AutismKB 2.0

Annotation Detail for SEMA5A


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Basic Information Top
Gene Symbol:SEMA5A ( FLJ12815,SEMAF,semF )
Gene Full Name: sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
Band: 5p15.31
Quick LinksEntrez ID:9037; OMIM: 609297; Uniprot ID:SEM5A_HUMAN; ENSEMBL ID: ENSG00000112902; HGNC ID: 10736
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04360Axon guidance
Pathway IDPathway Name
Axon guidance
No data
No data
Pathway IDPathway Name
500078Other semaphorin interactions
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2124Autistic disorder
Desease Name
Parkinson's disease
PSYCH
NEUROLOGICAL
Autism
Desease Name
Parkinson's disease
Autism
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C010914 2,4-diaminotoluene 2,4-diaminotoluene results in increased expression of SEMA5A mRNAincreases expression 20713471
C014949 acetylhydrazine acetylhydrazine results in decreased expression of SEMA5A mRNAdecreases expression 15282401
D001149 Arsenates [Atrazine co-treated with Arsenates] results in increased expression of SEMA5A mRNAaffects cotreatment|increases expression 18585445
C015001 arsenite [arsenite co-treated with Benzo(a)pyrene] results in decreased expression of SEMA5A mRNAaffects cotreatment|decreases expression 15894712
C015001 arsenite arsenite results in decreased expression of SEMA5A mRNAdecreases expression 15894712
D001280 Atrazine [Atrazine co-treated with Arsenates] results in increased expression of SEMA5A mRNAaffects cotreatment|increases expression 18585445
D001564 Benzo(a)pyrene [arsenite co-treated with Benzo(a)pyrene] results in decreased expression of SEMA5A mRNAaffects cotreatment|decreases expression 15894712
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of SEMA5A mRNAdecreases expression 15894712
20713471
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of SEMA5A mRNAincreases expression 12057914
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of SEMA5A mRNAincreases expression 20713471
C008493 methylselenic acid methylselenic acid results in increased expression of SEMA5A mRNAincreases expression 18548127
C029938 nickel sulfate nickel sulfate results in increased expression of SEMA5A mRNAincreases expression 16780908
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of SEMA5A mRNAaffects binding|increases activity|increases expression 19710929
D012645 Selenomethionine Selenomethionine affects the expression of SEMA5A mRNAaffects expression 17222674
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury Lipopolysaccharides 16.0318653653 11850527
MESH:D055371 Acute Lung Injury nickel sulfate 16.0311954676 16100012 19131640 12718980
MESH:D055371 Acute Lung Injury pirinixic acid 16.0318653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0120127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 7.076695378
MESH:D000236 Adenoma Methylcholanthrene 7.076695378 10545420
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.6316434500
MESH:D000382 Agricultural Workers' Diseases Atrazine 4.3811874814
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2119183758
MESH:D050197 Atherosclerosis Methylcholanthrene 3.5111922910
MESH:D001321 Autistic Disorder marker/mechanism 17028446
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2619483382
MESH:D001943 Breast Neoplasms 2,4-diaminotoluene 2.0811921183
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0820146248 17474063
MESH:D001943 Breast Neoplasms Methylcholanthrene 2.0817474063
MESH:D002277 Carcinoma Methylcholanthrene 4.0510545420
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0820419170
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 3.5716192471
MESH:D002779 Cholestasis pirinixic acid 2.9119176532
MESH:D003110 Colonic Neoplasms arsenite 2.6015037631
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 3.8116823706 11298694 16780908
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4718249437
MESH:D004487 Edema pirinixic acid 2.5912083418
MESH:D019446 Endotoxemia Lipopolysaccharides 4.5517637181 15821434 15328337
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0316530937
MESH:D005234 Fatty Liver arsenite 8.2718296743
MESH:D005234 Fatty Liver pirinixic acid 8.2719236843 20131406
MESH:D005334 Fever Lipopolysaccharides 4.1211852909 9205823
MESH:D005354 Fibrosarcoma Methylcholanthrene 5.0914633661 10962813
MESH:D005355 Fibrosis arsenite 4.2018296743
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7120471113
MESH:D006333 Heart Failure pirinixic acid 2.6020558911
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.4916366002
MESH:D006529 Hepatomegaly pirinixic acid 3.1318467677 19772884 16221962 19176532
MESH:D006943 Hyperglycemia pirinixic acid 3.2920558911
MESH:D007248 Infertility, Male Atrazine 3.7812948887
MESH:D007249 Inflammation Lipopolysaccharides 2.929205823 17237260 12878042 17255318 17963957
MESH:D007333 Insulin Resistance pirinixic acid 2.7016306350
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.7517255318
MESH:D007970 Leukopenia Lipopolysaccharides 4.8515821434
MESH:D008103 Liver Cirrhosis arsenite 3.4718296743
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 2.5412878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.5415474484
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.4921137059 20195826
MESH:D008113 Liver Neoplasms pirinixic acid 4.4920007298 15890375 16377806
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 3.341399818 598648
MESH:D055370 Lung Injury Lipopolysaccharides 4.1521114838
MESH:D008175 Lung Neoplasms arsenite 3.6416809336
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.6418569708 6695378 18520028 20135361 20464547 18816296 17053015 20064080 20869020
MESH:D008175 Lung Neoplasms Methylcholanthrene 3.6420970405 6695378 15390079 21163286 7750092 20512841 9230183 10545420 16337739 11893704 16271038 1399818 17909032
MESH:D008325 Mammary Neoplasms, Experimental 2,4-diaminotoluene 3.6411921183
MESH:D008654 Mesothelioma Atrazine 3.561916698
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2716381670
MESH:D009135 Muscular Diseases pirinixic acid 3.6416239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1819151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0316411023
MESH:D009369 Neoplasms Benzo(a)pyrene 4.9911141357
MESH:D009369 Neoplasms pirinixic acid 4.9917405874
MESH:D009389 Neovascularization, Pathologic arsenite 4.5715738583
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D010300 Parkinson Disease Atrazine 3.3117218051
MESH:D011014 Pneumonia Lipopolysaccharides 4.7112224865 11605937
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.3817292933
MESH:D011471 Prostatic Neoplasms methylselenic acid 3.3816205645
MESH:D015427 Reperfusion Injury pirinixic acid 2.4319058328
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.8010835634
MESH:D012135 Respiratory Sounds Atrazine 4.6511874814
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4110029692 19755658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.2715821434
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2117053015
Pathway ID Pathway Name
KEGG:04360 Axon guidance
REACT:18266 Axon guidance
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA35658
    • No data
    Releated disease ID Related disease Name
    PA445254Parkinson Disease
    No data
    Drug Bank Top

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    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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