AutismKB 2.0

Annotation Detail for MPZL1


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Basic Information Top
Gene Symbol:MPZL1 ( FLJ21047,MPZL1b,PZR,PZR1b,PZRa,PZRb )
Gene Full Name: myelin protein zero-like 1
Band: 1q24.2
Quick LinksEntrez ID:9019; OMIM: 604376; Uniprot ID:MPZL1_HUMAN; ENSEMBL ID: ENSG00000197965; HGNC ID: 7226
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04514Cell adhesion molecules (CAMs)
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2069Schizophrenia
Desease Name
PSYCH
schizophrenia
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of MPZL1 mRNAaffects expression 17562736
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of MPZL1 mRNAaffects cotreatment|increases expression 18164116
C006780 bisphenol A bisphenol A results in decreased expression of MPZL1 mRNAdecreases expression 20678512
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of MPZL1 mRNAaffects cotreatment|increases expression 18164116
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of MPZL1 mRNAdecreases expression 17108234
D015735 Mifepristone Mifepristone results in decreased expression of MPZL1 mRNAdecreases expression 17584828
C029938 nickel sulfate nickel sulfate results in decreased expression of MPZL1 mRNAdecreases expression 16780908
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of MPZL1 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of MPZL1 mRNAdecreases expression 19270015
D010634 Phenobarbital Phenobarbital results in increased expression of MPZL1 mRNAincreases expression 19482888
D014810 Vitamin E Vitamin E results in increased expression of MPZL1 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.726195326
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2617505938
MESH:D055371 Acute Lung Injury nickel sulfate 4.5319131640 12718980 11954676 16100012
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8514692618
MESH:D000236 Adenoma beta-Naphthoflavone 7.2519389873
MESH:D000236 Adenoma Diethylnitrosamine 7.256695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 11.2419061943 17620307 18056438 19052882 16434500 17162532
MESH:D018248 Adenoma, Liver Cell Phenobarbital 11.2417620307
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7815885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001862 Bone Resorption bisphenol A 4.0711985600
MESH:D001943 Breast Neoplasms bisphenol A 2.2317123778
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2317474063
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.1916050911
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.703084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.7019519916 18788625 19418558 19171122 16830150 17761372 20214788 19335982 18978308 18506893 21159647 19539802 20727157 16502159 18971187 17978847 10737359 16288022 20512989 19701751 16698587 16328049 18785209 16878318 16935385 17055752 20935162 19919837 19822196 3581430 18665156 10672840 19394651 18393292 19107877 3084413 19383236 19208518 16807293 20514400 17428255 19052882 20101231 17138121 16540662 17173139 17162532 18210153 20524982 20007298 16681979 16779866 20084675 18691550 16569478 18056438 11831363 18494052 20432363
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.7020007298 1701930 17173139 20935162 6705139
MESH:D002278 Carcinoma in Situ bisphenol A 5.2717123778
MESH:D002386 Cataract Acetaminophen 2.6910977129
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 2.9917174075 21159647 7505956 2727394
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.514080065
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.8719052882
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0216919318 11677210 16105132 15861022 17681005 17110522 17333356
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9219769572
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 3.9311298694 16780908 16823706
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2320387270
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.9211529661 11421492 16177239 12705907 19085960 15968718 12392966 12153990 15619225 18071297 2444490 11461765 11743745 14550746 16081117 16227642 19923254 17522070 16109766 19739265 17562736 11834606 19164858 11287661 19370779 17906064 12540782 10915739 18713872 19416960 11739529 16781746 16393943 14725611 10774834 12958197 12594235 14986274 10663392 16485898 19420014
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 3.9219107877
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:D004421 Dystonia Phenobarbital 4.221851702
MESH:C538011 Eales disease Vitamin E 5.029068938
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.4212538720
MESH:D004715 Endometriosis Mifepristone 4.5616134523
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.373659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.193922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.9820417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.726401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.517750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.303659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.4416302075
