AutismKB 2.0

Annotation Detail for CCNT2


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Basic Information Top
Gene Symbol:CCNT2 ( FLJ90560,MGC134840 )
Gene Full Name: cyclin T2
Band: 2q21.3
Quick LinksEntrez ID:905; OMIM: 603862; Uniprot ID:CCNT2_HUMAN; ENSEMBL ID: ENSG00000082258; HGNC ID: 1600
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Elongation arrest and recovery
Pausing and recovery of elongation
Transcription
Gene Expression
HIV Infection
No data
No data
Pathway IDPathway Name
500949RNA Polymerase II Pre-transcription Events
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of CCNT2 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of CCNT2 mRNAaffects expression 21346803
D001554 Benzene Benzene results in increased expression of CCNT2 mRNAincreases expression 15929907
D020111 Chlorodiphenyl (54% Chlorine) Chlorodiphenyl (54% Chlorine) results in increased expression of CCNT2 mRNAincreases expression 16934159
D016572 Cyclosporine Cyclosporine results in increased expression of CCNT2 mRNAincreases expression 20106945
D004958 Estradiol Estradiol results in decreased expression of CCNT2 mRNAdecreases expression 20068009
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CCNT2 mRNAaffects binding|decreases expression|increases activity 19710929
D014415 Tunicamycin Tunicamycin results in increased expression of CCNT2 mRNAincreases expression 17127020
C066075 vanadium pentoxide vanadium pentoxide affects the expression of CCNT2 mRNAaffects expression 17459161
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D000230 Adenocarcinoma Estradiol 2.1411473722
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7616434500
MESH:D000741 Anemia, Aplastic Benzene 4.5317661222 11369114 14761424
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3519483382
MESH:D001855 Bone Marrow Diseases Benzene 5.5516183116
MESH:D001943 Breast Neoplasms Benzene 2.3511921183 17162533
MESH:D001943 Breast Neoplasms Estradiol 2.3517289903 16675129 17261762 12948864 18497071 19861407 14630087 17018787
MESH:D001991 Bronchitis vanadium pentoxide 6.5617459161
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.7516111702
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.7116705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.7116705839
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.7116924424
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.956135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.9512371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 11.9518566989
MESH:D002779 Cholestasis Cyclosporine 8.2619486331
MESH:D002779 Cholestasis pirinixic acid 8.2619176532
MESH:D019465 Craniofacial Abnormalities Benzene 2.4515643154
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.7718551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.7718551238
MESH:D003872 Dermatitis Benzene 5.0215902427
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D003928 Diabetic Nephropathies Estradiol 3.5919279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.6721346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.6718551238 21346803
MESH:D056486 Drug-Induced Liver Injury Chlorodiphenyl (54% Chlorine) 6.6717851650
MESH:D004487 Edema pirinixic acid 2.6812083418
MESH:D016889 Endometrial Neoplasms Estradiol 3.1118566989 11473722 19148513
MESH:D005234 Fatty Liver Cyclosporine 8.2519224547
MESH:D005234 Fatty Liver pirinixic acid 8.2519236843 20131406
MESH:D005355 Fibrosis Cyclosporine 3.4012639820 12168785
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.508708960
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006402 Hematologic Diseases Benzene 4.8716183116
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7115720958
MESH:D006529 Hepatomegaly pirinixic acid 3.2518467677 16221962 19772884 19176532
MESH:D006558 Herpes Genitalis Estradiol 5.3515709030
MESH:D019584 Hot Flashes Estradiol 4.0717088409
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D006973 Hypertension Benzene 5.6117940673
MESH:D006973 Hypertension Cyclosporine 5.6110903974
MESH:D007333 Insulin Resistance Estradiol 7.6216627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 7.6216306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7615604871
MESH:D007674 Kidney Diseases Cyclosporine 6.3018776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 6.3015618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 19.2216705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 19.2216705839
MESH:D007680 Kidney Neoplasms Cyclosporine 19.2212371664
MESH:D007680 Kidney Neoplasms Estradiol 19.2215610895
MESH:D007938 Leukemia Benzene 3.4818335105 17119257 14694614 15935818
MESH:D007951 Leukemia, Myeloid Benzene 4.5217506065
MESH:D015470 Leukemia, Myeloid, Acute Benzene 2.7219478238
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.3514659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3515474484
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.637678174
MESH:D008113 Liver Neoplasms pirinixic acid 4.6320007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.572876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental Benzene 6.5712562636
MESH:D017563 Lung Diseases, Interstitial Benzene 5.1314698565
MESH:D008175 Lung Neoplasms Benzene 3.2812562636
MESH:D008175 Lung Neoplasms vanadium pentoxide 3.2812376484
MESH:D008223 Lymphoma Benzene 3.8817119257 17584886
MESH:D015674 Mammary Neoplasms, Animal Benzene 4.7312562636
MESH:D008325 Mammary Neoplasms, Experimental Benzene 6.6411921183
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.6411807958 16891317 17203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.8019453300
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1116801185
MESH:D009101 Multiple Myeloma Benzene 3.8017119195
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.7816810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.7816411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.3218551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.327678174 18551238
MESH:D009369 Neoplasms pirinixic acid 2.0317405874
MESH:D009389 Neovascularization, Pathologic Estradiol 4.0217289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4718481113 19348381
MESH:D009421 Nervous System Malformations Estradiol 3.8916427766 11399458
MESH:D009436 Neural Tube Defects Benzene 3.8015643154
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 16.3316049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 16.3316049721
MESH:D009784 Occupational Diseases Benzene 16.3315935809 15727169 15576619 17119257 16737584 17479406 15913788 17178637 15612468
MESH:D010051 Ovarian Neoplasms Benzene 5.2212562636
MESH:D010051 Ovarian Neoplasms Estradiol 5.2219401270
MESH:D011230 Precancerous Conditions Cyclosporine 3.4012371664
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0920887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.0516740699
MESH:D011565 Psoriasis Cyclosporine 2.2916882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D012640 Seizures 2,4-dinitrotoluene 6.3218551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.3218551238
MESH:D013274 Stomach Neoplasms Benzene 2.4212562636
MESH:D013953 Thymus Neoplasms Benzene 5.2410850423
MESH:D013978 Tibial Fractures Estradiol 5.0019048282
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.2416049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.2416049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.9610091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.9610091137
MESH:D014594 Uterine Neoplasms Benzene 4.5712562636
MESH:D014605 Uveitis Cyclosporine 4.301336536
MESH:D014985 Xerophthalmia Cyclosporine 4.7617120751
Pathway ID Pathway Name
REACT:1892 Elongation arrest and recovery
REACT:71 Gene Expression
REACT:6185 HIV Infection
REACT:769 Pausing and recovery of elongation
REACT:1788 Transcription
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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