AutismKB 2.0

Annotation Detail for SOCS3


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Basic Information Top
Gene Symbol:SOCS3 ( ATOD4,CIS3,Cish3,MGC71791,SOCS-3,SSI-3,SSI3 )
Gene Full Name: suppressor of cytokine signaling 3
Band: 17q25.3
Quick LinksEntrez ID:9021; OMIM: 604176; Uniprot ID:SOCS3_HUMAN; ENSEMBL ID: ENSG00000184557; HGNC ID: 19391
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04920Adipocytokine signaling pathway
hsa05160Hepatitis C
hsa04910Insulin signaling pathway
hsa04630Jak-STAT signaling pathway
hsa04120Ubiquitin mediated proteolysis
hsa04930Type II diabetes mellitus
No data
Pathway IDPathway Name
200033Signaling events mediated by PTP1B
200131IL23-mediated signaling events
200157EPO signaling pathway
200124IL6-mediated signaling events
200082IL2-mediated signaling events
200018IL4-mediated signaling events
200116ATF-2 transcription factor network
Pathway IDPathway Name
P00035Interferon-gamma signaling pathway
P00031Inflammation mediated by chemokine and cytokine signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1737Cholangiocarcinoma
1770Melanoma
1779Cervical cancer
1831Prostate cancer
1843Metastasis to lymph nodes
1856Obesity
1944Breast cancer
2025Polyarthritis
2007Liver tumor
2029Tuberculosis
2051Leukemia
2066Lung cancer
2094Ulcerative colitis
2102Polycystic ovary syndrome
2118Adenovirus infection
2205Uveitis
No data
No data
Desease Name
Dermatitis, atopic, susceptibility to, 4
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C063609 1,2-dimethyl-4-nitrobenzene 1,2-dimethyl-4-nitrobenzene results in decreased expression of SOCS3 mRNAdecreases expression 19784758
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of SOCS3 mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of SOCS3 mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen affects the expression of SOCS3 mRNAaffects expression 19784758
D000082 Acetaminophen Acetaminophen results in decreased expression of SOCS3 mRNAdecreases expression 19784758
D000082 Acetaminophen Acetaminophen results in increased expression of SOCS3 mRNAincreases expression 19784758
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SOCS3 mRNAaffects expression 16483693
D016718 Arachidonic Acid Arachidonic Acid promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of SOCS3 mRNA]increases expression|increases reaction 19063610
C081565 arachidonyltrifluoromethane arachidonyltrifluoromethane inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SOCS3 mRNA]decreases reaction|increases expression 19063610
D001151 Arsenic Arsenic affects the expression of SOCS3 mRNAaffects expression 18414638
D001151 Arsenic Arsenic results in increased expression of SOCS3 mRNAincreases expression 18039032
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of SOCS3 mRNAincreases expression 18687144
D001374 Azacitidine Azacitidine affects the expression of SOCS3 proteinaffects expression 18443271
D001554 Benzene Benzene results in increased expression of SOCS3 mRNAincreases expression 15929907
D001554 Benzene Benzene results in decreased expression of SOCS3 mRNAdecreases expression 15122651
15120971
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of SOCS3 mRNAdecreases expression 19784758
D003474 Curcumin Curcumin results in decreased expression of SOCS3 mRNAdecreases expression 18403477
C007262 deoxynivalenol deoxynivalenol results in increased expression of SOCS3 mRNAincreases expression 19625342
19805407
C007262 deoxynivalenol deoxynivalenol results in increased expression of SOCS3 proteinincreases expression 19625342
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Methylcholanthrene] results in decreased expression of SOCS3 proteinaffects cotreatment|decreases expression 20970405
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Methylcholanthrene] results in increased methylation of SOCS3 promoteraffects cotreatment|increases methylation 20970405
D004112 Dimercaprol Dimercaprol inhibits the reaction [Mustard Gas results in increased expression of SOCS3 mRNA]decreases reaction|increases expression 16377760
D004958 Estradiol Estradiol promotes the reaction [ESR1 protein binds to SOCS3 promoter]affects binding|increases reaction 16055089
D004958 Estradiol Estradiol results in increased expression of SOCS3 mRNAincreases expression 16055089
D004958 Estradiol fulvestrant inhibits the reaction [Estradiol results in increased expression of SOCS3 mRNA]decreases reaction|increases expression 16055089
D004958 Estradiol Estradiol affects the expression of SOCS3 mRNAaffects expression 15598610
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of SOCS3 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol inhibits the reaction [IL1B protein results in increased expression of SOCS3 mRNA]decreases reaction|increases expression 12072388
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of SOCS3 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of SOCS3 mRNAincreases expression 17351261
D005576 Forskolin Forskolin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SOCS3 mRNA]decreases reaction|increases expression 17407152
C070081 fulvestrant fulvestrant inhibits the reaction [Estradiol results in increased expression of SOCS3 mRNA]decreases reaction|increases expression 16055089
C070081 fulvestrant fulvestrant inhibits the reaction [Genistein results in increased expression of SOCS3 mRNA]decreases reaction|increases expression 16055089
D019833 Genistein fulvestrant inhibits the reaction [Genistein results in increased expression of SOCS3 mRNA]decreases reaction|increases expression 16055089
D019833 Genistein Genistein results in increased expression of SOCS3 mRNAincreases expression 16055089
D006581 Hexachlorobenzene Hexachlorobenzene results in increased expression of SOCS3 mRNAincreases expression 15159207
D007052 Ibuprofen Ibuprofen affects the expression of SOCS3 mRNAaffects expression 17070997
D008748 Methylcholanthrene [Diethylnitrosamine co-treated with Methylcholanthrene] results in decreased expression of SOCS3 proteinaffects cotreatment|decreases expression 20970405
