Annotation Detail for SYT8
Basic Information
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| Pathway ID | Pathway Name |
|---|
| P05734 | Synaptic vesicle trafficking |
| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| C023514 |
2,6-dinitrotoluene |
2,6-dinitrotoluene results in increased expression of SYT8 mRNA | increases expression | 20406850
|
| D000643 |
Ammonium Chloride |
Ammonium Chloride affects the expression of SYT8 mRNA | affects expression | 16483693
|
| D009151 |
Mustard Gas |
Mustard Gas results in increased expression of SYT8 mRNA | increases expression | 15674843
|
| C006253 |
pirinixic acid |
[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of SYT8 mRNA | affects binding|increases activity|increases expression | 19710929
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D000138 |
Acidosis |
|
Ammonium Chloride |
4.19 | 18287403 |
| MESH:D055371 |
Acute Lung Injury |
|
pirinixic acid |
3.58 | 18653653 |
| MESH:D018248 |
Adenoma, Liver Cell |
|
pirinixic acid |
4.11 | 16434500 |
| MESH:D001249 |
Asthma |
|
Mustard Gas |
2.80 | 10378619 |
| MESH:D001768 |
Blister |
|
Mustard Gas |
5.79 | 19167455 |
| MESH:D001778 |
Blood Coagulation Disorders |
|
pirinixic acid |
3.57 | 19483382 |
| MESH:D001989 |
Bronchiolitis Obliterans |
|
Mustard Gas |
5.79 | 15286001 |
| MESH:D029481 |
Bronchitis, Chronic |
|
Mustard Gas |
5.70 | 17687719 10378619 |
| MESH:D006528 |
Carcinoma, Hepatocellular |
|
2,6-dinitrotoluene |
1.79 | 16705839 |
| MESH:D002471 |
Cell Transformation, Neoplastic |
|
2,6-dinitrotoluene |
3.03 | 6135515 |
| MESH:D002779 |
Cholestasis |
|
pirinixic acid |
3.12 | 19176532 |
| MESH:D003490 |
Cyanosis |
|
2,6-dinitrotoluene |
4.58 | 18551238 |
| MESH:D003876 |
Dermatitis, Atopic |
|
pirinixic acid |
2.57 | 18249437 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
2,6-dinitrotoluene |
2.05 | 18551238 21346803 |
| MESH:D004487 |
Edema |
|
Mustard Gas |
8.32 | 11428647 9260866 11428631 11402378 |
| MESH:D004487 |
Edema |
|
pirinixic acid |
8.32 | 12083418 |
| MESH:D004890 |
Erythema |
|
Mustard Gas |
5.79 | 9357497 |
| MESH:D005234 |
Fatty Liver |
|
pirinixic acid |
3.19 | 19236843 20131406 |
| MESH:D006333 |
Heart Failure |
|
pirinixic acid |
2.76 | 20558911 |
| MESH:D006529 |
Hepatomegaly |
|
pirinixic acid |
3.55 | 18467677 19176532 16221962 19772884 |
| MESH:D006943 |
Hyperglycemia |
|
pirinixic acid |
3.58 | 20558911 |
| MESH:D007249 |
Inflammation |
|
Mustard Gas |
2.96 | 9357497 16001271 11402378 11428620 11428631 9260866 8975870 17524151 11428647 |
| MESH:D007333 |
Insulin Resistance |
|
pirinixic acid |
2.87 | 16306350 |
| MESH:D007680 |
Kidney Neoplasms |
|
2,6-dinitrotoluene |
3.32 | 16705839 |
| MESH:D008106 |
Liver Cirrhosis, Experimental |
|
pirinixic acid |
1.35 | 15474484 |
| MESH:D008113 |
Liver Neoplasms |
|
2,6-dinitrotoluene |
4.81 | 7678174 |
| MESH:D008113 |
Liver Neoplasms |
|
pirinixic acid |
4.81 | 16377806 20007298 15890375 |
| MESH:D008114 |
Liver Neoplasms, Experimental |
|
2,6-dinitrotoluene |
2.77 | 6135515 2876786 2876784 |
| MESH:D008171 |
Lung Diseases |
|
Mustard Gas |
3.70 | 18161513 18702808 |
| MESH:D008175 |
Lung Neoplasms |
|
Mustard Gas |
2.17 | 8781369 3148597 |
| MESH:D009135 |
Muscular Diseases |
|
pirinixic acid |
4.07 | 16239165 |
| MESH:D009203 |
Myocardial Infarction |
|
pirinixic acid |
2.27 | 19151258 |
| MESH:D015428 |
Myocardial Reperfusion Injury |
|
pirinixic acid |
3.25 | 16411023 |
| MESH:D009336 |
Necrosis |
|
2,6-dinitrotoluene |
4.49 | 7678174 18551238 |
| MESH:D009369 |
Neoplasms |
|
pirinixic acid |
2.11 | 17405874 |
| MESH:D009503 |
Neutropenia |
|
Mustard Gas |
4.43 | 7688884 16761898 |
| MESH:D009765 |
Obesity |
|
pirinixic acid |
1.88 | 20558911 |
| MESH:D009784 |
Occupational Diseases |
|
2,6-dinitrotoluene |
3.83 | 16049721 |
| MESH:D011041 |
Poisoning |
|
Mustard Gas |
4.26 | 15727166 |
| MESH:D011537 |
Pruritus |
|
Mustard Gas |
4.72 | 18058305 |
| MESH:D011658 |
Pulmonary Fibrosis |
|
Mustard Gas |
3.05 | 10334151 17266442 17720292 17620002 17894541 |
| MESH:D015427 |
Reperfusion Injury |
|
pirinixic acid |
2.55 | 19058328 |
| MESH:D012640 |
Seizures |
|
2,6-dinitrotoluene |
2.79 | 18551238 |
| MESH:D012871 |
Skin Diseases |
|
Mustard Gas |
2.79 | 12880345 15451306 16961503 |
| MESH:D001749 |
Urinary Bladder Neoplasms |
|
2,6-dinitrotoluene |
2.41 | 16049721 |
| MESH:D014571 |
Urologic Neoplasms |
|
2,6-dinitrotoluene |
4.95 | 10091137 |
Related Diseases/Disorders