670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.8815338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6016945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2712013081
MESH:D007248 Infertility, Male decitabine 10.4317581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 10.4317937319
MESH:D007248 Infertility, Male sodium arsenite 10.4315346721 12646999
MESH:D007249 Inflammation Diethylnitrosamine 7.6918785209
MESH:D007249 Inflammation Mustard Gas 7.698975870 11428631 17524151 11402378 9357497 11428647 11428620 9260866 16001271
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.6912200463 12878042
MESH:D007251 Influenza, Human Quercetin 4.3016624496
MESH:D007333 Insulin Resistance pirinixic acid 2.5016306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1516580747
MESH:D007627 Keloid Quercetin 4.7517086741
MESH:D007674 Kidney Diseases Acetaminophen 9.4115629191 12587719
MESH:D007674 Kidney Diseases Quercetin 9.4116962696
MESH:D007674 Kidney Diseases sodium arsenite 9.4120008137
MESH:D007680 Kidney Neoplasms Fluorouracil 3.1416985049
MESH:D007938 Leukemia arsenic trioxide 14.1615070760
MESH:D007938 Leukemia Benzene 14.1614694614 18335105 17119257 15935818
MESH:D007938 Leukemia decitabine 14.1618980019 19235587
MESH:D007938 Leukemia Quercetin 14.1617468513
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.6117077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.1016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.2714633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 14.9919077051
MESH:D007951 Leukemia, Myeloid Benzene 14.9917506065
MESH:D007951 Leukemia, Myeloid decitabine 14.9918454857 19117987 17236224
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 6.0020471514 19850784 16968895 16467208 17050201
MESH:D015470 Leukemia, Myeloid, Acute Benzene 6.0019478238
MESH:D015470 Leukemia, Myeloid, Acute decitabine 6.0019010910 17679729 18206229 18460780 19387464 18704418
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.2518055864
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.0819075265 17869043 15622746 16330433 17649720 11161223 17712046 15336539 15213294 12679006 19035177 15748426 12018890 19225113 9834237 16331271 11468182 16966277 16823087 16891316 17107899 19642359 17217047 12712474 16112521
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.1516882451
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.2317174718 11903743 17157831 11408273 16221502 16943688 16239168 21278145 17334410
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.2319638242 18407596 18665156 18522880 20032147
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 4.7212445418 16638106 14512876 18472094 15370692 16011737 12666154 20821823 17823541 14748882 14716496 15959796 12649538 18481824 15925388 17565644 17557913 18395095 14620537 18187930 18006644 17481882 12389079 12586293 17698563 18277467 15818738 18263696 12898905 17976157 17761835 16136751 17714472 18472332 18054572 12609069 18412020 16097048 18251166 17944888 18376398 15052691 12546737 17900296 18395914 17922224 16015684 12632512 17708605 15931870 18156304 18166357 15730626 15057751 18205269 11481614 15876570 15123356 17721639 18420326 12667390 16192424 18279442 18705752 18429990 14716833 10355542 15650968 15338365 17631135 15673190 16033810 13678700 17869086 18418968 12741479 15996030 18317297 18210741 15893842 16027843 17766677 12958196 14724832 17525996 16116963 16248980 18339082 12445421 15362042 17805973 17640975 12632514
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.7215474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 4.7212741479
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.7212878042
MESH:D008107 Liver Diseases Acetaminophen 6.1419014921 19784758 16610002 12969438 19460945 16611625 11587558 12587719
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.1416964402 15830285 17285989 16246199 15720792
MESH:D008107 Liver Diseases Diethylnitrosamine 6.1417034775
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9615123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.8016871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.8014706259 16899240
MESH:D008113 Liver Neoplasms arsenic trioxide 28.6114682389
MESH:D008113 Liver Neoplasms Butylated Hydroxytoluene 28.6118177683
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 28.6119294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 28.612862719 19812893 12112319 19254457 21167192 20101389 10737359 20452335 21278145 18648771 19426721 18754104 20492335 19294768 12771043 18644402 19642983 20583210 21071580 19850985 19996281 19090486 19638242 18978307 19073162 19551842 16942905 18977376 19833225 15175105 19690152 2422723 19255062 20501860 19256749 20118626 9163691 20434301 19427195 15885732 19499222 20137499 20405173 21047994
MESH:D008113 Liver Neoplasms Fluorouracil 28.6118383874 15113037 16603448 17045692
MESH:D008113 Liver Neoplasms pirinixic acid 28.6116377806 20007298 15890375