D008748 Methylcholanthrene [Diethylnitrosamine co-treated with Methylcholanthrene] results in increased methylation of SOCS3 promoteraffects cotreatment|increases methylation 20970405
D009151 Mustard Gas Dimercaprol inhibits the reaction [Mustard Gas results in increased expression of SOCS3 mRNA]decreases reaction|increases expression 16377760
D009151 Mustard Gas Mustard Gas results in increased expression of SOCS3 mRNAincreases expression 16377760
C063509 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SOCS3 mRNA]decreases reaction|increases expression 17407152
D015058 1-Naphthylisothiocyanate 1-Naphthylisothiocyanate results in increased expression of SOCS3 mRNAincreases expression 12832660
C029938 nickel sulfate nickel sulfate results in increased expression of SOCS3 mRNAincreases expression 16780908
D009578 Nitrobenzenes Nitrobenzenes analog results in decreased expression of SOCS3 mRNAdecreases expression 19784758
D010100 Oxygen [Tetrachlorodibenzodioxin co-treated with Oxygen deficiency] results in increased expression of SOCS3 mRNAaffects cotreatment|increases expression 19578757
D010126 Ozone Ozone results in increased expression of SOCS3 mRNAincreases expression 17460151
D010126 Ozone TTPA protein affects the reaction [Ozone results in increased expression of SOCS3 mRNA]affects reaction|increases expression 19555225
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SOCS3 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of SOCS3 mRNAdecreases expression 18445702
C006253 pirinixic acid pirinixic acid results in increased expression of SOCS3 mRNAincreases expression 12832660
D011070 Poly I-C Poly I-C results in increased expression of SOCS3 mRNAincreases expression 21195166
D011374 Progesterone Progesterone affects the expression of SOCS3 mRNAaffects expression 17251523
C116926 rofecoxib rofecoxib results in increased expression of SOCS3 mRNAincreases expression 17070997
C116926 rofecoxib rofecoxib results in increased expression of SOCS3 proteinincreases expression 17070997
C477523 SC 514 SC 514 results in decreased expression of SOCS3 mRNAdecreases expression 17407152
D013629 Tamoxifen Tamoxifen affects the expression of SOCS3 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Oxygen deficiency] results in increased expression of SOCS3 mRNAaffects cotreatment|increases expression 19578757
D013749 Tetrachlorodibenzodioxin Arachidonic Acid promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of SOCS3 mRNA]increases expression|increases reaction 19063610
D013749 Tetrachlorodibenzodioxin arachidonyltrifluoromethane inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SOCS3 mRNA]decreases reaction|increases expression 19063610
D013749 Tetrachlorodibenzodioxin Forskolin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SOCS3 mRNA]decreases reaction|increases expression 17407152
D013749 Tetrachlorodibenzodioxin N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SOCS3 mRNA]decreases reaction|increases expression 17407152
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of SOCS3 mRNAincreases expression 19063610
18691609
18684927
17407152
D013853 Thioacetamide Thioacetamide results in decreased expression of SOCS3 mRNAdecreases expression 19784758
D014212 Tretinoin Tretinoin results in increased expression of SOCS3 mRNAincreases expression 15982314
D014415 Tunicamycin Tunicamycin results in increased expression of SOCS3 mRNAincreases expression 17127020
C066075 vanadium pentoxide vanadium pentoxide results in increased expression of SOCS3 mRNAincreases expression 17459161
D015054 Zymosan Zymosan results in increased expression of SOCS3 mRNAincreases expression 15188379
D015054 Zymosan Zymosan results in increased expression of SOCS3 proteinincreases expression 16646036
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.1014745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.4115322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.1218287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.4917505938
MESH:D058186 Acute Kidney Injury Ibuprofen 4.066375363
MESH:D055371 Acute Lung Injury nickel sulfate 13.0412718980 16100012 19131640 11954676
MESH:D055371 Acute Lung Injury Oxygen 13.0416759491
MESH:D055371 Acute Lung Injury pirinixic acid 13.0418653653
MESH:D000230 Adenocarcinoma Estradiol 9.1311473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.1314692618
MESH:D000230 Adenocarcinoma Genistein 9.1311473722
MESH:D000230 Adenocarcinoma Ibuprofen 9.1310697514
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 9.693712494
MESH:D000236 Adenoma Diethylnitrosamine 9.6910737359 6695378
MESH:D000236 Adenoma Methylcholanthrene 9.6910545420 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 14.7117162532 19052882 16434500 19061943 18056438 17620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 14.7116434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 14.7116835633
MESH:D018246 Adrenocortical Adenoma Arsenic 4.7617306315
MESH:D019973 Alcohol-Related Disorders Curcumin 4.6317887948
MESH:D000505 Alopecia Tretinoin 3.2615955085
MESH:D000544 Alzheimer Disease Curcumin 6.1015590663
MESH:D000544 Alzheimer Disease Ibuprofen 6.1018351690
MESH:D000544 Alzheimer Disease Ozone 6.1015513908
MESH:D000707 Anaphylaxis Ibuprofen 4.819532969
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.7211748828
MESH:D000740 Anemia Zymosan 7.7218664788
MESH:D000741 Anemia, Aplastic Benzene 4.0311369114 14761424 17661222
MESH:D000799 Angioedema Acetaminophen 3.3910982225
MESH:D000860 Anoxia Oxygen 4.6120872349
MESH:D020261 Arsenic Poisoning Arsenic 2.7316251483 18414634 16835338 12569548
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.0311256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 15.3015885639
MESH:D001169 Arthritis, Experimental rofecoxib 15.3016690336
MESH:D001169 Arthritis, Experimental Tretinoin 15.3016412693
MESH:D001169 Arthritis, Experimental Zymosan 15.3015142272 15188379 16872482 17659584 15944321
MESH:D001172 Arthritis, Rheumatoid Curcumin 6.7316807698
MESH:D001172 Arthritis, Rheumatoid Ozone 6.7315570426
MESH:D001172 Arthritis, Rheumatoid Tretinoin 6.7316292516
MESH:D001249 Asthma Mustard Gas 7.0510378619
