AutismKB 2.0

Annotation Detail for NOL3


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Basic Information Top
Gene Symbol:NOL3 ( ARC,FLJ35304,MYP,NOP,NOP30 )
Gene Full Name: nucleolar protein 3 (apoptosis repressor with CARD domain)
Band: 16q22.1
Quick LinksEntrez ID:8996; OMIM: 605235; Uniprot ID:NOL3_HUMAN; ENSEMBL ID: ENSG00000140939; HGNC ID: 7869
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1766Renal Cell cancer
1875AIDS
1878Ischemia
1944Breast cancer
2053Colon cancer
2075Heart failure
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C014024 2,4,5,2',4',5'-hexachlorobiphenyl 2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of NOL3 mRNAincreases expression 20005886
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of NOL3 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of NOL3 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of NOL3 mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of NOL3 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NOL3 mRNAaffects expression 16483693
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of NOL3 mRNAaffects cotreatment|increases expression 18164116
D020111 Chlorodiphenyl (54% Chlorine) Chlorodiphenyl (54% Chlorine) results in increased expression of NOL3 mRNAincreases expression 16934159
C030123 coumarin coumarin results in increased expression of NOL3 mRNAincreases expression 18480146
D016572 Cyclosporine Cyclosporine results in decreased expression of NOL3 mRNAdecreases expression 20106945
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of NOL3 mRNAaffects cotreatment|increases expression 18164116
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of NOL3 mRNAincreases expression 19638242
D005419 Flavonoids Flavonoids results in decreased expression of NOL3 mRNAdecreases expression 18035473
D005665 Furosemide Furosemide affects the expression of NOL3 mRNAaffects expression 17497460
D006861 Hydrogen Peroxide Hydrogen Peroxide results in decreased expression of NOL3 proteindecreases expression 16157298
D010100 Oxygen Oxygen deficiency results in increased expression of NOL3 mRNAincreases expression 17914565
D010656 Phenylephrine Phenylephrine results in decreased phosphorylation of NOL3 proteindecreases phosphorylation 18171680
C006253 pirinixic acid pirinixic acid results in increased expression of NOL3 mRNAincreases expression 18301758
C025299 polyphenols polyphenols results in decreased expression of NOL3 mRNAdecreases expression 16293270
C031280 pyrazole pyrazole results in increased expression of NOL3 mRNAincreases expression 17945193
D012643 Selenium [Selenium co-treated with Vitamin E] results in decreased expression of NOL3 mRNAaffects cotreatment|decreases expression 19244175
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in decreased expression of NOL3 mRNAaffects cotreatment|decreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.4518287403
MESH:D055371 Acute Lung Injury Oxygen 8.8816759491
MESH:D055371 Acute Lung Injury pirinixic acid 8.8818653653
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 10.853712494
MESH:D000236 Adenoma beta-Naphthoflavone 10.8519389873
MESH:D000236 Adenoma Diethylnitrosamine 10.8510737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 9.7317162532 19061943 16434500 17620307 19052882 18056438
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.7316434500
MESH:D000799 Angioedema Acetaminophen 3.7410982225
MESH:D000860 Anoxia Oxygen 4.9520872349
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 4.0117460149
MESH:D050197 Atherosclerosis Oxygen 3.7416391483
MESH:D001321 Autistic Disorder Acetaminophen 1.4318445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.911440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.0419483382
MESH:D001919 Bradycardia Phenylephrine 4.4415306635
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.5517474063
MESH:D001943 Breast Neoplasms Oxygen 2.5517263869
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.8216050911
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 8.6716705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 8.6716705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 8.673581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.673084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 8.6720007298 19383236 3084413 20101231 17173139 19394651 16288022 19822196 20524982 18971187 19701751 18665156 19208518 20727157 19919837 20512989 17761372 19107877 19171122 18691550 16502159 18785209 11831363 20084675 17055752 20514400 10672840 3581430 17138121 18494052 19539802 16830150 18393292 10737359 16569478 18978308 17978847 19519916 19052882 16878318 16935385 19418558 20214788 20432363 18506893 16779866 18210153 16540662 16328049 21159647 17162532 18056438 16698587 17428255 18788625 16807293 19335982 20935162 16681979
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.627296757
MESH:D006332 Cardiomegaly Phenylephrine 3.4711179087 11754973 17124262 15728586 16170337 17287366
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 3.4416936243
MESH:D002386 Cataract Acetaminophen 2.5210977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 15.386135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 15.387505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 15.3812371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 15.3817174075 7505956 21159647 2727394
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.5919052882
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 12.9019486331 9022650
MESH:D002779 Cholestasis Cyclosporine 12.9019486331
MESH:D002779 Cholestasis pirinixic acid 12.9019176532
MESH:D003092 Colitis Selenium 3.6717936198
MESH:D003110 Colonic Neoplasms polyphenols 2.6616293270
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9119769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 10.5318551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 10.5318551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.7011906362 11298694 2524372 8156756 14531868 8970840 12868966 18759878
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3818249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.392952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 coumarin 4.6919647726
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.6920387270
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 25.3618551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 25.3621346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 25.3618289764 1440618 18692083 9328219 16192314 6482804 9022650 11289319 18648102 7440962 8291058 6679447 9653073
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 25.3615619225 16781746 12594235 19416960 14986274 11743745 12392966 15968718 19420014 19085960 12958197 12705907 16393943 12540782 19923254 16081117 17522070 18071297 16485898 11739529 2444490 11287661 18713872 16109766 10663392 14550746 17562736 11461765 11421492 16177239 19370779 11834606 19164858 10915739 12153990 17906064 10774834 16227642 11529661 19739265 14725611
MESH:D056486 Drug-Induced Liver Injury Chlorodiphenyl (54% Chlorine) 25.3617851650
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 25.3619107877
MESH:D056486 Drug-Induced Liver Injury polyphenols 25.3619370779
MESH:D056486 Drug-Induced Liver Injury pyrazole 25.3612499123
MESH:D056486 Drug-Induced Liver Injury Selenium 25.3615131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9919426721
MESH:D004417 Dyspnea Furosemide 10.4516935035
MESH:D004417 Dyspnea Oxygen 10.4520016425
MESH:C538011 Eales disease Vitamin E 4.609068938
MESH:D004487 Edema Furosemide 6.8011834646
MESH:D004487 Edema pirinixic acid 6.8012083418
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.0116302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.083581430
MESH:D005234 Fatty Liver Cyclosporine 12.4619224547
MESH:D005234 Fatty Liver Diethylnitrosamine 12.4621071580 20387270
MESH:D005234 Fatty Liver pirinixic acid 12.4619236843 20131406
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.916705139
MESH:D005355 Fibrosis Cyclosporine 3.0312168785 12639820
MESH:D005739 Gas Poisoning Oxygen 5.1120016425
MESH:D005756 Gastritis Acetaminophen 3.5716983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.118708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.937505956
MESH:D034381 Hearing Loss Furosemide 4.7317868369
MESH:D006330 Heart Defects, Congenital Vitamin E 2.9316080930
MESH:D006333 Heart Failure Furosemide 11.5116845234 16011733 12660669
MESH:D006333 Heart Failure pirinixic acid 11.5120558911
MESH:D006333 Heart Failure Selenium 11.5117162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3115720958
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.416705139
MESH:D006529 Hepatomegaly pirinixic acid 2.8916221962 19772884 19176532 18467677
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6616490937 16863852
MESH:D019584 Hot Flashes Vitamin E 3.8714716179
MESH:D006930 Hyperalgesia Acetaminophen 2.6116870215
MESH:D006934 Hypercalcemia Furosemide 4.9717652376
MESH:D053565 Hypercalciuria Furosemide 5.5417652376
MESH:D006943 Hyperglycemia pirinixic acid 3.0820558911
MESH:D006962 Hyperparathyroidism, Secondary Furosemide 5.7715086907
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.8315034207
MESH:D006973 Hypertension Cyclosporine 5.2410903974
MESH:D006973 Hypertension Phenylephrine 5.2412717712 8949925
MESH:D046110 Hypertension, Pregnancy-Induced Furosemide 5.1816612254
MESH:D006984 Hypertrophy Phenylephrine 4.4512791704 18502941
MESH:C537153 Hypomagnesemia primary Furosemide 5.5411041285
MESH:D007019 Hypoproteinemia Furosemide 5.7716096441
MESH:D007022 Hypotension Furosemide 4.5111041285
MESH:D007024 Hypotension, Orthostatic Furosemide 5.3115811171
MESH:D007249 Inflammation Diethylnitrosamine 8.1418785209
MESH:D007249 Inflammation Flavonoids 8.1417296493
MESH:D007249 Inflammation polyphenols 8.1416366677
MESH:D007251 Influenza, Human Selenium 10.6116624496
MESH:D007251 Influenza, Human Vitamin E 10.6116624496
MESH:D007333 Insulin Resistance pirinixic acid 2.5616306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.919022650 8074119
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3415604871
MESH:D007674 Kidney Diseases Acetaminophen 13.9512587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 13.9510903974 8314463 18776723
MESH:D007674 Kidney Diseases Furosemide 13.9511041285
MESH:D007674 Kidney Diseases Vitamin E 13.9512488133
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 9.6916518626
MESH:D007676 Kidney Failure, Chronic Selenium 9.6916518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 16.9916705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 16.9916705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 16.996582329
MESH:D007680 Kidney Neoplasms Cyclosporine 16.9912371664
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.7618407596 20032147 19638242 18522880 18665156
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.1315034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3415474484
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.3416169303
MESH:D008107 Liver Diseases Acetaminophen 6.4019460945 12587719 19784758 16611625 12969438 16610002 19014921 11587558