MESH:D008113 Liver Neoplasms Quercetin 28.6118980244
MESH:D008113 Liver Neoplasms sodium arsenite 28.6115276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 28.6116984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 21.6920377131
MESH:D008114 Liver Neoplasms, Experimental Benzene 21.6912562636
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 21.6915583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 21.6919539802 18164116 18544905 16842330 16267830 19519916 18079962 18253720 19009564 3124819 18775883 19126423 19004024 18093689 21159647 18308698 2563599 17942915 18282651 9362446 17174075 17854601
MESH:D008114 Liver Neoplasms, Experimental Quercetin 21.6919519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 21.6912151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.1915213294
MESH:D008171 Lung Diseases Mustard Gas 7.0818702808 18161513
MESH:D008171 Lung Diseases sodium arsenite 7.0819095001
MESH:D017563 Lung Diseases, Interstitial Benzene 4.6014698565
MESH:D008175 Lung Neoplasms arsenic trioxide 14.9019825857 11798837
MESH:D008175 Lung Neoplasms Benzene 14.9012562636
MESH:D008175 Lung Neoplasms Butylated Hydroxytoluene 14.9011246140 11696405 15390079 19359593 16337739 18597497 19925653
MESH:D008175 Lung Neoplasms Diethylnitrosamine 14.9021163286 20970405 20512841 6695378
MESH:D008175 Lung Neoplasms Fluorouracil 14.9015246190
MESH:D008175 Lung Neoplasms Mustard Gas 14.903148597 8781369
MESH:D008175 Lung Neoplasms Quercetin 14.9016280456
MESH:D008175 Lung Neoplasms sodium arsenite 14.9019931552 16712894 15276417 17306315 17077188
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 14.9019555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.5815086387
MESH:D008223 Lymphoma Benzene 7.3317119257 17584886
MESH:D008223 Lymphoma decitabine 7.3319470736
MESH:D015674 Mammary Neoplasms, Animal Benzene 4.2312562636
MESH:D008325 Mammary Neoplasms, Experimental Benzene 6.2211921183
MESH:D008325 Mammary Neoplasms, Experimental Butylated Hydroxytoluene 6.221500032
MESH:D008545 Melanoma decitabine 5.0916505122 17785578
MESH:D008545 Melanoma Dinitrochlorobenzene 5.0917334785 12202904
MESH:D008545 Melanoma sodium arsenite 5.0916487513 19082730
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3619513568
MESH:D009062 Mouth Neoplasms Fluorouracil 3.4716757204 18986760
MESH:D052016 Mucositis irinotecan 4.8017159606
MESH:D009101 Multiple Myeloma arsenic trioxide 11.3519417148 14977855 19549372 15949261 11468182
MESH:D009101 Multiple Myeloma Benzene 11.3517119195
MESH:D009101 Multiple Myeloma decitabine 11.3518172295
MESH:D009135 Muscular Diseases pirinixic acid 3.3016239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.4618349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.1116105982 16882451
MESH:D009190 Myelodysplastic Syndromes decitabine 7.1119157545 16882708 18608210 19010910
MESH:D009203 Myocardial Infarction pirinixic acid 5.4419151258
MESH:D009203 Myocardial Infarction Quercetin 5.4419595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8512213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.9116411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 7.9119207477
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.7616624393
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.683581430 9029167
MESH:D009362 Neoplasm Metastasis irinotecan 5.6818259882
MESH:D009369 Neoplasms decitabine 14.6419470736 17925555 19116145
MESH:D009369 Neoplasms Fluorouracil 14.6418600527 16928823 18239605
MESH:D009369 Neoplasms pirinixic acid 14.6417405874
MESH:D009369 Neoplasms Quercetin 14.6415185748
MESH:D009369 Neoplasms sodium arsenite 14.6411559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 8.8120056578
MESH:D009374 Neoplasms, Experimental Toluene 2,4-Diisocyanate 8.811670384
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.0114600291
MESH:D009436 Neural Tube Defects arsenic trioxide 11.4510525206
MESH:D009436 Neural Tube Defects Benzene 11.4515643154
MESH:D009436 Neural Tube Defects sodium arsenite 11.4512854658
MESH:D009447 Neuroblastoma irinotecan 7.018761367
MESH:D009447 Neuroblastoma Topotecan 7.0115176712
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.6218514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.6220387270
MESH:D017599 Neuroectodermal Tumors irinotecan 4.528761367
MESH:D020078 Neurogenic Inflammation Quercetin 4.1717929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9020387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.3016436463
MESH:D009503 Neutropenia Mustard Gas 3.787688884 16761898
MESH:D009765 Obesity pirinixic acid 1.7620558911
MESH:D009784 Occupational Diseases Benzene 9.0315727169 15576619 17119257 15913788 15612468 17479406 15935809 16737584 17178637
MESH:D009784 Occupational Diseases Toluene 2,4-Diisocyanate 9.0318394133 3040596 6091946 11077013 12585506 6091945 8156442
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.0219495926