MESH:D001249 Asthma Ozone 7.0517854713 16373670
MESH:D001249 Asthma Tretinoin 7.0516456186
MESH:D050197 Atherosclerosis Arsenic 13.4919371607 12928151
MESH:D050197 Atherosclerosis Curcumin 13.4918704882
MESH:D050197 Atherosclerosis Methylcholanthrene 13.4911922910
MESH:D050197 Atherosclerosis Oxygen 13.4916391483
MESH:D001284 Atrophy fulvestrant 4.4311514358
MESH:D001321 Autistic Disorder Acetaminophen 2.2318445737
MESH:D001321 Autistic Disorder Arachidonic Acid 2.2318582451
MESH:D001327 Autoimmune Diseases Curcumin 4.0619761891
MESH:D001471 Barrett Esophagus Tretinoin 3.9816935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.571440618 11289319
MESH:D001768 Blister Mustard Gas 4.7219167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 18.7219483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 18.7212125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 18.7219483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 18.7216197459 16206674
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.3415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.4715746008
MESH:D001855 Bone Marrow Diseases Benzene 4.7816183116
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.8917868700
MESH:D001930 Brain Injuries Progesterone 3.8315665606 15380490 15845082
MESH:D002545 Brain Ischemia Curcumin 9.0716770732
MESH:D002545 Brain Ischemia Ibuprofen 9.0715837124
MESH:D001932 Brain Neoplasms Curcumin 3.5617596214
MESH:D001943 Breast Neoplasms Benzene 10.3417162533 11921183
MESH:D001943 Breast Neoplasms Curcumin 10.3416243823 19250217 18462866 18593918
MESH:D001943 Breast Neoplasms Diethylnitrosamine 10.3417474063
MESH:D001943 Breast Neoplasms Estradiol 10.3417289903 17018787 12948864 16675129 18497071 14630087 17261762 19861407
MESH:D001943 Breast Neoplasms fulvestrant 10.3418984771
MESH:D001943 Breast Neoplasms Genistein 10.3416541309 16873071 17200150
MESH:D001943 Breast Neoplasms Hexachlorobenzene 10.3415061365 12709520
MESH:D001943 Breast Neoplasms Methylcholanthrene 10.3417474063
MESH:D001943 Breast Neoplasms Oxygen 10.3417263869
MESH:D001943 Breast Neoplasms Progesterone 10.3416175315 15562024 17614352
MESH:D001943 Breast Neoplasms Tamoxifen 10.3418629630 15565566 18855134 19059307 16818667 17440819 19155303 19189212 19066611 18984771 18425577 19103187 17242785 19244106 17893378 16273361 18821012 20005174 19221464 20390343 16202921 16873071 18997820 19410462 20065188 21152245 11161223 19115204 18815881 19200415 19142967 17261762 19011961 20544844 18351453 19189210 19289846 19288272 20135344 17049068 15668708 21138602 19487384 19084267 20859285
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 10.3420435547
MESH:D001943 Breast Neoplasms Tretinoin 10.3416873071 16166294 16443354
MESH:D016535 Bronchial Hyperreactivity Ozone 3.3315516495 18417511 16777450 14754758 19059883 18315731 17626835
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.7215286001
MESH:D001991 Bronchitis vanadium pentoxide 5.7917459161
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.5310378619 17687719
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.1516813970
MESH:D002100 Cachexia Ibuprofen 11.0915141370
MESH:D002100 Cachexia Ozone 11.0916183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.0216111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.3516097048 16011737 15700767 16227642 16192424 15673190 16124888 10355542 18705752 3786805 15721981 16050911
MESH:D002277 Carcinoma Curcumin 12.0018593918
MESH:D002277 Carcinoma Methylcholanthrene 12.0010545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 12.0016835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.3315504454 17687452
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.0719066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.7116168501
MESH:D006528 Carcinoma, Hepatocellular marker/mechanism 16831601
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 21.053581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 21.053084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 21.0517306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 21.0518788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 21.0516935385 20007298 19383236 16830150 10672840 21159647 18210153 18506893 17761372 20524982 19919837 19822196 18691550 20935162 19208518 11831363 17162532 19335982 20512989 16288022 17055752 17173139 20514400 16698587 16540662 16807293 19539802 19394651 19107877 19171122 18978308 17978847 18971187 20084675 19418558 18785209 16878318 17428255 20101231 3581430 18665156 19519916 16502159 17138121 19052882 16779866 18056438 20432363 3084413 16328049 18788625 16569478 20727157 10737359 18494052 18393292 16681979 20214788 19701751
MESH:D006528 Carcinoma, Hepatocellular Estradiol 21.0516924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 21.0516924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 21.0516924424
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 21.0517997003
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 21.051917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.8118414057
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.467296757
MESH:D002294 Carcinoma, Squamous Cell Arsenic 6.7817687452 18922899 15504454
MESH:D002294 Carcinoma, Squamous Cell Curcumin 6.7818462866
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 6.7816051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Arsenic 8.2318640142
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 8.2317572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.1118670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Arsenic 6.4715738583 17938729 19152805
MESH:D002318 Cardiovascular Diseases Genistein 6.4716332659
MESH:D002340 Carotid Artery Diseases Arsenic 3.9416973168 18022660
MESH:D002386 Cataract Acetaminophen 6.3310977129
MESH:D002386 Cataract Tretinoin 6.3317460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 13.517505956
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 13.5117174075 21159647 7505956 2727394
MESH:D002471 Cell Transformation, Neoplastic Estradiol 13.5118566989
