AutismKB 2.0

Annotation Detail for CCNT1


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Basic Information Top
Gene Symbol:CCNT1 ( CCNT,CYCT1,HIVE1 )
Gene Full Name: cyclin T1
Band: 12q13.11-q13.12
Quick LinksEntrez ID:904; OMIM: 143055; Uniprot ID:CCNT1_HUMAN; ENSEMBL ID: ENSG00000129315; HGNC ID: 1599
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Elongation arrest and recovery
Pausing and recovery of elongation
Transcription
Gene Expression
HIV Infection
No data
No data
Pathway IDPathway Name
500949RNA Polymerase II Pre-transcription Events
500741Formation of HIV-1 elongation complex containing HIV-1 Tat
500753Interactions of Tat with host cellular proteins
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1809HIV infection
1899Eosinophilia
1934Cancer
2192Lung disease
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C120275 2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone 2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone inhibits the reaction [CDK9 protein binds to CCNT1 protein]affects binding|decreases reaction 17631934
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of CCNT1 mRNAdecreases expression 12419474
D000638 Amiodarone Amiodarone results in increased expression of CCNT1 mRNAincreases expression 19774075
D003913 Dextroamphetamine Dextroamphetamine affects the expression of CCNT1 mRNAaffects expression 12205029
D003913 Dextroamphetamine SOD1 affects the reaction [Dextroamphetamine affects the expression of CCNT1 mRNA]affects expression|affects reaction 12205029
C415250 deferasirox deferasirox inhibits the reaction [CDK9 protein binds to CCNT1 protein]affects binding|decreases reaction 17631934
D006861 Hydrogen Peroxide Hydrogen Peroxide results in decreased expression of CCNT1 mRNAdecreases expression 12419474
D008070 Lipopolysaccharides Lipopolysaccharides results in decreased expression of CCNT1 mRNAdecreases expression 12057914
C004925 methylmercuric chloride methylmercuric chloride results in decreased expression of CCNT1 mRNAdecreases expression 19465457
D009151 Mustard Gas Mustard Gas results in increased expression of CCNT1 mRNAincreases expression 15674843
D037742 Nanotubes, Carbon Nanotubes, Carbon results in increased expression of CCNT1 mRNAincreases expression 15585362
D010656 Phenylephrine Phenylephrine inhibits the reaction [HEXIM1 protein binds to CCNT1 protein]affects binding|decreases reaction 17459355
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CCNT1 mRNAaffects binding|decreases expression|increases activity 19710929
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CCNT1 protein]affects binding|increases reaction 12917420
D014212 Tretinoin Tretinoin results in increased expression of CCNT1 mRNAincreases expression 15753651
D014212 Tretinoin Tretinoin results in increased expression of CCNT1 proteinincreases expression 15753651
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced methylmercuric chloride 9.056734493
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.0511752688 15322242 14514962
MESH:D055371 Acute Lung Injury Lipopolysaccharides 9.2411850527 18653653
MESH:D055371 Acute Lung Injury pirinixic acid 9.2418653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.1816434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.1816835633
MESH:D000505 Alopecia Tretinoin 3.6615955085
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 4.1310965797
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0011748828
MESH:D001145 Arrhythmias, Cardiac Amiodarone 9.3118218290 18057881 20041841
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 9.3117460149
MESH:D001169 Arthritis, Experimental Tretinoin 3.1116412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2716292516
MESH:D001249 Asthma Mustard Gas 5.0310378619
MESH:D001249 Asthma Tretinoin 5.0316456186
MESH:D001281 Atrial Fibrillation Amiodarone 3.9418651412 19698954
MESH:D001471 Barrett Esophagus Tretinoin 4.4716935849
MESH:D001768 Blister Mustard Gas 5.2419167455
MESH:D001778 Blood Coagulation Disorders Amiodarone 22.4419483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 22.4419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 22.4412125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 22.4416206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8015746008
MESH:D001919 Bradycardia Phenylephrine 4.6315306635
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9820435547
MESH:D001943 Breast Neoplasms Tretinoin 1.9816166294 16443354 16873071
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.2415286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.0717687719 10378619
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.6716813970
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8416835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.2616168501
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 1.891917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3016051514 16096774
