AutismKB 2.0

Annotation Detail for NAT1


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Basic Information Top
Gene Symbol:NAT1 ( AAC1,MNAT,NAT-1,NATI )
Gene Full Name: N-acetyltransferase 1 (arylamine N-acetyltransferase)
Band: 8p22
Quick LinksEntrez ID:9; OMIM: 108345; Uniprot ID:ARY1_HUMAN; ENSEMBL ID: ENSG00000171428; HGNC ID: 7645
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00983Drug metabolism - other enzymes
hsa01100Metabolic pathways
hsa00232Caffeine metabolism
Pathway IDPathway Name
Biological oxidations
No data
No data
Pathway IDPathway Name
500214Acetylation
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1709Parkinson disease
1755Cleft palate
1934Cancer
2064Spinal dysraphism
2094Ulcerative colitis
2146Lupus erythematosus
Desease Name
increased chromosome aberrations and higher lung cancer risk
Contact Allergy
colorectal cancer
mild and severe substance abuse
prostate cancer
CANCER
Hepatitis
Asthma
bladder cancer
higher N-acetylation activity
breast cancer
IMMUNE
urinary bladder cancer
lung cancer
von Hippel-Lindau tumour
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C015262 1,6-hexamethylene diisocyanate NAT1 protein polymorphism results in increased susceptibility to 1,6-hexamethylene diisocyanateincreases response to substance 11927838
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of NAT1 mRNAaffects expression 21346803
C012177 2-aminofluorene NAT1 protein results in increased acetylation of 2-aminofluoreneincreases acetylation 16003948
15796204
15627487
C012177 2-aminofluorene NAT1 protein results in increased metabolism of 2-aminofluoreneincreases metabolic processing 16815960
C012177 2-aminofluorene NAT1 protein results in increased acetylation of 2-aminofluoreneincreases acetylation 15796213
C003898 2-anisidine NAT1 protein results in increased activity of 2-anisidineincreases activity 15450435
C075748 2-(bromoacetylamino)fluorene 2-(bromoacetylamino)fluorene results in decreased activity of NAT1 proteindecreases activity 14714730
C075748 2-(bromoacetylamino)fluorene 2-(bromoacetylamino)fluorene results in decreased activity of and results in increased alkylation of NAT1 proteindecreases activity|increases alkylation 15106881
C009501 2-tolidine NAT1 protein results in increased activity of 2-tolidineincreases activity 15450435
C002385 3-morpholino-sydnonimine 3-morpholino-sydnonimine results in decreased activity of NAT1 proteindecreases activity 14672957
C117220 3-nitrobenzanthrone NAT1 protein results in increased activity of 3-nitrobenzanthroneincreases activity 15805261
C009505 4,4'-diaminodiphenylmethane NAT1 protein results in increased acetylation of 4,4'-diaminodiphenylmethaneincreases acetylation 16192314
C005969 4,4'-diphenylmethane diisocyanate NAT1 protein polymorphism results in increased susceptibility to 4,4'-diphenylmethane diisocyanateincreases response to substance 11927838
C013813 4-anisidine NAT1 protein results in increased acetylation of 4-anisidineincreases acetylation 15627487
C006757 4-biphenylamine NAT1 protein results in increased acetylation of 4-biphenylamineincreases acetylation 12088197
C006757 4-biphenylamine NAT1 protein results in increased activity of 4-biphenylamineincreases activity 15450435
C006757 4-biphenylamine NAT1 protein results in increased metabolism of 4-biphenylamineincreases metabolic processing 16815960
C023621 4-bromoaniline NAT1 protein results in increased acetylation of 4-bromoanilineincreases acetylation 15627487
C004658 4-chloroaniline NAT1 protein results in increased acetylation of 4-chloroanilineincreases acetylation 15627487
C013067 4-iodoaniline NAT1 protein results in increased acetylation of 4-iodoanilineincreases acetylation 15627487
C029728 4-phenylenediamine NAT1 protein results in increased acetylation of 4-phenylenediamineincreases acetylation 15350687
C017429 5-iodosalicylic acid 5-iodosalicylic acid results in decreased activity of NAT1 proteindecreases activity 15450435
C421010 9-(4'-aminophenyl)-9H-pyrido(3,4-b)indole NAT1 protein affects the metabolism of 9-(4'-aminophenyl)-9H-pyrido(3,4-b)indoleaffects metabolic processing 17067997
D000082 Acetaminophen Acetaminophen affects the expression of NAT1 mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in increased expression of NAT1 proteinincreases expression 16538041
C518327 aloe emodin aloe emodin results in decreased expression of and results in decreased activity of NAT1 proteindecreases activity|decreases expression 16314733
C518327 aloe emodin aloe emodin results in decreased expression of NAT1 mRNAdecreases expression 16314733
D000588 Amines NAT1 protein results in increased acetylation of Aminesincreases acetylation 15122594
D010129 4-Aminobenzoic Acid NAT1 protein results in increased acetylation of 4-Aminobenzoic Acidincreases acetylation 14508638
D010129 4-Aminobenzoic Acid NAT1 protein results in increased acetylation of 4-Aminobenzoic Acidincreases acetylation 16003948
15627487
15880531
D015081 2-Naphthylamine NAT1 protein results in increased activity of 2-Naphthylamineincreases activity 15450435
D019804 Mesalamine NAT1 protein results in increased acetylation of Mesalamineincreases acetylation 15627487
D010131 Aminosalicylic Acid NAT1 protein results in increased acetylation of Aminosalicylic Acidincreases acetylation 16003948
15627487
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NAT1 mRNAaffects expression 16483693
D000814 Aniline Compounds NAT1 protein results in increased acetylation of Aniline Compounds analogincreases acetylation 15627487
D001241 Aspirin Aspirin results in decreased activity of NAT1 proteindecreases activity 15796213
C006680 baicalein baicalein results in decreased expression of NAT1 mRNAdecreases expression 15796204
C006680 baicalein baicalein results in decreased expression of NAT1 proteindecreases expression 15796204
C029876 benzidine NAT1 protein results in increased activity of benzidineincreases activity 15450435
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of NAT1 mRNAincreases expression 19150397