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 13.5116192471
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.1516129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 13.9719052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 13.9716835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 13.9718291259
MESH:D002761 Cholangitis 1-Naphthylisothiocyanate 5.7512912871
MESH:D002779 Cholestasis 1-Naphthylisothiocyanate 16.5818164287 18590720 15500046 7624871 19486331 16629650 12927374 15913567
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 16.589022650 19486331
MESH:D002779 Cholestasis Ethinyl Estradiol 16.5817333356 15861022 17681005 16105132 11677210 17110522 16919318
MESH:D002779 Cholestasis pirinixic acid 16.5819176532
MESH:D002780 Cholestasis, Intrahepatic 1-Naphthylisothiocyanate 5.4010220858 19407337
MESH:D002822 Choriocarcinoma Tretinoin 4.7116461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.1012621046 8697196 15668235 16354765 15340226
MESH:D002972 Cleft Palate Tretinoin 5.109407595
MESH:D003092 Colitis Curcumin 8.2116782535 18200517 16804969
MESH:D003092 Colitis Tretinoin 8.2117035595
MESH:D003103 Coloboma Curcumin 4.1518809619
MESH:D003110 Colonic Neoplasms Curcumin 5.4619359593 16340194
MESH:D003110 Colonic Neoplasms Genistein 5.4617182828
MESH:D003110 Colonic Neoplasms rofecoxib 5.4612902858
MESH:D015179 Colorectal Neoplasms Azacitidine 2.7219934284
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.6914669216 17141729
MESH:D016510 Corneal Neovascularization Curcumin 4.4618497527
MESH:D019465 Craniofacial Abnormalities Benzene 3.5115643154
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.5110048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.519211117 10589399 9142499 9664655 16925845 17551590 9224671 14991402 8800419 9125849
MESH:D003711 Demyelinating Diseases Tamoxifen 3.9319031437
MESH:D003872 Dermatitis Benzene 4.3315902427
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 5.742524372 11906362 8156756 14531868 18759878 8970840 12868966 11298694
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 5.7416823706 16780908 11298694
MESH:D003876 Dermatitis, Atopic marker/mechanism
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2118249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.093621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 9.1918403477
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 9.1920387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 9.1916647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 9.1917107852
MESH:D003928 Diabetic Nephropathies Curcumin 12.8818204486
MESH:D003928 Diabetic Nephropathies Estradiol 12.8819279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 12.8819279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.0617187935
MESH:D056486 Drug-Induced Liver Injury 1-Naphthylisothiocyanate 16.3517522070 20133375 18289764 7624871
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 16.356482804 16192314 18648102 18289764 9022650 7440962 11289319 9328219 9653073 1440618 8291058 6679447 18692083
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 16.352444490 17906064 12392966 15968718 19923254 16227642 19164858 16109766 11529661 16177239 17562736 11834606 16485898 10774834 14725611 15619225 19416960 19420014 10915739 11421492 18713872 12958197 12705907 17522070 19370779 19085960 11287661 14986274 18071297 16081117 19739265 16781746 11739529 10663392 14550746 11743745 11461765 12594235 12540782 12153990 16393943
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 16.3517522070 3786805 4309450 7179309 21278145 3732212 10915739 16177239 2869522 16227642 15027814 19336974 10092053 6623471 15968718 9327722 7120509 11566570 7440962 19085960 6884620 15998439
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 16.3519107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 16.3520420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 16.3512963478
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.6519426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.4311462148
MESH:D004374 Ductus Arteriosus, Patent Ibuprofen 5.1718446180 16133044 18450898
MESH:D004381 Duodenal Ulcer Curcumin 3.6317351913
MESH:D004417 Dyspnea Oxygen 4.3820016425
MESH:D004487 Edema Arachidonic Acid 17.527990266 11698051 15177302 9599246 9831321 16716910
MESH:D004487 Edema Mustard Gas 17.529260866 11402378 11428631 11428647
MESH:D004487 Edema pirinixic acid 17.5212083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 17.5211000095 12711302
MESH:D004487 Edema Zymosan 17.527907874
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.4416714409 18230668 15322242
MESH:D004489 Edema, Cardiac Tretinoin 10.4418230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 12.8912538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 12.8917692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 12.8919031437
MESH:D004714 Endometrial Hyperplasia Genistein 4.1516402032
MESH:D016889 Endometrial Neoplasms marker/mechanism 16804899
MESH:D016889 Endometrial Neoplasms Estradiol 15.3511473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Genistein 15.3511473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 15.3519155303 20544844 16202921 17893378
MESH:D016889 Endometrial Neoplasms Tretinoin 15.3516569247
MESH:D004715 Endometriosis Ibuprofen 18.7615652904
MESH:D004715 Endometriosis Progesterone 18.7616134523
MESH:D004715 Endometriosis rofecoxib 18.7615652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 18.769294722 10568697
MESH:D019446 Endotoxemia Ibuprofen 4.5211545620
MESH:D004890 Erythema Mustard Gas 4.729357497
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.6616302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 1.993581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.7311564622
MESH:D005124 Eye Abnormalities Tretinoin 7.739664655 16938888
MESH:D005218 Fat Necrosis Thioacetamide 5.2716456712
MESH:D005234 Fatty Liver Carbon Tetrachloride 25.5912795759 16239168 19224547 15959796 61145 17595544 12631006 16045604
MESH:D005234 Fatty Liver Curcumin 25.5919297423
MESH:D005234 Fatty Liver Diethylnitrosamine 25.5921071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 25.5915345470