MESH:D010051 Ovarian Neoplasms arsenic trioxide 14.2819769630 16624393 12452020
MESH:D010051 Ovarian Neoplasms Benzene 14.2812562636
MESH:D010051 Ovarian Neoplasms decitabine 14.2819331143 19259094
MESH:D010051 Ovarian Neoplasms Quercetin 14.2819005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 14.2815276417 17306315
MESH:D010146 Pain Acetaminophen 2.2316870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 15.5215580305
MESH:D010190 Pancreatic Neoplasms decitabine 15.5219294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 15.5216540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 15.5215113037 16929163 19003803 16500647
MESH:D010190 Pancreatic Neoplasms Quercetin 15.5216965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4911578682
MESH:D010235 Paraganglioma arsenic trioxide 3.9719927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0412520081
MESH:D011014 Pneumonia Butylated Hydroxytoluene 4.9511893704
MESH:D011041 Poisoning Mustard Gas 3.6015727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3618163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.642563599
MESH:D011230 Precancerous Conditions Quercetin 8.6419056647
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.9811896295 11399792 11222880 11118676
MESH:D055728 Primary Myelofibrosis decitabine 4.5217616702
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.1419131511
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.1419082440 18626508
MESH:D011471 Prostatic Neoplasms Quercetin 2.1414715546 17292933
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.1416039940
MESH:D011537 Pruritus Ethinyl Estradiol 8.8216919318 15861022
MESH:D011537 Pruritus Mustard Gas 8.8218058305
MESH:D011657 Pulmonary Eosinophilia Toluene 2,4-Diisocyanate 5.4114606601
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.8517894541 10334151 17620002 17720292 17266442
MESH:D012004 Rectal Neoplasms Fluorouracil 3.8315538739 18722050 16160472 18286688
MESH:D015427 Reperfusion Injury pirinixic acid 2.2919058328
MESH:D012130 Respiratory Hypersensitivity Toluene 2,4-Diisocyanate 4.3020219652 7692837 16940033
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6418990726
MESH:D012140 Respiratory Tract Diseases Toluene 2,4-Diisocyanate 4.9118447907
MESH:D012208 Rhabdomyosarcoma decitabine 4.2119155313
MESH:D012220 Rhinitis Toluene 2,4-Diisocyanate 4.4019050374
MESH:D012221 Rhinitis, Allergic, Perennial Toluene 2,4-Diisocyanate 5.0715015336 12617775
MESH:D006255 Rhinitis, Allergic, Seasonal Toluene 2,4-Diisocyanate 5.3019075512
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.7616646077
MESH:D012554 Schistosomiasis japonica Quercetin 5.3316862918
MESH:D012871 Skin Diseases Mustard Gas 2.6615451306 12880345 16961503
MESH:D012878 Skin Neoplasms sodium arsenite 8.8718572023 19524636
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 8.878532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.8716192470
MESH:D012912 Sneezing Toluene 2,4-Diisocyanate 5.3019075512 19050374
MESH:D013088 Spermatocele Ethinyl Estradiol 3.7316709447
MESH:D016135 Spinal Dysraphism sodium arsenite 3.6412854658
MESH:D013274 Stomach Neoplasms arsenic trioxide 8.0217007042
MESH:D013274 Stomach Neoplasms Benzene 8.0212562636
MESH:D013274 Stomach Neoplasms decitabine 8.0219037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 8.0218456281
MESH:D013274 Stomach Neoplasms Fluorouracil 8.0219015929 17522103 16951190 18567086 19084572 18396642 17172411 15786421 16424979 17498489
MESH:D013274 Stomach Neoplasms irinotecan 8.0215723263
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9815669648
MESH:D013953 Thymus Neoplasms Benzene 4.7410850423
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6912697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 11.1019014326
MESH:D013964 Thyroid Neoplasms decitabine 11.1017967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 11.107505956
MESH:D014062 Tongue Neoplasms Fluorouracil 3.8116280240
MESH:D016171 Torsades de Pointes arsenic trioxide 3.7515213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 11.2911780464 20435036 12973940 12845720
MESH:D001749 Urinary Bladder Neoplasms decitabine 11.2917616700 19087683
MESH:D001749 Urinary Bladder Neoplasms Quercetin 11.2916720314
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 11.2916712894 17306315 11723127 16452187
MESH:D014581 Urticaria Acetaminophen 2.7810982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 8.8816803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 8.8811813266
MESH:D014594 Uterine Neoplasms Benzene 8.9012562636
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.9014692618
MESH:D014604 Uveal Neoplasms decitabine 4.7017785578
MESH:D014652 Vascular Diseases sodium arsenite 4.2117056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3812125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3514671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0415886252
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved