AutismKB 2.0

Annotation Detail for KCNH7


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Basic Information Top
Gene Symbol:KCNH7 ( ERG3,HERG3,Kv11.3,MGC45986 )
Gene Full Name: potassium voltage-gated channel, subfamily H (eag-related), member 7
Band: 2q24.2
Quick LinksEntrez ID:90134; OMIM: 608169; Uniprot ID:KCNH7_HUMAN; ENSEMBL ID: ENSG00000184611; HGNC ID: 18863
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of KCNH7 mRNAaffects expression 12734012
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.6916097048 16124888 15673190 3786805 15721981 16192424 15700767 10355542 16227642 16011737 18705752 16050911
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 1.8718788625
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 2.156884620 6623471 16227642 11566570 15968718 19336974 2869522 15998439 10915739 7120509 17522070 3786805 19085960 10092053 21278145 15027814 7440962 7179309 9327722 3732212 4309450 16177239
MESH:D005234 Fatty Liver Carbon Tetrachloride 3.7917595544 15959796 19224547 16045604 61145 12631006 16239168 12795759
MESH:D005355 Fibrosis Carbon Tetrachloride 4.3618705752
MESH:D006505 Hepatitis Carbon Tetrachloride 4.3819110552 19900420
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 5.6216899240
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.9915338365
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 3.0616943688 16221502 11408273 16239168 21278145 11903743 17157831 17334410 17174718
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 1.7615650968 18395914 18205269 14620537 17976157 12649538 10355542 15730626 17565644 18006644 20821823 15818738 12586293 12546737 12667390 15673190 17823541 15925388 15362042 17557913 14716496 17869086 15876570 18472332 17631135 18376398 14724832 17481882 18420326 12632514 11481614 12898905 18317297 14748882 15893842 17922224 15959796 16136751 12741479 16638106 16192424 17805973 17721639 18251166 18705752 15338365 17766677 18412020 18481824 18054572 12666154 15370692 18418968 17698563 15057751 14512876 18429990 17714472 16033810 17708605 13678700 16248980 16027843 15931870 16116963 12389079 15123356 18210741 18279442 18472094 17640975 12445418 12958196 17761835 18187930 16015684 16011737 18277467 18263696 12609069 17525996 18395095 16097048 15996030 14716833 17900296 18166357 18339082 18156304 15052691 12445421 12632512 17944888
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1715720792 16246199 15830285 16964402 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 5.0715123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 4.2616899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 2.3719294768
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.9112014681 15583823
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00308 inhibitor Ibutilide Anti-Arrhythmia Agents
DB00457 antagonist Minizide Antihypertensive Agents;Adrenergic alpha-Antagonists;Alpha-adrenergic Blocking Agents
DB00590 antagonist Doxazosin Antineoplastic Agents;Antihypertensive Agents;Vasodilator Agents;Adrenergic alpha-Antagonists;Alpha-adrenergic Blocking Agents;Antihyperplasia Agents
DB01110 antagonist Miconazole Antifungal Agents
DB01162 inhibitor Terazosin Antineoplastic Agents;Adrenergic alpha-Antagonists
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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