MESH:D005234 Fatty Liver pirinixic acid 25.5920131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 25.5914986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 2.9616709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.0211858732
MESH:D005334 Fever Arachidonic Acid 8.4911852909
MESH:D005334 Fever Ibuprofen 8.4916997862
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.576705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.0814745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.7419069698
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.5014633661 10962813
MESH:D005355 Fibrosis Carbon Tetrachloride 17.6318705752
MESH:D005355 Fibrosis Curcumin 17.6318705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 17.6320067830
MESH:D005355 Fibrosis Tretinoin 17.6317994277
MESH:D005534 Foot Diseases Arsenic 5.116392382
MESH:D005739 Gas Poisoning Oxygen 4.7720016425
MESH:D005756 Gastritis Acetaminophen 3.2216983495
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.2618462866
MESH:D005909 Glioblastoma Curcumin 10.2417596214
MESH:D005909 Glioblastoma Genistein 10.2416598420
MESH:D005909 Glioblastoma Tretinoin 10.2417312396
MESH:D005922 Glomerulonephritis, IGA deoxynivalenol 4.6615173396 16524712
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.637505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.1410696789
MESH:D006258 Head and Neck Neoplasms Curcumin 6.8818829502 18462866
MESH:D006258 Head and Neck Neoplasms Tretinoin 6.8816096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.7116084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.7211294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 5.729664655 14991402
MESH:D006333 Heart Failure pirinixic acid 2.2620558911
MESH:D006402 Hematologic Diseases Benzene 4.2516183116
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.9411000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.1815929193 18665440 17276928
MESH:D006505 Hepatitis 1-Naphthylisothiocyanate 24.8918590720
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 24.896705139
MESH:D006505 Hepatitis Carbon Tetrachloride 24.8919110552 19900420
MESH:D006505 Hepatitis Thioacetamide 24.8916456712
MESH:D006505 Hepatitis Zymosan 24.8919110552
MESH:D006529 Hepatomegaly pirinixic acid 6.8319772884 18467677 16221962 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 6.8316120746 12621046 15340226
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.6117701891
MESH:D006558 Herpes Genitalis Estradiol 4.5815709030
MESH:D019584 Hot Flashes Estradiol 3.3017088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.598697196 18606429 15340226 16959395 16354765
MESH:D006930 Hyperalgesia Acetaminophen 6.4716870215
MESH:D006930 Hyperalgesia Tretinoin 6.4716870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.0916899240
MESH:D006937 Hypercholesterolemia Curcumin 3.6618704882
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.1416778211
MESH:D006943 Hyperglycemia pirinixic acid 2.8020558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.0717050553
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.5115034207
MESH:D006973 Hypertension Arsenic 7.639931084 11953799 16076760
MESH:D006973 Hypertension Benzene 7.6317940673
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 7.6318850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.6615338365
MESH:D006984 Hypertrophy Ibuprofen 4.5816672835
MESH:D006987 Hypesthesia Arsenic 5.1116093927
MESH:D007021 Hypospadias Ethinyl Estradiol 3.3816945680 16569931
MESH:D007235 Infant, Premature, Diseases Ibuprofen 5.3816133044
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 3.9715869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.0512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 5.9217937319
MESH:D007248 Infertility, Male fulvestrant 5.9211514358
MESH:D007249 Inflammation Arachidonic Acid 28.3815177302 9831321 17371808
MESH:D007249 Inflammation Curcumin 28.3817151092 16956363 18403477
MESH:D007249 Inflammation Diethylnitrosamine 28.3818785209
MESH:D007249 Inflammation Ibuprofen 28.383291741
MESH:D007249 Inflammation Mustard Gas 28.3817524151 11428647 9357497 9260866 8975870 11428631 11402378 16001271 11428620
MESH:D007249 Inflammation Progesterone 28.3815869954
MESH:D007249 Inflammation Tamoxifen 28.3819457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 28.3812200463 12878042
MESH:D007249 Inflammation Zymosan 28.3811289658 8014878
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.0218596194 18200517
MESH:D007333 Insulin Resistance Estradiol 6.2116627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 6.2116306350
MESH:D007410 Intestinal Diseases rofecoxib 8.7115831440
MESH:D007410 Intestinal Diseases Tretinoin 8.7117994277
MESH:D007414 Intestinal Neoplasms Curcumin 3.8410783313
MESH:D007417 Intestinal Polyps rofecoxib 4.9611245490
MESH:D043183 Irritable Bowel Syndrome Zymosan 5.3917553498
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.579022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.6216580747
MESH:D007569 Jaw Abnormalities Tretinoin 8.6215992940 17551590
MESH:D007642 Keratosis Arsenic 4.5512749816 16930632
MESH:D007674 Kidney Diseases Acetaminophen 5.0115629191 12587719
MESH:D007674 Kidney Diseases Estradiol 5.0115618244
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 10.336582329
MESH:D007680 Kidney Neoplasms Estradiol 10.3315610895
MESH:D007680 Kidney Neoplasms Tamoxifen 10.3318625569
MESH:D007889 Leiomyoma Curcumin 4.1618555241
MESH:D007938 Leukemia Azacitidine 17.2419148494
MESH:D007938 Leukemia Benzene 17.2414694614 18335105 15935818 17119257
MESH:D007938 Leukemia Curcumin 17.2418462866
MESH:D007938 Leukemia Genistein 17.2418980019 17468513
MESH:D007938 Leukemia Tretinoin 17.2417143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 3.8116106398
MESH:D007951 Leukemia, Myeloid Azacitidine 13.8719077051
MESH:D007951 Leukemia, Myeloid Benzene 13.8717506065
MESH:D007951 Leukemia, Myeloid Tretinoin 13.8716482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Azacitidine 5.7317596541 18720364