C056005 bromoacetanilide bromoacetanilide results in decreased activity of NAT1 proteindecreases activity 14714730
C056005 bromoacetanilide bromoacetanilide results in decreased activity of and results in increased alkylation of NAT1 proteindecreases activity|increases alkylation 15106881
D002220 Carbamazepine Carbamazepine results in increased expression of NAT1 mRNAincreases expression 17112801
D002338 Carotenoids NAT1 protein polymorphism affects the susceptibility to Carotenoidsaffects response to substance 15095308
D020111 Chlorodiphenyl (54% Chlorine) Chlorodiphenyl (54% Chlorine) results in increased expression of NAT1 mRNAincreases expression 17851650
D002995 Clofibric Acid Clofibric Acid affects the expression of NAT1 mRNAaffects expression 17602206
D016572 Cyclosporine Cyclosporine results in decreased expression of NAT1 mRNAdecreases expression 20106945
C010920 dihydrofolate dihydrofolate results in decreased activity of NAT1 proteindecreases activity 16003948
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of NAT1 mRNAaffects cotreatment|increases expression 19619570
D004958 Estradiol Estradiol results in increased expression of NAT1 mRNAincreases expression 19619570
D005419 Flavonoids Flavonoids results in decreased expression of NAT1 mRNAdecreases expression 18035473
D015073 2-Acetylaminofluorene 2-Acetylaminofluorene analog results in decreased activity of NAT1 proteindecreases activity 15025497
D015073 2-Acetylaminofluorene NAT1 protein results in decreased acetylation of 2-Acetylaminofluorenedecreases acetylation 15025497
D015073 2-Acetylaminofluorene NAT1 protein results in increased activity of 2-Acetylaminofluoreneincreases activity 15450435
D005492 Folic Acid Folic Acid results in decreased activity of NAT1 proteindecreases activity 16003948
D005492 Folic Acid Folic Acid results in decreased activity of NAT1 protein modified formdecreases activity 16003948
D005492 Folic Acid NAT1 protein results in increased acetylation of Folic Acid metaboliteincreases acetylation 15627487
D006202 Hair Dyes NAT1 protein polymorphism affects the susceptibility to Hair Dyesaffects response to substance 12663508
D006861 Hydrogen Peroxide Hydrogen Peroxide results in decreased activity of NAT1 proteindecreases activity 15644493
D006881 Hydroxyacetylaminofluorene Hydroxyacetylaminofluorene results in decreased activity of NAT1 proteindecreases activity 15720122
D007213 Indomethacin Indomethacin results in increased expression of NAT1 mRNAincreases expression 16184411
C533894 LG 100815 LG 100815 results in decreased expression of NAT1 mRNAdecreases expression 16951191
D008727 Methotrexate Methotrexate results in decreased activity of NAT1 proteindecreases activity 16003948
D008727 Methotrexate Methotrexate results in decreased activity of NAT1 protein modified formdecreases activity 16003948
C001368 N-hydroxy-2-aminofluorene NAT1 protein results in increased acetylation of N-hydroxy-2-aminofluoreneincreases acetylation 12088197
C001365 N-hydroxy-4-acetylaminobiphenyl N-hydroxy-4-acetylaminobiphenyl results in decreased activity of NAT1 proteindecreases activity 15720122
C001365 N-hydroxy-4-acetylaminobiphenyl N-hydroxy-4-acetylaminobiphenyl results in decreased activity of NAT1 proteindecreases activity 15720122
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of NAT1 mRNAincreases expression 17616710
C062198 octa-2,4,6-trienoic acid octa-2,4,6-trienoic acid results in decreased expression of NAT1 mRNAdecreases expression 16951191
D017239 Paclitaxel Paclitaxel results in decreased activity of NAT1 mRNAdecreases activity 17564303
D017239 Paclitaxel Paclitaxel results in decreased activity of NAT1 proteindecreases activity 17564303
D017239 Paclitaxel Paclitaxel results in decreased expression of NAT1 mRNAdecreases expression 15015580
D030421 Peroxynitrous Acid Peroxynitrous Acid results in decreased activity of NAT1 proteindecreases activity 14672957
15644493
D011084 Polycyclic Hydrocarbons, Aromatic NAT1 protein results in increased acetylation of Polycyclic Hydrocarbons, Aromaticincreases acetylation 15122594
D011342 Procainamide NAT1 protein results in increased acetylation of Procainamideincreases acetylation 16003948
C017947 sodium arsenite sodium arsenite results in increased expression of NAT1 mRNAincreases expression 12016162
D013418 Sulfamethazine NAT1 protein results in increased acetylation of Sulfamethazineincreases acetylation 16482518
D013467 Sulindac Sulindac results in decreased expression of NAT1 mRNAdecreases expression 11828994
D013629 Tamoxifen NAT1 protein results in decreased susceptibility to Tamoxifendecreases response to substance 20628863
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of NAT1 mRNAaffects cotreatment|increases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of NAT1 mRNAincreases expression 19619570
D014051 Toluene 2,4-Diisocyanate NAT1 gene polymorphism affects the susceptibility to Toluene 2,4-Diisocyanateaffects response to substance 18447907
D014051 Toluene 2,4-Diisocyanate NAT1 protein polymorphism results in increased susceptibility to Toluene 2,4-Diisocyanateincreases response to substance 11927838
D014635 Valproic Acid Valproic Acid results in increased expression of NAT1 mRNAincreases expression 19101580
C085514 wogonin wogonin results in decreased expression of NAT1 mRNAdecreases expression 15816529
C085514 wogonin wogonin results in decreased expression of NAT1 proteindecreases expression 15816529
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Sulindac 10.8214745880
MESH:D000008 Abdominal Neoplasms Tamoxifen 10.8214745880
MESH:D000014 Abnormalities, Drug-Induced Carbamazepine 15.158986270
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 15.1512039119
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 15.1511752688 14514962 15322242
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 15.158875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.3419490988
MESH:D000138 Acidosis Ammonium Chloride 2.9118287403
MESH:D058186 Acute Kidney Injury Folic Acid 7.2617003819 16316344 16595132
