AutismKB 2.0

Annotation Detail for CCRL2


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Basic Information Top
Gene Symbol:CCRL2 ( CKRX,CRAM,CRAM-A,CRAM-B,FLJ55815,HCR,MGC116710,MGC34104 )
Gene Full Name: chemokine (C-C motif) receptor-like 2
Band: 3p21.31
Quick LinksEntrez ID:9034; OMIM: 608379; Uniprot ID:CCRL2_HUMAN; ENSEMBL ID: ENSG00000121797; HGNC ID: 1612
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
P00031Inflammation mediated by chemokine and cytokine signaling pathway
No data
Related Diseases/Disorders Top
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Desease IDDesease Name
1781Rheumatoid arthritis
Desease Name
Celiac Disease
IMMUNE
No data
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of CCRL2 mRNAincreases expression 19933214
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of CCRL2 mRNAdecreases expression 18648102
D001151 Arsenic Arsenic results in decreased expression of CCRL2 mRNAdecreases expression 16835338
D016572 Cyclosporine Cyclosporine results in increased expression of CCRL2 mRNAincreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of CCRL2 mRNAdecreases expression 18042831
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CCRL2 mRNAaffects cotreatment|increases expression 17942748
C016599 mono-(2-ethylhexyl)phthalate mono-(2-ethylhexyl)phthalate results in increased expression of CCRL2 mRNAincreases expression 16809437
C041786 palm oil palm oil results in decreased expression of CCRL2 mRNAdecreases expression 18042831
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CCRL2 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CCRL2 mRNAincreases expression 19933214
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1311752688 14514962 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2617505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8514692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.863712494
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6616835633
MESH:D018246 Adrenocortical Adenoma Arsenic 5.5317306315
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D020261 Arsenic Poisoning marker/mechanism 16835338
MESH:D020261 Arsenic Poisoning Arsenic 2.9112569548 16835338 18414634 16251483
MESH:D001161 Arteriosclerosis Dietary Fats 10.7915238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 10.7911256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7815885639
MESH:D050197 Atherosclerosis Arsenic 3.3612928151 19371607
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.341440618 11289319
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D001943 Breast Neoplasms Dietary Fats 1.9720435547
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9720435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.6915504454 17687452
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 3.237296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Arsenic 3.2317306315 16507464
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.767296757
MESH:D002294 Carcinoma, Squamous Cell Arsenic 2.7415504454 17687452 18922899
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.2718640142
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4718670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Arsenic 3.5815738583 19152805 17938729
MESH:D002340 Carotid Artery Diseases Arsenic 4.4918022660 16973168
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.037505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.0312371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3416835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 14.279022650 19486331
MESH:D002779 Cholestasis Cyclosporine 14.2719486331
MESH:D002779 Cholestasis Ethinyl Estradiol 14.2717681005 16919318 17333356 16105132 17110522 15861022 11677210
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1812621046 15668235 15340226 8697196 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2417141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.068156756 2524372 12868966 11298694 11906362 8970840 18759878 14531868
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.713621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 3.8618289764 18692083 1440618 9328219 18648102 6679447 11289319 8291058 9022650 9653073 7440962 16192314 6482804
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.8620420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:D050171 Dyslipidemias Dietary Fats 3.6018367378
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2215322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.4212538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.219294722 10568697
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.153581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver Cyclosporine 14.3019224547
MESH:D005234 Fatty Liver Dietary Fats 14.3019551842 19004024 17967931 18296743
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.3015345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.346705139
MESH:D005355 Fibrosis Cyclosporine 16.3012168785 12639820
MESH:D005355 Fibrosis Dietary Fats 16.3018296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 16.3020067830
MESH:D005534 Foot Diseases Arsenic 5.886392382
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.508708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.267505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4310048152 11294989
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7115720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.756705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1516120746 15340226 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3616354765 15340226 18606429 16959395 8697196
MESH:D006937 Hypercholesterolemia Dietary Fats 3.8021332399
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.6517050553
MESH:D006949 Hyperlipidemias Dietary Fats 3.8321332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2015034207
MESH:D006973 Hypertension Arsenic 8.9816076760 11953799 9931084
MESH:D006973 Hypertension Cyclosporine 8.9810903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.9818670907 18850075
MESH:D006987 Hypesthesia Arsenic 5.8816093927
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0716569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6217937319
MESH:D007249 Inflammation Dietary Fats 5.2420412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.2412878042 12200463
MESH:D007333 Insulin Resistance Dietary Fats 3.2318457598 11836018
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.348074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7615604871
MESH:D007642 Keratosis Arsenic 5.2812749816 16930632
MESH:D007674 Kidney Diseases Cyclosporine 2.4418776723 10903974 8314463
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.856582329
MESH:D007680 Kidney Neoplasms Cyclosporine 7.8512371664
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.6817339181
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9818296743
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.319327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008107 Liver Diseases Arsenic 2.5811134558
MESH:D008113 Liver Neoplasms Arsenic 4.7916368122
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.7916984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.133712494 1399818 6587162 598648
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.1312151625
MESH:D008175 Lung Neoplasms Arsenic 2.4717976673 17306315 19168569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.4719555203 11884234
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1116801185
MESH:D017202 Myocardial Ischemia Arsenic 9.5615371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.5612213967
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.543581430
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4719348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4514600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.806679447
MESH:D009436 Neural Tube Defects Arsenic 7.8016620997
MESH:D020078 Neurogenic Inflammation Arsenic 4.6017056641
MESH:D009765 Obesity Dietary Fats 2.3320132043 17217161 11836018 16723640 19632207 20518802 18674790 18457598 21332399
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.614026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.343988306
MESH:D010051 Ovarian Neoplasms Arsenic 2.8017306315
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9111578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.747296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.4216093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.2815371236 16905509 6392382
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.796228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.4012371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4811896295 11222880 11118676 11399792
MESH:D011471 Prostatic Neoplasms Arsenic 3.5816140617
MESH:D011507 Proteinuria Arsenic 4.2221343184
MESH:D011537 Pruritus Ethinyl Estradiol 3.6016919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.2916882103
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.523692021
MESH:D012871 Skin Diseases marker/mechanism 16835338
MESH:D012871 Skin Diseases Arsenic 2.7917938729 19834688 17050553 16759981 15952646 16702368 17548696 16353154 17453740 6392382 18709164
MESH:D012878 Skin Neoplasms Arsenic 6.0017050553 17029826 19538983 16251483 15504454 17976673
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 6.0016192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2616709447
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3315669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.046582329 7505956 3712494 6587162 1399818
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.448074119
MESH:D001749 Urinary Bladder Neoplasms Arsenic 5.4415987713 11144890 19429237 17306315 18640142 17976673 19322015
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5414692618
MESH:D014605 Uveitis Cyclosporine 4.301336536
MESH:D014652 Vascular Diseases Arsenic 5.0217056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7514671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
MESH:D015430 Weight Gain Dietary Fats 3.9216723640
MESH:D014985 Xerophthalmia Cyclosporine 4.7617120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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