MESH:D008107 Liver Diseases Diethylnitrosamine 6.4017034775
MESH:D008107 Liver Diseases polyphenols 6.4016698588
MESH:D017114 Liver Failure, Acute Acetaminophen 3.1417185352 16871587
MESH:D008113 Liver Neoplasms 2,4,5,2',4',5'-hexachlorobiphenyl 13.8316835634 18644402
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 13.837678174
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 13.8321295105 19389873
MESH:D008113 Liver Neoplasms Diethylnitrosamine 13.8319256749 20101389 21071580 16942905 20118626 19812893 10737359 19499222 20434301 20137499 9163691 19690152 21047994 19254457 19642983 19073162 20405173 20452335 19850985 19427195 21167192 18648771 19833225 12771043 18978307 18977376 15885732 18754104 19294768 12112319 19551842 21278145 2422723 19638242 19996281 18644402 19255062 15175105 20492335 19426721 20583210 2862719 20501860 19090486
MESH:D008113 Liver Neoplasms pirinixic acid 13.8315890375 16377806 20007298
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 13.582876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 13.58598648 3712494 6587162 1399818
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 13.5818164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 13.5821159647 18544905 19004024 19126423 16267830 18164116 19539802 18253720 9362446 18079962 18093689 18775883 17854601 3124819 2563599 16842330 19009564 19519916 17942915 18308698 18282651 17174075
MESH:D008171 Lung Diseases Vitamin E 3.1016863852
MESH:D055370 Lung Injury Oxygen 4.4018339021
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.4620970405 20512841 21163286 6695378
MESH:D008175 Lung Neoplasms Vitamin E 2.4611062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.6915318939
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4619513568
MESH:D008654 Mesothelioma Selenium 2.7515107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.6816801185
MESH:D009135 Muscular Diseases pirinixic acid 3.4016239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1019151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.8616411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 9.9818551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 9.987678174 18551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.563581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.563581430 9029167
MESH:D009369 Neoplasms 2,4,5,2',4',5'-hexachlorobiphenyl 5.198820588
MESH:D009369 Neoplasms pirinixic acid 5.1917405874
MESH:D009397 Nephrocalcinosis Furosemide 5.7715086907
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1919348381 18481113
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.846679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.8818514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.8820387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.0120387270
MESH:D053206 Nocturnal Enuresis Furosemide 5.7717945291
MESH:D009765 Obesity pirinixic acid 1.7920558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 14.5012819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 14.5016049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 14.506482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.913988306
MESH:D010146 Pain Acetaminophen 2.3016870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.3816540662
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 8.957296757
MESH:D010212 Papilloma Hydrogen Peroxide 8.9512065085
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.366228378
MESH:D010954 Plasmacytoma Selenium 4.7815087411
MESH:D011141 Polyuria Furosemide 5.5417945291
MESH:D011230 Precancerous Conditions Cyclosporine 8.6312371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.632563599
MESH:D011471 Prostatic Neoplasms Vitamin E 3.3415084515
MESH:D011565 Psoriasis Cyclosporine 2.1916882103
MESH:D015427 Reperfusion Injury Furosemide 6.6316526316
MESH:D015427 Reperfusion Injury pirinixic acid 6.6319058328
MESH:D012128 Respiratory Distress Syndrome, Adult Furosemide 9.3616096441 15912074 12394941
MESH:D012128 Respiratory Distress Syndrome, Adult Oxygen 9.3618339021 17627322
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.293692021
MESH:D012640 Seizures 2,4-dinitrotoluene 5.6218551238
MESH:D012640 Seizures 2,6-dinitrotoluene 5.6218551238
MESH:D012852 Sinusitis Phenylephrine 4.597327846
MESH:D012871 Skin Diseases Vitamin E 2.4118709164
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 3.0212065085
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.7818456281
MESH:D013274 Stomach Neoplasms Furosemide 2.7817052386
MESH:D020521 Stroke Vitamin E 3.4316517955
MESH:D013398 Sudden Infant Death Oxygen 5.4312563064
MESH:D013705 Temporomandibular Joint Disorders polyphenols 5.1517997062
MESH:D013733 Testicular Diseases pyrazole 4.716499806
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 6.843712494 6587162 1399818 6582329 7505956
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 6.847505956
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.0316049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.0316049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.038074119
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 11.6310091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 11.6310091137
MESH:D014581 Urticaria Acetaminophen 2.8710982225
MESH:D014605 Uveitis Cyclosporine 3.881336536
MESH:D014689 Venous Insufficiency coumarin 5.6712708602
MESH:D014985 Xerophthalmia Cyclosporine 4.3417120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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