MESH:D058186 Acute Kidney Injury Sulindac 7.267897758
MESH:D000230 Adenocarcinoma Estradiol 6.0211473722
MESH:D000230 Adenocarcinoma Indomethacin 6.0216537180
MESH:D000230 Adenocarcinoma Sulindac 6.0211910360
MESH:D000236 Adenoma 2-Acetylaminofluorene 16.6910737359
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 16.693712494
MESH:D000236 Adenoma Folic Acid 16.6916963246
MESH:D000236 Adenoma Indomethacin 16.6911497255
MESH:D000236 Adenoma Sulindac 16.6910223192
MESH:D002759 Adenoma, Bile Duct 2-Acetylaminofluorene 5.356705139
MESH:D018248 Adenoma, Liver Cell 2-aminofluorene 8.6819052882
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.6816835633
MESH:D011125 Adenomatous Polyposis Coli Sulindac 4.0319003578 12394442 15623613 11874996 17611924 11535846 16460482
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.0415276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.2416712894 17306315
OMIM:607154 ALLERGIC RHINITIS 4,4'-diphenylmethane diisocyanate 5.357973495
MESH:D016301 Alveolar Bone Loss Indomethacin 4.7117225004
MESH:D000544 Alzheimer Disease Folic Acid 4.0117116317
MESH:D000544 Alzheimer Disease Indomethacin 4.0115579461 17627676
MESH:D000550 Amblyopia Valproic Acid 4.5717688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.3811748828
MESH:D000799 Angioedema Acetaminophen 3.1810982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.0517497229
MESH:D001014 Aortic Aneurysm Indomethacin 4.2310231640
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 4.2410388637
MESH:D018771 Arthralgia Indomethacin 4.512160914
MESH:D001172 Arthritis, Rheumatoid Indomethacin 4.3911248219
MESH:D001172 Arthritis, Rheumatoid Methotrexate 4.3917286800
MESH:D001249 Asthma 1,6-hexamethylene diisocyanate 7.1410934080
MESH:D001249 Asthma 4,4'-diphenylmethane diisocyanate 7.148156442 11077012 6091945 10934080 15891530 10797510
MESH:D001249 Asthma Toluene 2,4-Diisocyanate 7.1417015710 20032816 170078 11467998 15590890 6091945 6091946 11742282 18394133 3040596 10934080 12684321 7684630 16210060 12762349 15855793 15590891 8156442 19187332 10797510 12585506 16792590 11077013
MESH:D055963 Asthma, Aspirin-Induced Aspirin 4.1520485159 12372130
MESH:D001321 Autistic Disorder Acetaminophen 2.0718445737
MESH:D001321 Autistic Disorder Folic Acid 2.0721388746
MESH:D001321 Autistic Disorder Valproic Acid 2.0718558336 18316065 18396377 17507914 17688650 20603192 18177632 15238991 18940202 19232924 17157402 18775368 19460635 16609825 18985861
MESH:D001477 Bartter Syndrome Indomethacin 4.3510684365
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.3611289319 1440618
MESH:D001714 Bipolar Disorder Carbamazepine 6.3120046352 17594078
MESH:D001714 Bipolar Disorder Valproic Acid 6.3120046352 17594078
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.4612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.1315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 6.5315746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 6.538888407
MESH:D001859 Bone Neoplasms Paclitaxel 3.9715867366
MESH:D001913 Bowen's Disease Sulindac 4.6911207687
MESH:D001929 Brain Edema Indomethacin 4.3611481608
MESH:D002545 Brain Ischemia Indomethacin 3.7712524144
MESH:D001932 Brain Neoplasms Aspirin 3.8515481559
MESH:D001943 Breast Neoplasms 4-biphenylamine 7.0817671175
MESH:D001943 Breast Neoplasms Aspirin 7.0815161893
MESH:D001943 Breast Neoplasms Estradiol 7.0814630087 12948864 17261762 17018787 16675129 19861407 18497071 17289903
MESH:D001943 Breast Neoplasms Folic Acid 7.0816777985
MESH:D001943 Breast Neoplasms Indomethacin 7.0817401462
MESH:D001943 Breast Neoplasms Methotrexate 7.0816978400
MESH:D001943 Breast Neoplasms Paclitaxel 7.0811325840 16244791 18223236 18323546 16115903 15136595 18234424 16273361
MESH:D001943 Breast Neoplasms Sulindac 7.0816642371
MESH:D001943 Breast Neoplasms Tamoxifen 7.0816818667 19189212 19289846 19115204 21138602 19142967 18997820 19189210 17440819 19059307 19487384 16202921 20390343 11161223 19200415 17242785 17049068 15565566 20065188 19084267 16873071 18815881 19288272 17893378 18821012 20544844 19410462 19221464 15668708 20135344 21152245 19155303 19103187 18351453 18984771 18629630 16273361 18855134 20859285 20005174 19011961 19244106 19066611 17261762 18425577
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 7.0820435547
MESH:D001943 Breast Neoplasms Toluene 2,4-Diisocyanate 7.0811921183
MESH:D016535 Bronchial Hyperreactivity 4,4'-diphenylmethane diisocyanate 7.838156442
MESH:D016535 Bronchial Hyperreactivity Toluene 2,4-Diisocyanate 7.838156442 12507178 15590891
MESH:D002056 Burns Indomethacin 4.0710459503
MESH:D002100 Cachexia Indomethacin 4.3611239499 15625704 15141370 16537180
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.8116111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.2816835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 3.8719066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 19.6116705839
MESH:D006528 Carcinoma, Hepatocellular 2-Acetylaminofluorene 19.613581430 3084413 6705139 17761372 10737359
MESH:D006528 Carcinoma, Hepatocellular 2-aminofluorene 19.6119052882
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 19.617296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 19.613084413
MESH:D006528 Carcinoma, Hepatocellular Estradiol 19.6116924424
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 19.6116391822
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 19.6116313753
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 19.6117306315 15276417 16507464
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 19.6116924424
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 4.0811053908
MESH:D018276 Carcinoma, Medullary Indomethacin 4.7018791128 14736730 11352223
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 5.467296757
MESH:D002292 Carcinoma, Renal Cell Indomethacin 5.4617341418
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 4.1015482327 12636206
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.1018572023