MESH:D006332 Cardiomegaly Phenylephrine 6.9811754973 17287366 15728586 16170337 17124262 11179087
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.9818670907 18850075 16120746
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9115710769 19225199
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 3.5516936243
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.1718974383
MESH:D002386 Cataract Tretinoin 3.1217460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.6716129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2116835633
MESH:D002779 Cholestasis pirinixic acid 2.8619176532
MESH:D002822 Choriocarcinoma Tretinoin 5.2616461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.8312621046 8697196 15340226 16354765 15668235
MESH:D002972 Cleft Palate Tretinoin 5.839407595
MESH:D003092 Colitis Tretinoin 3.7817035595
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4615322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.469224671 17551590 9211117 16925845 9664655 10589399 14991402 8800419 9142499 9125849
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4518249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D056486 Drug-Induced Liver Injury Amiodarone 3.9015265979 18218290
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.9020420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8011462148
MESH:D004487 Edema Mustard Gas 11.7511402378 9260866 11428631 11428647
MESH:D004487 Edema pirinixic acid 11.7512083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 11.7511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 12.2716714409 15322242 18230668
MESH:D004489 Edema, Cardiac Tretinoin 12.2718230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.1416569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0710568697 9294722
MESH:D019446 Endotoxemia Lipopolysaccharides 4.4815328337 17637181 15821434
MESH:D004890 Erythema Mustard Gas 5.249357497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.9711564622
MESH:D005124 Eye Abnormalities Tretinoin 8.9716938888 9664655
MESH:D005234 Fatty Liver Amiodarone 7.9914986274
MESH:D005234 Fatty Liver pirinixic acid 7.9919236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5311858732
MESH:D005334 Fever Lipopolysaccharides 4.069205823 11852909
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.8620067830
MESH:D005355 Fibrosis Tretinoin 8.8617994277
MESH:D005909 Glioblastoma Tretinoin 3.0417312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6910696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2216096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.2616084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6211294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 6.6214991402 9664655
MESH:D006333 Heart Failure pirinixic acid 2.5720558911
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.4316366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3911000095
MESH:D006529 Hepatomegaly Amiodarone 14.8615265979
MESH:D006529 Hepatomegaly pirinixic acid 14.8619176532 16221962 18467677 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 14.8612621046 15340226 16120746
MESH:D015658 HIV Infections 2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone 8.3017631934
MESH:D015658 HIV Infections deferasirox 8.3017631934
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1416354765 8697196 16959395 18606429 15340226
MESH:D006930 Hyperalgesia Tretinoin 3.2516870215
MESH:D006937 Hypercholesterolemia Amiodarone 3.938137927 9751232
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.6416778211
MESH:D006943 Hyperglycemia pirinixic acid 3.2320558911
MESH:D006973 Hypertension Phenylephrine 5.378949925 12717712
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.3718670907 18850075
MESH:D006984 Hypertrophy Phenylephrine 4.6112791704 18502941
MESH:D007037 Hypothyroidism Amiodarone 4.5918020914 17991464
MESH:D007249 Inflammation Lipopolysaccharides 8.5517237260 17963957 9205823 17255318 12878042
MESH:D007249 Inflammation Mustard Gas 8.559357497 8975870 16001271 11428620 11402378 17524151 11428631 9260866 11428647
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.5512200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.6616306350
MESH:D007410 Intestinal Diseases Tretinoin 3.8417994277
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.6917255318
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.1216580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.1217551590 15992940
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 4.3316518626
MESH:D007938 Leukemia Tretinoin 2.7917143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.7519285840 16932348 16482212
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0817596541 19850784 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.1919642359 19075265 9834237 17361223 17294898 19225113 17339181 19029980 17217047 17506722 16891316 16788101 16823087 12679006 17712046 17368321 17649720 16935935 19035177 17301526 16140955 15748426 17107899 16331271 16766008