MESH:D015470 Leukemia, Myeloid, Acute Benzene 5.7319478238
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 5.7316294345 19850784 17596541
MESH:D054429 Leukemia, Myelomonocytic, Juvenile Azacitidine 4.7819299654
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 6.7717339181
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 6.7717649720 17339181 17368321 17712046 19225113 9834237 16766008 16140955 16823087 19035177 16331271 17107899 17217047 19642359 16935935 17361223 16891316 17294898 19029980 17301526 15748426 12679006 17506722 16788101 19075265
MESH:D015458 Leukemia, T-Cell Curcumin 4.3416106398
MESH:D017880 Limb Deformities, Congenital Tretinoin 2.999224671
MESH:D008064 Lipidoses Tamoxifen 2.8417567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 5.7616943688 11408273 17157831 17334410 11903743 16239168 21278145 17174718 16221502
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 5.7618407596 20032147 18522880 19638242 18665156
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 2.919327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 19.2715650968 15123356 12609069 14716496 18481824 17714472 20821823 12666154 15996030 18210741 14716833 14748882 12649538 17823541 16136751 14512876 16116963 17721639 17565644 15370692 15052691 15673190 11481614 17708605 17922224 18429990 18395095 17761835 15057751 18205269 12445418 18187930 17976157 16027843 18317297 17698563 18166357 13678700 12741479 12632512 17944888 12632514 16033810 12389079 16638106 18279442 14724832 15876570 15931870 12445421 17869086 17766677 12958196 18006644 17481882 14620537 16097048 16192424 16011737 17640975 18420326 15925388 18472094 18339082 15959796 17525996 18054572 12546737 17900296 12667390 18705752 12586293 15893842 18472332 18263696 15818738 18395914 18156304 16015684 17631135 16248980 12898905 17557913 17805973 15338365 18376398 15730626 18251166 18412020 10355542 15362042 18277467 18418968
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 19.2718705752 17355460 18006644
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 19.2714716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 19.2717823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 19.2715474484
MESH:D008106 Liver Cirrhosis, Experimental Poly I-C 19.2718166357
MESH:D008106 Liver Cirrhosis, Experimental rofecoxib 19.2717565644
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 19.2718564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 19.2712878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 19.2715474484 17127702 11172339 14739098 12085344 15334695 16097051 12679928 16511523 16098781 18031379 18395095 18458672 15075984 12891558 18263696 17292413 11682029 15288472 11481614 17629604 18416461 16248980 12531686 16343077 17050028 15158331 15288473 15316131 16126171 15465738 18615449 15362042 18380797 18032466 18606216 10677585 18295389 12175628 15716488 17355460 16489207 15095483 12557150 15078482
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 19.2716248980 18397230
MESH:D008107 Liver Diseases marker/mechanism 19784758
MESH:D008107 Liver Diseases 1-Naphthylisothiocyanate 17.3317184895
MESH:D008107 Liver Diseases Acetaminophen 17.3312969438 16610002 19784758 12587719 19460945 11587558 16611625 19014921
MESH:D008107 Liver Diseases Arsenic 17.3311134558
MESH:D008107 Liver Diseases Carbon Tetrachloride 17.3317285989 16964402 15830285 16246199 15720792
MESH:D008107 Liver Diseases Curcumin 17.3316956363
MESH:D008107 Liver Diseases Diethylnitrosamine 17.3317034775
MESH:D008107 Liver Diseases Thioacetamide 17.3315158337 18374380 16337175
MESH:D017093 Liver Failure Carbon Tetrachloride 3.7315123358
MESH:D017114 Liver Failure, Acute Acetaminophen 14.0316871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 14.0316899240 14706259
MESH:D017114 Liver Failure, Acute Thioacetamide 14.0315313186 15633222 12479984 17276928
MESH:D008113 Liver Neoplasms Arsenic 15.5616368122
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 15.5619294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 15.5619833225 15885732 12112319 19254457 19996281 19642983 20583210 21071580 12771043 18648771 10737359 15175105 20137499 19812893 19255062 20452335 19427195 20501860 19499222 21167192 19256749 18754104 19073162 20118626 21278145 18977376 19638242 2422723 16942905 18978307 21047994 20434301 20405173 19850985 20492335 19090486 9163691 2862719 19551842 20101389 18644402 19426721 19690152 19294768
MESH:D008113 Liver Neoplasms pirinixic acid 15.5615890375 16377806 20007298
MESH:D008113 Liver Neoplasms Tamoxifen 15.5616684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 15.5616984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 23.911399818 6587162 3712494 598648
MESH:D008114 Liver Neoplasms, Experimental Benzene 23.9112562636
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 23.9115583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 23.9119539802 19519916 21159647 18775883 16842330 18253720 9362446 19126423 18544905 18164116 19009564 18093689 19004024 17942915 17174075 3124819 17854601 18282651 2563599 18079962 18308698 16267830
MESH:D008114 Liver Neoplasms, Experimental Hexachlorobenzene 23.911423854
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 23.91598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 23.9112151625
MESH:D008171 Lung Diseases Mustard Gas 6.6118161513 18702808
MESH:D008171 Lung Diseases Ozone 6.618266340 19066396
MESH:D017563 Lung Diseases, Interstitial Benzene 4.3614698565
MESH:D055370 Lung Injury Asbestos, Crocidolite 12.8217365036
MESH:D055370 Lung Injury Oxygen 12.8218339021
MESH:D055370 Lung Injury Ozone 12.8220417186
MESH:D008175 Lung Neoplasms Arsenic 18.9217306315 19168569 17976673
MESH:D008175 Lung Neoplasms Azacitidine 18.9221224363
MESH:D008175 Lung Neoplasms Benzene 18.9212562636
MESH:D008175 Lung Neoplasms Curcumin 18.9219359593 18462866 16243823
MESH:D008175 Lung Neoplasms Diethylnitrosamine 18.9221163286 20970405 6695378 20512841
MESH:D008175 Lung Neoplasms Methylcholanthrene 18.9216271038 20512841 16337739 6695378 20970405 15390079 11893704 1399818 17909032 21163286 10545420 7750092 9230183
