AutismKB 2.0

Annotation Detail for KLHL13


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Basic Information Top
Gene Symbol:KLHL13 ( BKLHD2,FLJ10262,MGC74791 )
Gene Full Name: kelch-like 13 (Drosophila)
Band: Xq24
Quick LinksEntrez ID:90293; OMIM: 300655; Uniprot ID:KLH13_HUMAN; ENSEMBL ID: ENSG00000003096; HGNC ID: 22931
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04120Ubiquitin mediated proteolysis
No data
Pathway IDPathway Name
200010Aurora B signaling
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
HEMATOLOGICAL
serum markers of iron status
Desease Name
Serum markers of iron status
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of KLHL13 mRNAaffects expression 17562736
D001104 Arbutin Arbutin results in increased expression of KLHL13 mRNAincreases expression 17103032
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of KLHL13 mRNAdecreases expression 20382639
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of KLHL13 mRNAaffects expression 17484886
C011890 kojic acid kojic acid results in increased expression of KLHL13 mRNAincreases expression 16595896
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000799 Angioedema Acetaminophen 4.4510982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.2616227642 16124888 15700767 16192424 15721981 18705752 15673190 16050911 10355542 3786805 16097048 16011737
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.973084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 2.9718788625
MESH:D002386 Cataract Acetaminophen 2.7710977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.9620889678
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.0219416960 17522070 15968718 16485898 19085960 11421492 11461765 15619225 14986274 14550746 12705907 11739529 16109766 12153990 17906064 19370779 16081117 19923254 18071297 10774834 11834606 17562736 14725611 11743745 16781746 10663392 11287661 16393943 19739265 11529661 16227642 12540782 10915739 2444490 12958197 12594235 16177239 19164858 12392966 18713872 19420014
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 4.0216227642 10092053 17522070 7179309 4309450 3786805 19085960 19336974 11566570 3732212 16177239 6884620 15968718 7120509 9327722 6623471 10915739 15027814 7440962 15998439 2869522 21278145
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.7119426721
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1420426865
MESH:D005234 Fatty Liver Carbon Tetrachloride 3.5412795759 15959796 17595544 12631006 16239168 19224547 16045604 61145
MESH:D005355 Fibrosis Carbon Tetrachloride 3.9418705752
MESH:D005756 Gastritis Acetaminophen 4.2916983495
MESH:D006505 Hepatitis Carbon Tetrachloride 4.0319900420 19110552
MESH:D006930 Hyperalgesia Acetaminophen 2.9916870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 5.0716899240
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.5715338365
MESH:D007674 Kidney Diseases Acetaminophen 2.3815629191 12587719
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9816943688 16221502 11408273 17157831 17174718 21278145 11903743 16239168 17334410
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 1.7515650968 17823541 15893842 18277467 15996030 16136751 12958196 17869086 14724832 16248980 16027843 18054572 14716833 12389079 16033810 17714472 10355542 18412020 13678700 15925388 18481824 16015684 17721639 14716496 18205269 18251166 18166357 18376398 12741479 17698563 11481614 15052691 17525996 15730626 20821823 18472094 15876570 18472332 17557913 17708605 15123356 15673190 17944888 17481882 18156304 18210741 18279442 14620537 17766677 12666154 16097048 15338365 15057751 12649538 18705752 17761835 12445421 14748882 18420326 15818738 15362042 15931870 18339082 14512876 18187930 12898905 12586293 16638106 12609069 12546737 17900296 12445418 18395095 17805973 17640975 15370692 12632512 12632514 16192424 18395914 12667390 17922224 17631135 18006644 18429990 18317297 18418968 15959796 16011737 18263696 17976157 16116963 17565644
MESH:D008107 Liver Diseases Acetaminophen 4.1419014921 16610002 19784758 11587558 12969438 16611625 19460945 12587719
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.1416964402 15720792 17285989 15830285 16246199
MESH:D017093 Liver Failure Carbon Tetrachloride 4.6515123358
MESH:D017114 Liver Failure, Acute Acetaminophen 10.5916871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 10.5916899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 2.3219294768
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.9012014681 15583823
MESH:D008114 Liver Neoplasms, Experimental kojic acid 6.9018544905
MESH:D008546 Melanoma, Experimental Acetaminophen 4.0519513568
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1818514411
MESH:D010146 Pain Acetaminophen 2.6916870215
MESH:D014581 Urticaria Acetaminophen 3.3810982225
Pathway ID Pathway Name
KEGG:04120 Ubiquitin mediated proteolysis
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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