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.0517572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 1.9818670907 16120746 18850075
MESH:D002318 Cardiovascular Diseases Folic Acid 6.2016755160
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 6.2016936243
MESH:D002386 Cataract Acetaminophen 2.1710977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 20.297505956
MESH:D002471 Cell Transformation, Neoplastic 4-biphenylamine 20.2915746073
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 20.2920889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 20.2912371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 20.2918566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 20.2919524636 20056578
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.4320734317
MESH:D018281 Cholangiocarcinoma 2-aminofluorene 8.2519052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.2516835633
MESH:D002764 Cholecystitis Indomethacin 4.5111181007
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 6.229022650 19486331
MESH:D002779 Cholestasis Cyclosporine 6.2219486331
MESH:D043171 Chromosomal Instability 4-biphenylamine 6.3517671175
MESH:D002971 Cleft Lip Folic Acid 3.6021254359
MESH:D002972 Cleft Palate Folic Acid 5.0321254359 8946559
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.0315668235 8697196 12621046 15340226 16354765
MESH:D003093 Colitis, Ulcerative Mesalamine 4.9017339853
MESH:D003110 Colonic Neoplasms Aspirin 5.1112411196
MESH:D003110 Colonic Neoplasms Indomethacin 5.1115625704 15786552 11260862 15936596 15637740 15963497
MESH:D003110 Colonic Neoplasms Sulindac 5.1112902858 12458338
MESH:D015179 Colorectal Neoplasms 4-biphenylamine 7.1817671175
MESH:D015179 Colorectal Neoplasms Aspirin 7.1817047198
MESH:D015179 Colorectal Neoplasms Folic Acid 7.1817087956 17245555 16963246 17116713 16985020
MESH:D015179 Colorectal Neoplasms Indomethacin 7.1817054584 12606626 18059344 11197048
MESH:D015179 Colorectal Neoplasms Paclitaxel 7.1818802399
MESH:D015179 Colorectal Neoplasms Sulindac 7.1811197048 18059344 10666051 11076880
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.5117141729 14669216
MESH:D003233 Conjunctivitis, Allergic 4,4'-diphenylmethane diisocyanate 5.777973495
MESH:D018352 Coronavirus Infections Indomethacin 5.0517302372
MESH:D019465 Craniofacial Abnormalities Carbamazepine 4.649014606
MESH:D019465 Craniofacial Abnormalities Methotrexate 4.6412039119 9562676
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 4.6420055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Valproic Acid 4.6417688650 16575769 8888407
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.3818551238
MESH:D003550 Cystic Fibrosis Methotrexate 3.6819747007
MESH:D003711 Demyelinating Diseases Tamoxifen 3.7319031437
MESH:D017449 Dermatitis, Allergic Contact 1,6-hexamethylene diisocyanate 15.2418759878
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 15.2412868966 14531868 18759878 11906362 8156756 8970840 2524372 11298694
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diphenylmethane diisocyanate 15.2412868966 18759878
MESH:D017449 Dermatitis, Allergic Contact 4-phenylenediamine 15.2418759875 16533241 16823706 19470301 11906362 11298694
MESH:D017449 Dermatitis, Allergic Contact Toluene 2,4-Diisocyanate 15.2415491423 12956900 18759878
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 12.443621924 2952479
MESH:D003877 Dermatitis, Contact 4-phenylenediamine 12.4411531941
MESH:D003877 Dermatitis, Contact Toluene 2,4-Diisocyanate 12.4417010967
MESH:D003882 Dermatomyositis Methotrexate 4.5120191521
MESH:D003924 Diabetes Mellitus, Type 2 Folic Acid 3.8716886840
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 3.8717107852
MESH:D003928 Diabetic Nephropathies Estradiol 7.0019279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 7.0019279558
MESH:D003930 Diabetic Retinopathy Sulindac 4.5612861449 17621415
MESH:D003967 Diarrhea Indomethacin 3.207237001 7907874
OMIM:607208 DRAVET SYNDROME Carbamazepine 4.8111748493
MESH:D004342 Drug Hypersensitivity Carbamazepine 3.9816538176 16538175 20216337 15057820
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 14.8518551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 14.859328219 7440962 6482804 18289764 18648102 6679447 11289319 16192314 8291058 18692083 9022650 1440618 9653073
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 14.8512153990 2444490 11743745 19923254 17562736 16109766 12540782 17522070 19164858 16081117 14550746 16227642 16485898 11421492 19416960 11834606 19370779 19739265 16393943 11287661 19420014 12958197 18713872 15619225 16781746 10915739 11461765 19085960 14725611 15968718 12392966 18071297 11529661 17906064 10663392 16177239 10774834 12705907 11739529 14986274 12594235
MESH:D056486 Drug-Induced Liver Injury Carbamazepine 14.8517465707
MESH:D056486 Drug-Induced Liver Injury Chlorodiphenyl (54% Chlorine) 14.8517851650
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 14.8520420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 14.8519641884 1733752
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.4419426721
MESH:D004362 Drug Toxicity Carbamazepine 6.7420216337
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 6.7411462148
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 4.5018446180 16326151 18043480 17190690 12774134 16133044
MESH:D004381 Duodenal Ulcer Indomethacin 3.5311535926 11595431 17045617 16699067 11991626 10671773 17329845 11595415 17151854 17351913 17202747
MESH:D004421 Dystonia Valproic Acid 3.451851702
MESH:D004487 Edema Aspirin 8.3217259670
MESH:D004487 Edema Indomethacin 8.3216100529 8985016 7907874 7990266 19703484 8273558 10653021
MESH:D004487 Edema Tetrachlorodibenzodioxin 8.3211000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.2418230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Carbamazepine 7.4717654737
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 7.4719031437
MESH:D016889 Endometrial Neoplasms Estradiol 9.9211473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Folic Acid 9.9217301261
MESH:D016889 Endometrial Neoplasms Tamoxifen 9.9220544844 19155303 17893378 16202921
