AutismKB 2.0

Annotation Detail for HAP1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:HAP1 ( HAP2,HIP5,HLP,hHLP1 )
Gene Full Name: huntingtin-associated protein 1
Band: 17q21.2
Quick LinksEntrez ID:9001; OMIM: 600947; Uniprot ID:HAP1_HUMAN; ENSEMBL ID: ENSG00000173805; HGNC ID: 4812
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05016Huntington's disease
No data
No data
Pathway IDPathway Name
P00029Huntington disease
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1745Huntington disease
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of HAP1 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of HAP1 mRNAaffects expression 16483693
D004054 Diethylstilbestrol Diethylstilbestrol results in decreased expression of HAP1 mRNAdecreases expression 17005392
D008070 Lipopolysaccharides Lipopolysaccharides results in decreased expression of HAP1 mRNAdecreases expression 12057914
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of HAP1 mRNAincreases expression 12057914
D009151 Mustard Gas Mustard Gas results in increased expression of HAP1 mRNAincreases expression 15674843
C017947 sodium arsenite sodium arsenite results in decreased expression of HAP1 proteindecreases expression 19072884
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.0218287403
MESH:D055371 Acute Lung Injury Lipopolysaccharides 4.3818653653 11850527
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.2215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.4217306315 16712894
MESH:D000686 Amyloidosis Diethylstilbestrol 4.8615469931
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D001249 Asthma Mustard Gas 2.7810378619
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001768 Blister Mustard Gas 5.6219167455
MESH:D001943 Breast Neoplasms Diethylstilbestrol 2.6015324884 17129689
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.6215286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.5017687719 10378619
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.833084413
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 4.8315948411 16924424
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 4.8317306315 16507464 15276417
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.4518572023
MESH:D002386 Cataract Acetaminophen 2.7510977129
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 3.1919524636 20056578
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.9412952375 16002989
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6516081117 14550746 19085960 12153990 11287661 19923254 14986274 2444490 18071297 19164858 11834606 12392966 10915739 11739529 16227642 10663392 19739265 19420014 14725611 10774834 11461765 15619225 16781746 16485898 17906064 18713872 19416960 11743745 12958197 12594235 12705907 11529661 16109766 16393943 16177239 12540782 17562736 11421492 17522070 19370779 15968718
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D004487 Edema Mustard Gas 3.6311428647 9260866 11402378 11428631
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 5.1616402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 3.6616804899 15700306
MESH:D019446 Endotoxemia Lipopolysaccharides 4.8617637181 15821434 15328337
MESH:D004890 Erythema Mustard Gas 5.629357497
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.8316513791 16534752 16611131 16002989 15751030
MESH:D005334 Fever Lipopolysaccharides 4.3211852909 9205823
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 14.4116452187
MESH:D005833 Genital Neoplasms, Female sodium arsenite 14.4116452187
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.6916366002
MESH:D006689 Hodgkin Disease sodium arsenite 3.4312676792
MESH:D006930 Hyperalgesia Acetaminophen 2.9516870215
MESH:D006965 Hyperplasia Diethylstilbestrol 4.8512960047 14722030
MESH:D007021 Hypospadias Diethylstilbestrol 5.0016002989
MESH:D007246 Infertility Diethylstilbestrol 4.7415036965
MESH:D007248 Infertility, Male sodium arsenite 3.1915346721 12646999
MESH:D007249 Inflammation Lipopolysaccharides 5.919205823 12878042 17255318 17237260 17963957
MESH:D007249 Inflammation Mustard Gas 5.918975870 11402378 11428620 16001271 17524151 11428631 9260866 11428647 9357497
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.9817255318
MESH:D007674 Kidney Diseases Acetaminophen 6.5112587719 15629191
MESH:D007674 Kidney Diseases sodium arsenite 6.5120008137
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 3.7315003126 14681315 16762066
MESH:D007859 Learning Disorders Diethylstilbestrol 4.4817184923
MESH:D007970 Leukopenia Lipopolysaccharides 5.1615821434
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 2.2612878042
MESH:D008107 Liver Diseases Acetaminophen 1.6911587558 12969438 16611625 19014921 12587719 19784758 16610002 19460945
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5416871587 17185352
MESH:D008113 Liver Neoplasms Diethylstilbestrol 5.1215890375 16712894
MESH:D008113 Liver Neoplasms sodium arsenite 5.1215276417 16712894
MESH:D008171 Lung Diseases Mustard Gas 8.2218702808 18161513
MESH:D008171 Lung Diseases sodium arsenite 8.2219095001
MESH:D055370 Lung Injury Lipopolysaccharides 4.4221114838
MESH:D008175 Lung Neoplasms Mustard Gas 2.723148597 8781369
MESH:D008175 Lung Neoplasms sodium arsenite 2.7216712894 19931552 17306315 17077188 15276417
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.6115166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.6915700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 6.0416002989
MESH:D008545 Melanoma sodium arsenite 2.0616487513 19082730
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D009369 Neoplasms Diethylstilbestrol 5.7015313581
MESH:D009369 Neoplasms sodium arsenite 5.7011559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 4.0820056578
MESH:D009421 Nervous System Malformations Diethylstilbestrol 4.5211399458
MESH:D009436 Neural Tube Defects sodium arsenite 3.3312854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1418514411
MESH:D009503 Neutropenia Mustard Gas 4.3216761898 7688884
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.5117306315 15276417
MESH:D010146 Pain Acetaminophen 2.6516870215
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.6914722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 5.0915687265 16977796
MESH:D011014 Pneumonia Lipopolysaccharides 5.0212224865 11605937
MESH:D011041 Poisoning Mustard Gas 4.1515727166
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 4.5717184923
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 3.3415846301 15046698 17136230
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.3416039940
MESH:D011537 Pruritus Mustard Gas 4.5518058305
MESH:D011658 Pulmonary Fibrosis Mustard Gas 3.0217620002 17894541 10334151 17266442 17720292
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.9210835634
MESH:D012871 Skin Diseases Mustard Gas 2.7815451306 12880345 16961503
MESH:D012878 Skin Neoplasms sodium arsenite 2.8218572023 19524636
MESH:D013088 Spermatocele Diethylstilbestrol 5.2316709447 16002989
MESH:D016135 Spinal Dysraphism sodium arsenite 4.0412854658
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.4715821434
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 5.6216712894 16452187 17306315
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 5.6217306315 16452187 16712894 11723127
MESH:D014581 Urticaria Acetaminophen 3.3310982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 10.5716175088
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 10.5711813266
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.6914652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 4.4515809267 16690809
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.8516002989 16513791
MESH:D014652 Vascular Diseases sodium arsenite 4.8917056641
Pathway ID Pathway Name
KEGG:05016 Huntington's disease
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29188
  • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018