AutismKB 2.0

Annotation Detail for SH2D2A


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Basic Information Top
Gene Symbol:SH2D2A ( F2771,SCAP,TSAD,VRAP )
Gene Full Name: SH2 domain containing 2A
Band: 1q23.1
Quick LinksEntrez ID:9047; OMIM: 604514; Uniprot ID:SH22A_HUMAN; ENSEMBL ID: ENSG00000027869; HGNC ID: 10821
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04370VEGF signaling pathway
No data
Pathway IDPathway Name
200161Signaling events mediated by VEGFR1 and VEGFR2
200113ErbB1 downstream signaling
Pathway IDPathway Name
P00056VEGF signaling pathway
P00005Angiogenesis
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2231Arthritis
Desease Name
rheumatoid arthritis
multiple sclerosis
IMMUNE
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of SH2D2A mRNAdecreases expression 17555576
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of SH2D2A mRNAincreases expression 17616710
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 5.0117505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.9014692618
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 4.2311256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.9315885639
MESH:D002779 Cholestasis Ethinyl Estradiol 3.2417681005 17110522 16919318 15861022 16105132 11677210 17333356
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.8612538720
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 2.8615623463 16510608 15264214 15547733 15547721 16805852 15150132 15878914 16704527
MESH:D005234 Fatty Liver Ethinyl Estradiol 3.3615345470
MESH:D007021 Hypospadias Ethinyl Estradiol 4.5716569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 4.0712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.7917937319
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.2911578682
MESH:D011537 Pruritus Ethinyl Estradiol 4.2016919318 15861022
MESH:D013088 Spermatocele Ethinyl Estradiol 5.0116709447
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 2.3317575124 12958204
MESH:D019851 Thrombophilia Ethinyl Estradiol 4.2311994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.6215669648
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.9714692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 4.0914671159 15869587
Pathway ID Pathway Name
KEGG:04370 VEGF signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA35729
    • No data
    No data
    Releated drug ID Related drug Name
    PA448478l-arginine
    PA450635nitric oxide
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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