MESH:D004715 Endometriosis Indomethacin 12.1115652904
MESH:D004715 Endometriosis Sulindac 12.1115652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 12.119294722 10568697
MESH:D019446 Endotoxemia Indomethacin 3.8618509659
MESH:D004751 Enteritis Indomethacin 4.0910567023 17763956 16328016
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 4.3517980183
MESH:D004802 Eosinophilia 4,4'-diphenylmethane diisocyanate 11.608156442
MESH:D004802 Eosinophilia Indomethacin 11.6011298111
MESH:D004802 Eosinophilia Toluene 2,4-Diisocyanate 11.608156442
MESH:D004816 Epidermal Necrolysis, Toxic Carbamazepine 4.6416415921 16538176 20485159 19915237 18855540
MESH:D004831 Epilepsies, Myoclonic Carbamazepine 9.1017275665
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 9.103659116 17275665
MESH:D004828 Epilepsies, Partial Carbamazepine 8.1916628512 17116037 15008574
MESH:D004828 Epilepsies, Partial Valproic Acid 8.1916628512 3922381
MESH:D004827 Epilepsy Carbamazepine 5.8219620853 18234410 19700373 7988514 19439326 17178248 17465707 821787 20417680 9014606
MESH:D004827 Epilepsy Valproic Acid 5.8218234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.047562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Carbamazepine 9.607750514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 9.607750514
MESH:D004830 Epilepsy, Tonic-Clonic Carbamazepine 8.7415276670 3659116
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 8.743659116
MESH:D004916 Erythromelalgia Carbamazepine 5.0719549232
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 14.573581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 14.5720426865
MESH:D004938 Esophageal Neoplasms Indomethacin 14.5711005569
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 14.5716805852 15878914 15150132 16510608 15547721 15264214 16704527 15623463 15547733
MESH:D004938 Esophageal Neoplasms Paclitaxel 14.5716481741
MESH:D004938 Esophageal Neoplasms Sulindac 14.5712235107
MESH:D005076 Exanthema Carbamazepine 4.8220485159
MESH:D017889 Exfoliation Syndrome Folic Acid 4.8416504073
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.5111564622
MESH:D005128 Eye Diseases Toluene 2,4-Diisocyanate 5.1018447907
MESH:D005234 Fatty Liver Cyclosporine 9.7719224547
MESH:D005234 Fatty Liver Tamoxifen 9.7714986274 19224547
MESH:D005234 Fatty Liver Valproic Acid 9.7719224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 2.8116709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.8211858732
MESH:D005315 Fetal Diseases Valproic Acid 4.2216575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.518888407 18558336
MESH:D005334 Fever 4,4'-diphenylmethane diisocyanate 8.067973495
MESH:D005334 Fever Indomethacin 8.0610431976 11852909 17627676
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.366705139
MESH:D018221 Fibromatosis, Abdominal Sulindac 10.8014745880
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 10.8014745880
MESH:D018222 Fibromatosis, Aggressive Sulindac 9.4919069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 9.4919069698
MESH:D005354 Fibrosarcoma Indomethacin 4.2510962813
MESH:D005355 Fibrosis baicalein 16.0919474275
MESH:D005355 Fibrosis Cyclosporine 16.0912168785 12639820
MESH:D005355 Fibrosis Indomethacin 16.0917994277
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 16.0920067830
MESH:D005499 Folliculitis Indomethacin 4.5111298111
MESH:D005756 Gastritis Acetaminophen 15.2916983495
MESH:D005756 Gastritis Folic Acid 15.2917171786
MESH:D005756 Gastritis Indomethacin 15.2915046732
MESH:D005764 Gastroesophageal Reflux Sulindac 4.3911910360
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.0316452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.578708960
MESH:D005901 Glaucoma Folic Acid 4.4816504073
MESH:D005909 Glioblastoma Aspirin 9.6912870263
MESH:D005909 Glioblastoma baicalein 9.6919804834
MESH:D005909 Glioblastoma Indomethacin 9.6912870263
MESH:D005910 Glioma Indomethacin 2.9316487511 18371953
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 3.7611849393
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.437505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 3.9310696789
MESH:D006073 Gout Indomethacin 4.7011248219
MESH:D006086 Graft vs Host Disease Methotrexate 4.5116518429
MESH:D006261 Headache Aspirin 4.3015240983
MESH:D006258 Head and Neck Neoplasms Indomethacin 3.2815482327
MESH:D006330 Heart Defects, Congenital Folic Acid 5.5917286298 16524890
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.5910048152 11294989
MESH:D006390 Hemangioendothelioma 2-Acetylaminofluorene 4.656705139
MESH:D006394 Hemangiosarcoma 2-Acetylaminofluorene 8.296705139
MESH:D006394 Hemangiosarcoma 4-chloroaniline 8.2915200160
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.7715720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.7511000095
MESH:D006501 Hepatic Encephalopathy Indomethacin 3.9815633222
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 2.906705139
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.0615135802
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.2715340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.3715709030
MESH:D006679 HIV Seropositivity Folic Acid 4.8417209195
MESH:D006689 Hodgkin Disease sodium arsenite 2.6212676792
MESH:D019584 Hot Flashes Estradiol 3.1017088409
MESH:D006849 Hydrocephalus Valproic Acid 4.2217688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.3815340226 16959395 8697196 18606429 16354765
MESH:D012001 Hyperacusis Aspirin 5.1015240983
MESH:D006930 Hyperalgesia Acetaminophen 6.1016870215
MESH:D006930 Hyperalgesia Indomethacin 6.1012727271
MESH:D034321 Hyperamylasemia Indomethacin 5.0517883296
MESH:D006940 Hyperemia Indomethacin 4.3612524144
MESH:D020138 Hyperhomocysteinemia Carbamazepine 8.0010459572
MESH:D020138 Hyperhomocysteinemia Folic Acid 8.0016865747 16397167 16395265 16433478 16755160
MESH:D006949 Hyperlipidemias Indomethacin 3.5717546600
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 9.0215034207
MESH:D006965 Hyperplasia Carbamazepine 9.0218773962