MESH:D008175 Lung Neoplasms Mustard Gas 18.928781369 3148597
MESH:D008175 Lung Neoplasms Ozone 18.928597069 7614698
MESH:D008175 Lung Neoplasms Tamoxifen 18.9218625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 18.9211884234 19555203
MESH:D008175 Lung Neoplasms vanadium pentoxide 18.9212376484
MESH:D008223 Lymphoma Benzene 6.8317584886 17119257
MESH:D008223 Lymphoma Curcumin 6.8318462866
MESH:D016399 Lymphoma, T-Cell Curcumin 4.2616173963
MESH:D015674 Mammary Neoplasms, Animal Benzene 8.6012562636
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 8.6019428831
MESH:D008325 Mammary Neoplasms, Experimental Benzene 19.8011921183
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 19.8017203775 16891317 11408345 11807958
MESH:D008325 Mammary Neoplasms, Experimental Genistein 19.8014578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Ibuprofen 19.8010697514
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 19.8011408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 19.8011731420 14580682 16827153 19196722 19196723
MESH:D020149 Manganese Poisoning Estradiol 11.1419453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.1419453300
MESH:D008527 Medulloblastoma Tretinoin 2.6017453147
MESH:D008545 Melanoma Curcumin 4.6017885582 18462866
MESH:D008545 Melanoma Tamoxifen 4.6012393984 19393235
MESH:D008545 Melanoma Tretinoin 4.6016752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.7415990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.1419513568
MESH:D008569 Memory Disorders Curcumin 3.7417263510
MESH:D008591 Meningomyelocele Tretinoin 3.9916940565
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.0016166281 16966607 18303189
MESH:D008679 Metaplasia Ozone 4.6510496685
MESH:D009006 Monosomy Azacitidine 5.6319299654
MESH:D009101 Multiple Myeloma Azacitidine 10.5018443271 19549372
MESH:D009101 Multiple Myeloma Benzene 10.5017119195
MESH:D009101 Multiple Myeloma Curcumin 10.5019372569
MESH:D009102 Multiple Organ Failure Zymosan 4.8018160304 15259001 15241586 12130978 10479408 15213630 12879239 15834315 10890648 17724436
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.4717962980
MESH:D009135 Muscular Diseases pirinixic acid 3.0816239165
MESH:D009190 Myelodysplastic Syndromes Azacitidine 6.8317611569 19805378 17596541 18720364
MESH:D009190 Myelodysplastic Syndromes Tretinoin 6.8317596541
MESH:D009203 Myocardial Infarction Genistein 5.0117141266
MESH:D009203 Myocardial Infarction pirinixic acid 5.0119151258
MESH:D017202 Myocardial Ischemia Arsenic 7.8415371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 7.8412213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 12.2016810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 12.2017141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 12.2016411023
MESH:D009361 Neoplasm Invasiveness Curcumin 3.9518495463
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 8.333581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 8.339029167 3581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 8.3319393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.3619410462
MESH:D009369 Neoplasms pirinixic acid 4.1517405874
MESH:D009369 Neoplasms Tretinoin 4.1516946489 16594593
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 9.3412497104
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 9.3419189210 19196722 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 3.2917289903
MESH:D009395 Nephritis, Interstitial Ibuprofen 4.546375363
MESH:D009410 Nerve Degeneration Ibuprofen 4.0510961664
MESH:D009421 Nervous System Malformations Estradiol 19.9916427766 11399458
MESH:D009421 Nervous System Malformations Genistein 19.9916427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 19.9914600291
MESH:D009421 Nervous System Malformations Tretinoin 19.999125849
MESH:D009423 Nervous System Neoplasms Curcumin 5.1818462866
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 14.946679447
MESH:D009436 Neural Tube Defects Arsenic 14.9416620997
MESH:D009436 Neural Tube Defects Benzene 14.9415643154
MESH:D009436 Neural Tube Defects Tretinoin 14.949142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 6.9918514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 6.9920387270
MESH:D020078 Neurogenic Inflammation Arsenic 3.9717056641
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.6620387270
MESH:D009503 Neutropenia Mustard Gas 3.5716761898 7688884
MESH:D009765 Obesity Curcumin 4.1819297423
MESH:D009765 Obesity pirinixic acid 4.1820558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 7.894026338 6482804
MESH:D009784 Occupational Diseases Benzene 7.8917119257 16737584 15576619 15913788 17479406 15727169 15935809 15612468 17178637
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.573988306
MESH:D010003 Osteoarthritis Ibuprofen 7.397009135
MESH:D010003 Osteoarthritis rofecoxib 7.3916690336
MESH:D010024 Osteoporosis Curcumin 6.4318719352
MESH:D010024 Osteoporosis Genistein 6.4319401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.6816169203
MESH:D010051 Ovarian Neoplasms Arsenic 20.5117306315
MESH:D010051 Ovarian Neoplasms Benzene 20.5112562636
MESH:D010051 Ovarian Neoplasms Curcumin 20.5119020741 18462866
MESH:D010051 Ovarian Neoplasms Estradiol 20.5119401270
MESH:D010051 Ovarian Neoplasms Genistein 20.5119005980
MESH:D010051 Ovarian Neoplasms Progesterone 20.5116525653 17393432
MESH:D010051 Ovarian Neoplasms Tretinoin 20.5116936753
MESH:D010146 Pain Acetaminophen 9.2716870215
MESH:D010146 Pain Ibuprofen 9.273291741
MESH:D010146 Pain Tretinoin 9.2716870215
MESH:D010149 Pain, Postoperative Ibuprofen 10.2416678543
MESH:D010149 Pain, Postoperative rofecoxib 10.2418165598 16678543
MESH:D010190 Pancreatic Neoplasms Curcumin 10.9419401701 17440100 19196508
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 10.9416540662
MESH:D010190 Pancreatic Neoplasms Ibuprofen 10.9412384795
MESH:D010190 Pancreatic Neoplasms Tretinoin 10.9415976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.2811578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.067296757
MESH:D010382 Peliosis Hepatis 1-Naphthylisothiocyanate 12.2820133375