MESH:D005234 Fatty Liver Diethylnitrosamine 8.3920387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.3915345470
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D006330 Heart Defects, Congenital Vitamin E 3.0816080930
MESH:D006529 Hepatomegaly Phenobarbital 3.7416109766
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7616863852 16490937
MESH:D019584 Hot Flashes Vitamin E 4.2914716179
MESH:D006930 Hyperalgesia Acetaminophen 2.8616870215
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0716945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6217937319
MESH:D007249 Inflammation Diethylnitrosamine 2.4718785209
MESH:D007251 Influenza, Human Vitamin E 4.5316624496
MESH:D007333 Insulin Resistance bisphenol A 3.4116393666
MESH:D007674 Kidney Diseases Acetaminophen 6.3315629191 12587719
MESH:D007674 Kidney Diseases Vitamin E 6.3312488133
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.9919638242 20032147 18522880 18665156 18407596
MESH:D008103 Liver Cirrhosis Phenobarbital 6.9921047994
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 1.9016169303
MESH:D008107 Liver Diseases Acetaminophen 6.7612969438 11587558 19014921 12587719 19784758 16610002 19460945 16611625
MESH:D008107 Liver Diseases Diethylnitrosamine 6.7617034775
MESH:D008107 Liver Diseases Phenobarbital 6.7619363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4317185352 16871587
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 7.9421295105 19389873
MESH:D008113 Liver Neoplasms Diethylnitrosamine 7.942862719 19254457 21071580 18648771 19090486 19426721 20583210 20452335 2422723 18644402 19850985 12771043 19551842 19638242 19255062 21278145 19294768 19812893 20492335 15175105 10737359 20137499 21167192 18754104 19256749 20101389 19996281 19690152 18978307 19833225 9163691 19499222 20118626 21047994 19642983 12112319 18977376 16942905 20501860 19073162 20405173 19427195 15885732 20434301
MESH:D008113 Liver Neoplasms Phenobarbital 7.9419812893 8742319 19073162 15975961 21047994 19482888
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 10.6618164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.6617942915 3124819 17854601 19539802 2563599 18775883 21159647 18093689 17174075 16267830 9362446 18079962 18253720 18544905 18164116 19009564 16842330 19126423 19519916 18308698 19004024 18282651
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 10.662563599 1399818 18308698 17172636 6150874
MESH:D008171 Lung Diseases Vitamin E 3.3116863852
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.556695378 20970405 20512841 21163286
MESH:D008175 Lung Neoplasms Vitamin E 2.5511062179
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.7617484760
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.649029167 3581430
MESH:D009421 Nervous System Malformations bisphenol A 4.2116427766 11399458
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.7618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.7620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.4420387270
MESH:D010018 Osteomalacia Phenobarbital 4.6517016548
MESH:D010049 Ovarian Diseases bisphenol A 5.2711985600
MESH:D010051 Ovarian Neoplasms Mifepristone 3.1816525653
MESH:D010146 Pain Acetaminophen 2.5616870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.4716540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.4716965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9111578682
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.712563599
MESH:D011230 Precancerous Conditions Phenobarbital 9.712563599
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 4.2410548101
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.4120887781
MESH:D011471 Prostatic Neoplasms bisphenol A 3.3016740699
MESH:D011471 Prostatic Neoplasms Vitamin E 3.3015084515
MESH:D011537 Pruritus Ethinyl Estradiol 3.6016919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 4.8112752131
MESH:D011629 Puberty, Precocious bisphenol A 5.0710548101
MESH:D012640 Seizures Phenobarbital 2.8216876388 3137016 4039156 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 5.116407741
MESH:D012871 Skin Diseases Vitamin E 2.4818709164
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2616709447
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D020521 Stroke Vitamin E 3.6816517955
MESH:D019966 Substance-Related Disorders bisphenol A 4.2716684133 16045194
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3315669648
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.707505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.701399818
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D014591 Uterine Diseases bisphenol A 5.3314652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5414692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7515869587 14671159
Pathway ID Pathway Name
KEGG:04514 Cell adhesion molecules (CAMs)
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30931
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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