MESH:D007970 Leukopenia Lipopolysaccharides 4.7815821434
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.349224671
MESH:D008064 Lipidoses Amiodarone 3.5517567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 5.0012878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 5.0015474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.0012878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 5.0016248980 18397230
MESH:D008113 Liver Neoplasms pirinixic acid 4.3120007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.3116984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.1412151625
MESH:D008133 Long QT Syndrome Amiodarone 3.6217391786 15350150 11989578
MESH:D008171 Lung Diseases Amiodarone 7.7412587719
MESH:D008171 Lung Diseases Mustard Gas 7.7418702808 18161513
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.5818516814
MESH:D055370 Lung Injury Lipopolysaccharides 4.0821114838
MESH:D008175 Lung Neoplasms Mustard Gas 2.428781369 3148597
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.4219555203 11884234
MESH:D008527 Medulloblastoma Tretinoin 2.8017453147
MESH:D008545 Melanoma Tretinoin 1.9516752155
MESH:D008591 Meningomyelocele Tretinoin 4.5016940565
MESH:D009041 Motion Sickness Dextroamphetamine 5.621613127
MESH:D009135 Muscular Diseases pirinixic acid 3.5816239165
MESH:D009181 Mycoses Amiodarone 5.0017974566 12754197
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1117596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1619151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0612213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9916411023
MESH:D009369 Neoplasms pirinixic acid 4.9917405874
MESH:D009369 Neoplasms Tretinoin 4.9916594593 16946489
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.7314600291
MESH:D009421 Nervous System Malformations Tretinoin 9.739125849
MESH:D009436 Neural Tube Defects Tretinoin 3.099142499
MESH:D009503 Neutropenia Mustard Gas 4.0316761898 7688884
MESH:D009765 Obesity pirinixic acid 1.8220558911
MESH:D010051 Ovarian Neoplasms Tretinoin 2.3616936753
MESH:D010146 Pain Tretinoin 2.9516870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.4815976015
MESH:D010212 Papilloma Hydrogen Peroxide 4.1612065085
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3512520081
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 5.6011550810
MESH:D011014 Pneumonia Lipopolysaccharides 4.6411605937 12224865
MESH:D011041 Poisoning Mustard Gas 3.8515727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6218163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2711896295 11222880 11118676 11399792
MESH:D011507 Proteinuria Tretinoin 3.6616636307
MESH:D011537 Pruritus Mustard Gas 4.1718058305
MESH:D011625 Pterygium Tretinoin 4.8816723453
MESH:D011658 Pulmonary Fibrosis Amiodarone 5.9112490602 12832656 11597910
MESH:D011658 Pulmonary Fibrosis Mustard Gas 5.9110334151 17266442 17720292 17894541 17620002
MESH:D015427 Reperfusion Injury pirinixic acid 2.4119058328
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.7610835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9018990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.1616116481 16283617
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.1718724381
MESH:D012852 Sinusitis Phenylephrine 4.787327846
MESH:D012871 Skin Diseases Mustard Gas 2.7312880345 15451306 16961503
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 9.6212065085
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.6216192470
MESH:D012878 Skin Neoplasms Tretinoin 9.6216467112
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013276 Stomach Ulcer Amiodarone 3.3718087811
MESH:D013610 Tachycardia Amiodarone 4.3511238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.2519225199
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.2115821434
MESH:D013959 Thyroid Diseases Amiodarone 12.3819731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 12.3812697716
MESH:D013964 Thyroid Neoplasms Tretinoin 3.0617045167 16026305
MESH:D013971 Thyrotoxicosis Amiodarone 4.9318020914 19584973
MESH:D014062 Tongue Neoplasms Tretinoin 3.8416051514
MESH:D016171 Torsades de Pointes Amiodarone 4.2711989578 17467628
MESH:D014376 Tuberculosis Tretinoin 3.2616040207
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.7316129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.7116752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6912125929
MESH:D014820 Vitiligo Tretinoin 4.1216761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3515886252
MESH:D009396 Wilms Tumor Tretinoin 4.0216287080
Pathway ID Pathway Name
REACT:1892 Elongation arrest and recovery
REACT:71 Gene Expression
REACT:6185 HIV Infection
REACT:769 Pausing and recovery of elongation
REACT:1788 Transcription
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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