AutismKB 2.0

Annotation Detail for KALRN


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Basic Information Top
Gene Symbol:KALRN ( ARHGEF24,DUET,DUO,FLJ12332,FLJ16443,FLJ18196,FLJ18623,HAPIP,TRAD )
Gene Full Name: kalirin, RhoGEF kinase
Band: 3q21.1-q21.2
Quick LinksEntrez ID:8997; OMIM: 604605; Uniprot ID:KALRN_HUMAN; ENSEMBL ID: ENSG00000160145; HGNC ID: 4814
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Signaling by GPCR
Signalling by NGF
Signaling by Rho GTPases
Pathway IDPathway Name
200079Arf6 downstream pathway
200165Regulation of RAC1 activity
200041EPHB forward signaling
Pathway IDPathway Name
P00029Huntington disease
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1740Alzheimer's disease
1918Atherosclerosis
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of KALRN mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of KALRN mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of KALRN mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of KALRN mRNAincreases expression 20458559
C015001 arsenite arsenite results in decreased expression of KALRN mRNAdecreases expression 18929588
C015001 arsenite TRP53 protein affects the reaction [arsenite results in decreased expression of KALRN mRNA]affects reaction|decreases expression 18929588
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of KALRN mRNAaffects cotreatment|increases expression 18164116
C055494 caffeic acid phenethyl ester [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of KALRN mRNAaffects cotreatment|decreases expression 20360939
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of KALRN mRNAaffects expression 17484886
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of KALRN mRNAaffects cotreatment|increases expression 18164116
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of KALRN mRNAaffects cotreatment|decreases expression 20360939
D005419 Flavonoids Flavonoids results in decreased expression of KALRN mRNAdecreases expression 18035473
C025462 sulindac sulfide sulindac sulfide results in decreased expression of KALRN mRNAdecreases expression 16184548
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of KALRN mRNAdecreases expression 18796159
C025643 vinclozolin vinclozolin affects the expression of KALRN mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9611752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.6818287403
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3019825857 11798837
MESH:D000236 Adenoma beta-Naphthoflavone 7.0319389873
MESH:D000236 Adenoma Diethylnitrosamine 7.0310737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.4516434500 17162532 19061943 17620307 18056438 19052882
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.4516835633
MESH:D000544 Alzheimer Disease sulindac sulfide 3.1018759972
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0211748828
MESH:D000799 Angioedema Acetaminophen 3.9810982225
MESH:D001008 Anxiety Disorders vinclozolin 3.7019015723
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.2316206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.2312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9617474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9620435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.4211589617
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.8815700767 16124888 16227642 18705752 15721981 16192424 15673190 10355542 3786805 16097048 16011737 16050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8616835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 9.0016705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.003084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 9.0011135700 14691202 15553829 16217749 15073043
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 9.0018788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 9.0011831363 17173139 16830150 16288022 3581430 17761372 19383236 18788625 20935162 19701751 19519916 19919837 19107877 18506893 16698587 19052882 20512989 18210153 19822196 16502159 20007298 16328049 17428255 19539802 18056438 17978847 18971187 20514400 16935385 18393292 20084675 19171122 16569478 17138121 18785209 20727157 18691550 16878318 19394651 3084413 17162532 19208518 20432363 17055752 20524982 10672840 16807293 21159647 18494052 16540662 20214788 20101231 16779866 18978308 10737359 18665156 16681979 19335982 19418558
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfide 3.4712391285
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.0119014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.1912490120
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4118670907 18850075 16120746
MESH:D002386 Cataract Acetaminophen 2.6310977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.886135515
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 6.882727394 17174075 21159647 7505956
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.5719052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.5716835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1315668235 15340226 12621046 8697196 16354765
MESH:D003110 Colonic Neoplasms arsenite 2.6015037631
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1317141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 4.2812609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.4910525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4910048152 20055451 15322242
MESH:D003456 Cryptorchidism vinclozolin 4.4414966744
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.1218551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.1815213294
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.2820387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2817107852
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.2518551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.2516393943 16781746 19420014 12705907 12392966 11421492 10774834 14986274 19923254 19739265 2444490 12153990 12540782 16109766 15619225 11834606 16485898 19085960 17562736 16227642 19370779 11461765 11739529 14725611 19164858 15968718 11743745 17522070 12594235 12958197 11529661 10915739 14550746 19416960 18713872 18071297 10663392 16081117 17906064 11287661 16177239
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 12.256623471 17522070 11566570 16177239 10092053 4309450 6884620 15998439 19336974 16227642 3786805 7440962 3732212 21278145 15027814 15968718 7120509 19085960 7179309 9327722 2869522 10915739
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 12.2519107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.2520420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8211462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4611000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0416714409 15322242 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.109294722 10568697
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2516302075
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3312903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0711564622
MESH:D005234 Fatty Liver arsenic trioxide 19.5315073043
MESH:D005234 Fatty Liver arsenite 19.5318296743
MESH:D005234 Fatty Liver Carbon Tetrachloride 19.5312631006 17595544 12795759 16239168 15959796 61145 19224547 16045604
MESH:D005234 Fatty Liver Diethylnitrosamine 19.5321071580 20387270
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D005355 Fibrosis arsenite 15.4718296743
MESH:D005355 Fibrosis Carbon Tetrachloride 15.4718705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 15.4720067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.3616904648
MESH:D005756 Gastritis Acetaminophen 3.8116983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.0516973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.4316417039
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3711294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.6919900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0015340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1816354765 8697196 18606429 15340226 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.7616870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6516899240