MESH:D006967 Hypersensitivity Toluene 2,4-Diisocyanate 4.0411019492 10880147
MESH:D006973 Hypertension Cyclosporine 3.9610903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 3.9618670907 18850075
MESH:D007077 Ileal Diseases Indomethacin 4.3618306037 10574470
MESH:D007079 Ileitis Indomethacin 4.7010647630 10651667 16133968
MESH:D007235 Infant, Premature, Diseases Indomethacin 4.7116133044
MESH:D007248 Infertility, Male sodium arsenite 2.5515346721 12646999
MESH:D007249 Inflammation aloe emodin 15.0619352036
MESH:D007249 Inflammation Flavonoids 15.0617296493
MESH:D007249 Inflammation Indomethacin 15.063291741 12568917 7812673
MESH:D007249 Inflammation Sulindac 15.063291741
MESH:D007249 Inflammation Tamoxifen 15.0619457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 15.0612878042 12200463
MESH:D007333 Insulin Resistance Estradiol 2.5216627594 16393666
MESH:D007410 Intestinal Diseases Indomethacin 3.7011713966 11855677 17329856 11686837 18236018 15831440 15610444 10210152 17994277
MESH:D007414 Intestinal Neoplasms Sulindac 4.0710213222 10223192 12663524 12584176 12628509 12351151
MESH:D007417 Intestinal Polyps Sulindac 4.3911245490 12394442
MESH:D019586 Intracranial Hypertension Indomethacin 4.7115241188
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.369022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 2.7516580747
MESH:D007579 Jejunal Diseases Indomethacin 4.3610574470 16133968 18306037
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.7815604871
MESH:D007674 Kidney Diseases Acetaminophen 14.7012587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 14.708314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 14.7015618244
MESH:D007674 Kidney Diseases Indomethacin 14.7017190690
MESH:D007674 Kidney Diseases sodium arsenite 14.7020008137
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 3.6916518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 17.6716705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 17.676582329
MESH:D007680 Kidney Neoplasms Cyclosporine 17.6712371664
MESH:D007680 Kidney Neoplasms Estradiol 17.6715610895
MESH:D007680 Kidney Neoplasms Tamoxifen 17.6718625569
MESH:D007805 Language Development Disorders Methotrexate 4.509562676
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.3711703811 12228301 10320625
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 3.4310785260 15631656 16572323
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 3.5618360721
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.5616294345 17596541
MESH:D007964 Leukocytosis Indomethacin 4.7116537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.0517980183
MESH:D008064 Lipidoses Tamoxifen 2.6815342952 17567588
MESH:D008080 Liposarcoma Paclitaxel 4.2217353645
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.0511479899
MESH:D008103 Liver Cirrhosis Methotrexate 3.3114986274
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 7.059327722 15034207
MESH:D008105 Liver Cirrhosis, Biliary Sulindac 7.0512468960
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.0614716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 4.0618194892
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 4.0618564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.0612878042
MESH:D008107 Liver Diseases Acetaminophen 5.4416610002 16611625 11587558 19784758 12587719 12969438 19014921 19460945
MESH:D008107 Liver Diseases Folic Acid 5.4416877991
MESH:D008107 Liver Diseases Sulindac 5.4416867024 14986274
MESH:D017114 Liver Failure, Acute Acetaminophen 2.6717185352 16871587
MESH:D008113 Liver Neoplasms 2-Acetylaminofluorene 24.1818001218 14678523 16273603 11376686 10672840 10737359
MESH:D008113 Liver Neoplasms 2-aminofluorene 24.1820492335 20452335 19499222 19850985
MESH:D008113 Liver Neoplasms 4-biphenylamine 24.1815761837
MESH:D008113 Liver Neoplasms 9-(4'-aminophenyl)-9H-pyrido(3,4-b)indole 24.1812970073
MESH:D008113 Liver Neoplasms Clofibric Acid 24.1817602206
MESH:D008113 Liver Neoplasms Hydroxyacetylaminofluorene 24.189163691
MESH:D008113 Liver Neoplasms sodium arsenite 24.1816712894 15276417
MESH:D008113 Liver Neoplasms Tamoxifen 24.1816684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 24.1816984957
MESH:D008114 Liver Neoplasms, Experimental 2-Acetylaminofluorene 10.66534488 1399818 6150874
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.663712494 598648 6587162 1399818
MESH:D008114 Liver Neoplasms, Experimental 4-biphenylamine 10.6611376689
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.6612151625
MESH:D008171 Lung Diseases sodium arsenite 2.7219095001
MESH:D017563 Lung Diseases, Interstitial Methotrexate 9.2718516814
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 9.2717228818
MESH:D008175 Lung Neoplasms 2-Acetylaminofluorene 10.9011376686
MESH:D008175 Lung Neoplasms 4-biphenylamine 10.9017671175
MESH:D008175 Lung Neoplasms Indomethacin 10.9016537180 11497255 11053908
MESH:D008175 Lung Neoplasms Polycyclic Hydrocarbons, Aromatic 10.9010814675
MESH:D008175 Lung Neoplasms sodium arsenite 10.9017306315 17077188 16712894 19931552 15276417
MESH:D008175 Lung Neoplasms Sulindac 10.9015713900 19359593
MESH:D008175 Lung Neoplasms Tamoxifen 10.9018625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 10.9019555203 11884234
MESH:D008180 Lupus Erythematosus, Systemic Carbamazepine 5.1416628512
MESH:D008180 Lupus Erythematosus, Systemic Folic Acid 5.1417718048
MESH:D008223 Lymphoma Methotrexate 3.4717352296
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 3.5614749477
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.1219428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 4.5116891317 17203775 11408345 11807958
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 4.5119196723 19196722 16827153 14580682 11731420
MESH:D020149 Manganese Poisoning Estradiol 10.4519453300
MESH:D020149 Manganese Poisoning Tamoxifen 10.4519453300
MESH:D019767 Maxillofacial Abnormalities Folic Acid 5.0416832597
MESH:D008545 Melanoma Paclitaxel 6.0316342250 12025231 12040289
