AutismKB 2.0

Annotation Detail for SCRN2


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Basic Information Top
Gene Symbol:SCRN2 ( Ses2 )
Gene Full Name: secernin 2
Band: 17q21
Quick LinksEntrez ID:90507; OMIM: NA; Uniprot ID:SCRN2_HUMAN; ENSEMBL ID: ENSG00000141295; HGNC ID: 30381
Relate to Another Database: SFARIGene; denovo-db
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Chemical ID Chemical Name Interaction Interaction Action Publication
D003474 Curcumin Curcumin results in decreased expression of SCRN2 mRNAdecreases expression 17198877
D016572 Cyclosporine Cyclosporine results in decreased expression of SCRN2 mRNAdecreases expression 20106945
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of SCRN2 mRNAaffects cotreatment|increases expression 17183730
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of SCRN2 mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 4.118875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.3519490988
MESH:D019973 Alcohol-Related Disorders Curcumin 5.8017887948
MESH:D000544 Alzheimer Disease Curcumin 2.6815590663
MESH:D000550 Amblyopia Valproic Acid 5.9617688650
MESH:D001008 Anxiety Disorders Valproic Acid 3.9017497229
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.8016807698
MESH:D050197 Atherosclerosis Curcumin 3.5318704882
MESH:D001321 Autistic Disorder Valproic Acid 1.9818316065 16609825 18985861 18396377 17157402 18775368 17507914 15238991 17688650 19460635 20603192 18177632 18558336 18940202 19232924
MESH:D001327 Autoimmune Diseases Curcumin 5.0519761891
MESH:D001714 Bipolar Disorder Valproic Acid 3.2417594078 20046352
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.638888407
MESH:D002545 Brain Ischemia Curcumin 4.9616770732
MESH:D001932 Brain Neoplasms Curcumin 4.3317596214
MESH:D001943 Breast Neoplasms Curcumin 2.7019250217 18462866 18593918 16243823
MESH:D002277 Carcinoma Curcumin 4.1618593918
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 3.0818414057
MESH:D002294 Carcinoma, Squamous Cell Curcumin 2.8518462866
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.7912371664
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.8220734317
MESH:D002779 Cholestasis Cyclosporine 3.2119486331
MESH:D003092 Colitis Curcumin 4.7416782535 16804969 18200517
MESH:D003103 Coloboma Curcumin 4.9818809619
MESH:D003110 Colonic Neoplasms Curcumin 2.5519359593 16340194
MESH:D016510 Corneal Neovascularization Curcumin 5.4618497527
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.9116575769 17688650 8888407
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 2.7718403477
MESH:D003928 Diabetic Nephropathies Curcumin 4.3818204486
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 2.2519641884 1733752
MESH:D004381 Duodenal Ulcer Curcumin 4.5517351913
MESH:D004421 Dystonia Valproic Acid 4.511851702
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.7117275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.643922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.1120417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.966254150 7562514 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.867750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.693659116
MESH:D005234 Fatty Liver Curcumin 15.7919297423
MESH:D005234 Fatty Liver Cyclosporine 15.7919224547
MESH:D005234 Fatty Liver Valproic Acid 15.7914986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 5.6116575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.648888407 18558336
MESH:D005355 Fibrosis Curcumin 10.8018705752
MESH:D005355 Fibrosis Cyclosporine 10.8012168785 12639820
MESH:D005770 Gastrointestinal Neoplasms Curcumin 5.2618462866
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.858708960
MESH:D005909 Glioblastoma Curcumin 3.7217596214
MESH:D006258 Head and Neck Neoplasms Curcumin 3.9118462866 18829502
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 5.0515720958
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 5.6017701891
MESH:D006849 Hydrocephalus Valproic Acid 5.5017688650
MESH:D006937 Hypercholesterolemia Curcumin 4.4818704882
MESH:D006973 Hypertension Cyclosporine 2.2110903974
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 5.1916612254
MESH:D007249 Inflammation Curcumin 3.0616956363 17151092 18403477
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.3318200517 18596194
MESH:D007414 Intestinal Neoplasms Curcumin 4.6110783313
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.1615604871
MESH:D007674 Kidney Diseases Cyclosporine 2.548314463 18776723 10903974
MESH:D007680 Kidney Neoplasms Cyclosporine 3.0812371664
MESH:D007889 Leiomyoma Curcumin 5.0318555241
MESH:D007938 Leukemia Curcumin 3.4118462866
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 4.6316106398
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.2017596541 16294345
MESH:D015458 Leukemia, T-Cell Curcumin 5.2716106398
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 2.2817355460 18705752 18006644
MESH:D008107 Liver Diseases Curcumin 2.6816956363
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.9817228818
MESH:D008175 Lung Neoplasms Curcumin 2.2816243823 19359593 18462866
MESH:D008223 Lymphoma Curcumin 3.8618462866
MESH:D016399 Lymphoma, T-Cell Curcumin 5.2616173963
MESH:D008545 Melanoma Curcumin 2.4517885582 18462866
MESH:D008569 Memory Disorders Curcumin 4.6617263510
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.5116801185
MESH:D008881 Migraine Disorders Valproic Acid 3.4718803445 18765137
MESH:D009101 Multiple Myeloma Curcumin 3.7919372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 5.5517962980
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.458888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.3517596541
MESH:D009361 Neoplasm Invasiveness Curcumin 4.8818495463
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 5.2612497104
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.1617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.6519348381 18481113
MESH:D009423 Nervous System Neoplasms Curcumin 6.3518462866
MESH:D009436 Neural Tube Defects Valproic Acid 3.3716359493 8888407
MESH:D009765 Obesity Curcumin 2.8219297423
MESH:D010024 Osteoporosis Curcumin 3.6918719352
MESH:D010051 Ovarian Neoplasms Curcumin 2.9118462866 19020741
MESH:D010190 Pancreatic Neoplasms Curcumin 3.0419401701 19196508 17440100
MESH:D011230 Precancerous Conditions Cyclosporine 3.5912371664
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.4620603192
MESH:D011471 Prostatic Neoplasms Curcumin 3.6211398177 15129424 18226269 18769126 12497104 18156803 10851300
MESH:D019310 Pseudolymphoma Valproic Acid 5.2612752131 11422049
MESH:D011565 Psoriasis Cyclosporine 2.3316882103
MESH:D011656 Pulmonary Emphysema Curcumin 4.9219168576
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 4.4910666014 18379247
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.6419155313
MESH:D012509 Sarcoma Curcumin 4.5118462866
MESH:D012559 Schizophrenia Valproic Acid 2.1015737665 19110320
MESH:D012640 Seizures Valproic Acid 2.9915475178 17978042 11738929 16876388 3137016 14763951 11044598 1511512
MESH:D018805 Sepsis Curcumin 4.4218389075
MESH:D016135 Spinal Dysraphism Valproic Acid 4.0919490988
MESH:D013226 Status Epilepticus Valproic Acid 5.2612833885
MESH:D013276 Stomach Ulcer Curcumin 3.9216631530 19188055
MESH:D014178 Translocation, Genetic Valproic Acid 5.9617262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 5.153119515
MESH:D001749 Urinary Bladder Neoplasms Curcumin 3.0118593936
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.208888407
MESH:D014565 Urogenital Neoplasms Curcumin 5.9018462866
MESH:D014605 Uveitis Cyclosporine 4.711336536
MESH:D014985 Xerophthalmia Cyclosporine 5.1617120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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