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 12.2812520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 3.7616093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.556392382 15371236 16905509
MESH:D010538 Peritonitis Ozone 8.9816369182
MESH:D010538 Peritonitis Zymosan 8.9817826846 11985352 18977430 15979727 19641140 19088179 17371808 15259001 14761945 18557954 18760300
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.026228378
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.4610923243
MESH:D011014 Pneumonia Ozone 3.9518007984 18381685 18929643
MESH:D011041 Poisoning Mustard Gas 3.4015727166
MESH:D017119 Porphyria Cutanea Tarda Hexachlorobenzene 9.719918132
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 9.7118163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.182563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.7511399792 11896295 11222880 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.4920887781
MESH:D011471 Prostatic Neoplasms Arsenic 2.0316140617
MESH:D011471 Prostatic Neoplasms Azacitidine 2.0318324645
MESH:D011471 Prostatic Neoplasms Curcumin 2.0315129424 11398177 18226269 18769126 18156803 10851300 12497104
MESH:D011471 Prostatic Neoplasms Estradiol 2.0316740699
MESH:D011471 Prostatic Neoplasms Genistein 2.0316925846 15378649 15256057
MESH:D011471 Prostatic Neoplasms Ibuprofen 2.0317409433
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0315067354
MESH:D011507 Proteinuria Arsenic 13.2221343184
MESH:D011507 Proteinuria Ibuprofen 13.226375363
MESH:D011507 Proteinuria Tretinoin 13.2216636307
MESH:D011537 Pruritus Ethinyl Estradiol 8.0615861022 16919318
MESH:D011537 Pruritus Mustard Gas 8.0618058305
MESH:D011625 Pterygium Tretinoin 4.3516723453
MESH:D011656 Pulmonary Emphysema Curcumin 4.1419168576
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 5.2915814490 17365031 17322281 17975199
MESH:D011658 Pulmonary Fibrosis Mustard Gas 5.2917894541 17620002 10334151 17720292 17266442
MESH:D015427 Reperfusion Injury pirinixic acid 2.1619058328
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 8.1418379247 10666014
MESH:D012128 Respiratory Distress Syndrome, Adult Oxygen 8.1417627322 18339021
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4218990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.043692021
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.6916283617 16116481
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.6918045962
MESH:D012509 Sarcoma Curcumin 3.7318462866
MESH:D018805 Sepsis Curcumin 8.4918389075
MESH:D018805 Sepsis Zymosan 8.4911441115
MESH:D012871 Skin Diseases Arsenic 4.7019834688 6392382 16702368 17453740 16353154 17050553 18709164 16759981 17938729 17548696 15952646
MESH:D012871 Skin Diseases Mustard Gas 4.7012880345 15451306 16961503
MESH:D012878 Skin Neoplasms Arsenic 8.1715504454 17029826 19538983 17050553 17976673 16251483
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.1716192470
MESH:D012878 Skin Neoplasms Tretinoin 8.1716467112
MESH:D013088 Spermatocele Ethinyl Estradiol 10.0616709447
MESH:D013088 Spermatocele Tamoxifen 10.0616709447
MESH:D013119 Spinal Cord Injuries Progesterone 9.4015862959 16503802
MESH:D013119 Spinal Cord Injuries Tamoxifen 9.4019457130
MESH:D013274 Stomach Neoplasms Benzene 3.1612562636
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.1618456281
MESH:D013274 Stomach Neoplasms Tretinoin 3.1617261132
MESH:D013276 Stomach Ulcer Curcumin 3.1216631530 19188055
MESH:D013398 Sudden Infant Death Oxygen 5.1012563064
MESH:D013921 Thrombocytopenia 1-Naphthylisothiocyanate 4.3720133375
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.2111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.7815669648
MESH:D013953 Thymus Neoplasms Benzene 4.5110850423
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.4512697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 10.003712494 1399818 6582329 7505956 6587162
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 10.007505956
MESH:D013964 Thyroid Neoplasms Tretinoin 10.0017045167 16026305
MESH:D013978 Tibial Fractures Estradiol 4.2319048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.4016051514
MESH:D014376 Tuberculosis Tretinoin 2.9516040207
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 10.398074119
MESH:D001749 Urinary Bladder Neoplasms Arsenic 10.3915987713 19322015 18640142 11144890 17976673 17306315 19429237
MESH:D001749 Urinary Bladder Neoplasms Curcumin 10.3918593936
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 10.3917572228 8653321 16712894
MESH:D014565 Urogenital Neoplasms Curcumin 4.8218462866
MESH:D014581 Urticaria Acetaminophen 2.5710982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.2916129372
MESH:D014594 Uterine Neoplasms Benzene 8.1812562636
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.1814692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.1616752155
MESH:D014605 Uveitis Zymosan 4.9511006244
MESH:D014652 Vascular Diseases Arsenic 4.2917056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.1412125929
MESH:D020301 Vasospasm, Intracranial Ibuprofen 4.7519057314
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.1414671159 15869587
MESH:D014820 Vitiligo Tretinoin 3.6416761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8015886252
MESH:D009396 Wilms Tumor Tretinoin 3.5916287080
Pathway ID Pathway Name
KEGG:04920 Adipocytokine signaling pathway
KEGG:05160 Hepatitis C
KEGG:04910 Insulin signaling pathway
KEGG:04630 Jak-STAT signaling pathway
KEGG:04380 Osteoclast differentiation
REACT:6900 Signaling in Immune system
KEGG:04930 Type II diabetes mellitus
KEGG:04120 Ubiquitin mediated proteolysis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134885765
    • Releated gene ID Related gene Name
    PA198IL6
    PA283MAPK8
    Releated disease ID Related disease Name
    PA443624Carcinoma, Renal Cell
    PA443879Dermatitis, Atopic
    PA443890Diabetes Mellitus, Type 2
    Releated drug ID Related drug Name
    PA164749376interferon alfacon-1
    PA450970pioglitazone
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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