MESH:D008545 Melanoma sodium arsenite 6.0319082730 16487513
MESH:D008545 Melanoma Sulindac 6.0316642371
MESH:D008545 Melanoma Tamoxifen 6.0312393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.5315990972
MESH:D008546 Melanoma, Experimental Acetaminophen 2.9319513568
MESH:D008607 Mental Retardation Carbamazepine 3.479014606
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.1216801185
MESH:D008708 Methemoglobinemia 4-biphenylamine 4.8112030840
MESH:D008881 Migraine Disorders Aspirin 9.9115240983
MESH:D008881 Migraine Disorders Indomethacin 9.9111903285
MESH:D008881 Migraine Disorders Valproic Acid 9.9118803445 18765137
MESH:D009062 Mouth Neoplasms Indomethacin 3.4812636206
MESH:D052016 Mucositis Methotrexate 4.6317488658
MESH:D009101 Multiple Myeloma Paclitaxel 3.2114749477
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.448888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 2.7517596541
MESH:D009203 Myocardial Infarction Aspirin 3.2512692751
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.4912213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 2.7716810080
MESH:D009224 Myotonia Congenita Carbamazepine 4.8220399394
MESH:D009325 Nausea Aspirin 4.5515240983
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.2118551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 11.063581430
MESH:D009362 Neoplasm Metastasis Indomethacin 11.0611053908 11239499 16537180
MESH:D009362 Neoplasm Metastasis Paclitaxel 11.0615867366
MESH:D009362 Neoplasm Metastasis Tamoxifen 11.0619393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.2619410462
MESH:D009369 Neoplasms sodium arsenite 2.1811559025
MESH:D009374 Neoplasms, Experimental Indomethacin 11.8215625704 10663608
MESH:D009374 Neoplasms, Experimental sodium arsenite 11.8220056578
MESH:D009374 Neoplasms, Experimental Toluene 2,4-Diisocyanate 11.821670384
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.3419200415 19196722 19189210
MESH:D009389 Neovascularization, Pathologic Estradiol 3.0917289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.7817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.7318481113 19348381
MESH:D009421 Nervous System Malformations Carbamazepine 12.9216990009
MESH:D009421 Nervous System Malformations Estradiol 12.9211399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 12.9214600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 13.666679447
MESH:D009436 Neural Tube Defects Folic Acid 13.6617438019
MESH:D009436 Neural Tube Defects sodium arsenite 13.6612854658
MESH:D009436 Neural Tube Defects Valproic Acid 13.668888407 16359493
MESH:D019636 Neurodegenerative Diseases Acetaminophen 11.0918514411
MESH:D019636 Neurodegenerative Diseases Indomethacin 11.0912349958
MESH:D019636 Neurodegenerative Diseases Sulindac 11.0916850258 17266991
MESH:D009503 Neutropenia Folic Acid 3.9116322990
MESH:D007752 Obstetric Labor, Premature Indomethacin 4.516374098
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 17.0812819281 16049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 17.084026338 6482804
MESH:D009784 Occupational Diseases 4,4'-diphenylmethane diisocyanate 17.086091945 8156442
MESH:D009784 Occupational Diseases Toluene 2,4-Diisocyanate 17.0818394133 6091946 8156442 12585506 6091945 3040596 11077013
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.363988306
MESH:D010003 Osteoarthritis Aspirin 6.607009135
MESH:D010003 Osteoarthritis Indomethacin 6.607009135
MESH:D010014 Osteolysis Paclitaxel 4.3315867366
MESH:D010018 Osteomalacia Carbamazepine 4.8217016548
MESH:D010051 Ovarian Neoplasms Estradiol 6.4619401270
MESH:D010051 Ovarian Neoplasms Paclitaxel 6.4611161223
MESH:D010051 Ovarian Neoplasms sodium arsenite 6.4615276417 17306315
MESH:D010146 Pain Acetaminophen 15.6216870215
MESH:D010146 Pain Aspirin 15.626995502 6363464
MESH:D010146 Pain Carbamazepine 15.6215215642
MESH:D010146 Pain Indomethacin 15.6217627676 3291741 17440234 13679232
MESH:D010146 Pain Sulindac 15.623291741
MESH:D010149 Pain, Postoperative Indomethacin 4.0212538197 18702446
MESH:D010190 Pancreatic Neoplasms Sulindac 3.0911504793 16820089
MESH:D010195 Pancreatitis Indomethacin 3.3315028970 17883296
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 7.227296757
MESH:D010212 Papilloma Hydrogen Peroxide 7.2212065085
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.0516537180
MESH:D010267 Parapsoriasis Carbamazepine 5.0616538176
MESH:D020734 Parkinsonian Disorders Indomethacin 3.5512349958
OMIM:167400 PAROXYSMAL EXTREME PAIN DISORDER Carbamazepine 5.2717145499 17679678
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.0511903285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.5912520081
MESH:D010437 Peptic Ulcer Indomethacin 4.5011148446
MESH:D010438 Peptic Ulcer Hemorrhage Aspirin 4.8911156591
MESH:D010518 Periodontitis Indomethacin 4.2517225004
MESH:D020795 Photophobia Aspirin 5.1015240983
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 3.816228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 2.9418163543
MESH:D011230 Precancerous Conditions Cyclosporine 2.6712371664
MESH:D011248 Pregnancy Complications Carbamazepine 4.529014606
MESH:D047928 Premature Birth Indomethacin 4.4917000239
MESH:D011297 Prenatal Exposure Delayed Effects Carbamazepine 12.649014606
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 12.6411399792 11222880 11118676 11896295
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 12.6420603192
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.3020887781
MESH:D011471 Prostatic Neoplasms Estradiol 2.2916740699
MESH:D011471 Prostatic Neoplasms Paclitaxel 2.2917172428 16729912 17136230 16356831
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.2916039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.2915067354
MESH:D011507 Proteinuria Indomethacin 3.5711849393
MESH:D019310 Pseudolymphoma Carbamazepine 10.409591791 12752131
MESH:D019310 Pseudolymphoma Valproic Acid 10.4012752131 11422049
MESH:D011565 Psoriasis Cyclosporine 4.9816882103
MESH:D011565 Psoriasis Methotrexate 4.9817410198
MESH:D011657 Pulmonary Eosinophilia Toluene 2,4-Diisocyanate 4.9614606601