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9318670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1915338365
MESH:D007248 Infertility, Male vinclozolin 3.0916467254
MESH:D007249 Inflammation Diethylnitrosamine 8.5418785209
MESH:D007249 Inflammation Flavonoids 8.5417296493
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.5412878042 12200463
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 4.6610783313
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4216580747
MESH:D007674 Kidney Diseases Acetaminophen 6.3912587719 15629191
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 6.3915369732
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.0416705839
MESH:D007938 Leukemia arsenic trioxide 2.8715070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.8812560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.4216972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.4914633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.8419077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1516467208 20471514 17050201 19850784 16968895
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 8.129834237 15622746 17712046 17869043 16112521 17217047 17649720 16966277 11468182 19225113 15213294 12018890 16891316 15748426 17107899 12679006 19035177 11161223 19642359 12712474 19075265 16331271 16823087 15336539 16330433
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 8.1216766008
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.4516882451
MESH:D007984 Leydig Cell Tumor vinclozolin 4.8516417039
MESH:D008103 Liver Cirrhosis arsenite 11.3418296743
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 11.3421278145 16943688 16239168 11408273 16221502 17334410 17174718 17157831 11903743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 11.3418522880 19638242 20032147 18407596 18665156
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.3118472094 17766677 18395914 12586293 16248980 15362042 17714472 18481824 18376398 14716833 15925388 12667390 15931870 15893842 12389079 13678700 14716496 15959796 14620537 17525996 18210741 15650968 14512876 17900296 17823541 15996030 17922224 11481614 12898905 18420326 16638106 15876570 16015684 18317297 17698563 18429990 17805973 12741479 15370692 18279442 17557913 15057751 15338365 17640975 18412020 16011737 14748882 18705752 18054572 18395095 15818738 17565644 16136751 17721639 17869086 16027843 18472332 17944888 17481882 18418968 12649538 16192424 12546737 17976157 18251166 18166357 12666154 12958196 12445418 18263696 18277467 20821823 18006644 18205269 12632514 17631135 15673190 16116963 17708605 16097048 17761835 18339082 15730626 18187930 12445421 12609069 15052691 16033810 14724832 12632512 10355542 18156304 15123356
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3112878042
MESH:D008107 Liver Diseases Acetaminophen 6.5919784758 16611625 19460945 11587558 19014921 12587719 12969438 16610002
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.5915720792 16964402 16246199 17285989 15830285
MESH:D008107 Liver Diseases Diethylnitrosamine 6.5917034775
MESH:D017093 Liver Failure Carbon Tetrachloride 4.2715123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.6716871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.6716899240 14706259
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 18.387678174
MESH:D008113 Liver Neoplasms arsenic trioxide 18.3814682389
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 18.3821295105 19389873
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 18.3819294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 18.3820492335 20452335 18978307 21278145 19255062 19638242 20118626 19499222 20434301 18754104 20405173 19426721 21047994 12112319 20583210 19812893 19551842 19690152 19090486 18644402 21071580 20137499 2422723 19294768 19642983 12771043 19833225 18977376 19256749 18648771 9163691 19254457 20501860 20101389 19996281 15175105 21167192 19427195 19850985 19073162 10737359 16942905 15885732 2862719
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 18.3816984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 24.052876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 24.0520377131
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 24.0518164116
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 24.0512014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 24.052563599 19539802 17854601 16267830 3124819 18079962 18093689 19009564 19004024 18544905 17942915 18775883 18308698 16842330 19126423 18282651 21159647 9362446 18164116 19519916 17174075 18253720
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 24.0512151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4115213294
MESH:D008175 Lung Neoplasms arsenic trioxide 4.9319825857 11798837
MESH:D008175 Lung Neoplasms arsenite 4.9316809336
MESH:D008175 Lung Neoplasms Diethylnitrosamine 4.9321163286 20512841 20970405 6695378
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.9319555203 11884234
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6719513568
MESH:D009101 Multiple Myeloma arsenic trioxide 3.1619417148 19549372 15949261 11468182 14977855
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.8118349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.1816882451 16105982
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.9818551238 7678174
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.0516624393
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.593581430 9029167
MESH:D009389 Neovascularization, Pathologic arsenite 4.5315738583
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3114600291
MESH:D009436 Neural Tube Defects arsenic trioxide 3.1710525206
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.4118514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.4120387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2520387270
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.5116049721
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4319769630 16624393 12452020
MESH:D010146 Pain Acetaminophen 2.4616870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.3615580305
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.3616540662
MESH:D010235 Paraganglioma arsenic trioxide 4.2519927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.622563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.8811222880 11118676 11399792 11896295
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 9.8819015723 18220299 18042343
MESH:D011469 Prostatic Diseases vinclozolin 5.0518220299
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2619131511
MESH:D011472 Prostatitis vinclozolin 5.0518629315
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.0516646077
MESH:D012640 Seizures 2,6-dinitrotoluene 2.5918551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0816192470
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.4617007042
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.4618456281
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.4019014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.407505956
MESH:D016171 Torsades de Pointes arsenic trioxide 4.0815213294
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.1816049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.1812845720 20435036 12973940 11780464
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.4310091137
MESH:D014581 Urticaria Acetaminophen 3.0610982225
MESH:D014594 Uterine Neoplasms sulindac sulfide 4.7518645019
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
Pathway ID Pathway Name
REACT:14797 Signaling by GPCR
REACT:11044 Signaling by Rho GTPases
REACT:11061 Signalling by NGF
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29189
    • No data
    No data
    Releated drug ID Related drug Name
    PA448976choline
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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