MESH:D051437 Renal Insufficiency Folic Acid 8.6015728788
MESH:D051437 Renal Insufficiency Methotrexate 8.6017352296
MESH:D012128 Respiratory Distress Syndrome, Adult 4,4'-diphenylmethane diisocyanate 5.037973495
MESH:D012130 Respiratory Hypersensitivity 4,4'-diphenylmethane diisocyanate 7.7116940033
MESH:D012130 Respiratory Hypersensitivity Toluene 2,4-Diisocyanate 7.717692837 20219652 16940033
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.2218990726
MESH:D012140 Respiratory Tract Diseases Toluene 2,4-Diisocyanate 4.4618447907
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 2.883692021
MESH:D012208 Rhabdomyosarcoma Valproic Acid 3.5719155313
MESH:D012220 Rhinitis Aspirin 7.4212372130
MESH:D012220 Rhinitis Toluene 2,4-Diisocyanate 7.4219050374
MESH:D012221 Rhinitis, Allergic, Perennial Toluene 2,4-Diisocyanate 4.6212617775 15015336
MESH:D006255 Rhinitis, Allergic, Seasonal Toluene 2,4-Diisocyanate 4.8519075512
MESH:D012559 Schizophrenia Folic Acid 3.4416641680
MESH:D012559 Schizophrenia Valproic Acid 3.4415737665 19110320
MESH:D012640 Seizures 2,4-dinitrotoluene 7.3118551238
MESH:D012640 Seizures Carbamazepine 7.319046859 15946322 16938433 19414003 9844417 16180713 16876388
MESH:D012640 Seizures Valproic Acid 7.3111738929 3137016 16876388 1511512 14763951 15475178 11044598 17978042
MESH:D012851 Sinus Thrombosis, Intracranial Aspirin 4.6312269725
MESH:D012871 Skin Diseases Folic Acid 3.0518709164
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 7.4512065085
MESH:D012878 Skin Neoplasms sodium arsenite 7.4519524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 7.4516192470
MESH:D012893 Sleep Disorders Carbamazepine 4.4819414003
MESH:D012912 Sneezing Toluene 2,4-Diisocyanate 4.8519075512 19050374
MESH:D013088 Spermatocele Tamoxifen 3.6316709447
MESH:D013118 Spinal Cord Diseases Folic Acid 4.8416361298
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.3919457130
MESH:D016135 Spinal Dysraphism sodium arsenite 7.8312854658
MESH:D016135 Spinal Dysraphism Valproic Acid 7.8319490988
MESH:D013226 Status Epilepticus Valproic Acid 3.8812833885
MESH:D013262 Stevens-Johnson Syndrome Carbamazepine 4.5815057820 18855540 19694795 20485159 19915237 16415921 16538176
MESH:D013272 Stomach Diseases Indomethacin 3.7715472012 16280098 10215738 18545984 10486359 10192188 17207306 18209964 15038085 17160473 16113693 17638125 16184426
MESH:D013274 Stomach Neoplasms Folic Acid 4.0917171786
MESH:D013274 Stomach Neoplasms Indomethacin 4.0915609394
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 4.0917575124 12958204
MESH:D013274 Stomach Neoplasms Paclitaxel 4.0918396642 18506536
MESH:D013276 Stomach Ulcer Indomethacin 3.0311523592 16397915 15255614 1323529 11595431 12077510 12467913 16150113 17657623 18181030 18299717 17977527 18237397 12787963 18193104 18209962 12498302 15138204 16169175 11906479 14567935 18431645 17135157 16755016 16252198 16631530 11729361 15104355 12500499 17627676 16934674 10878458 11145282 10750652 11595415 10423059 18543354 17895592 18087811 17918041 18726076 17654042
MESH:D020521 Stroke Aspirin 7.4716403987
MESH:D020521 Stroke Folic Acid 7.4716517955
MESH:D013576 Syndactyly Methotrexate 4.429562676
MESH:D024801 Tauopathies Paclitaxel 4.1616930453
MESH:D013927 Thrombosis Aspirin 3.9617672075
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.2412697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 5.663712494 1399818 6587162 6582329 7505956
MESH:D013964 Thyroid Neoplasms Indomethacin 5.6618791128 14736730 11352223
MESH:D013978 Tibial Fractures Estradiol 4.0219048282
MESH:D014178 Translocation, Genetic Valproic Acid 4.5717262798
MESH:D014456 Ulcer Indomethacin 4.2517380554 10574470
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 3.873119515
MESH:D001749 Urinary Bladder Neoplasms marker/mechanism 16003747
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 23.1416049721
MESH:D001749 Urinary Bladder Neoplasms 2-Acetylaminofluorene 23.141399818 15867355 15289314
MESH:D001749 Urinary Bladder Neoplasms 2-Naphthylamine 23.1411144890
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 23.148074119
MESH:D001749 Urinary Bladder Neoplasms 4-biphenylamine 23.146654951 11144890 12376482 17671175
MESH:D001749 Urinary Bladder Neoplasms benzidine 23.1412500666 16003747 11144890
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 23.1411723127 16712894 16452187 17306315
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 23.1417572228 16712894 8653321
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.018888407
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 3.6710091137
MESH:D014581 Urticaria Acetaminophen 6.9210982225
MESH:D014581 Urticaria Aspirin 6.9210982225 20485159
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.2011813266
MESH:D014594 Uterine Neoplasms Sulindac 3.9918645019
MESH:D014605 Uveitis Cyclosporine 3.321336536
MESH:D014652 Vascular Diseases sodium arsenite 3.7817056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 3.9312125929
MESH:D014839 Vomiting Indomethacin 4.0911897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.5915886252
MESH:D014985 Xerophthalmia Cyclosporine 3.7817120751
Pathway ID Pathway Name
REACT:13433 Biological oxidations
KEGG:00232 Caffeine metabolism
KEGG:00983 Drug metabolism - other enzymes
KEGG:01100 Metabolic pathways
KEGG:03013 RNA transport
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA17
    • Releated gene ID Related gene Name
    PA17NAT1
    Releated disease ID Related disease Name
    PA443560Breast Neoplasms
    PA447252sulfamethoxazole idiosyncratic adverse drug reactions
    Releated drug ID Related drug Name
    PA450196letrozole
    PA450112isoniazid
    PA451545sulfanilamide
    PA452604xenobiotics
    PA451544sulfamethoxazole
    Drug Bank Top
    No data
    Drugbank ID Action Drug Name Description
    DB01015 substrate Sulfamethoxazole and Trimethoprim Tablets Anti-Infective Agents;Anti-Infectives;Sulfonamides
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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